Filorga

Filorga Time-Filler 5xp Gel Cream

Name: Filorga - Time-Filler 5xp Gel Cream
Brand: Filorga

Efficacy100/100IrritancyHigh

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Works for

2 of 2 advertised claims delivered

Anti-aging

18 ingredients credited for this claim

Strong support

What the product description says

“Inspired by five areas of expertise from aesthetic medicine, Filorga’s Time-Fuller 5XP Correction Cream Gel targets five types of wrinkles to help smooth their appearance expression lines, deep wrinkles, dryness wrinkles, surface wrinkles and neck wrinkles.”

Source: Mankind

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains adenosine.

These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: aspartic acid, dipeptide diaminobutyroyl benzylamide diacetate, folic acid, palmitoyl tetrapeptide-7, palmitoyl tripeptide-1, retinyl acetate, serine, threonine.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

AdenosineKey activeEffect: HighMight help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)~0.25–0.5%

ThreonineKey activeEffect: MediumAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.25–0.5%

Aspartic acidKey activeEffect: MediumAn amino-acid that helps increase skin hydration and might help to slightly improve skin firmness, potentially reducing lines and wrinkles~0.25–0.5%

Dipeptide diaminobutyroyl benzylamide diacetateKey activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.5%

Folic acidKey activeEffect: MediumCan help stimulate collagen production in skin. While available studies are promising, more research is needed to confirm the efficacy in skin~0.1–0.15%

SerineKey activeEffect: MediumAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.25–0.45%

Retinyl acetateKey activeEffect: Medium~0.25–0.45%

Palmitoyl tetrapeptide-7Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.55%

Palmitoyl tripeptide-1Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.55%

Zinc pcaEffect: LowA compound that combines zinc with a hydrating ingredient PCA. Might to be helpful against acne and clogged pores. Can help calm down inflammation in skin. Could be helpful in reducing the formation of free radicals in skin. Might help to reduce fine lines in wrinkles, but solid evidence is missing~1.2–1.4%

HydroxyprolineEffect: LowIs helpful in restoring skin barrier function supporting its moisture levels. Is claimed to stimulte collagen production in skin but evidence is lacking~0.25–0.5%

Glucosamine hclEffect: LowMight be able to stimulate production of skin's natural moisturizing compounds such as hyaluronic acid. Could be helpful for evening the skin tone.~0.25–0.5%

Prunus amygdalus dulcis oilEffect: LowAn emollient that softens the skin~0.3–0.55%

NiacinamideUnder-dosedEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~0.2–0.35%

Ascorbic acidUnder-dosedEffect: HighThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging~0.25–0.5%

NiacinUnder-dosedEffect: MediumA form of vitamin B3. It is similar in action to niacinamide, but is more likely to cause red flashes in skin as the side effect~0.2–0.4%

TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.25–0.5%

Anigozanthos flavidus extractEffect: Low, below effective doseClaimed to have anti-oxidant properties but no evidence is available~0.25–0.5%

Moisturizing

47 ingredients credited for this claim

Strong support

What the product description says

“Inspired by five areas of expertise from aesthetic medicine, Filorga’s Time-Fuller 5XP Correction Cream Gel targets five types of wrinkles to help smooth their appearance expression lines, deep wrinkles, dryness wrinkles, surface wrinkles and neck wrinkles.”

Source: Mankind

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: alanine, aspartic acid.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: squalane, cetyl alcohol.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: dipeptide diaminobutyroyl benzylamide diacetate, palmitoyl tetrapeptide-7, palmitoyl tripeptide-1

Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~0.25–0.5%

Sodium lactateKey active· HumectantEffect: HighHelps attract water to the upper layer of the skin. Is often used to adjust the pH level of the product~0.25–0.5%

SqualaneKey active· Emollient, OcclusiveEffect: HighAn oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.~1.9–2.4%

ThreonineKey activeEffect: HighAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.25–0.5%

TyrosineKey activeEffect: High~0.25–0.45%

Aspartic acidKey active· HumectantEffect: HighAn amino-acid that helps increase skin hydration and might help to slightly improve skin firmness, potentially reducing lines and wrinkles~0.25–0.5%

