Ascorbic Acid (Vitamin C)

Skin was found to be significantly lighter in color and higher in elas-ticity on the treated side, compared to the untreated side, after 8 weeks of product use (Figure 1A,B), whereas skin radiance im-proved significantly after both 4 and 8 weeks of use. No significant changes in skin moisture level (P > .9999) or TEWL.

Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial

In comparison with baseline, the product induced a significant improvement of skin hydration (−19% of TEWL), a significant improvement of dark spots (+7%) and a significant improvement of SQOOH/SQ ratio (−16%). The product was evaluated very well by >90% of the treated subjects regarding cosmetic acceptability.

Skin protective effects of an antipollution, antioxidant serum containing Deschampsia antar tica extract, ferulic acid and vitamin C: a controlled single-blind, prospective trial in women living in urbanized, high air pollution area

A highly significant increase in the density of skin microrelief and a decrease of the deep furrows were demonstrated. Ultrastructural evidence of the elastic tissue repair was also obtained and well corroborated the favorable results of the clinical and skin surface examinations. Topical application of 5% vitamin C cream was an effective and welltolerated treatment. It led to a clinically apparent improvement of the photodamaged skin and induced modifications of skin relief and ultrastructure, suggesting a positive influence of topical vitamin C on parameters characteristic for sun-induced skin ageing.

Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. placebo

Twice-daily application of 5% topical vitamin C led to a clinically apparent improvement of the skin symptoms and allows beneficial effects on skin elasticity and thickness. Bateman purpura, a classical sign of photoaging whose origin has not clearly been recognized could be improved by vitamin C applied on to the skin.

Bateman purpura (dermatoporosis): a localized scurvy treated by topical vitamin C – double-blind randomized placebo-controlled clinical trial

Comparing the mean granulation scores across the different days showed that there was no significant difference between the two groups on the first and third days, but significant differences were observed on seventh and fourteen days. In the intervention region, the mean granulation scores on days 7 and 14 were 3.07 and 1.83, respectively. In the control region, the corresponding scores were 3.90 and 2.67, respectively, on days 7 and 14

The Effects of Topical Vitamin C Solution on Burn Wounds Granulation: A Randomized Clinical Trial

Skin lightening was observed in most of the patients in all the three groups. However, improvement in POM of more than 50% was observed in 73.34% of patients on GA peel, in 56.67% of patients on lactic peel, and in 26.67% of patients on topical vitamin C application.

Clinical efficacy and safety of 20% glycolic peel, 15% lactic peel, and topical 20% vitamin C in constitutional type of periorbital melanosis: a comparative study

Biometric assessments indicated a significant increase (versus the baseline value) of skin hydration (corneometer; from 55 ± 9 to 74 ± 8, P < 0.0001) and a significant reduction in the ‘crow’s feet’ volume (fringe analysis; from 1.8 ± 1.1 mm3 to 1.5 ± 1.0 mm3 , P < 0.002) as early as after 3 months of treatment with vitamin C⁄ madecassoside. After 6 months of daily applications, a significant increase in cutaneous elasticity was observed (Ur⁄ Ue cutometer values; from 0.68 ± 0.11 to 0.83 ± 0.15, P < 0.0001). Significant differences were observed in the global score before and after treatment, starting as early as 3 months after the application of the vitamin C⁄ madecassoside cream. After 6 months of treatment, the global score decreased in all the treated volunteers, with an improvement of at least 23.5% (mean = 29.5%; with a reduction in the global score from 32.7 ± 2.6 to 23.1 ± 3.0, mean ± SD).

Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin