Retinal

Appears on 1 avoid lists

Included in 22 routines

Summary

Works for
  • Evens skin tone
  • Anti-blemish
  • Anti-aging
Irritancy risk
HIGH
WIMJ Team

One step removed from the biologically active in skin form of vitamin A. Once converted to the retinoic acid in the skin, retinal is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. Concentrations of 0.05% and 0.1% are shown to be effective. It can, however, be irritating

Products with Retinal

PROMISES
FULFILLED
100 /100
IRRITANCY
MEDIUM
Works for
  • Anti-aging
  • Anti-oxidation
  • Exfoliation
  • Moisturizing
+ 2 more
Key ingredients
  • niacinamide
  • gluconolactone
  • retinal
  • tetrahexyldecyl ascorbate
  • ceramide np
  • palmitoyl tetrapeptide-7
+ 25 more
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PROMISES
FULFILLED
100 /100
IRRITANCY
MEDIUM
Works for
  • Anti-aging
  • Anti-oxidation
  • Evens skin tone
  • Anti-blemish
+ 1 more
Key ingredients
  • retinal
  • betaine
  • butyrospermum parkii butter
  • camellia oleifera leaf extract
  • caprylic/capric triglyceride
+ 8 more
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PROMISES
FULFILLED
100 /100
IRRITANCY
MEDIUM
Works for
  • Anti-aging
  • Anti-oxidation
  • Evens skin tone
  • Anti-blemish
+ 1 more
Key ingredients
  • retinal
  • bakuchiol
  • astaxanthin
  • caprylic/capric triglyceride
  • helianthus annuus seed cera
+ 6 more
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PROMISES
FULFILLED
100 /100
IRRITANCY
MEDIUM
Works for
  • Anti-aging
  • Exfoliation
  • Moisturizing
  • Evens skin tone
+ 2 more
Key ingredients
  • lactic acid
  • retinal
  • palmitoyl oligopeptide
  • palmitoyl tetrapeptide-7
  • palmitoyl tripeptide-38
  • carnitine
+ 8 more
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PROMISES
FULFILLED
100 /100
IRRITANCY
HIGH
Works for
  • Anti-aging
  • Anti-oxidation
  • Exfoliation
  • Evens skin tone
+ 2 more
Key ingredients
  • salicylic acid
  • retinal
  • bakuchiol
  • caprylic/capric triglyceride
  • centella asiatica extract
  • cetearyl alcohol
+ 6 more
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PROMISES
FULFILLED
100 /100
IRRITANCY
HIGH
Works for
  • Anti-aging
  • Anti-oxidation
  • Exfoliation
  • Moisturizing
+ 2 more
Key ingredients
  • gluconolactone
  • retinal
  • ceramide 3
  • allantoin
  • glycerin
  • helianthus annuus seed oil
+ 4 more
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PROMISES
FULFILLED
100 /100
IRRITANCY
MEDIUM
Works for
  • Anti-aging
  • Evens skin tone
  • Anti-blemish
Key ingredients
  • retinal
  • bisabolol
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PROMISES
FULFILLED
100 /100
IRRITANCY
HIGH
Works for
  • Anti-aging
  • Anti-oxidation
  • Exfoliation
  • Moisturizing
+ 2 more
Key ingredients
  • niacinamide
  • ascorbic acid
  • retinal
  • niacinamide
  • alanine
  • aminobutyric acid
+ 30 more
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PROMISES
FULFILLED
100 /100
IRRITANCY
HIGH
Works for
  • Anti-aging
  • Exfoliation
  • Moisturizing
  • Evens skin tone
+ 1 more
Key ingredients
  • retinyl retinoate
  • retinal
  • 3-o-ethyl ascorbic acid
  • copper heptapeptide-14 pantothenate
  • heptapeptide-15 palmitate
+ 19 more
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PROMISES
FULFILLED
100 /100
IRRITANCY
MEDIUM
Works for
  • Anti-aging
  • Evens skin tone
  • Anti-blemish
Key ingredients
  • retinal
  • phenylethyl resorcinol
  • tranexamic acid
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Questions

Clinical trials review

Number of participants Participants Interventions Punchline
40 40 healthy Korean female volunteers >30 years old. The exclusion criteria were facial dermatosis, a known allergy to any cosmetic ingredient, and prior use of topical or systemic retinoids or steroids. Either the RAL 0.1% or RAL 0.05% cream was applied twice daily. The study duration was 12 weeks and included four assessment visits: an inclusion visit in week 0 (baseline), and three further visits at 4, 8, and 12 weeks The 3-month application improved overall photoaging in both RAL 0.1% (95%) and RAL 0.05% groups (95%). Both RAL 0.1% and RAL 0.05% afforded significant textural improvements (13.7% and 12.6%, respectively), reduced the TEWL (14.5%, 17.9%), and increased hydration (10.2%, 6.0%); however, no statistical differences were observed between two groups. Only RAL 0.1% significantly improved the melanin index (by 6.5%)

Efficacy and safety of retinaldehyde 0.1% and 0.05% creams used to treat photoaged skin: A randomized double-blind controlled trial

Number of participants Participants Interventions Punchline
40 Women over 35 years of age, with moderate to severe photodamage Patients applied either retinaldehyde 0.05% on their faces once daily for 1 year, or were left untreated (emollient only, control group). Compared to the control group, retinaldehyde treatment induced a significant increase in epidermal thickness of the temple, as well as in cutaneous elasticity (p < 0.01). Similarly, retinaldehyde treatment tended to increase dermal thickness and reduce cutaneous stiffness, but no statistical difference could be observed between the two groups.

Efficacy of topical 0.05% retinaldehyde in skin aging by ultrasound and rheological techniques

Number of participants Participants Interventions Punchline
55 Subjects included were female volunteers (age 35-55 years) with skin phototype I-III according to Fitzpatrick classification with at least 1 deep, long (≥1 cm) wrinkle on the flat part of the crow’s feet area, and the presence of periorbicular fine lines and wrinkles. Facial hygiene regimens had to be kept unchanged and be well tolerated for at least 4 weeks before inclusion Participants were randomized in 2 treatment groups: (1) Daily application of the antiaging cream for 8 weeks or (2) Three sequential GA peels (20%, 50%, and 70%), 2-3 weeks apart. : Efficacy of both treatments was similar in reducing crow’s feet wrinkles depth (STm 7.61%, P = .0007 vs 4.34%, P = .0348; P = .3049 intergroup) and volume, crow’s feet and periorbital wrinkle length, and number of fine lines and wrinkles at end of treatments. The efficacy of the cream in refining skin texture was superior to the peels (contrast: 5.61%, P = .0025 vs +3.54, P = .08; P intergroup = .0252). The 8-week treatment with the antiaging cream was well tolerated; adverse events were fewer and of milder intensity than with the peels, (12-fold lower incidence of physical signs).

Antiaging efficacy of a retinaldehyde-based cream compared with glycolic acid peel sessions: A randomized controlled study

Scientifc sources

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