Glutamic acidKey active· HumectantEffect: HighAn amino-acid that helps attract water to the upper layer of the skin~0.25–0.5%

GlutathioneKey activeEffect: HighA peptide that can help neutralize free radicals in skin and reduce melanin production resulting in skin lightening effect and reduction in hyperpigmentation. It can also help attract moisture to the upper layer of the skin~0.25–0.5%

GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~4.3–5.3%

Arginine hclKey activeEffect: HighAn amino acid that is naturally present in skin and helps keep it hydrated. When used together with AHAs, it can reduce their irritating effect on the skin~0.25–0.5%

GlycineKey active· HumectantEffect: HighHelps to attract water to the upper layer of the skin and can help restore the skin barrier function~0.25–0.5%

Histidine hclKey activeEffect: HighA salt of an amino-acid that helps attract water to the upper layer of the skin. Might be helpful in restoring the skin barrier function~0.25–0.5%

CyanocobalaminKey activeEffect: HighCan support skin barrier function and reduce inflammation in skin~0.25–0.5%

HydroxyprolineKey activeEffect: HighIs helpful in restoring skin barrier function supporting its moisture levels. Is claimed to stimulte collagen production in skin but evidence is lacking~0.25–0.5%

Imperata cylindrica root extractKey active· HumectantEffect: HighA plat extract that might help neutralize free radicals in skin and attract water to its upper layer~1.6–1.9%

InositolKey active· HumectantEffect: High~0.2–0.4%

IsoleucineKey activeEffect: HighAn amino acid that can help attract water to the upper layer of the skin and support skin's barrier function~0.25–0.5%

Lysine hclKey activeEffect: High~0.25–0.5%

AlanineKey active· HumectantEffect: HighAn amino-acid that helps to attract water to the upper layer of the skin and might help to lighten the skin, but solid evidence is lacking~0.25–0.5%

Calcium pantothenateKey activeEffect: HighHelps support skin barrier function improving skin hydration and reducing sensitivity~0.15–0.25%

Palmitoyl tetrapeptide-7Hero· EmollientEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.55%

Palmitoyl tripeptide-1Hero· EmollientEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.55%

Biosaccharide gum-1Key active· HumectantEffect: HighHelps attract water to the upper layer of the skin and is claimed to provide a longer-lasting hydration because of its ability to create a water-binding film on the surface of the skin~0.25–0.5%

Zinc pcaKey active· HumectantEffect: HighA compound that combines zinc with a hydrating ingredient PCA. Might to be helpful against acne and clogged pores. Can help calm down inflammation in skin. Could be helpful in reducing the formation of free radicals in skin. Might help to reduce fine lines in wrinkles, but solid evidence is missing~1.2–1.4%

Dipeptide diaminobutyroyl benzylamide diacetateHeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.5%

Glucosamine hclKey active· HumectantEffect: HighMight be able to stimulate production of skin's natural moisturizing compounds such as hyaluronic acid. Could be helpful for evening the skin tone.~0.25–0.5%

SerineKey activeEffect: HighAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.25–0.45%

GlucoseKey active· HumectantEffect: MediumHelps attract water to the upper layer of the skin. Could be helpful in restoring the skin barrier function~0.25–0.5%

Hydrogenated vegetable oilKey active· EmollientEffect: MediumAn oil from a mixture of different vegetables. Helps soften the upper layer of the skin~0.3–0.55%

ProlineKey activeEffect: Medium~0.3–0.5%

Propylheptyl caprylateKey active· EmollientEffect: MediumHelps soften the upper layer of the skin~4.2–5.1%

Prunus amygdalus dulcis oilKey active· EmollientEffect: MediumAn emollient that softens the skin~0.3–0.55%

Cetyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together~0.5–0.75%

Crithmum maritimum extractKey activeEffect: MediumAn algae extract that might have anti-oxidant properties~0.25–0.45%

AdenosineKey activeEffect: MediumMight help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)~0.25–0.5%

BiotinEffect: LowMight have some moisturising properties. Is not effective when applied topically beyond some moisturizing effect~0.25–0.5%

Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~0.3–0.55%

Glyceryl caprylate· EmollientEffect: LowAn emollient that can also help water and oil mix together, as well as prevent bacteria growth in products~0.3–0.6%

