GLUCONOLACTONE

Description

A polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals

Sources

Scientific paper review

A comparative study of gluconolactone versus benzoyl peroxide in the treatment of acne
n Participants Interventions Punchline
150 76 male and 74 female patients with mild to moderate acne (older than 12 years, free from intercurrent disease, and not taking systemic antibiotics, corticosteroids, retinoids, anticonvulsants or androgens in the 30 days prior to starting the trial. No topical acne therapy was allowed in the two weeks before the trial. Female patients were not to have commenced or ceased the oral contraceptive pill in the six months before the trial, and males were to be without beards and moustaches.) The patients were randomized into three treatment groups: benzoyl peroxide 5% (n = 50), gluconolatone 14% (n = 50) and its vehicle (placebo) (n = 50). Gluconolactone group: lotion with 14% aqueous solution of gluconolactone. Placebo: its vehicle ie. base lotion minus the gluconolactone. The benzoyl peroxide: a commercially available 5% benzoyl peroxide water-based lotion. Duration: 12 weeks 14% Gluconolactone lotion is effective as a topical treatment for acne. Gluconolactone is as effective as benzoyl peroxide in reducing the number of inflamed and total lesions, though slightly less effective in reducing the number of non-inflamed lesions. Clinical assessment and self-report of sideeffects showed that the gluconolactone was far better tolerated by facial skin.

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