Tretinoin
In 25 skincare routines
Summary
Works for
- Anti-aging
- Anti-oxidation
- Evens skin tone
- Mattifying
- Anti-blemish
Irritancy risk
3
HighBioavailable form of Vitamin A that is the most effective known topical ingredients for reducing wrinkles, improving skin firmness, treating acne, as well as hyperpigmentation. It is not available over-the counter in many countries, including US and UK
Where this fits
Products with Tretinoin
MuselyThe Anti-Aging Creamniacinamidetretinoincyclopentasiloxane +5 actives
Anti-blemish Moisturizing +3
Price unavailable
CORDES® VASCremeVitamin Ctretinoinisopropyl myristate
Anti-blemish Evens skin tone +3
Fragrance
Price unavailable
Ortho DermatologicsAltreno LotionMineral oiltretinoinglycerin +2 actives
Anti-blemish Anti-aging +3
Price unavailable
Galderma RetacnylCream 0.025% 0.05% Tretinointretinoinglycerinisopropyl myristate +1 actives
Anti-aging Anti-blemish +2
Price unavailable
Menarini GroupA-Ret Tretinoin Gel 0.025%tretinoincaprylic/capric triglyceridecyclopentasiloxane
Anti-aging Anti-blemish +3
Price unavailable
Similar ingredients
Anti-aging
1-TRIMETHYL-2-CYCLOHEXENYL-1-PENTEN-3-ONEACETYL GLUCOSAMINEAn effective moisturizing ingredient that also has been shown to be effective in evening out the skin tone and reducing hyperpigmentation. It can help somewhat reduce wrinkles in skinGLYCOLIC ACIDAn alpha-hydroxy acid (AHA) that helps to remove the dead skin cells on the surface of the skin reveling a more even, smoother complexation. It is also able to stimulate collagen production with long-term use. Could help to reduce pore congestion. It can be irritating to the skin. Apply sunscreen daily if using products with glycolic acidHEPTAPEPTIDE-15 PALMITATEA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinklesPALMITOYL HEXAPEPTIDE-12A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinklesRETINOLTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritatingTETRAHEXYLDECYL ASCORBATEBeing a lipid soluble form of vitamin C, it is more stable. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. GLUCONOLACTONEA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicalsMALTOBIONIC ACIDA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is genter than AHAs. In addition, it helps attract water to the upper layer of the skin. It has been shown to be helpful against acne and clogged pores. Might help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicalsLACTOBIONIC ACIDA polyhydroxy acid (PHA) that helps shed dead cells from the surface of the skin revealing a smoother, more even skin. PHAs tend to be gentler on the skin compared to AHAs (for example, glycolic acid). It also has hydrating properties and helps attract water to the upper layer of the skin. It can help calm down inflammation in skin and support restoration of the barrier function. It has an anti-oxidant effect as well. It can help reduce fine line, wrinkles and improve skin elasticity GLUCONIC ACIDA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in imporved hydration levels. It has been shown to be helpful against acne and clogged pores. Might help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicalsRETINYL PROPIONATEThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores, even thought its potency is not as well established as in case of retinol or retinaldehydeBAKUCHIOLA plant extract that is, though different in chemical structure, acts similar to retinoids. First studies show that it can help reduce fine lines and wrinkles, improve skin tone, reduce clogged pores and blemishes, and reduce inflammation. There is no conclusive evidence that bakuchiol is as effective as retinol however. The study that directly compared retinol with bakuchiol used bakuchiol applied twice daily compared to once per day for the retinol. According to this study, bakuchiol is less irritating than retinol. Bakuchiol is extracted from seeds of Babchi plant. Other parts of the plant contain coumarins that could cause allergic and irritant reactions. These compounds should be removed in the extraction process when bakuchiol is produced, but it is a good idea to be cautious and stay away from products that include the Babchi plant extracts other than purified bakuchiol to avoid irritationADAPALENEA retinoid that is effective against acne and keratosis pilaris. It can also help reduce signs of aging (fine lines, wrinkles, loss of elasticity) and can improve skin toneRETINYL RETINOATEA "hybrid" of retinol and retinoic acid. It is more stable than retinol and is likely to be more effective based on the early research data available. Is as irritating as retinolRETINYL LINOLEATEAn ester of a retinoid and linoleic acid. Three steps removed from the bioactive form of retinoid, retinoic acid. Once converted to retinoic acid in skin, it can help reduce wrinkles, stimulate collagen production, even out skin tone and reduce blemishes. The concentrations used in cosmetic products are often not high enough to have a positive effect in skin. PALMITOYL DIPEPTIDE-28 D-SERINE DIPEPTIDE-7 PALMITAMIDECIS-RETINOIC