Coenzyme aEffect: LowHelps soften the upper layer of the skin and dissolve other ingredients in a product~0.25–0.45%

Dicaprylyl carbonate· EmollientEffect: LowHelps products spread more easily and works as an emollient to soften skin~2.3–2.8%

Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~0.5–0.75%

Propylene carbonateEffect: LowIs used to dissolve other ingredients and create nice product texture~0.3–0.6%

Caprylic/capric triglycerideUnder-dosedEffect: HighA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin~0.4–0.65%

NiacinUnder-dosedEffect: HighA form of vitamin B3. It is similar in action to niacinamide, but is more likely to cause red flashes in skin as the side effect~0.2–0.4%

Anigozanthos flavidus extractEffect: Low, below effective doseClaimed to have anti-oxidant properties but no evidence is available~0.25–0.5%

Evens skin tone

Not advertised by the brand · 7 ingredients credited for this claim

Strong support

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: glutathione

The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually can help even out the skin tone: alanine, glucosamine hcl.

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

Glucosamine hclKey activeEffect: MediumMight be able to stimulate production of skin's natural moisturizing compounds such as hyaluronic acid. Could be helpful for evening the skin tone.~0.25–0.5%

AlanineEffect: LowAn amino-acid that helps to attract water to the upper layer of the skin and might help to lighten the skin, but solid evidence is lacking~0.25–0.5%

TaurineEffect: LowCould be helpful in reducing inflammation in skin, evening out the skin tone and neutralizing free radicals, but more research is needed to confirm its effectiveness~0.25–0.5%

NiacinUnder-dosedEffect: MediumA form of vitamin B3. It is similar in action to niacinamide, but is more likely to cause red flashes in skin as the side effect~0.2–0.4%

Anti-oxidation

Not advertised by the brand · 13 ingredients credited for this claim

Strong support

This product contains antioxidants (glutathione) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

The following ingredients - imperata cylindrica root extract also can have an antioxidant effect, but there is less evidence to confirm their effectiveness in skin.

Imperata cylindrica root extractKey activeEffect: MediumA plat extract that might help neutralize free radicals in skin and attract water to its upper layer~1.6–1.9%

AdenosineEffect: LowMight help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)~0.25–0.5%

Pyridoxine hclEffect: LowMight help neutralize free radicals in skin~0.15–0.3%

TaurineEffect: LowCould be helpful in reducing inflammation in skin, evening out the skin tone and neutralizing free radicals, but more research is needed to confirm its effectiveness~0.25–0.5%

Glucosamine hclEffect: LowMight be able to stimulate production of skin's natural moisturizing compounds such as hyaluronic acid. Could be helpful for evening the skin tone.~0.25–0.5%

Crithmum maritimum extractEffect: LowAn algae extract that might have anti-oxidant properties~0.25–0.45%

Prunus amygdalus dulcis oilEffect: LowAn emollient that softens the skin~0.3–0.55%

TocopherolUnder-dosedEffect: HighPure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.25–0.5%

Tocopheryl acetateEffect: Low, below effective doseA more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.~0.3–0.55%

Anigozanthos flavidus extractEffect: Low, below effective doseClaimed to have anti-oxidant properties but no evidence is available~0.25–0.5%

Can it cause trouble?

Irritancy

3 strong irritants: Parfum, Anigozanthos flavidus extract + 1 more — patch-test recommended

High risk

We flagged 26 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.

IngredientFunctionIrritationEst. amount

ParfumAn aromatic blend of unspecified and possibly irritating ingredientsHigh~0.4–0.6%est.

Anigozanthos flavidus extractClaimed to have anti-oxidant properties but no evidence is availableHigh~0.25–0.5%est.

Benzyl alcoholA preservative. Can be used to mask unpleasant smell. Can be irritatingHigh~0.25–0.45%est.

P-anisic acidHelps preserve products. Can mask unpleasant smell. Could be irritatingHigh~0.25–0.5%est.

Ascorbic acidThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of agingHigh~0.25–0.5%est.

Retinyl acetate—High~0.25–0.45%est.

NiacinA form of vitamin B3. It is similar in action to niacinamide, but is more likely to cause red flashes in skin as the side effectHigh~0.2–0.4%est.

Imperata cylindrica root extractA plat extract that might help neutralize free radicals in skin and attract water to its upper layerMedium~1.6–1.9%est.

Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymerA gelling agent that thickens the product consistency and leaves the skin with a velvety finishMedium~1.4–1.7%est.

1,2-hexanediolA preservativeMedium~0.45–0.65%est.

Glyceryl linoleateHelps oil and water mix togetherMedium~0.45–0.7%est.

Caprylic/capric triglycerideA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerinMedium~0.4–0.65%est.

Tocopheryl acetateA more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.Medium~0.3–0.55%est.

Polysorbate 60Helps oil and water mix togetherMedium~0.3–0.6%est.

Sodium lactateHelps attract water to the upper layer of the skin. Is often used to adjust the pH level of the productMedium~0.25–0.5%est.

Caprylyl glycolHelps preserve products and creates a nice product textureMedium~0.3–0.55%est.

Citric acidCan work as an exfoliant but is typically used to adjust the product pHMedium~0.25–0.5%est.

Levulinic acidHelps stabilize a product formulationMedium~0.25–0.45%est.

Potassium sorbateA preservativeMedium~0.3–0.5%est.

Sodium citrateHelps to control the skin's pH level. Maintains the skin's natural film of amino-lactic acids and oils. Helps to preserve productsMedium~0.25–0.5%est.

Calcium chlorideHelps create a thicker product consistency. Might be irritatingMedium~0.25–0.5%est.

Acrylates/c10-30 alkyl acrylate crosspolymerMaintains the texture of skincare products. Allows the product to spread evenly. Helps oil and water mix togetherMedium~0.3–0.55%est.

GlutathioneA peptide that can help neutralize free radicals in skin and reduce melanin production resulting in skin lightening effect and reduction in hyperpigmentation. It can also help attract moisture to the upper layer of the skinMedium~0.25–0.5%est.

TaurineCould be helpful in reducing inflammation in skin, evening out the skin tone and neutralizing free radicals, but more research is needed to confirm its effectivenessMedium~0.25–0.5%est.

Pyridoxine hclMight help neutralize free radicals in skinMedium~0.15–0.3%est.

Thiamine hclCan help attract water to the upper layer of the skin. Is studied as a mosquito repellentMedium~0.1–0.15%est.

Comedogenic

2 ingredients rated 2 or more on the 0–5 pore-clogging scale

2 flagged

These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.

IngredientFunctionRatingEst. amount

Crithmum maritimum extractAn algae extract that might have anti-oxidant properties3/5~0.25–0.45%est.

Hydrogenated vegetable oilAn oil from a mixture of different vegetables. Helps soften the upper layer of the skin2/5~0.3–0.55%est.

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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%

Formula

Irritation risk: Low

Plain old water

More about Water

Glycerin~4.3–5.3%

Key active

Irritation risk: Low

Works for

Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin

Propylheptyl caprylate~4.2–5.1%

Key active

Irritation risk: Low

Works for

Moisturizing

Helps soften the upper layer of the skin

More about Propylheptyl caprylate

Silica~3.1–3.8%

Formula

Irritation risk: Low

Used to absorb oil and can temporarily mattify skin

More about Silica

Dicaprylyl carbonate~2.3–2.8%

Formula

Irritation risk: Low

Works for

Moisturizing

Helps products spread more easily and works as an emollient to soften skin

More about Dicaprylyl carbonate

Squalane~1.9–2.4%

Key active

Irritation risk: Low

Works for

Moisturizing

An oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.

