Wellderma

Wellderma PDRN Exosome Hydro Ampoule

Name: Wellderma - PDRN Exosome Hydro Ampoule
Brand: Wellderma

Efficacy100/100IrritancyMedium

See all ingredients

Works for

Moisturizing

Niacinamide, Hexapeptide-9 + 24 more

Works well

What the product description says

“PDRN Exosome Hydro Ampoule”

From product name

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: arginine, glycerin.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: arginine, caprylic/capric triglyceride.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: acetyl hexapeptide-8, hexapeptide-9, niacinamide, tripeptide-1, tripeptide-29

NiacinamideHeroEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~2.3–2.8%

Hexapeptide-9Hero· HumectantEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.45%

Tripeptide-1Hero· EmollientEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.5%

Tripeptide-29HeroEffect: High~0.25–0.45%

Acetyl hexapeptide-8Hero· HumectantEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.45%

GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~4.4–5.4%

Caprylic/capric triglycerideKey active· Emollient, OcclusiveEffect: HighA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin~1.9–2.4%

Hydrolyzed collagenKey active· Humectant, EmollientEffect: HighA typically plant-derived compound that is supposed mimic human collagen. Cannot penetrate the skin barrier so is not particularly useful in skincare products beyond attracting water to the upper layer of the skin~0.45–0.7%

AtelocollagenKey activeEffect: HighA protein that helps to attract moisture to the upper layer of the skin and might be helpful in reducing fine lines and wrinkles~0.45–0.7%

Soluble collagenKey active· HumectantEffect: HighA typically plant-derived compound that is supposed mimic human collagen. Cannot penetrate the skin barrier so is not particularly useful in skincare products beyond attracting water to the upper layer of the skin~0.4–0.65%

CollagenKey activeEffect: MediumCannot penetrate the skin barrier so is not particularly useful in skincare products~0.35–0.6%

Collagen amino acidsKey activeEffect: HighHelp attract water to the upper layer of the skin, soften it and support the skin barrier function~0.3–0.55%

DimethiconeKey active· Emollient, OcclusiveEffect: HighA silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish~0.3–0.55%

CyclopentasiloxaneKey active· EmollientEffect: MediumA silicone that helps improve the product texture and spreadability. Can absorb oil creating a short-term mattifying effect on the skin~0.3–0.55%

ArginineKey active· Humectant, OcclusiveEffect: HighAn amino acid that is naturally present in skin and helps keep it hydrated. When used together with AHAs, it can reduce their irritating effect on the skin~0.25–0.45%

AdenosineKey activeEffect: MediumMight help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)~0.25–0.45%

CyanocobalaminKey activeEffect: HighCan support skin barrier function and reduce inflammation in skin~0.2–0.4%

Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~3.9–4.8%

Hydrogenated polydecene· EmollientEffect: LowHelps to soften the upper layer of the skin and create a nice product texture~1.4–1.7%

Oryza sativa extractEffect: LowA grain extract that helps to create a thicker product consistency. It might have some anti-oxidant properties and help attract water to the upper layer of the skin~1–1.3%

Glyceryl stearate· EmollientEffect: LowAn emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together~0.3–0.55%

Pentylene glycol· EmollientEffect: LowUsed to preserve products, dissolve other ingredients and create a nice product texture~0.3–0.55%

BiotinEffect: LowMight have some moisturising properties. Is not effective when applied topically beyond some moisturizing effect~0.25–0.45%

Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~0.2–0.35%

AllantoinUnder-dosedHelps calm down inflammation in skin and can help reduce itching. Helps to repair the skin barrier and keep skin hydrated~0.55–0.8%

Dipotassium glycyrrhizateUnder-dosedA salt derived from licorice. Works as an emollient to soften the upper layer of the skin and can help calm down inflammation. Might be helpful for skin lightening~0.25–0.45%

Anti-aging

Niacinamide, Atelocollagen + 8 more

Works well

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains adenosine, niacinamide.