ACIDDECAPEPTIDE-22A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinklesOCTAPEPTIDE-2A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinklesACETYL TYROSINAMIDEAn amino acid derivative. A manufacturer's study shows that it can help somewhat reduce wrinkles when used in combination with a low concentration of glycolic acid. No independent human in-vivo studies of this compound are availableHYDROXYPINACOLONE RETINOATEA derivative of the most potent form of vitamin A, retinoic acid. The ingredient can be sold under name Granactive Retinoid. Note that if a skincare brand discloses the concentration of Granactive Retinoid in a product, the concentration refers to a diluted form of Hydroxypinacolone Retinoate: 1% of Granactive Retinoid corresponds to 0.1% of Hydroxypinacolone Retinoate. Hydroxypinacolone Retinoate (HPR) is a unique derivative of retinoic acid because it can directly work in the skin and does not require additional conversion steps. According to studies done by the manufacturer on models of human skin (not real people), this derivative is more effective than other cosmetic versions of retinoids (such as retinol, retinaldehyde, and retinyl palmitate), and, at the same time, causes less irritation. It has been also demonstrated to be more stable than retinol which makes formulating with easier and increases the chances that a product with it will maintain its effectiveness after opening. The packaging should still ideally be air-tight. HPR is available over the counter in the EU, UK, Asia, Australia and New Zealand, but is only with a prescription in Canada.RETINALOne step removed from the biologically active in skin form of vitamin A. Once converted to the retinoic acid in the skin, retinal is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. Concentrations of 0.05% and 0.1% are shown to be effective. It can, however, be irritatingASCORBIC ACIDThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of agingNIACINAMIDEIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture
Anti-oxidation
ASCORBIC ACIDThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of agingRETINOLTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritatingETHYLBISIMINOMETHYLGUAIACOL MANGANESE CHLORIDEA potent anti-oxidant that can help neutralize free radicals in skin and protect from harmful effects of sun exposure, even though more studies are needed to confirm its effectiveness in topical applicationsTOCOPHEROLPure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itselfERGOTHIONEINECan help neutralize free radicals in skin. Preliminary studies show that it can be more effective than coenzyme Q10 but studies on effective concentration for topical applications are lackingGLYCYRRHETINIC ACIDActive compound of licorice root. Works to calm down inflammation, as an anti-oxidant, and might be helpful in lightening the skin and reducing hyperpigmentationTETRAHEXYLDECYL ASCORBATEBeing a lipid soluble form of vitamin C, it is more stable. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. UBIQUINONECoenzyme Q10. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergenFERULIC ACIDA potent anti-oxidant that has been shown to be effective in neutralizing free radicals in skin. There seem to have a synergetic effect of ferulic acid, vitamin E and C, meaning that when the ingredients are used together, they enhance each other's ability protect the skin against free radicals. Ferulic acid also helps to stabilize other ingredients - including vitamins C and E. It can help to even out the skin tone. Ferulic acid is approved for use as a sunscreen ingredient in Japan in concentrations up to 10% VITIS VINIFERA SEED EXTRACTA plant extract that contains resveratrol and other anti-oxidant compounds that can help neutralize free radicals, reduce inflammation in skin and even out its tone. Can be also used to stabilize the product formulationLACTOBIONIC ACIDA polyhydroxy acid (PHA) that helps shed dead cells from the surface of the skin revealing a smoother, more even skin. PHAs tend to be gentler on the skin compared to AHAs (for example, glycolic acid). It also has hydrating properties and helps attract water to the upper layer of the skin. It can help calm down inflammation in skin and support restoration of the barrier function. It has an anti-oxidant effect as well. It can help reduce fine line, wrinkles and improve skin elasticity TOCOTRIENOLSA type of vitamin E that is more powerful in neutralizing free radicals compared to its other formsCARNOSINEA type of peptide. It attracts water to the upper layer of the skin. It can help neutralize free radicals in skin combatting the sun damageLYCOPENEHelps neutralize free radicals in skin combating sun damage. Adds a red color to the productHYDROXYDECYL UBIQUINONEAn analogue of coenzyme Q10 that has a lower molecular weight, which can improve its ability to penetrate the skin. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergenRESVERATROLHelps neutralize free radicals in skin and might help reduce fine lines and wrinkles, as well as even out the skin toneGLUCONIC ACIDA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in imporved hydration levels. It has been shown to be helpful against acne and clogged pores. Might help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicalsASTAXANTHINHelps neutralize free radicals in skin and might help to calm down inflammationGALACTOMYCES FERMENT FILTRATEA yeast ferment filtrate (also known as Pitera - a trademarked name for the filtrate reserved by the SK-II brand). It helps attract water to the upper layer of the skin, can help neutralize antioxidants and can be helpful in evening out the skin tone. It might be somewhat helpful in preventing premature skin aging but solid evidence is lacking. A small manufacturer study also shows that, when used in high concentrations, it can help reduce sebum production and help against blocked pores3-GLYCERYL ASCORBATEA moisturizing vitamin C derivative. It is considered to be one of the most stable ones. It is effective in neutralizing free radicals and can help to even out the skin tone if used in high enough concentration3-O-ETHYL ASCORBIC ACIDA vitamin C derivative that is more stable but less potent than pure form of vitamin C. Can help neutralize free radicals and help reduce hyperpigmentation, but the required concentration is likely to be much higher than for the pure form of vitamin C, limiting the ingredient's effectiveness in productsMADECASSOSIDEAn antioxidant that is typically derived from plant Centella Asiatica. It can help neutralize free radicals in skin and support skin barrier function. It could, however, itself be irritating. It is often unstable in formulationsBAKUCHIOLA plant extract that is, though different in chemical structure, acts similar to retinoids. First studies show that it can help reduce fine lines and wrinkles, improve skin tone, reduce clogged pores and blemishes, and reduce inflammation. There is no conclusive evidence that bakuchiol is as effective as retinol however. The study that directly compared retinol with bakuchiol used bakuchiol applied twice daily compared to once per day for the retinol. According to this study, bakuchiol is less irritating than retinol. Bakuchiol is extracted from seeds of Babchi plant. Other parts of the plant contain coumarins that could cause allergic and irritant reactions. These compounds should be removed in the extraction process when bakuchiol is produced, but it is a good idea to be cautious and stay away from products that include the Babchi plant extracts other than purified bakuchiol to avoid irritationAZELAIC ACIDIs produced by a yeast that lives on normal human skin. It is used in medicine as a topical treatment for mild to moderate acne. It has a mild exfoliating effect. It can also help reduce hyperpigmentation, helps calm down inflammation and can help neutralize free radicalsKOJIC ACIDHelps to reduce hyperpigmentation and neutralize free radicals. Can be irritatingRETINYL LINOLEATEAn ester of a retinoid and linoleic acid. Three steps removed from the bioactive form of retinoid, retinoic acid. Once converted to retinoic acid in skin, it can help reduce wrinkles, stimulate collagen production, even out skin tone and reduce blemishes. The concentrations used in cosmetic products are often not high enough to have a positive effect in skin. ARGININE PCAAn amino-acid. Helps attract water to the upper layer of the skin and can help neutralize free radicals in skinTHIOCTIC ACIDASIATICOSIDEAn active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (madecasosside, asiatic
acid and madecassic acid), asiaticoside has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritatingCAMELLIA SEED OILOil from tea seeds. Can help neutralize free radicals in skinPHLORETINAn antioxidant. Can help neutralize free radicals in skinCAMELLIA OLEIFERA LEAF EXTRACTA plant extract that can help neutralize free radicals and reduce inflammation, even though it is not usually used in sufficient concentration in cosmeticsEPIGALLOCATECHIN GALLATYL GLUCOSIDEA synthetic version of green tea polyphenol that helps neutralize free radicals in skinDIMETHYLMETHOXY CHROMANOLCan help neutralize free radicals in skinSUPEROXIDE DISMUTASEAn antioxidant enzyme that is naturally present in skin. It can help support skin barrier function and reduce inflammation in skin. It is used in topical medications for inflammatory skin conditions including atopic dermatitis (eczema) and psoriasis. There are three types of natural Superoxide Dismutase in human skin. The compound used in topical treatments and cosmetics are mimics of typically one of these natural variantsCAMELLIA SINENSIS CATECHINSA group of chemical compounds extracted from Green Tea. They can help neutralize free radicals in skin. Might be able to help repair sun damage and clam down inflammation in skinGLUTATHIONEA peptide that can help neutralize free radicals in skin and reduce melanin production resulting in skin lightening effect and reduction in hyperpigmentation. It can also help attract moisture to the upper layer of the skinPOLYGONUM AVICULARE EXTRACTA plant extract that contains a flavanol Juglanin. It can help neutralize free radicals in skin and reduce inflammationASCORBYL TETRAISOPALMITATEA vitamin C derivative. Studies show that is might be effective in reducing hyperpigmentation, but there are no studies confirming that it is effectively converted into the bioavailable form of Vitamin C in skin. It is not clear how this derivative compares in effectiveness to the topical application of bioavailable form of vitamin C (L-ascorbic acid) PENTAPEPTIDE-34 TRIFLUOROACETATEA type of peptide that works as a great moisturizer. It might also have some anti-aging effect and help neutralize free radicals in skin
