Works for:
based on ingredients and %- Moisturizing
- Anti-blemish
- Anti-oxidation
- Anti-aging
Can it cause trouble?
- Irritation risk: high
- Comedogenic risk ingredients: 5
Key actives
Product Summary
"Perricone MD - The Acne Relief Soothing Regimen" is effective for: Anti-inflammatory, Moisturizing, Anti-aging, Exfoliation, Anti-blemish and Evens skin tone
Ingredient callouts
- This product contains acids (lactic acid 0.80% - 1.20%). Their concentration is low, and they will not have a strong exfoliating effect. Instead, they work to support the skin natural acid mantle and to attract water (as humectants). Lactic acid is particularly good in attracting water to the upper layer of the skin and improving the skin barrier.
- What makes this product special is the inclusion of Cannabidiol, or CBD (0.30% - 0.50%). CBD is a new active in skincare, and the research about it is still ongoing. It is already clear though that CBD can bind to skin cell receptors. It can help reduce inflammation, itching, and help support skin barrier function. It also has a promise in reducing acne.
- This product contains an effective form of Retinoids (vitamin A): retinol 0.25% - 0.45%. Retinoids are potent multitasking actives. They work to improve and prevent early signs of aging, reduce hyperpigmentation (age spots and post-acne marks), and prevent inflamed blemishes and clogged pores. The downside of Retinoids is that they can be irritating. If you are not already using a Retinoid in your routine, it is best to start slowly and apply the Retinoid product only a few times per week. If your skin tolerates it well, you can gradually increase the frequency to daily.
- Ceramides (ceramide np 0.30% - 0.60%). Ceramides are a type of lipids that our skin produces itself. They are a building block of the skin's barrier. Ceramides used in skincare are synthetic or extracted from plants. They work well for softening the skin surface and "patch holes" in the skin's barrier.
- Humectants (sodium pca 0.10% - 0.25%, sodium lactate 0.15% - 0.25%, glycerin 0.30% - 0.60%, betaine 0.25% - 0.45%, glycerin 0.30% - 0.55%, arginine 0.25% - 0.45%, glycerin 0.30% - 0.60%, citrulline 1.40% - 1.70%, glycerin 3.80% - 4.60% and citrulline 0.25% - 0.45%). These ingredients help attract water to the upper layer of the skin and improve the skin hydration.
About the brand
According to Cruelty-Free Kitty "Perricone MD" is cruelty free and so is its parent company.
Price
The product retails for 199.00$ in the United States.
For a detailed price comparison: click here.
Anti-aging
This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains retinol.
These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: tocotrienols.
Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
A type of vitamin E that is more powerful in neutralizing free radicals compared to its other forms
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
An exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)
Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself
Anti-blemish
What does the product description say?
The Acne Relief Soothing Regimen
Source: From product name
This product can help reduce breakouts and clogged pores because it contains the following ingredient: retinol, salicylic acid. These ingredients is used for treating acne and can have a noticeable effect.
The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually works: cannabidiol - derived from extract or tincture or resin of cannabis
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
Used for skin exfoliation. It has an anti-inflammatory and anti-bacterial effect, helps to unclog pores, prevent blemishes and speed up healing of the existing ones. Sometimes referred to as a BHA (beta-hydroxy acid)
CBD. Can bind to skin cell receptors and can reduce inflammation, itching, and help support skin barrier function
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
Helps calm down inflammation in skin and can help reduce itching. Helps to repair the skin barrier and keep skin hydrated
Anti-oxidation
This product contains antioxidants (retinol, tocotrienols) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
A type of vitamin E that is more powerful in neutralizing free radicals compared to its other forms
CBD. Can bind to skin cell receptors and can reduce inflammation, itching, and help support skin barrier function
A plant extract that has some anti-oxidant and anti-bacterial properties. Can be irritating
A great emollient that can also have anti-oxidant properties
Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself
Can have some moisturizing properties due to its sugar content
A plant extract that can contain an antioxidant compound
An active component of chamomile plant that historically has been used to calm down irritated skin. A recent study shows that bisabolol indeed can have some anti-inflammatory effect on skin, even though conclusive data is lacking. Bisabolol has a sweet floral scent and can be added to products for its aromatic properties
A more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.
A plant extract containing sugars that might help attract water to the upper layer of the skin. Is claimed by the manufacturer to help reduce pore size but evidence is lacking
Evens skin tone
This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: retinol.
In addition, this product contains salicylic acid. This ingredient (ingredients) might help reduce hyperpigmentation, but the effect, if any, is likely to be small.
Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
Used for skin exfoliation. It has an anti-inflammatory and anti-bacterial effect, helps to unclog pores, prevent blemishes and speed up healing of the existing ones. Sometimes referred to as a BHA (beta-hydroxy acid)
An exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
A salt derived from licorice. Works as an emollient to soften the upper layer of the skin and can help calm down inflammation. Might be helpful for skin lightening
Exfoliation
This product can help exfoliate the skin. In other words, it helps break down the bonds between dead cells on the surface of the skin and speed up the skin turnover. Skin often appears softer and brighter after exfoliation, but overdoing it can result in disrupted skin barrier. The following ingredient is doing the exfoliating job in this product: retinol, salicylic acid.
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
Used for skin exfoliation. It has an anti-inflammatory and anti-bacterial effect, helps to unclog pores, prevent blemishes and speed up healing of the existing ones. Sometimes referred to as a BHA (beta-hydroxy acid)
An exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)
Helps calm down inflammation in skin and can help reduce itching. Helps to repair the skin barrier and keep skin hydrated
Moisturizing
What does the product description say?
It is an ultra-gentle cream designed to calm and smooth skin's appearance without irritating even the most sensitive skin.
Source: Perricone MD
This product can help improve hydration of the skin with the two types of ingredients.
The first type is called “humectants”:
these ingredients help attract water.
When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from
within deeper layers of the skin. The following ingredients in this product do the job:
arginine, betaine.
This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: arginine, bis-diglyceryl polyacyladipate-2.
The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: cannabidiol - derived from extract or tincture or resin of cannabis, ceramide np
A good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.
A plant oil that due to its high linoleic acid content can help strengthen skin's barrier function and soften its upper layer
A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin
Helps attract water to the upper layer of the skin. Is often used to adjust the pH level of the product
An amino acid that is naturally present in skin and helps keep it hydrated. When used together with AHAs, it can reduce their irritating effect on the skin
Helps attract water to the upper layer of the skin and improves the product texture
Helps soften the upper layer of the skin and reduce water loss from its surface
CBD. Can bind to skin cell receptors and can reduce inflammation, itching, and help support skin barrier function
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
Softens the upper layer of the skin and can support skin barrier function
Helps soften the upper layer of the skin
A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish
An amino-acid that helps attract water to the upper layer of the skin
Naturally present in skin and helps to attract water to its upper layer
An oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.
Helps soften the upper layer of the skin
A great emollient that can also have anti-oxidant properties
Help soften the upper layer of the skin
Helps attract water to the upper layer of the skin and soften it
Helps soften the upper layer of the skin
A non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together
A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture
An emollient that can also help water and oil mix together, as well as prevent bacteria growth in products
An emollient that softens the skin
Helps soften the upper layer of the skin, dissolve other ingredients and create a thicker product consistency
Helps soften the upper layer of the skin while creating a non-greasy feel on the skin. Helps to dissolve other ingredients
An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together
A salt derived from licorice. Works as an emollient to soften the upper layer of the skin and can help calm down inflammation. Might be helpful for skin lightening
An exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)
Helps calm down inflammation in skin and can help reduce itching. Helps to repair the skin barrier and keep skin hydrated
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
Can have some moisturizing properties due to its sugar content
An emollient that softens skin and creates a nice product texture
A plant extract containing sugars that might help attract water to the upper layer of the skin. Is claimed by the manufacturer to help reduce pore size but evidence is lacking
Used mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin
Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself
How honest is this product?
| Promise | Can it deliver? |
|---|---|
| Moisturizing | |
| Anti-blemish |
Total Promises Fulfilled score: 100/100.
We receive a small commission for purchases made through these links at no cost for you. Thank you for your support! Learn more
Potential irritants
Comedogenic ingredients
User reviews (0)
Averages from community submissions.
No reviews yet for this product.
Be the first to share your experience!
Tried this product?
Help capture what the ingredient list can't—texture, finish, pilling, scent, and more. Answer what you can, skip the rest.
Takes ~30 seconds.
Reviews are shown in aggregate. No personal details.
| Product | Similarity | Price | Irritancy |
|---|---|---|---|
 Perricone MD The Acne Relief Soothing Regimen | Current | $199.00 | |
YEOUTH Daytime Defense | 60% | $54.85 | |
Honest Beauty Clearing Night Serum With Honestly Pure Retinol | 58% | - | |
 CeraVe Salicylic Acid Acne Control Gel, Acne Treatment for Face | 57% | $19.99 | |
 InstaNatural Age Defying And Skin Clearing Serum | 57% | $-1.00 | |
 Glo Skin Beauty Beta‐Clarity BHA Drops | 56% | $43.20 |
Key Actives
Potential irritants
Comedogenic ingredients
All ingredients
Ingredient list view
Water, Sd alcohol 40-b, Glycerin, C12-15 alkyl lactate, Pvp, Dimethicone, Polysorbate 20, Citrulline, Squalane, Lactic acid, Succinic acid, Polyacrylamide, Dimethicone/vinyl dimethicone crosspolymer, C13-14 isoparaffin, Laureth-7, Phenoxyethanol, Sodium benzoate, Potassium sorbate, Salicylic acid, Water, Sd alcohol 40-b, Glycerin, Dicaprylyl ether, Niacinamide, Citrulline, Arginine, Methyl gluceth-20, Cetearyl alcohol, Carbomer, Xanthan gum, Tocopheryl acetate, Retinol, Citric acid, Sodium hydroxide, Disodium edta, Peg-20 methyl glucose sesquistearate, Peg-100 stearate, Glyceryl stearate, Methyl glucose sesquistearate, Polysorbate 20, Phenoxyethanol, Sodium benzoate, Potassium sorbate, Water, Glycerin, Betaine, Coco-caprylate, Triethylhexanoin, Sodium acrylates copolymer, Calendula officinalis flower extract, Cannabis sativa seed oil, Ceteareth-30, Cetearyl alcohol, Glyceryl stearate, Mauritia flexuosa fruit oil, Polyglyceryl-3 methylglucose distearate, Glyceryl caprylate, Cannabidiol - derived from extract or tincture or resin of cannabis, Bisabolol, Lecithin, Ceramide np, Dipotassium glycyrrhizate, Tocopherol, Caprylhydroxamic acid, 1,2-hexanediol, Water, Glycerin, Glyceryl stearate, Aluminum starch octenylsuccinate, Cetearyl alcohol, Bis-diglyceryl polyacyladipate-2, Cetyl alcohol, Vitis vinifera seed oil, Dicaprylyl ether, Hydrogenated palm kernel glycerides, Squalane, Calendula officinalis flower extract, Unknown, Cannabidiol - derived from extract or tincture or resin of cannabis, Glyceryl caprylate, Bisabolol, Ectoin, Citrullus lanatus fruit extract, Allantoin, Dipotassium glycyrrhizate, Xanthan gum, Pyrus malus fruit extract, Hydrogenated palm glycerides, Tocotrienols, Tocopherol, Glycine soja oil, Caprylhydroxamic acid, Ceteareth-20, 1,2-hexanediol, Sodium polyacrylate, Lens esculenta fruit extract, Sodium lactate, Elaeis guineensis oil, Sodium pca, Potassium sorbate, Sodium benzoate
- Glycerol and the skin: holistic approach to its origin and functions
- Dimethicone as a protective ingredient in topical medications
- Final Report on the Safety Assessment of Dimethicone Copolyol
- Dermatologic compositions comprising pyrrolidone-5-carboxylic acid and at least one entity chosen from citrulline, arginine and asparagine, and uses thereof in the treatment of atopic dermatitis
- Epidermal and dermal effects of topical lactic acid
- Dual Effects of Alpha-Hydroxy Acids on the Skin
- Safety Assessment of Isoparaffins as Used in Cosmetics
- Salicylic acid as a peeling agent: a comprehensive review
- Beta Hydroxy Acids
- A review of toxicity from topical salicylic acid preparations
- Glycolic Acid Peels Versus Salicylic–Mandelic Acid Peels in Active Acne Vulgaris and Post‐Acne Scarring and Hyperpigmentation: A Comparative Study
- Niacinamide - mechanisms of action and its topical use in dermatology
- Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology, 3(2), 88–93. doi:10.1111/j.1473-2130.2004.00115.x
- Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety
- Improvement of naturally aged skin with vitamin A (retinol)
- A comparative study of the effects of retinol and retinoic acid on histological, molecular, and clinical properties of human skin
- Amended Safety Assessment of Triglycerides as Used in Cosmetics
- Final Report on the Safety Assessment of Acrylates Copolymer and 33 Related Cosmetic Ingredients
- Topical application of Calendula officinalis (L.): Formulation and evaluation of hydrophilic cream with antioxidant activity
- The seamy side of natural medicines: contact sensitization to arnica (Arnica montana L.) and marigold (Calendula officinalis L.)
- Final report on the safety assessment of Calendula officinalis extract and Calendula officinalis
- Contact dermatitis as an adverse reaction to some topically used European herbal medicinal products – part 1: Achillea millefolium–Curcuma longa
- Hemp (Cannabis sativa L.) seed oil: Analytical and phytochemical characterization of unsaponifiable fraction
- Hemp (Cannabis sativa L.) as a Resource for Green Cosmetics
- α-(-)-Bisabolol Reduces Pro-Inflammatory Cytokine Production and Ameliorates Skin Inflammation
- Skin hydration is significantly increased by a cream formulated to mimic the skin’s own natural moisturizing systems
- Topically Applied Ceramides Interact with the Stratum Corneum Lipid Matrix in Compromised Ex Vivo Skin
- Ameliorating effect of dipotassium glycyrrhizinate on an IL-4- and IL-13-induced atopic dermatitis-like skin-equivalent model
- Final report on the safety assessment of Glycyrrhetinic Acid, Potassium Glycyrrhetinate, Disodium Succinoyl Glycyrrhetinate, Glyceryl Glycyrrhetinate, Glycyrrhetinyl Stearate, Stearyl Glycyrrhetinate, Glycyrrhizic Acid, Ammonium Glycyrrhizate, Dipotassium Glycyrrhizate, Disodium Glycyrrhizate, Trisodium Glycyrrhizate, Methyl Glycyrrhizate, and Potassium Glycyrrhizinate.
- Vitamin E in dermatology
- Vitamin E and Skin Health
- The influence of alkane chain length on the skin irritation potential of 1,2-alkanediols
- Safety assessment of bis-diglyceryl polyacyladipate-2 and bis-diglyceryl polyacyladipate-1 as used in cosmetics
- Analyzing Lycopene Content in Fruits
- Profile of wound healing process induced by allantoin
- Safety Assessment of Tocopherols and Tocotrienols as Used in Cosmetics
- Tocotrienol‐rich fraction attenuates UV‐induced inflammaging: A bench to bedside study
- Tocotrienols: Vitamin E beyond tocopherols
- Clinical evaluation of photoprotective effect by a topical antioxidants combination (tocopherols and tocotrienols)
- Tocotrienols: the unsaturated sidekick shifting new paradigms in vitamin E therapeutics
- Genetic Architecture of Palm Oil Fatty Acid Composition in Cultivated Oil Palm (Elaeis guineensis Jacq.) Compared to Its Wild Relative E. oleifera (H.B.K) Cortés
- Nutrient composition of Nigerian palm kernel from the dura and tenera varieties of the oil palm (Elaeis guineensis)