These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: acetyl hexapeptide-8, atelocollagen, folic acid, hexapeptide-9, tripeptide-1, tripeptide-29.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

NiacinamideKey activeEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~2.3–2.8%

AtelocollagenKey activeEffect: MediumA protein that helps to attract moisture to the upper layer of the skin and might be helpful in reducing fine lines and wrinkles~0.45–0.7%

AdenosineKey activeEffect: HighMight help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)~0.25–0.45%

Tripeptide-1Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.5%

Hexapeptide-9Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.45%

Acetyl hexapeptide-8Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.45%

Tripeptide-29Key activeEffect: Medium~0.25–0.45%

Folic acidKey activeEffect: MediumCan help stimulate collagen production in skin. While available studies are promising, more research is needed to confirm the efficacy in skin~0.2–0.35%

Sodium ascorbyl phosphateEffect: Low, below effective doseA stable derivative of vitamin C. It is oil-soluble which means it is more likely to penetrate the skin compared to the pure form of vitamin C (which is water-soluble), but it is less bio-available and is way less effective in stimulating collagen and reducing wrinkles compared to the pure form of vitamin C (L-ascorbic acid) and its other derivatives (for example, magnesium ascorbyl phosphate). At the same time, this vitamin C derivative has been shown in studies to be effective in reducing acne, blemishes and clogged pores. It is less irritating then the pure form of vitamin C~0.25–0.45%

Ascorbic acidUnder-dosedThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging~0.25–0.4%

Anti-blemish

Side benefit · Niacinamide, Ginkgo biloba leaf extract + 2 more

Works well

This product can help reduce breakouts and clogged pores because it contains the following ingredient: niacinamide. This ingredient is used for treating acne and can have a noticeable effect.

Ginkgo biloba leaf extractEffect: LowA plant extract that might help neutralize free radicals and reduce inflammation in skin. It can be irritating~0.25–0.45%

AllantoinEffect: Low, below effective doseHelps calm down inflammation in skin and can help reduce itching. Helps to repair the skin barrier and keep skin hydrated~0.55–0.8%

Sodium ascorbyl phosphateUnder-dosedA stable derivative of vitamin C. It is oil-soluble which means it is more likely to penetrate the skin compared to the pure form of vitamin C (which is water-soluble), but it is less bio-available and is way less effective in stimulating collagen and reducing wrinkles compared to the pure form of vitamin C (L-ascorbic acid) and its other derivatives (for example, magnesium ascorbyl phosphate). At the same time, this vitamin C derivative has been shown in studies to be effective in reducing acne, blemishes and clogged pores. It is less irritating then the pure form of vitamin C~0.25–0.45%

Evens skin tone

Side benefit · Niacinamide, Dipotassium glycyrrhizate + 1 more

Works well

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: niacinamide

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

Dipotassium glycyrrhizateEffect: Low, below effective doseA salt derived from licorice. Works as an emollient to soften the upper layer of the skin and can help calm down inflammation. Might be helpful for skin lightening~0.25–0.45%

Anti-oxidation

Side benefit · Ficus carica fruit extract, Ginkgo biloba leaf extract + 6 more

May help

This product contains antioxidants (ficus carica fruit extract, ginkgo biloba leaf extract, pyridoxine) that might be able to help neutralize free radicals in skin to lessen the damage it gets from the UV light (sun). There is not enough evidence to confirm their effectiveness in skin though.

Ficus carica fruit extractKey activeEffect: MediumA plant extract that can help neutralize free radicals. The concentrations typically used in cosmetics are too small to have an effect~0.25–0.45%

Ginkgo biloba leaf extractKey activeEffect: MediumA plant extract that might help neutralize free radicals and reduce inflammation in skin. It can be irritating~0.25–0.45%

PyridoxineKey activeEffect: MediumMight help neutralize free radicals in skin, but evidence of effectiveness in skin is lacking. It might be irritating~0.15–0.3%

AdenosineEffect: LowMight help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)~0.25–0.45%

Punica granatum fruit extractEffect: LowA fruit extract that is used to add a fragrance to the product. It might have some antioxidant properties~0.25–0.45%

Can it cause trouble?

Irritancy

1 strong irritant: Parfum

Medium risk

We flagged 16 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.

IngredientFunctionIrritationEst. amount

Punica granatum fruit extractA fruit extract that is used to add a fragrance to the product. It might have some antioxidant propertiesHigh~0.25–0.45%est.

Ginkgo biloba leaf extractA plant extract that might help neutralize free radicals and reduce inflammation in skin. It can be irritatingHigh~0.25–0.45%est.

Ascorbic acidThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of agingHigh~0.25–0.4%est.

PyridoxineMight help neutralize free radicals in skin, but evidence of effectiveness in skin is lacking. It might be irritatingHigh~0.15–0.3%est.

ParfumAn aromatic blend of unspecified and possibly irritating ingredientsHigh~0.1–0.15%est.

Caprylic/capric triglycerideA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerinMedium~1.9–2.4%est.

Ficus carica fruit extractA plant extract that can help neutralize free radicals. The concentrations typically used in cosmetics are too small to have an effectMedium~0.25–0.45%est.

Polysorbate 60Helps oil and water mix togetherMedium~0.25–0.5%est.

Pentylene glycolUsed to preserve products, dissolve other ingredients and create a nice product textureMedium~0.3–0.55%est.

Polyglyceryl-2 stearateHelps water and oil mix togetherMedium~0.25–0.5%est.

Sodium ascorbyl phosphateA stable derivative of vitamin C. It is oil-soluble which means it is more likely to penetrate the skin compared to the pure form of vitamin C (which is water-soluble), but it is less bio-available and is way less effective in stimulating collagen and reducing wrinkles compared to the pure form of vitamin C (L-ascorbic acid) and its other derivatives (for example, magnesium ascorbyl phosphate). At the same time, this vitamin C derivative has been shown in studies to be effective in reducing acne, blemishes and clogged pores. It is less irritating then the pure form of vitamin CMedium~0.25–0.45%est.

Thiamine hclCan help attract water to the upper layer of the skin. Is studied as a mosquito repellentMedium~0.2–0.4%est.

Caprylyl glycolHelps preserve products and creates a nice product textureMedium~0.2–0.35%est.

Disodium edtaStabilizes the product formulationMedium~0.15–0.3%est.

1,2-hexanediolA preservativeMedium~0.15–0.25%est.

HydroxyacetophenoneUsed to increase effectiveness of preservativesMedium~0.1–0.2%est.

Comedogenic

Clean of flagged comedogenic ingredients

None flagged

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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%

Formula

Irritation risk: Low

Plain old water

More about Water

Glycerin~4.4–5.4%

Key active

Irritation risk: Low

Works for

Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin

Butylene glycol~3.9–4.8%

Formula

Irritation risk: Low

Works for

Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol

Glycereth-26~3–3.6%

Formula

Irritation risk: Low

Helps create a thicker product consistency

More about Glycereth-26

Niacinamide~2.3–2.8%

Hero · Moisturizing, Anti-blemish

Irritation risk: Low

Works for

Anti-agingAnti-blemishEvens skin toneMoisturizingReduces irritationAntibacterialAnti-inflammatoryReduces redness

Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production

More about Niacinamide

Caprylic/capric triglyceride~1.9–2.4%

Key activeIrritant · medium

Irritation risk: Medium

Works for

Moisturizing

A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin

More about Caprylic/capric triglyceride

Dipropylene glycol~1.5–1.8%

Formula

Irritation risk: Low

Helps to dissolve other ingredients in a formulation. Slows down the rate of product drying

More about Dipropylene glycol

Hydrogenated polydecene~1.4–1.7%

Formula

Irritation risk: Low

Works for

Moisturizing

Helps to soften the upper layer of the skin and create a nice product texture

More about Hydrogenated polydecene

Oryza sativa~1.2–1.5%

Formula

Irritation risk: Low

More about Oryza sativa

Oryza sativa extract~1–1.3%

Formula

Irritation risk: Low

Works for

MoisturizingAnti-oxidation

A grain extract that helps to create a thicker product consistency. It might have some anti-oxidant properties and help attract water to the upper layer of the skin

More about Oryza sativa extract

Allantoin~0.55–0.8%

Under-dosed

Irritation risk: Low

Works for

MoisturizingAnti-inflammatoryReduces irritationReduces rednessAnti-blemishExfoliation

Helps calm down inflammation in skin and can help reduce itching. Helps to repair the skin barrier and keep skin hydrated

More about Allantoin

Whey filtrate~0.55–0.85%

Formula

Irritation risk: Low

More about Whey filtrate

Milk exosomes~0.6–0.9%

Formula

Irritation risk: Low

More about Milk exosomes

Atelocollagen~0.45–0.7%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-aging

A protein that helps to attract moisture to the upper layer of the skin and might be helpful in reducing fine lines and wrinkles

