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Hydroxypinacolone Retinoate

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In 92 skincare routines

Summary

Works for

  • Anti-aging
  • Evens skin tone
  • Anti-blemish
  • Exfoliation

Irritancy risk

3
High

A derivative of the most potent form of vitamin A, retinoic acid. The ingredient can be sold under name Granactive Retinoid. Note that if a skincare brand discloses the concentration of Granactive Retinoid in a product, the concentration refers to a diluted form of Hydroxypinacolone Retinoate: 1% of Granactive Retinoid corresponds to 0.1% of Hydroxypinacolone Retinoate. Hydroxypinacolone Retinoate (HPR) is a unique derivative of retinoic acid because it can directly work in the skin and does not require additional conversion steps. According to studies done by the manufacturer on models of human skin (not real people), this derivative is more effective than other cosmetic versions of retinoids (such as retinol, retinaldehyde, and retinyl palmitate), and, at the same time, causes less irritation. It has been also demonstrated to be more stable than retinol which makes formulating with easier and increases the chances that a product with it will maintain its effectiveness after opening. The packaging should still ideally be air-tight. HPR is available over the counter in the EU, UK, Asia, Australia and New Zealand, but is only with a prescription in Canada.

Where this fits

Anti-AgingRoutines for texture and fine lines.Acne & PoresRelevant for breakouts and oil control.

Products with Hydroxypinacolone Retinoate

Image skincare - AGELESS+ retinol treatment crème 1.2% retinol complexImage skincareAGELESS+ retinol treatment crème 1.2% retinol complex
acetyl tetrapeptide-2retinolhydroxypinacolone retinoate +22 actives
Anti-aging Moisturizing +4
Price unavailable
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Dr. Brandt - Glow Overnight Retinol OilDr. BrandtGlow Overnight Retinol Oil
hydroxypinacolone retinoateretinolceramide np +9 actives
Evens skin tone Anti-aging +4
Price unavailable
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IOPE - Expert Retinol RX™ 2% Reti-Jection SerumIOPEExpert Retinol RX™ 2% Reti-Jection Serum
hydroxypinacolone retinoateniacinamideretinol +11 actives
Anti-aging Anti-oxidation +4
Price unavailable
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epii - HPR Pro ShotepiiHPR Pro Shot
madecassosideretinalretinol +16 actives
Anti-blemish Moisturizing +4
Price unavailable
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ENDOCARE Renewal - Retinol Serum | Cantabria LabsENDOCARE RenewalRetinol Serum | Cantabria Labs
Vitamin Chydroxypinacolone retinoateniacinamide +5 actives
Anti-aging Evens skin tone +4
Price unavailable
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Dermalogica - Daily Skin Health Dynamic Skin Retinol SerumDermalogicaDaily Skin Health Dynamic Skin Retinol Serum
hydroxypinacolone retinoateretinolceramide np +8 actives
Anti-aging Evens skin tone +4
Price unavailable
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Elizabeth Arden - Ceramide Retinol + HPR Water CreamElizabeth ArdenCeramide Retinol + HPR Water Cream
acetyl tetrapeptide-9hydroxypinacolone retinoateretinol +11 actives
Moisturizing Anti-aging +4
Fragrance
Price unavailable
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Raz Skincare - A-Retinoid 5%Raz SkincareA-Retinoid 5%
hydroxypinacolone retinoateAgran oilVitamin E
Anti-aging Evens skin tone +3
Price unavailable
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Murad UK - Retinol Youth Renewal SerumMurad UKRetinol Youth Renewal Serum
hydroxypinacolone retinoateretinolretinyl linoleate +17 actives
Evens skin tone Moisturizing +4
Fragrance
Price unavailable
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Beauty Pie - Youthbomb Hand & Body 360° Repair ConcentrateBeauty PieYouthbomb Hand & Body 360° Repair Concentrate
niacinamidehydroxypinacolone retinoateglycolic acid +9 actives
Anti-aging Exfoliation +2
Fragrance
Price unavailable
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Clinical trials review

Source

The number of open comedones, closed comedones and papules showed statistically significant decrease over time. Closed comedones responded faster than open comedones with significant difference seen as early as day 45. Both open and closed comedones continued to decrease in lesion count throughout the entire study period. The number of papules decreased throughout the treatment period with significant difference between baseline and days 90 and 120. Median sebumeter values showed significant decrease over time. Mild itching was experienced by 3-13% of patients from days 15 to 120, with highest percentage at day 45. Mild burning occurred in 7% of patients at day 45 but was absent at days 90 and 120. No edema was reported by any of the patients throughout the study period.

Filipino patients diagnosed with mild-moderate acne (Grades 0-3 by Leeds Acne Grading System Revised correlated with grades 1-2 on Plewig scale and Kligman, 1975). Patients having undergone treatment for acne including cosmeceuticals within 3 weeks previous to the start of the study. Exclusion criteria: patients with concomitant systemic conditions, receiving systemic treatments and with other concomitant dermatoses at the time of study; pregnant or breast-feeding women.n=30Biretix Duo (active ingredients: Hydroxypinacolone Retinoate, Retinol, Salicylic Acid) was applied to the whole face in the morning and night after washing with hypoallergenic bar soap. A broad spectrum sunscreen was also applied in the morning and patients were advised to avoid sun exposure. The results were assessed at baseline, day 45, day 90 and day 120

Safety and Efficacy of Retinsphere® Technology and Biopep-15 in the treatment of Acne in Asian Population

Source

a significative improvement of all the observed characteristics has been recorded. Also the global skin photoaging evaluation, performed at the times T0 and T12 with the Glogau scale, showed a significative improvement (P<0.001).

