Perricone MD Prebiotic Acne Therapy 30-Day Regimen

Perricone MD Prebiotic Acne Therapy 30-Day Regimen

Efficacy100/100IrritancyHigh

Works for

Exfoliation
Retinol, Lactic acid
Works well
What the product description says
“The powerful combination of retinol, citrulline and niacinamide helps to accelerate surface skin exfoliation and renewal,”
Source: Perricone MD

This product can help exfoliate the skin. In other words, it helps break down the bonds between dead cells on the surface of the skin and speed up the skin turnover. Skin often appears softer and brighter after exfoliation, but overdoing it can result in disrupted skin barrier. The following ingredient is doing the exfoliating job in this product: retinol.

RetinolKey activeEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~0.15–0.65%
Lactic acidUnder-dosedAn exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)~0.15–0.5%
Anti-blemish
Retinol, Niacinamide
Works well
What the product description says
“Prebiotic Acne Therapy 30-Day Regimen”
Source: Perricone MD

This product can help reduce breakouts and clogged pores because it contains the following ingredient: retinol. This ingredient is used for treating acne and can have a noticeable effect.

RetinolHeroEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~0.15–0.65%
NiacinamideUnder-dosedIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~0.15–0.5%
Cleansing
Sodium cocoyl isethionate, Peg-100 stearate + 8 more
Cleanses gently
What the product description says
“Acne Relief Gentle & Soothing Cleanser (2 fl oz / 59 mL)”
Source: Perricone MD

This product works by removing dirt and oil from the surface of the skin. It uses a combination of mild cleansing agents (carbomer, cetearyl alcohol, glyceryl stearate, laureth-7, methyl glucose sesquistearate, peg-100 stearate, peg-20 methyl glucose sesquistearate, polysorbate 20, sodium cocoyl isethionate, xanthan gum) and should be able to cleanse the skin gently. Still keep in mind that any cleansing can disrupt the skin barrier, and most people do not need to cleanse their skin more than once per day.

Sodium cocoyl isethionateEffect: HighHelps water and oil mix together. Can be used as a cleansing agent~7.5–11.2%
Peg-100 stearateEffect: HighHelps oil and water mix togehter and creates a nice product texture~0.2–0.75%
Xanthan gumEffect: HighUsed to create a thicker product consistency~0.15–0.5%
Peg-20 methyl glucose sesquistearateEffect: HighHelps oil and water mix together~0.15–0.65%
CarbomerEffect: HighHelps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations~0.15–0.5%
Cetearyl alcoholEffect: HighA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture~0.15–0.7%
Glyceryl stearateEffect: HighAn emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together~0.15–0.65%
Laureth-7Effect: HighHelps oil and water mix together~0.15–0.55%
Methyl glucose sesquistearateEffect: HighHelps water and oil mix together~0.15–0.6%
Polysorbate 20Effect: HighHelps oil and water mix together~0.1–0.45%

Can it cause trouble?

Irritancy
2 strong irritants: Sd alcohol 40-b, Retinol — patch-test recommended
High risk
We flagged 14 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Sd alcohol 40-bCan be drying and contribute to skin irritation. Used in formulars to dissolve other ingredients, create a thinner product consistency or for its antibacterial propertiesHigh~0.3–0.7%est.
RetinolTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritatingHigh~0.15–0.65%est.
Sodium cocoyl isethionateHelps water and oil mix together. Can be used as a cleansing agentMedium~7.5–11.2%est.
PolyacrylamideUsed to improve product texture and help oil and water mix togetherMedium~1.4–2.2%est.
Caprylyl glycolHelps preserve products and creates a nice product textureMedium~1–1.5%est.
Laureth-7Helps oil and water mix togetherMedium~0.45–1.05%est.
PvpHelps evenly disperse other ingredients in a formulation and create an even layer on the surface of the skinMedium~0.3–0.75%est.
Lactic acidAn exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)Medium~0.15–0.5%est.
Potassium sorbateA preservativeMedium~0.15–0.5%est.
Tocopheryl acetateA more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.Medium~0.15–0.65%est.
Citric acidCan work as an exfoliant but is typically used to adjust the product pHMedium~0.15–0.7%est.
Disodium edtaStabilizes the product formulationMedium~0.15–0.6%est.
Peg-20 methyl glucose sesquistearateHelps oil and water mix togetherMedium~0.15–0.65%est.
Methyl glucose sesquistearateHelps water and oil mix togetherMedium~0.15–0.6%est.
Comedogenic
2 ingredients rated 2 or more on the 0–5 pore-clogging scale
2 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Ethylhexyl palmitateAn emollient that helps soften the skin and create a nice product texture3/5~4.6–6.9%est.
Cetearyl alcoholA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture2/5~0.15–0.7%est.

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Ingredients

Filter by role to see what each ingredient is doing.

Glycerin~22–34%
Formula
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Sodium cocoyl isethionate~7.5–11.2%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps water and oil mix together. Can be used as a cleansing agent

More about Sodium cocoyl isethionate
Ethylhexyl palmitate~4.6–6.9%
Comedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
Moisturizing

An emollient that helps soften the skin and create a nice product texture

More about Ethylhexyl palmitate
Silica cetyl silylate~3.4–5.1%
Formula
Sucrose~2.4–3.6%
Formula
Irritation risk
Low
Works for
Moisturizing

Can help attract water to the upper layer of the skin. In crystal form, it can work as a gentle exfoliant, gentler than the salt scrub. Helps stabilize the emulsion

More about Sucrose
Squalane~2.1–3.2%
Formula
Irritation risk
Low
Works for
Moisturizing

An oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.

More about Squalane
Polyacrylamide~1.4–2.2%
Irritant · medium
Irritation risk
Medium

Used to improve product texture and help oil and water mix together

More about Polyacrylamide
Water~1.2–1.7%
Formula
Irritation risk
Low

Plain old water

More about Water
Caprylyl glycol~1–1.5%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol
C13-14 isoparaffin~0.8–1.2%
Formula
Irritation risk
Low
Works for
Moisturizing

Helps soften the upper layer of the skin, dissolve other ingredients and create a thicker product consistency

More about C13-14 isoparaffin
Laureth-7~0.45–1.05%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps oil and water mix together

More about Laureth-7
Phenoxyethanol~0.35–0.85%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Water~0.35–0.8%
Formula
Irritation risk
Low

Plain old water

More about Water
Sd alcohol 40-b~0.3–0.7%
Irritant · high
Irritation risk
High
Works for
Antibacterial

Can be drying and contribute to skin irritation. Used in formulars to dissolve other ingredients, create a thinner product consistency or for its antibacterial properties

More about Sd alcohol 40-b
Glycerin~0.3–0.7%
Formula
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
C12-15 alkyl lactate~0.35–0.8%
Formula
Pvp~0.3–0.75%
Irritant · medium
Irritation risk
Medium

Helps evenly disperse other ingredients in a formulation and create an even layer on the surface of the skin

More about Pvp
Dimethicone~0.3–0.75%
Formula
Irritation risk
Low
Works for
MoisturizingMattifying

A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish

More about Dimethicone
Polysorbate 20~0.15–0.65%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about Polysorbate 20
Citrulline~0.15–0.55%
Formula
Irritation risk
Low
Works for
Moisturizing

An amino-acid that helps attract water to the upper layer of the skin

More about Citrulline
Squalane~0.2–0.75%
Formula
Irritation risk
Low
Works for
Moisturizing

An oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.

More about Squalane
Lactic acid~0.15–0.5%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
Evens skin toneMoisturizingExfoliationAnti-aging

An exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)

More about Lactic acid
Succinic acid~0.15–0.5%
Formula
Irritation risk
Low
More about Succinic acid
Polyacrylamide~0.15–0.65%
Irritant · medium
Irritation risk
Medium

Used to improve product texture and help oil and water mix together

More about Polyacrylamide
Dimethicone/vinyl dimethicone crosspolymer~0.15–0.5%
Formula
Irritation risk
Low

Used to stabilize product formulations and create a nice product texture

More about Dimethicone/vinyl dimethicone crosspolymer
C13-14 isoparaffin~0.15–0.65%
Formula
Irritation risk
Low
Works for
Moisturizing

Helps soften the upper layer of the skin, dissolve other ingredients and create a thicker product consistency

More about C13-14 isoparaffin
Laureth-7~0.15–0.55%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps oil and water mix together

More about Laureth-7
Phenoxyethanol~0.15–0.55%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Sodium benzoate~0.15–0.5%
Formula
Irritation risk
Low

A preservative

More about Sodium benzoate
Potassium sorbate~0.15–0.5%
Irritant · medium
Irritation risk
Medium

A preservative

More about Potassium sorbate
Water~0.15–0.5%
Formula
Irritation risk
Low

Plain old water

More about Water
Sd alcohol 40-b~0.15–0.5%
Irritant · high
Irritation risk
High
Works for
Antibacterial

Can be drying and contribute to skin irritation. Used in formulars to dissolve other ingredients, create a thinner product consistency or for its antibacterial properties

More about Sd alcohol 40-b
Glycerin~0.15–0.6%
Formula
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Dicaprylyl ether~0.15–0.65%
Formula
Irritation risk
Low
Works for
Moisturizing

Helps soften the upper layer of the skin while creating a non-greasy feel on the skin. Helps to dissolve other ingredients

More about Dicaprylyl ether
Niacinamide~0.15–0.5%
Under-dosed
Irritation risk
Low
Works for
Anti-agingAnti-blemishEvens skin toneMoisturizingReduces irritationAnti-inflammatoryAntibacterialReduces redness

Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production

More about Niacinamide
Citrulline~0.1–0.5%
Formula
Irritation risk
Low
Works for
Moisturizing

An amino-acid that helps attract water to the upper layer of the skin

More about Citrulline
Arginine~0.1–0.45%
Formula
Irritation risk
Low
Works for
Moisturizing

An amino acid that is naturally present in skin and helps keep it hydrated. When used together with AHAs, it can reduce their irritating effect on the skin

More about Arginine
Methyl gluceth-20~0.1–0.5%
Formula
Irritation risk
Low
Works for
Moisturizing

Helps attract water to the upper layer of the skin and soften it

More about Methyl gluceth-20
Cetearyl alcohol~0.15–0.7%
Comedogenic 2/5
Irritation risk
Low
Comedogenicity
2/5
Works for
CleansingMoisturizing

A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture

More about Cetearyl alcohol
Carbomer~0.15–0.5%
Formula
Irritation risk
Low
Works for
Cleansing

Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations

More about Carbomer
Xanthan gum~0.15–0.5%
Formula
Irritation risk
Low
Works for
Cleansing

Used to create a thicker product consistency

More about Xanthan gum
Tocopheryl acetate~0.15–0.65%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidation

A more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.

More about Tocopheryl acetate
Retinol~0.15–0.65%
Hero · Anti-blemishIrritant · high
Irritation risk
High
Works for
Anti-agingEvens skin toneAnti-blemishMattifyingExfoliationAnti-oxidation

Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating

More about Retinol
Citric acid~0.15–0.7%
Irritant · medium
Irritation risk
Medium

Can work as an exfoliant but is typically used to adjust the product pH

More about Citric acid
Sodium hydroxide~0.15–0.65%
Formula
Irritation risk
Low

Used to adjust the product's pH

More about Sodium hydroxide
Disodium edta~0.15–0.6%
Irritant · medium
Irritation risk
Medium

Stabilizes the product formulation

More about Disodium edta
Peg-20 methyl glucose sesquistearate~0.15–0.65%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps oil and water mix together

More about Peg-20 methyl glucose sesquistearate
Peg-100 stearate~0.2–0.75%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix togehter and creates a nice product texture

More about Peg-100 stearate
Glyceryl stearate~0.15–0.65%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together

More about Glyceryl stearate
Methyl glucose sesquistearate~0.15–0.6%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps water and oil mix together

More about Methyl glucose sesquistearate
Polysorbate 20~0.1–0.45%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about Polysorbate 20
Phenoxyethanol~0.1–0.4%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Sodium benzoate~0.05–0.3%
Formula
Irritation risk
Low

A preservative

More about Sodium benzoate
Potassium sorbate~0.1–0.35%
Irritant · medium
Irritation risk
Medium

A preservative

More about Potassium sorbate
Ingredient list view

Glycerin, Sodium cocoyl isethionate, Ethylhexyl palmitate, Silica cetyl silylate, Sucrose, Squalane, Polyacrylamide, Water, Caprylyl glycol, C13-14 isoparaffin, Laureth-7, Phenoxyethanol, Water, Sd alcohol 40-b, Glycerin, C12-15 alkyl lactate, Pvp, Dimethicone, Polysorbate 20, Citrulline, Squalane, Lactic acid, Succinic acid, Polyacrylamide, Dimethicone/vinyl dimethicone crosspolymer, C13-14 isoparaffin, Laureth-7, Phenoxyethanol, Sodium benzoate, Potassium sorbate, Water, Sd alcohol 40-b, Glycerin, Dicaprylyl ether, Niacinamide, Citrulline, Arginine, Methyl gluceth-20, Cetearyl alcohol, Carbomer, Xanthan gum, Tocopheryl acetate, Retinol, Citric acid, Sodium hydroxide, Disodium edta, Peg-20 methyl glucose sesquistearate, Peg-100 stearate, Glyceryl stearate, Methyl glucose sesquistearate, Polysorbate 20, Phenoxyethanol, Sodium benzoate, Potassium sorbate

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$89.00
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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
Perricone MDPrebiotic Acne Therapy 30-Day RegimenYOUR PRODUCTCleaning SupplyRetinol 24 + Peptide Face Wash, Smoothing, Sulfate-FreeCosMedixClarity SerumMedicubeKojic Acid Turmeric Toning Cleanser
Match—77%72%71%
Price$89.00—$55.00−$34.00$16.53−$72.47
Shared key ingredients—5 of 184 of 184 of 18
Key difference—Mineral OilSalicylic AcidMadecassoside
Irritancy High Medium High High
Drying alcohol Contains drying alcohol — Contains drying alcohol —
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Perricone MD Prebiotic Acne Therapy 30-Day Regimen
Perricone MDPrebiotic Acne Therapy 30-Day Regimen

Affiliate links · As an Amazon Associate, WIMJ earns from qualifying purchases.

As an Amazon Associate, WIMJ earns from qualifying purchases.