Evens skin tone
1-TRIMETHYL-2-CYCLOHEXENYL-1-PENTEN-3-ONEACETYL GLUCOSAMINEAn effective moisturizing ingredient that also has been shown to be effective in evening out the skin tone and reducing hyperpigmentation. It can help somewhat reduce wrinkles in skinGLYCOLIC ACIDAn alpha-hydroxy acid (AHA) that helps to remove the dead skin cells on the surface of the skin reveling a more even, smoother complexation. It is also able to stimulate collagen production with long-term use. Could help to reduce pore congestion. It can be irritating to the skin. Apply sunscreen daily if using products with glycolic acidLACTIC ACIDAn exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiom) NIACINAMIDEIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moistureHYDROXYPINACOLONE RETINOATEA derivative of the most potent form of vitamin A, retinoic acid. The ingredient can be sold under name Granactive Retinoid. Note that if a skincare brand discloses the concentration of Granactive Retinoid in a product, the concentration refers to a diluted form of Hydroxypinacolone Retinoate: 1% of Granactive Retinoid corresponds to 0.1% of Hydroxypinacolone Retinoate. Hydroxypinacolone Retinoate (HPR) is a unique derivative of retinoic acid because it can directly work in the skin and does not require additional conversion steps. According to studies done by the manufacturer on models of human skin (not real people), this derivative is more effective than other cosmetic versions of retinoids (such as retinol, retinaldehyde, and retinyl palmitate), and, at the same time, causes less irritation. It has been also demonstrated to be more stable than retinol which makes formulating with easier and increases the chances that a product with it will maintain its effectiveness after opening. The packaging should still ideally be air-tight. HPR is available over the counter in the EU, UK, Asia, Australia and New Zealand, but is only with a prescription in Canada.LACTOBIONIC ACIDA polyhydroxy acid (PHA) that helps shed dead cells from the surface of the skin revealing a smoother, more even skin. PHAs tend to be gentler on the skin compared to AHAs (for example, glycolic acid). It also has hydrating properties and helps attract water to the upper layer of the skin. It can help calm down inflammation in skin and support restoration of the barrier function. It has an anti-oxidant effect as well. It can help reduce fine line, wrinkles and improve skin elasticity TETRAHEXYLDECYL ASCORBATEBeing a lipid soluble form of vitamin C, it is more stable. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. GLUCONOLACTONEA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicalsMALTOBIONIC ACIDA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is genter than AHAs. In addition, it helps attract water to the upper layer of the skin. It has been shown to be helpful against acne and clogged pores. Might help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicalsELLAGIC ACIDCan help neutralize free radicals in skin. It can help prevent and treat hyperpigmentation and even out the skin toneORCHID LEAF/ROOT/STEM EXTRACTA plant extract that can help even out skin tone and reduce hyperpigmentation when used in high concentrationHYDROXYPHENOXY PROPIONIC ACIDHelps reduce hypepigmentation and even out the skin toneMANDELIC ACIDHelps shed the upper layer of dead cells from the surface of the skin revealing smoother, brighter skin. It can help to reduce hyperpigmentation. It has anti-bacterial properties, and might help to reduce blemishes, as well as fine lines and wrinkles. It is considered to be gentler than glycolic acidGLUCONIC ACIDA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in imporved hydration levels. It has been shown to be helpful against acne and clogged pores. Might help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicalsRETINYL PROPIONATEThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores, even thought its potency is not as well established as in case of retinol or retinaldehyde3-GLYCERYL ASCORBATEA moisturizing vitamin C derivative. It is considered to be one of the most stable ones. It is effective in neutralizing free radicals and can help to even out the skin tone if used in high enough concentration3-O-ETHYL ASCORBIC ACIDA vitamin C derivative that is more stable but less potent than pure form of vitamin C. Can help neutralize free radicals and help reduce hyperpigmentation, but the required concentration is likely to be much higher than for the pure form of vitamin C, limiting the ingredient's effectiveness in productsUNDECYLENOYL PHENYLALANINEAn amino-acid based compound that is effective in reducing hyperpigmentation. It can help lighten sun spots and support more even skin tone. BAKUCHIOLA plant extract that is, though different in chemical structure, acts similar to retinoids. First studies show that it can help reduce fine lines and wrinkles, improve skin tone, reduce clogged pores and blemishes, and reduce inflammation. There is no conclusive evidence that bakuchiol is as effective as retinol however. The study that directly compared retinol with bakuchiol used bakuchiol applied twice daily compared to once per day for the retinol. According to this study, bakuchiol is less irritating than retinol. Bakuchiol is extracted from seeds of Babchi plant. Other parts of the plant contain coumarins that could cause allergic and irritant reactions. These compounds should be removed in the extraction process when bakuchiol is produced, but it is a good idea to be cautious and stay away from products that include the Babchi plant extracts other than purified bakuchiol to avoid irritationADAPALENEA retinoid that is effective against acne and keratosis pilaris. It can also help reduce signs of aging (fine lines, wrinkles, loss of elasticity) and can improve skin toneAZELAIC ACIDIs produced by a yeast that lives on normal human skin. It is used in medicine as a topical treatment for mild to moderate acne. It has a mild exfoliating effect. It can also help reduce hyperpigmentation, helps calm down inflammation and can help neutralize free radicalsTRANEXAMIC ACIDAn amino acid that is effective in reducing hyperpigmentation and evening out the skin toneKOJIC ACIDHelps to reduce hyperpigmentation and neutralize free radicals. Can be irritatingALPHA-ARBUTINMight help reduce hyperpigmentation when used regularly over a long period of time. Is more effective than beta-arbutinPOTASSIUM AZELOYL DIGLYCINATEA derivative of azelaic acid. It is obtained by reacting
the chloride of azelaic acid with two molecules of glycine (an amino acid) and potassium hydroxide. It is less studied than azelaic acid, but the available research suggests that it also can be effective in reducing skin redness, hyperpigmentation and blemishes. There are claims that it is more bio-available and more effective than azelaic acid, but no comparison study is available. Potassium azeloyl diglycinate is better soluble in water compared with azelaic acid. Because of this property, products with potassium azeloyl digclycinate can have a nicer textureGLUTATHIONEA peptide that can help neutralize free radicals in skin and reduce melanin production resulting in skin lightening effect and reduction in hyperpigmentation. It can also help attract moisture to the upper layer of the skinPOTASSIUM METHOXYSALICYLATECan help reduce hyperpigmentationRETINALOne step removed from the biologically active in skin form of vitamin A. Once converted to the retinoic acid in the skin, retinal is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. Concentrations of 0.05% and 0.1% are shown to be effective. It can, however, be irritatingRETINOLTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritatingASCORBIC ACIDThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of agingISOBUTYLAMIDO THIAZOLYL RESORCINOLSometimes referred to as Thiamidol (patented by Beiersdorf). A compound that can reduce melanin production in skin. Can help to fade pigmentation spots quicker and even out the skin tone. It is a relatively new compound and the research on it is ongoing. The first studies show that it might be as effective in reducing hyperpigmentation as hydroquinone but with fewer side effectsHYDROQUINONE
Mattifying
RETINOLTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritatingACETYL CARNITINE HCLMight be helpful in decreasing sebum production making the skin less oily. Is claimed to be able to support ceramide production in skin that leads to better hydration, but evidence is lacking. Is able to attract water to the upper layer of the skinCARNITINE HCLMight be helpful in decreasing sebum production making the skin less oily. Is claimed to be able to support ceramide production in skin that leads to better hydration, but evidence is lacking. Is able to attract water to the upper layer of the skinCARNITINE
Anti-blemish
SALICYLIC ACIDUsed for skin exfoliation. It has an anti-inflammatory and anti-bacterial effect, helps to unclog pores, prevent blemishes and speed up healing of the existing ones. Sometimes referred to as a BHA (beta-hydroxy acid)NIACINAMIDEIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moistureSODIUM ASCORBYL PHOSPHATEA stable derivative of vitamin C. It is oil-soluble which means it is more likely to penetrate the skin compared to the pure form of vitamin C (which is water-soluble), but it is less bio-available and is way less effective in stimulating collagen and reducing wrinkles compared to the pure form of vitamin C (L-ascorbic acid) and its other derivatives (for example, magnesium ascorbyl phosphate). At the same time, this vitamin C derivative has been shown in studies to be effective in reducing acne, blemishes and clogged pores. It is less irritating then the pure form of vitamin CETHYL LINOLEATEHelps reduce acne and blemishes. Helps to soften the upper layer of the skin and reduce inflammation. Might be helpful in reducing hyperpigmentation and evening out the skin tone, but evidence of effectiveness in skin are lackingCHITOSANInhibits acne-causing bacteria on the surface of the skin. Can help to reduce inflammation caused by bacteria. Helps neutralize free radicals in skin. Helps to attract water to the upper layer of the skinBENZOYL PEROXIDEA potent anti-bacterial ingredient that is effective against acne. Often leads to skin dryness and can be irritatingZINC ASPARTATECan help reduce acne and blemishes and reduce inflammation in skinGLUCONIC ACIDA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in imporved hydration levels. It has been shown to be helpful against acne and clogged pores. Might help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicalsBAKUCHIOLA plant extract that is, though different in chemical structure, acts similar to retinoids. First studies show that it can help reduce fine lines and wrinkles, improve skin tone, reduce clogged pores and blemishes, and reduce inflammation. There is no conclusive evidence that bakuchiol is as effective as retinol however. The study that directly compared retinol with bakuchiol used bakuchiol applied twice daily compared to once per day for the retinol. According to this study, bakuchiol is less irritating than retinol. Bakuchiol is extracted from seeds of Babchi plant. Other parts of the plant contain coumarins that could cause allergic and irritant reactions. These compounds should be removed in the extraction process when bakuchiol is produced, but it is a good idea to be cautious and stay away from products that include the Babchi plant extracts other than purified bakuchiol to avoid irritationSULFURADAPALENEA retinoid that is effective against acne and keratosis pilaris. It can also help reduce signs of aging (fine lines, wrinkles, loss of elasticity) and can improve skin toneBETAINE SALICYLATEExfoliating acid, a "relative" of salicylic acidPOTASSIUM AZELOYL DIGLYCINATEA derivative of azelaic acid. It is obtained by reacting
the chloride of azelaic acid with two molecules of glycine (an amino acid) and potassium hydroxide. It is less studied than azelaic acid, but the available research suggests that it also can be effective in reducing skin redness, hyperpigmentation and blemishes. There are claims that it is more bio-available and more effective than azelaic acid, but no comparison study is available. Potassium azeloyl diglycinate is better soluble in water compared with azelaic acid. Because of this property, products with potassium azeloyl digclycinate can have a nicer textureCOLLOIDAL SULFURRETINYL RETINOATEA "hybrid" of retinol and retinoic acid. It is more stable than retinol and is likely to be more effective based on the early research data available. Is as irritating as retinolHYDROXYPINACOLONE RETINOATEA derivative of the most potent form of vitamin A, retinoic acid. The ingredient can be sold under name Granactive Retinoid. Note that if a skincare brand discloses the concentration of Granactive Retinoid in a product, the concentration refers to a diluted form of Hydroxypinacolone Retinoate: 1% of Granactive Retinoid corresponds to 0.1% of Hydroxypinacolone Retinoate. Hydroxypinacolone Retinoate (HPR) is a unique derivative of retinoic acid because it can directly work in the skin and does not require additional conversion steps. According to studies done by the manufacturer on models of human skin (not real people), this derivative is more effective than other cosmetic versions of retinoids (such as retinol, retinaldehyde, and retinyl palmitate), and, at the same time, causes less irritation. It has been also demonstrated to be more stable than retinol which makes formulating with easier and increases the chances that a product with it will maintain its effectiveness after opening. The packaging should still ideally be air-tight. HPR is available over the counter in the EU, UK, Asia, Australia and New Zealand, but is only with a prescription in Canada.RETINALOne step removed from the biologically active in skin form of vitamin A. Once converted to the retinoic acid in the skin, retinal is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. Concentrations of 0.05% and 0.1% are shown to be effective. It can, however, be irritatingRETINOLTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritatingAZELAIC ACIDIs produced by a yeast that lives on normal human skin. It is used in medicine as a topical treatment for mild to moderate acne. It has a mild exfoliating effect. It can also help reduce hyperpigmentation, helps calm down inflammation and can help neutralize free radicals