Female patients (age 28-81 years) with photoaged skin classified with the Glogau scale n=10Product: product containing a new retinoic complex (hydroxypinacolone retinoate and retinol, associated with papain, Maca andina, Cupressus sempervirens, moisturizing complex, folic acid and vitamin E). Treatment consisted of applying the product twice daily for 8 weeks together with a topical photoprotector. No sun-exposure or artificial-UV exposure was admitted.

Clinical evaluation of the efficacy of a new retinoic-complex (Retinsphere®) product for the treatment of skin photoaging

Source

A 41% mean reduction in the GAGS score was observed; a 40.8% mean reduction of total lesions was recorded; 15.3% of patients experienced mild to moderate local side effects (dryness, peeling, erythema, burning). No patients stopped the treatment because of these side effects.

Caucasian patients (28 males and 70 females), with an age ranging from 15 to 40 yearsn=98Product: A fixed combination of 0.1% hydroxypinacolone retinoate (synthetic esther of 9-cis-retinoic acid), 1% retinol in glycospheres and 2% papain in glycospheres in aqueous gel. Participants were treated with the product once daily for 12 weeks

Treatment of mild to moderate acne with a fixed combination of hydroxypinacolone retinoate, retinol glycospheres and papain glycospheres

Source

Most of patients had satisfactory therapeutic response with a reduction of GAGS global score of 70%. Digital images confirmed clinical improvement (Figure 1). Micro-comedones and macro-comedones showed respectively a reduction of 38% and of 65%. Follicular biopsy proved a reduction about 60% in the density of micro and macro- comedones. No patients dropped out the study because of side effects and tolerability was very good in 90% of our sample.

(9F/11M) (mean age: 30, range. 18-40 yrs) with mild to moderate acnen=20Participants were treated with an association of hydroxypinacolone retinoate, a new retinoid, allowed in cosmetic formulas, and Retinol entrapped into Glycospheres Technology, containing Papain, R-NMF (Rebuilt-Natural Moisturizer Factor), tocopherol (Vit. E), glycerol, Treolase, Aloe Barbadenis. During the course of the study, no other topical or systemic treatment was allowed

Evaluation of efficacy and safety of the combinated use of two topic retinoids to treat mild / moderate acne.

Source

In percentage terms, the reduction of the MASI at the end of the study on the side treated with the product was 74% (31%) vs. a reduction of 55% (36%) on the side that received the vehicle with SPF, with this being a significant difference (P = 0.009).

Inclusion criteria: Aged over 18 years; Absence of treatment for melasma in the last 3 months; No desire to get pregnant in the forthcoming months and use of contraceptives; No concomitant diseases; No administration of another topical or systemic product that may interfere or affect the process; No allergy to the product ingredients. 67% of patients cited a history of sensitive skin.n=28The product included retinol glycospheres and hydroxypinacolone retinoate, as well as N-acetylglucosamine, kojic acid, Cromabright and Natriquest, copper and iron ions, albatin & alistin, and niacinamide. The formulation contains 10% of hydrating active ingredients and 3% anti-irritant, anti-inflammatory active ingredients. The treatment protocol included the application of the active cream with sun protection factor SPF 50 (Neoretin discrom control gel cream—IFC Pharmaceuticals) during the day and active serum (Neoretin discrom control serum booster fluid—IFC Pharmaceuticals) at night on one side of the face vs. vehicle gelcream with SPF 50 during the day and vehicle serum during the night on the other side of the face; thus, the patient was also the control group. The vehicle had the same photoprotector as the study product.

Assessment of the efficacy and tolerance of a new combination of retinoids and depigmenting agents in the treatment of melasma

Scientific sources

Similar ingredients

Anti-aging

1-Trimethyl-2-Cyclohexenyl-1-Penten-3-OneAcetyl GlucosamineAn effective moisturizing ingredient that also has been shown to be effective in evening out the skin tone and reducing hyperpigmentation. It can help somewhat reduce wrinkles in skinHeptapeptide-15 PalmitateA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

Anti-blemish

Salicylic AcidUsed for skin exfoliation. It has an anti-inflammatory and anti-bacterial effect, helps to unclog pores, prevent blemishes and speed up healing of the existing ones. Sometimes referred to as a BHA (beta-hydroxy acid)NiacinamideIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moistureSodium Ascorbyl PhosphateA stable derivative of vitamin C. It is oil-soluble which means it is more likely to penetrate the skin compared to the pure form of vitamin C (which is water-soluble), but it is less bio-available and is way less effective in stimulating collagen and reducing wrinkles compared to the pure form of vitamin C (L-ascorbic acid) and its other derivatives (for example, magnesium ascorbyl phosphate). At the same time, this vitamin C derivative has been shown in studies to be effective in reducing acne, blemishes and clogged pores. It is less irritating then the pure form of vitamin CEthyl LinoleateHelps reduce acne and blemishes. Helps to soften the upper layer of the skin and reduce inflammation. Might be helpful in reducing hyperpigmentation and evening out the skin tone, but evidence of effectiveness in skin are lacking

Exfoliation

Glycolic AcidAn alpha-hydroxy acid (AHA) that helps to remove the dead skin cells on the surface of the skin reveling a more even, smoother complexation. It is also able to stimulate collagen production with long-term use. Could help to reduce pore congestion. It can be irritating to the skin. Apply sunscreen daily if using products with glycolic acidLactic AcidAn exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiom) RetinolTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating