Dr. Denese

Dr. Denese Body Rx Tightening Cream

Name: Dr. Denese - Body Rx Tightening Cream
Brand: Dr. Denese

Efficacy100/100IrritancyHigh

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Works for

3 of 3 advertised claims delivered

Moisturizing

Ceramide ng, Palmitoyl hexapeptide-12 + 24 more

Strong evidence

What the product description says

“A body moisturizer and skin tightening treatment with the most innovative Retinol Technology to visibly tighten and even skin tone.”

Source: Dr. Denese

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: arginine, glycerin.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: arginine, bis-diglyceryl polyacyladipate-2.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: ceramide ng, palmitoyl hexapeptide-12

GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~1–1.2%

Phenyl trimethiconeKey active· OcclusiveEffect: HighA type of silicone that can decrease loss of moisture from the skin surface. It helps create a nice product texture~4.4–5.4%

Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~0.4–0.6%

SqualaneKey active· Emollient, OcclusiveEffect: HighAn oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.~0.5–0.75%

ArginineKey active· Humectant, OcclusiveEffect: HighAn amino acid that is naturally present in skin and helps keep it hydrated. When used together with AHAs, it can reduce their irritating effect on the skin~0.25–0.4%

Bis-diglyceryl polyacyladipate-2Key active· Emollient, OcclusiveEffect: HighHelps soften the upper layer of the skin and reduce water loss from its surface~0.5–0.75%

Butyrospermum parkii butterKey active· Emollient, OcclusiveEffect: HighA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals~1.2–1.5%

Cannabis sativa seed oilKey active· EmollientEffect: HighA plant oil that due to its high linoleic acid content can help strengthen skin's barrier function and soften its upper layer~4.8–5.9%

Caprylic/capric triglycerideKey active· Emollient, OcclusiveEffect: HighA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin~1.5–1.8%

Ceramide ngHero· EmollientEffect: HighA type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin~0.35–0.6%

DimethiconeKey active· Emollient, OcclusiveEffect: HighA silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish~0.55–0.85%

DimethiconolKey active· Emollient, OcclusiveEffect: HighA silicone that makes products more spreadable and keeps skin smooth. Helps to add gloss to skin and may visually fill in fine lines/wrinkles for short time~0.25–0.5%

Hydrolyzed sodium hyaluronateKey activeEffect: HighAttracts water into the upper layer of the skin~0.35–0.6%

Palmitoyl hexapeptide-12HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.5%

Pantothenic acidKey activeEffect: HighHelps attract water to the upper layer of the skin and may help reduce inflammation in skin~0.25–0.45%

PhospholipidsKey activeEffect: MediumEmollients that are naturaly present in skin. In addition, they help water and oil mix together in the product~0.25–0.5%

CyclopentasiloxaneKey active· EmollientEffect: MediumA silicone that helps improve the product texture and spreadability. Can absorb oil creating a short-term mattifying effect on the skin~2–2.4%

Cetearyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture~1.7–2%

Cetyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together~0.5–0.75%

C12-15 alkyl benzoateKey active· EmollientEffect: MediumEnhances the product texture and makes it more spreadable. Helps reduce water loss from the outer layer of skin. Extands the shelf life by preventing bacteria growth~0.3–0.55%

Glyceryl stearate citrate· EmollientEffect: LowHelps oil and water mix together while softening the upper layer of the skin~0.7–1.05%

Hydroxymethoxyphenyl decanoneEffect: LowAn anti-oxidant. Is also called 6-paradol. It might be able to neutralize free radicals in skin. The manufacturer claims that it is able to stimulate synthesis of hyaluronic acid in skin, but there is no evidence of effectiveness of this ingredient so far. The only evidence of efficacy for this ingredient so far come from small lab tests. This ingredient comes together with Caprylic/Capric Triglyceride as part of the complex called SymDecanox HA produced by a cosmetic ingredient supplier Symrise.~0.2–0.4%

Glyceryl caprylate· EmollientEffect: LowAn emollient that can also help water and oil mix together, as well as prevent bacteria growth in products~0.6–0.95%

Ananas sativus fruit extractEffect: LowA fruit extract that might help to attract water to the upper layer of the skin, but there is no evidence for any other benefits to the skin~0.25–0.45%

Garcinia mangostana fruit extractEffect: LowA fruit extract that might have some anti-oxidant properties~0.25–0.45%

Tribehenin· EmollientEffect: LowUsed to create a thicker product consistency and soften the upper layer of the skin~0.3–0.5%

Evens skin tone

Hydroxypinacolone retinoate, Punica granatum extract + 1 more

Strong evidence

What the product description says

“A body moisturizer and skin tightening treatment with the most innovative Retinol Technology to visibly tighten and even skin tone.”

Source: Dr. Denese

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: hydroxypinacolone retinoate.

The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually can help even out the skin tone: punica granatum extract.

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

Hydroxypinacolone retinoateHeroEffect: HighA derivative of the most potent form of vitamin A, retinoic acid. The ingredient can be sold under name Granactive Retinoid. Note that if a skincare brand discloses the concentration of Granactive Retinoid in a product, the concentration refers to a diluted form of Hydroxypinacolone Retinoate: 1% of Granactive Retinoid corresponds to 0.1% of Hydroxypinacolone Retinoate. Hydroxypinacolone Retinoate (HPR) is a unique derivative of retinoic acid because it can directly work in the skin and does not require additional conversion steps. According to studies done by the manufacturer on models of human skin (not real people), this derivative is more effective than other cosmetic versions of retinoids (such as retinol, retinaldehyde, and retinyl palmitate), and, at the same time, causes less irritation. It has been also demonstrated to be more stable than retinol which makes formulating with easier and increases the chances that a product with it will maintain its effectiveness after opening. The packaging should still ideally be air-tight. HPR is available over the counter in the EU, UK, Asia, Australia and New Zealand, but is only with a prescription in Canada.~0.01–0.05%

Punica granatum extractEffect: LowA plant extract that can help neutralize free radicals in skin and even out the skin tone, but is typically used in products in a concentration that is too low to be effective~0.25–0.45%

Retinyl palmitateUnder-dosedEffect: MediumThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect~0.25–0.45%

Anti-aging

Hydroxypinacolone retinoate, Palmitoyl hexapeptide-12 + 3 more

Strong evidence

What the product description says

“Powered by Retinol, Hyaluronic Acid, Peptides and more to visibly improve crepey skin, superficial lines, wrinkles on your arms, chest, abdomen, above your knees and more.”

Source: Dr. Denese

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains hydroxypinacolone retinoate, palmitoyl hexapeptide-12.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

Palmitoyl hexapeptide-12Key activeEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.5%

Butyrospermum parkii butterEffect: LowA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals~1.2–1.5%

Ascorbyl palmitateEffect: Low, below effective doseBeing a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.~0.25–0.45%

Anti-blemish

Not advertised by the brand · Hydroxypinacolone retinoate, Pantothenic acid + 1 more

Strong evidence

This product can help reduce breakouts and clogged pores because it contains the following ingredient: hydroxypinacolone retinoate. This ingredient is used for treating acne and can have a noticeable effect.

The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually works: pantothenic acid

Pantothenic acidKey activeEffect: MediumHelps attract water to the upper layer of the skin and may help reduce inflammation in skin~0.25–0.45%

Anti-oxidation

Not advertised by the brand · Punica granatum extract, Actinidia chinensis fruit extract + 8 more

Moderate evidence

This product contains antioxidants (punica granatum extract) that might be able to help neutralize free radicals in skin to lessen the damage it gets from the UV light (sun). There is not enough evidence to confirm their effectiveness in skin though.

Punica granatum extractKey activeEffect: MediumA plant extract that can help neutralize free radicals in skin and even out the skin tone, but is typically used in products in a concentration that is too low to be effective~0.25–0.45%

Actinidia chinensis fruit extractEffect: LowA plant extract that might have some anti-oxidant properties, but evidence of effectiveness in skin is lacking~0.25–0.5%

Garcinia mangostana fruit extractEffect: LowA fruit extract that might have some anti-oxidant properties~0.25–0.45%

Zingiber officinale root extractEffect: LowA plant extract that can contain an irritating essential oil. Might have some anti-oxidant effect, but evidence is lacking~0.2–0.35%

Psidium guajava fruit extractEffect: LowA fruit extract that might have some anti-oxidant effect~0.25–0.45%

BisabololEffect: Low, below effective doseAn active component of chamomile plant that historically has been used to calm down irritated skin. A recent study shows that bisabolol indeed can have some anti-inflammatory effect on skin, even though conclusive data is lacking. Bisabolol has a sweet floral scent and can be added to products for its aromatic properties~0.2–0.4%

Tocopheryl acetateEffect: Low, below effective doseA more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.~0.25–0.5%

Can it cause trouble?

Irritancy

4 strong irritants: Retinyl palmitate, Zingiber officinale root extract + 2 more — patch-test recommended

High risk

We flagged 22 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.

IngredientFunctionIrritationEst. amount

Retinyl palmitateThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effectHigh~0.25–0.45%est.

Zingiber officinale root extractA plant extract that can contain an irritating essential oil. Might have some anti-oxidant effect, but evidence is lackingHigh~0.2–0.35%est.

Actinidia chinensis fruit extractA plant extract that might have some anti-oxidant properties, but evidence of effectiveness in skin is lackingHigh~0.25–0.5%est.

Garcinia mangostana fruit extractA fruit extract that might have some anti-oxidant propertiesHigh~0.25–0.45%est.

Psidium guajava fruit extractA fruit extract that might have some anti-oxidant effectHigh~0.25–0.45%est.

Hydroxypinacolone retinoateA derivative of the most potent form of vitamin A, retinoic acid. The ingredient can be sold under name Granactive Retinoid. Note that if a skincare brand discloses the concentration of Granactive Retinoid in a product, the concentration refers to a diluted form of Hydroxypinacolone Retinoate: 1% of Granactive Retinoid corresponds to 0.1% of Hydroxypinacolone Retinoate. Hydroxypinacolone Retinoate (HPR) is a unique derivative of retinoic acid because it can directly work in the skin and does not require additional conversion steps. According to studies done by the manufacturer on models of human skin (not real people), this derivative is more effective than other cosmetic versions of retinoids (such as retinol, retinaldehyde, and retinyl palmitate), and, at the same time, causes less irritation. It has been also demonstrated to be more stable than retinol which makes formulating with easier and increases the chances that a product with it will maintain its effectiveness after opening. The packaging should still ideally be air-tight. HPR is available over the counter in the EU, UK, Asia, Australia and New Zealand, but is only with a prescription in Canada.High~0.01–0.05%est.

ParfumAn aromatic blend of unspecified and possibly irritating ingredientsHigh~0.1–0.15%est.

Cannabis sativa seed oilA plant oil that due to its high linoleic acid content can help strengthen skin's barrier function and soften its upper layerMedium~4.8–5.9%est.

Methyl glucose sesquistearateHelps water and oil mix togetherMedium~2.3–2.9%est.

Caprylic/capric triglycerideA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerinMedium~1.5–1.8%est.

Peg-10 phytosterolHelps oil and water mix togetherMedium~0.3–0.6%est.

Ascorbyl palmitateBeing a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.Medium~0.25–0.45%est.

Tocopheryl acetateA more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.Medium~0.25–0.5%est.

Ananas sativus fruit extractA fruit extract that might help to attract water to the upper layer of the skin, but there is no evidence for any other benefits to the skinMedium~0.25–0.45%est.

Punica granatum extractA plant extract that can help neutralize free radicals in skin and even out the skin tone, but is typically used in products in a concentration that is too low to be effectiveMedium~0.25–0.45%est.

Leuconostoc/radish root ferment filtrateA preservative that comes from radishes fermented by a bacteria. New research suggests that the preservation properties in the ingredient come from an ammonium salt that is not present naturally in radish root but used in its cultivation. Is problematic because the exact amount of the preservative agents is difficult to determineMedium~0.25–0.45%est.

Sodium stearoyl glutamateHelps oil and water mix togetherMedium~0.3–0.6%est.

Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymerA gelling agent that thickens the product consistency and leaves the skin with a velvety finishMedium~0.25–0.45%est.

Polysorbate 60Helps oil and water mix togetherMedium~0.25–0.45%est.

Acrylates/c10-30 alkyl acrylate crosspolymerMaintains the texture of skincare products. Allows the product to spread evenly. Helps oil and water mix togetherMedium~0.15–0.3%est.

Disodium edtaStabilizes the product formulationMedium~0.15–0.3%est.

EthylhexylglycerinA preservativeMedium~0.1–0.2%est.

Comedogenic

2 ingredients rated 2 or more on the 0–5 pore-clogging scale

2 flagged

These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.

IngredientFunctionRatingEst. amount

Butyrospermum parkii butterA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals3/5~1.2–1.5%est.

Cetearyl alcoholA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture2/5~1.7–2%est.

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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%

Formula

Irritation risk: Low

Plain old water

More about Water

Cannabis sativa seed oil~4.8–5.9%

Key activeIrritant · medium

Irritation risk: Medium

Works for

Moisturizing

A plant oil that due to its high linoleic acid content can help strengthen skin's barrier function and soften its upper layer

More about Cannabis sativa seed oil

Phenyl trimethicone~4.4–5.4%

Key active

Irritation risk: Low

Works for

Moisturizing

A type of silicone that can decrease loss of moisture from the skin surface. It helps create a nice product texture

More about Phenyl trimethicone

Dodecane~3–3.6%

Formula

Irritation risk: Low

More about Dodecane

Methyl glucose sesquistearate~2.3–2.9%

Irritant · medium

Irritation risk: Medium

Works for

Cleansing

Helps water and oil mix together

More about Methyl glucose sesquistearate

Cyclopentasiloxane~2–2.4%

Key active

Irritation risk: Low

Works for

MattifyingMoisturizing

A silicone that helps improve the product texture and spreadability. Can absorb oil creating a short-term mattifying effect on the skin

More about Cyclopentasiloxane

Cetearyl alcohol~1.7–2%

Key activeComedogenic 2/5

Irritation risk: Low
Comedogenicity: 2/5

Works for

CleansingMoisturizing

A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture

More about Cetearyl alcohol

Caprylic/capric triglyceride~1.5–1.8%

Key activeIrritant · medium

Irritation risk: Medium

Works for

Moisturizing

A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin

More about Caprylic/capric triglyceride

Butyrospermum parkii butter~1.2–1.5%

Key activeComedogenic 3/5

Irritation risk: Low
Comedogenicity: 3/5

Works for

MoisturizingAnti-agingAnti-oxidation

A great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals

More about Butyrospermum parkii butter

Glycerin~1–1.2%

Key active

Irritation risk: Low

Works for

Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin

Glyceryl stearate citrate~0.7–1.05%

Formula

Irritation risk: Low

Works for

CleansingMoisturizing

Helps oil and water mix together while softening the upper layer of the skin

More about Glyceryl stearate citrate

Glyceryl caprylate~0.6–0.95%

Formula

Irritation risk: Low

Works for

CleansingMoisturizing

An emollient that can also help water and oil mix together, as well as prevent bacteria growth in products

More about Glyceryl caprylate

Dimethicone~0.55–0.85%

Key active

Irritation risk: Low

Works for

MoisturizingMattifying

A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish

More about Dimethicone

Bis-diglyceryl polyacyladipate-2~0.5–0.75%

Key active

Irritation risk: Low

Works for

Moisturizing

Helps soften the upper layer of the skin and reduce water loss from its surface

More about Bis-diglyceryl polyacyladipate-2

Cetyl alcohol~0.5–0.75%

Key active

Irritation risk: Low

Works for

CleansingMoisturizing

A non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together

More about Cetyl alcohol

Squalane~0.5–0.75%

Key active

Irritation risk: Low

Works for

Moisturizing

An oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.

More about Squalane

Sodium hyaluronate~0.4–0.6%

Key active

Irritation risk: Low

Works for

Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate

Hydrolyzed sodium hyaluronate~0.35–0.6%

Key active

Irritation risk: Low

Works for

Moisturizing

Attracts water into the upper layer of the skin

More about Hydrolyzed sodium hyaluronate

Ceramide ng~0.35–0.6%

Hero · Moisturizing

Irritation risk: Low

Works for

MoisturizingAnti-inflammatory

A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin

More about Ceramide ng

Peg-10 phytosterol~0.3–0.6%

Irritant · medium

Irritation risk: Medium

Works for

Cleansing

Helps oil and water mix together

More about Peg-10 phytosterol

Palmitoyl hexapeptide-12~0.3–0.5%

Hero · Moisturizing

Irritation risk: Low

Works for

Anti-agingMoisturizing

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl hexapeptide-12

Phospholipids~0.25–0.5%

Key active

Irritation risk: Low

Works for

Moisturizing

Emollients that are naturaly present in skin. In addition, they help water and oil mix together in the product

More about Phospholipids

Retinyl palmitate~0.25–0.45%

Under-dosedIrritant · high

Irritation risk: High

Works for

Anti-agingEvens skin toneAnti-blemishExfoliation

Three steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect

More about Retinyl palmitate

Pantothenic acid~0.25–0.45%

Key active

Irritation risk: Low

Works for

MoisturizingReduces irritationReduces rednessAnti-blemish

Helps attract water to the upper layer of the skin and may help reduce inflammation in skin

More about Pantothenic acid

Ascorbyl palmitate~0.25–0.45%

Irritant · medium

Irritation risk: Medium

Works for

Anti-oxidationAnti-aging

Being a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.

More about Ascorbyl palmitate

Tocopheryl acetate~0.25–0.5%

Irritant · medium

Irritation risk: Medium

Works for

Anti-oxidation

A more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.

More about Tocopheryl acetate

Bisabolol~0.2–0.4%

Formula

Irritation risk: Low

Works for

Reduces irritationAnti-inflammatoryAnti-oxidation

An active component of chamomile plant that historically has been used to calm down irritated skin. A recent study shows that bisabolol indeed can have some anti-inflammatory effect on skin, even though conclusive data is lacking. Bisabolol has a sweet floral scent and can be added to products for its aromatic properties

More about Bisabolol

Zingiber officinale root extract~0.2–0.35%

Irritant · high

Irritation risk: High

Works for

Anti-oxidation

A plant extract that can contain an irritating essential oil. Might have some anti-oxidant effect, but evidence is lacking

More about Zingiber officinale root extract

Averrhoa carambola fruit extract~0.25–0.45%

Formula

Irritation risk: Low

More about Averrhoa carambola fruit extract

Passiflora incarnata fruit extract~0.25–0.45%

Formula

Irritation risk: Low

More about Passiflora incarnata fruit extract

Actinidia chinensis fruit extract~0.25–0.5%

Irritant · high

Irritation risk: High

Works for

Anti-oxidation

A plant extract that might have some anti-oxidant properties, but evidence of effectiveness in skin is lacking

More about Actinidia chinensis fruit extract

Garcinia mangostana fruit extract~0.25–0.45%

Irritant · high

Irritation risk: High

Works for

Anti-oxidationMoisturizing

A fruit extract that might have some anti-oxidant properties

More about Garcinia mangostana fruit extract

Ananas sativus fruit extract~0.25–0.45%

Irritant · medium

Irritation risk: Medium

Works for

Moisturizing

A fruit extract that might help to attract water to the upper layer of the skin, but there is no evidence for any other benefits to the skin

More about Ananas sativus fruit extract

Punica granatum extract~0.25–0.45%

Key activeIrritant · medium

Irritation risk: Medium

Works for

Anti-oxidationEvens skin tone

A plant extract that can help neutralize free radicals in skin and even out the skin tone, but is typically used in products in a concentration that is too low to be effective

More about Punica granatum extract

Litchi chinensis fruit extract~0.25–0.45%

Formula

Irritation risk: Low

More about Litchi chinensis fruit extract

Zizyphus jujuba fruit extract~0.25–0.45%

Formula

Irritation risk: Low

More about Zizyphus jujuba fruit extract

Psidium guajava fruit extract~0.25–0.45%

Irritant · high

Irritation risk: High

Works for

Anti-oxidation

A fruit extract that might have some anti-oxidant effect

More about Psidium guajava fruit extract

Leuconostoc/radish root ferment filtrate~0.25–0.45%

Irritant · medium

Irritation risk: Medium

A preservative that comes from radishes fermented by a bacteria. New research suggests that the preservation properties in the ingredient come from an ammonium salt that is not present naturally in radish root but used in its cultivation. Is problematic because the exact amount of the preservative agents is difficult to determine

More about Leuconostoc/radish root ferment filtrate

Dimethyl isosorbide~0.25–0.45%

Formula

Irritation risk: Low

Used to dissolve other ingredients in a product and can enhance their ability to penetrate the skin

More about Dimethyl isosorbide

Hydroxypinacolone retinoate~0.01–0.05%

Hero · Anti-aging, Evens skin tone, Anti-blemishIrritant · high

Irritation risk: High

Works for

Evens skin toneAnti-blemishAnti-agingExfoliation

A derivative of the most potent form of vitamin A, retinoic acid. The ingredient can be sold under name Granactive Retinoid. Note that if a skincare brand discloses the concentration of Granactive Retinoid in a product, the concentration refers to a diluted form of Hydroxypinacolone Retinoate: 1% of Granactive Retinoid corresponds to 0.1% of Hydroxypinacolone Retinoate. Hydroxypinacolone Retinoate (HPR) is a unique derivative of retinoic acid because it can directly work in the skin and does not require additional conversion steps. According to studies done by the manufacturer on models of human skin (not real people), this derivative is more effective than other cosmetic versions of retinoids (such as retinol, retinaldehyde, and retinyl palmitate), and, at the same time, causes less irritation. It has been also demonstrated to be more stable than retinol which makes formulating with easier and increases the chances that a product with it will maintain its effectiveness after opening. The packaging should still ideally be air-tight. HPR is available over the counter in the EU, UK, Asia, Australia and New Zealand, but is only with a prescription in Canada.

More about Hydroxypinacolone retinoate

C12-15 alkyl benzoate~0.3–0.55%

Key active

Irritation risk: Low

Works for

Moisturizing

Enhances the product texture and makes it more spreadable. Helps reduce water loss from the outer layer of skin. Extands the shelf life by preventing bacteria growth

More about C12-15 alkyl benzoate

Tribehenin~0.3–0.5%

Formula

Irritation risk: Low

Works for

Moisturizing

Used to create a thicker product consistency and soften the upper layer of the skin

More about Tribehenin

Sodium stearoyl glutamate~0.3–0.6%

Irritant · medium

Irritation risk: Medium

Works for

Cleansing

Helps oil and water mix together

More about Sodium stearoyl glutamate

Arginine~0.25–0.4%

Key active

Irritation risk: Low

Works for

Moisturizing

An amino acid that is naturally present in skin and helps keep it hydrated. When used together with AHAs, it can reduce their irritating effect on the skin

More about Arginine

Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer~0.25–0.45%

Irritant · medium

Irritation risk: Medium

A gelling agent that thickens the product consistency and leaves the skin with a velvety finish

More about Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer

Polysorbate 60~0.25–0.45%

Irritant · medium

Irritation risk: Medium

Works for

Cleansing

Helps oil and water mix together

More about Polysorbate 60

Dimethiconol~0.25–0.5%

Key active

Irritation risk: Low

Works for

Moisturizing

A silicone that makes products more spreadable and keeps skin smooth. Helps to add gloss to skin and may visually fill in fine lines/wrinkles for short time

More about Dimethiconol

Hydroxymethoxyphenyl decanone~0.2–0.4%

Formula

Irritation risk: Low

Works for

Anti-oxidationMoisturizing

An anti-oxidant. Is also called 6-paradol. It might be able to neutralize free radicals in skin. The manufacturer claims that it is able to stimulate synthesis of hyaluronic acid in skin, but there is no evidence of effectiveness of this ingredient so far. The only evidence of efficacy for this ingredient so far come from small lab tests. This ingredient comes together with Caprylic/Capric Triglyceride as part of the complex called SymDecanox HA produced by a cosmetic ingredient supplier Symrise.

More about Hydroxymethoxyphenyl decanone

Xanthan gum~0.2–0.35%

Formula

Irritation risk: Low

Works for

Cleansing

Used to create a thicker product consistency

More about Xanthan gum

Acrylates/c10-30 alkyl acrylate crosspolymer~0.15–0.3%

Irritant · medium

Irritation risk: Medium

Maintains the texture of skincare products. Allows the product to spread evenly. Helps oil and water mix together

More about Acrylates/c10-30 alkyl acrylate crosspolymer

Disodium edta~0.15–0.3%

Irritant · medium

Irritation risk: Medium

Stabilizes the product formulation

More about Disodium edta

Phenoxyethanol~0.15–0.3%

Formula

Irritation risk: Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol

Ethylhexylglycerin~0.1–0.2%

Irritant · medium

Irritation risk: Medium

A preservative

More about Ethylhexylglycerin

Parfum~0.1–0.15%

Irritant · high

Irritation risk: High

An aromatic blend of unspecified and possibly irritating ingredients

More about Parfum

Ingredient list view

Water, Cannabis sativa seed oil, Phenyl trimethicone, Dodecane, Methyl glucose sesquistearate, Cyclopentasiloxane, Cetearyl alcohol, Caprylic/capric triglyceride, Butyrospermum parkii butter, Glycerin, Glyceryl stearate citrate, Glyceryl caprylate, Dimethicone, Bis-diglyceryl polyacyladipate-2, Cetyl alcohol, Squalane, Sodium hyaluronate, Hydrolyzed sodium hyaluronate, Ceramide ng, Peg-10 phytosterol, Palmitoyl hexapeptide-12, Phospholipids, Retinyl palmitate, Pantothenic acid, Ascorbyl palmitate, Tocopheryl acetate, Bisabolol, Zingiber officinale root extract, Averrhoa carambola fruit extract, Passiflora incarnata fruit extract, Actinidia chinensis fruit extract, Garcinia mangostana fruit extract, Ananas sativus fruit extract, Punica granatum extract, Litchi chinensis fruit extract, Zizyphus jujuba fruit extract, Psidium guajava fruit extract, Leuconostoc/radish root ferment filtrate, Dimethyl isosorbide, Hydroxypinacolone retinoate, C12-15 alkyl benzoate, Tribehenin, Sodium stearoyl glutamate, Arginine, Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, Polysorbate 60, Dimethiconol, Hydroxymethoxyphenyl decanone, Xanthan gum, Acrylates/c10-30 alkyl acrylate crosspolymer, Disodium edta, Phenoxyethanol, Ethylhexylglycerin, Parfum

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
	Dr. DeneseBody Rx Tightening CreamYOUR PRODUCT	HickapBedtime Magic Repairing Night Cream	Seriøst Bedre HudA-vitamincremen	Peter Thomas RothGreen Releaf Therapeutic Sleep Cream
Match	—	61%	60%	60%
Price	$79.00	—	—	$88.00+$9.00
Shared key ingredients	—	6 of 20	6 of 20	7 of 20
Key difference	—	Bakuchiol	Niacinamide	Gluconolactone
Irritancy	High	Medium	Medium	Medium
Drying alcohol	—	—	—	—
	View product	Shop	Shop	Shop

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Product summary

Based on the ingredient list, "Dr. Denese - Body Rx Tightening Cream" can work well for skin moisturization. To work well, any moisturizer needs to include a combination of water-binding and emollient ingredients. Dr. Denese - Body Rx Tightening Cream ticks this box. Humectants in this product (arginine, glycerin and sodium hyaluronate) help to increase the water content in the upper layer of the skin. (These ingredients do so by "capturing" water molecules from the outside air or from within the deeper layers of the skin). Ceramide ng, cannabis sativa seed oil, arginine, bis-diglyceryl polyacyladipate-2 and butyrospermum parkii butter in this product help decrease the water evoporation from the skin, so that it stays hydrated for longer. These ingredients also soften the skin and take away the feeling of tightness and dryness.

Ingredient callouts

this moisturizer contains an effective form of retinoids (vitamin A): hydroxypinacolone retinoate 0.01% - 0.05%. Retinoids are potent multitasking actives. They work to improve and prevent early signs of aging, reduce hyperpigmentation (age spots and post-acne marks), and prevent inflamed blemishes and clogged pores. The downside of retinoids is that they can be irritating. If you are not already using a retinoid in your routine, it is best to start slowly and apply the retinoid product only a few times per week. If your skin tolerates it well, you can gradually increase the frequency to daily. Because of the irritation risk of retinoids, we recommend to have another, retinoid-free moisturizer in your routine to use on the alternative days or when your skin feels dry.
Another benefit is that this moisturizer contain ceramides (ceramide ng 0.35% - 0.60%). Ceramides are an important part of our natural skin barrier. The ceramides used in skincare are synthetic or come from plants. They help soften the skin and can help "fill the gaps" in the skin barrier, keeping the skin hydrated and resilient for longer.
This moistruizer also contains peptides (palmitoyl hexapeptide-12 0.30% - 0.50%). Peptides is a very big group of ingredients. They all consist of a different combination of amino-acids. Our skin produces peptides naturally. Some of them work as natural anti-biotics, promote wound-healing and production of collagen. The scientists are still studying how effective the topical application of peptides is, but it is very likely that peptides in skincare are helpful. They might be able to support skin barrier restoration and even have an anti-aging benefit. At the very least, they certainly help attract water to the skin and support the hydration in this way.

Irritation risk

This formulation includes some common irritants, including ingredients that do not provide a benefit for the skin. We assess the overall irritancy of this moisturizer to be high. For a detailed overview of all potential irritants: click here

You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 21 studies and safety reviews.

1
Hemp (Cannabis sativa L.) seed oil: Analytical and phytochemical characterization of unsaponifiable fractionpubs.acs.org
2
Hemp (Cannabis sativa L.) as a Resource for Green Cosmeticstandfonline.com
3
Glycerol and the skin: holistic approach to its origin and functionsncbi.nlm.nih.gov
4
Dimethicone as a protective ingredient in topical medicationsjaad.org
5
Final Report on the Safety Assessment of Dimethicone Copolyoljournals.sagepub.com
6
Safety assessment of bis-diglyceryl polyacyladipate-2 and bis-diglyceryl polyacyladipate-1 as used in cosmeticsncbi.nlm.nih.gov
7
Hyaluronic acid: A key molecule in skin agingncbi.nlm.nih.gov
8
Hyaluronan (Hyaluronic Acid): a natural moisturizer for skin careresearchgate.net
9
Topical emulsions containing ceramides: Effects on the skin barrier function and anti‐inflammatory propertiesonlinelibrary.wiley.com
10
Topically Applied Ceramides Interact with the Stratum Corneum Lipid Matrix in Compromised Ex Vivo Skinncbi.nlm.nih.gov
11
α-(-)-Bisabolol Reduces Pro-Inflammatory Cytokine Production and Ameliorates Skin Inflammationresearchgate.net
12
Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): A review of recent researchsciencedirect.com
13
Extract of Punica granatum inhibits skin photoaging induced by UVB irradiationncbi.nlm.nih.gov
14
Topical microemulsion containing Punica granatum extract: its control over skin erythema and melanin in healthy Asian subjectsncbi.nlm.nih.gov
15
Safety Assessment of Punica granatum -Derived Ingredients as Used in Cosmeticscir-safety.org
16
Guava: phytochemical composition of a potential source of antioxidants for cosmetic and/or dermatological applicationsscielo.br
17
Activity enhancement of ferulic acid with dimethyl isosorbride in cosmetic compositionspatents.google.com
18
Antiaging effects of retinoid hydroxypinacolone retinoate on skin models. (2018). Journal of the American Academy of Dermatology, 79(3), AB44. doi:10.1016/j.jaad.2018.05.215 jaad.org
19
Treatment of mild to moderate acne with a fixed combination of hydroxypinacolone retinoate, retinol glycospheres and papain glycospheresscopus.com
20
COMPOSITION COMPRISING A CROSSLINKED HYALURONIC ACID (HA) IN COMBINATION WITH A LOW-MOLECULAR HA AND/OR AN AGENT STIMULATING ENDOGENOUS HA SYNTHESISfreepatentsonline.com
21
Designing topical hyaluronic acid technology—Size does matteronlinelibrary.wiley.com

Dr. DeneseBody Rx Tightening Cream

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