More about Atelocollagen

Desamido collagen~0.45–0.65%

Formula

Irritation risk: Low

More about Desamido collagen

Hydrolyzed collagen~0.45–0.7%

Key active

Irritation risk: Low

Works for

Moisturizing

A typically plant-derived compound that is supposed mimic human collagen. Cannot penetrate the skin barrier so is not particularly useful in skincare products beyond attracting water to the upper layer of the skin

More about Hydrolyzed collagen

Soluble collagen~0.4–0.65%

Key active

Irritation risk: Low

Works for

Moisturizing

More about Soluble collagen

Collagen~0.35–0.6%

Key active

Irritation risk: Low

Works for

Moisturizing

Cannot penetrate the skin barrier so is not particularly useful in skincare products

More about Collagen

Collagen amino acids~0.3–0.55%

Key active

Irritation risk: Low

Works for

Moisturizing

Help attract water to the upper layer of the skin, soften it and support the skin barrier function

More about Collagen amino acids

Procollagen~0.3–0.55%

Formula

Irritation risk: Low

More about Procollagen

Sodium dna~0.25–0.5%

Formula

Irritation risk: Low

More about Sodium dna

Cyanocobalamin~0.25–0.45%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-inflammatory

Can support skin barrier function and reduce inflammation in skin

More about Cyanocobalamin

Ficus carica fruit extract~0.25–0.45%

Key activeIrritant · medium

Irritation risk: Medium

Works for

Anti-oxidation

A plant extract that can help neutralize free radicals. The concentrations typically used in cosmetics are too small to have an effect

More about Ficus carica fruit extract

Punica granatum fruit extract~0.25–0.45%

Irritant · high

Irritation risk: High

Works for

Anti-oxidation

A fruit extract that is used to add a fragrance to the product. It might have some antioxidant properties

More about Punica granatum fruit extract

Morus alba fruit extract~0.25–0.5%

Formula

Irritation risk: Low

More about Morus alba fruit extract

Ginkgo biloba leaf extract~0.25–0.45%

Key activeIrritant · high

Irritation risk: High

Works for

Anti-oxidationAntibacterialAnti-blemishAnti-inflammatory

A plant extract that might help neutralize free radicals and reduce inflammation in skin. It can be irritating

More about Ginkgo biloba leaf extract

Adenosine~0.25–0.45%

Key active

Irritation risk: Low

Works for

Anti-agingMoisturizingAnti-oxidation

Might help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)

More about Adenosine

Dipotassium glycyrrhizate~0.25–0.45%

Under-dosed

Irritation risk: Low

Works for

MoisturizingAnti-inflammatoryEvens skin tone

A salt derived from licorice. Works as an emollient to soften the upper layer of the skin and can help calm down inflammation. Might be helpful for skin lightening

More about Dipotassium glycyrrhizate

Glyceryl stearate~0.3–0.55%

Formula

Irritation risk: Low

Works for

CleansingMoisturizing

An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together

More about Glyceryl stearate

Peg-100 stearate~0.35–0.6%

Formula

Irritation risk: Low

Works for

Cleansing

Helps oil and water mix togehter and creates a nice product texture

More about Peg-100 stearate

Polysorbate 60~0.25–0.5%

Irritant · medium

Irritation risk: Medium

Works for

Cleansing

Helps oil and water mix together

More about Polysorbate 60

Pentylene glycol~0.3–0.55%

Irritant · medium

Irritation risk: Medium

Works for

Moisturizing

Used to preserve products, dissolve other ingredients and create a nice product texture

More about Pentylene glycol

Isopentyldiol~0.25–0.45%

Formula

Irritation risk: Low

Helps dissolve other ingredients in a formulation

More about Isopentyldiol

Lactobacillus/collagen ferment filtrate~0.25–0.45%

Formula

Irritation risk: Low

More about Lactobacillus/collagen ferment filtrate

Arginine~0.25–0.45%

Key active

Irritation risk: Low

Works for

Moisturizing

An amino acid that is naturally present in skin and helps keep it hydrated. When used together with AHAs, it can reduce their irritating effect on the skin

More about Arginine

Carbomer~0.25–0.45%

Formula

Irritation risk: Low

Works for

Cleansing

Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations

More about Carbomer

Cyclopentasiloxane~0.3–0.55%

Key active

Irritation risk: Low

Works for

MoisturizingMattifying

A silicone that helps improve the product texture and spreadability. Can absorb oil creating a short-term mattifying effect on the skin

More about Cyclopentasiloxane

Polyglyceryl-2 stearate~0.25–0.5%

Irritant · medium

Irritation risk: Medium

Works for

Cleansing

Helps water and oil mix together

More about Polyglyceryl-2 stearate

Dimethicone/vinyl dimethicone crosspolymer~0.25–0.45%

Formula

Irritation risk: Low

Used to stabilize product formulations and create a nice product texture

More about Dimethicone/vinyl dimethicone crosspolymer

Dimethicone~0.3–0.55%

Key active

Irritation risk: Low

Works for

MoisturizingMattifying

A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish

More about Dimethicone

Sodium ascorbyl phosphate~0.25–0.45%

Under-dosedIrritant · medium

Irritation risk: Medium

Works for

Anti-blemishAnti-oxidationAnti-aging

A stable derivative of vitamin C. It is oil-soluble which means it is more likely to penetrate the skin compared to the pure form of vitamin C (which is water-soluble), but it is less bio-available and is way less effective in stimulating collagen and reducing wrinkles compared to the pure form of vitamin C (L-ascorbic acid) and its other derivatives (for example, magnesium ascorbyl phosphate). At the same time, this vitamin C derivative has been shown in studies to be effective in reducing acne, blemishes and clogged pores. It is less irritating then the pure form of vitamin C

More about Sodium ascorbyl phosphate

Hexapeptide-9~0.25–0.45%

Hero · Moisturizing

Irritation risk: Low

Works for

MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Hexapeptide-9

Acetyl hexapeptide-8~0.25–0.45%

Hero · Moisturizing

Irritation risk: Low

Works for

MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Acetyl hexapeptide-8

Tripeptide-1~0.25–0.5%

Hero · Moisturizing

Irritation risk: Low

Works for

MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Tripeptide-1

Tripeptide-29~0.25–0.45%

Hero · Moisturizing

Irritation risk: Low

Works for

MoisturizingAnti-aging

More about Tripeptide-29

Xanthan gum~0.25–0.5%

Formula

Irritation risk: Low

Works for

Cleansing

Used to create a thicker product consistency

More about Xanthan gum

Stearyl alcohol~0.3–0.5%

Formula

Irritation risk: Low

Works for

Cleansing

An emollient that helps soften the skin

More about Stearyl alcohol

Biotin~0.25–0.45%

Formula

Irritation risk: Low

Works for

Moisturizing

Might have some moisturising properties. Is not effective when applied topically beyond some moisturizing effect

More about Biotin

Ascorbic acid~0.25–0.4%

Under-dosedIrritant · high

Irritation risk: High

Works for

Anti-oxidationEvens skin toneAnti-aging

The most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging

More about Ascorbic acid

Riboflavin~0.2–0.4%

Formula

Irritation risk: Low

More about Riboflavin

Cyanocobalamin~0.2–0.4%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-inflammatory

Can support skin barrier function and reduce inflammation in skin

More about Cyanocobalamin

Thiamine hcl~0.2–0.4%

Irritant · medium

Irritation risk: Medium

Can help attract water to the upper layer of the skin. Is studied as a mosquito repellent

More about Thiamine hcl

Folic acid~0.2–0.35%

Key active

Irritation risk: Low

Works for

Anti-aging

Can help stimulate collagen production in skin. While available studies are promising, more research is needed to confirm the efficacy in skin

More about Folic acid

Pyridoxine~0.15–0.3%

Key activeIrritant · high

Irritation risk: High

Works for

Anti-oxidation

Might help neutralize free radicals in skin, but evidence of effectiveness in skin is lacking. It might be irritating

More about Pyridoxine

Caprylyl glycol~0.2–0.35%

Irritant · medium

Irritation risk: Medium

Works for

Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol

Disodium edta~0.15–0.3%

Irritant · medium

Irritation risk: Medium

Stabilizes the product formulation

More about Disodium edta

1,2-hexanediol~0.15–0.25%

Irritant · medium

Irritation risk: Medium

A preservative

More about 1,2-hexanediol

Hydroxyacetophenone~0.1–0.2%

Irritant · medium

Irritation risk: Medium

Used to increase effectiveness of preservatives

More about Hydroxyacetophenone

Parfum~0.1–0.15%

Irritant · high

Irritation risk: High

An aromatic blend of unspecified and possibly irritating ingredients

More about Parfum

Ingredient list view

Water, Glycerin, Butylene glycol, Glycereth-26, Niacinamide, Caprylic/capric triglyceride, Dipropylene glycol, Hydrogenated polydecene, Oryza sativa, Oryza sativa extract, Allantoin, Whey filtrate, Milk exosomes, Atelocollagen, Desamido collagen, Hydrolyzed collagen, Soluble collagen, Collagen, Collagen amino acids, Procollagen, Sodium dna, Cyanocobalamin, Ficus carica fruit extract, Punica granatum fruit extract, Morus alba fruit extract, Ginkgo biloba leaf extract, Adenosine, Dipotassium glycyrrhizate, Glyceryl stearate, Peg-100 stearate, Polysorbate 60, Pentylene glycol, Isopentyldiol, Lactobacillus/collagen ferment filtrate, Arginine, Carbomer, Cyclopentasiloxane, Polyglyceryl-2 stearate, Dimethicone/vinyl dimethicone crosspolymer, Dimethicone, Sodium ascorbyl phosphate, Hexapeptide-9, Acetyl hexapeptide-8, Tripeptide-1, Tripeptide-29, Xanthan gum, Stearyl alcohol, Biotin, Ascorbic acid, Riboflavin, Cyanocobalamin, Thiamine hcl, Folic acid, Pyridoxine, Caprylyl glycol, Disodium edta, 1,2-hexanediol, Hydroxyacetophenone, Parfum

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Amazon USPrice as of 11/11 18:34 GMT

$21.00

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
	WelldermaPDRN Exosome Hydro AmpouleYOUR PRODUCT	EqqualberryNAD+ Peptide Boosting Serum	ArenciaDeep Water Surge Serum 30	Bliv:UCollagen Bouncing Serum Pad
Match	—	82%	82%	82%
Price	$21.00	$17.70−$3.30	$15.74−$5.26	$19.17−$1.83
Shared key ingredients	—	8 of 22	8 of 22	7 of 22
Key difference	—	Acetyl Tetrapeptide-3	Copper Tripeptide-1	Copper Tripeptide-1
Irritancy	Medium	Medium	Medium	Medium
Drying alcohol	—	—	—	—
	View product	Shop	Shop	Shop

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Product summary

"Wellderma - PDRN Exosome Hydro Ampoule" is effective for: Anti-blemish, Moisturizing, Evens skin tone and Anti-aging

Ingredient callouts

A good concentration of Niacinamide (2.30% - 2.80%). Niacinamide is a well-studied multi-tasking active. It is stable, and can work well in almost any hydrating formulation. There is solid evidence that Niacinamide can help support skin barrier, regulate oil production and reduce acne and clogged pores. It also helps to fight photodamage and improve the skin tone, reducing pigmentation marks.
This product also contains Vitamin C (Ascorbic Acid). It can be an effective active for anti-aging and evening out the skin tone, but in this product it is used for stabilizing other ingredients in the formulation. In this concentration (0.25% - 0.40%) it cannot have a noticeable benefit for the skin.
Peptides (tripeptide-29 0.25% - 0.45%, tripeptide-1 0.25% - 0.50%, acetyl hexapeptide-8 0.25% - 0.45% and hexapeptide-9 0.25% - 0.45%). There are many different kind of Peptides and they are naturally present in our skin. They all are a combination of aminoacids. Some of them work as natural antibiotics, promote wound-healing and production of collagen. The science is still not settled on how effective Peptides are in skincare, but it is very likely that they have a benefit. They might help restore the skin barrier and fight the signs of aging. At the very least, Peptides work as humectants: they attract water to the upper layer of the skin and improve its hydration.
Adenosine 0.25% - 0.45%. It is a chemical present inside our skin cells. A clinical trial confirmed that topical application of Adenosine in a low concentration can reduce dynamic wrinkles (these are the wrinkles that appear with age in a places where our mimic is the most active, for example, in the corners of the eyes or on the forehead).
Humectants (acetyl hexapeptide-8 0.25% - 0.45%, hexapeptide-9 0.25% - 0.45%, arginine 0.25% - 0.45%, soluble collagen 0.40% - 0.65%, hydrolyzed collagen 0.45% - 0.70% and glycerin 4.40% - 5.40%). These ingredients help attract water to the upper layer of the skin and improve the skin hydration.