More about Squalane

Imperata cylindrica root extract~1.6–1.9%

Key activeIrritant · medium

Irritation risk: Medium

Works for

MoisturizingAnti-oxidationAnti-inflammatory

A plat extract that might help neutralize free radicals in skin and attract water to its upper layer

More about Imperata cylindrica root extract

Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer~1.4–1.7%

Irritant · medium

Irritation risk: Medium

A gelling agent that thickens the product consistency and leaves the skin with a velvety finish

More about Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer

Zinc pca~1.2–1.4%

Key active

Irritation risk: Low

Works for

Anti-inflammatoryMoisturizingAnti-blemishAnti-agingAnti-oxidation

A compound that combines zinc with a hydrating ingredient PCA. Might to be helpful against acne and clogged pores. Can help calm down inflammation in skin. Could be helpful in reducing the formation of free radicals in skin. Might help to reduce fine lines in wrinkles, but solid evidence is missing

More about Zinc pca

Sucrose palmitate~0.95–1.15%

Formula

Irritation risk: Low

Works for

Cleansing

More about Sucrose palmitate

Polyacrylate crosspolymer-6~0.65–1%

Formula

Irritation risk: Low

More about Polyacrylate crosspolymer-6

Phenoxyethanol~0.55–0.85%

Formula

Irritation risk: Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol

Butylene glycol~0.5–0.75%

Formula

Irritation risk: Low

Works for

Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol

1,2-hexanediol~0.45–0.65%

Irritant · medium

Irritation risk: Medium

A preservative

More about 1,2-hexanediol

Parfum~0.4–0.6%

Irritant · high

Irritation risk: High

An aromatic blend of unspecified and possibly irritating ingredients

More about Parfum

Cetyl alcohol~0.5–0.75%

Key active

Irritation risk: Low

Works for

CleansingMoisturizing

A non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together

More about Cetyl alcohol

Glyceryl linoleate~0.45–0.7%

Irritant · medium

Irritation risk: Medium

Works for

Cleansing

Helps oil and water mix together

More about Glyceryl linoleate

Stearalkonium hectorite~0.35–0.65%

Formula

Irritation risk: Low

Used to create an even product consistency

More about Stearalkonium hectorite

Caprylic/capric triglyceride~0.4–0.65%

Under-dosedIrritant · medium

Irritation risk: Medium

Works for

Moisturizing

A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin

More about Caprylic/capric triglyceride

Tocopheryl acetate~0.3–0.55%

Irritant · medium

Irritation risk: Medium

Works for

Anti-oxidation

A more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.

More about Tocopheryl acetate

Propylene carbonate~0.3–0.6%

Formula

Irritation risk: Low

Works for

Moisturizing

Is used to dissolve other ingredients and create nice product texture

More about Propylene carbonate

Polysorbate 60~0.3–0.6%

Irritant · medium

Irritation risk: Medium

Works for

Cleansing

Helps oil and water mix together

More about Polysorbate 60

Sorbitan isostearate~0.3–0.55%

Formula

Irritation risk: Low

Works for

Cleansing

Helps oil and water mix together

More about Sorbitan isostearate

Prunus amygdalus dulcis oil~0.3–0.55%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-oxidationAnti-aging

An emollient that softens the skin

More about Prunus amygdalus dulcis oil

Sodium chloride~0.3–0.55%

Formula

Irritation risk: Low

Used to stabilize mixtures of oil and water, and create thicker, gel-like product textures

More about Sodium chloride

Biosaccharide gum-1~0.25–0.5%

Key active

Irritation risk: Low

Works for

Moisturizing

Helps attract water to the upper layer of the skin and is claimed to provide a longer-lasting hydration because of its ability to create a water-binding film on the surface of the skin

More about Biosaccharide gum-1

Carbomer~0.25–0.5%

Formula

Irritation risk: Low

Works for

Cleansing

Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations

More about Carbomer

Sodium phytate~0.25–0.5%

Formula

Irritation risk: Low

Used to stabilize product formulations

More about Sodium phytate

Hydrogenated vegetable oil~0.3–0.55%

Key activeComedogenic 2/5

Irritation risk: Low
Comedogenicity: 2/5

Works for

Moisturizing

An oil from a mixture of different vegetables. Helps soften the upper layer of the skin

More about Hydrogenated vegetable oil

Adenosine~0.25–0.5%

Key active

Irritation risk: Low

Works for

Anti-agingMoisturizingAnti-oxidation

Might help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)

More about Adenosine

Anigozanthos flavidus extract~0.25–0.5%

Irritant · high

Irritation risk: High

Works for

Anti-oxidationMoisturizingAnti-aging

Claimed to have anti-oxidant properties but no evidence is available

More about Anigozanthos flavidus extract

Benzyl alcohol~0.25–0.45%

Irritant · high

Irritation risk: High

A preservative. Can be used to mask unpleasant smell. Can be irritating

More about Benzyl alcohol

Sodium hydroxide~0.25–0.5%

Formula

Irritation risk: Low

Used to adjust the product's pH

More about Sodium hydroxide

Sodium lactate~0.25–0.5%

Key activeIrritant · medium

Irritation risk: Medium

Works for

Moisturizing

Helps attract water to the upper layer of the skin. Is often used to adjust the pH level of the product

More about Sodium lactate

Caprylyl glycol~0.3–0.55%

Irritant · medium

Irritation risk: Medium

Works for

Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol

Sodium hyaluronate~0.25–0.5%

Key active

Irritation risk: Low

Works for

Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate

Citric acid~0.25–0.5%

Irritant · medium

Irritation risk: Medium

Can work as an exfoliant but is typically used to adjust the product pH

More about Citric acid

Levulinic acid~0.25–0.45%

Irritant · medium

Irritation risk: Medium

Helps stabilize a product formulation

More about Levulinic acid

Glyceryl caprylate~0.3–0.6%

Formula

Irritation risk: Low

Works for

CleansingMoisturizing

An emollient that can also help water and oil mix together, as well as prevent bacteria growth in products

More about Glyceryl caprylate

Potassium sorbate~0.3–0.5%

Irritant · medium

Irritation risk: Medium

A preservative

More about Potassium sorbate

Polysorbate 20~0.3–0.55%

Formula

Irritation risk: Low

Works for

Cleansing

Helps oil and water mix together

More about Polysorbate 20

Sodium citrate~0.25–0.5%

Irritant · medium

Irritation risk: Medium

Helps to control the skin's pH level. Maintains the skin's natural film of amino-lactic acids and oils. Helps to preserve products

More about Sodium citrate

Dipeptide diaminobutyroyl benzylamide diacetate~0.25–0.5%

Hero · Moisturizing

Irritation risk: Low

Works for

MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Dipeptide diaminobutyroyl benzylamide diacetate

Crithmum maritimum extract~0.25–0.45%

Key activeComedogenic 3/5

Irritation risk: Low
Comedogenicity: 3/5

Works for

MoisturizingAnti-oxidation

An algae extract that might have anti-oxidant properties

More about Crithmum maritimum extract

Glucose~0.25–0.5%

Key active

Irritation risk: Low

Works for

Moisturizing

Helps attract water to the upper layer of the skin. Could be helpful in restoring the skin barrier function

More about Glucose

Tocopherol~0.25–0.5%

Under-dosed

Irritation risk: Low

Works for

Anti-oxidationMoisturizingAnti-agingAnti-inflammatory

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol

P-anisic acid~0.25–0.5%

Irritant · high

Irritation risk: High

Helps preserve products. Can mask unpleasant smell. Could be irritating

More about P-anisic acid

Potassium chloride~0.3–0.5%

Formula

Irritation risk: Low

More about Potassium chloride

Calcium chloride~0.25–0.5%

Irritant · medium

Irritation risk: Medium

Helps create a thicker product consistency. Might be irritating

More about Calcium chloride

Acrylates/c10-30 alkyl acrylate crosspolymer~0.3–0.55%

Irritant · medium

Irritation risk: Medium

Maintains the texture of skincare products. Allows the product to spread evenly. Helps oil and water mix together

More about Acrylates/c10-30 alkyl acrylate crosspolymer

Magnesium sulfate~0.3–0.55%

Formula

Irritation risk: Low

Used to create a thicker product consistency

More about Magnesium sulfate

Glutamine~0.25–0.5%

Formula

Irritation risk: Low

More about Glutamine

Sodium phosphate~0.25–0.5%

Formula

Irritation risk: Low

Helps stabilize the product formulation

More about Sodium phosphate

Ascorbic acid~0.25–0.5%

Under-dosedIrritant · high

Irritation risk: High

Works for

Evens skin toneAnti-oxidationAnti-aging

The most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging

More about Ascorbic acid

Sodium acetate~0.25–0.5%

Formula

Irritation risk: Low

More about Sodium acetate

Lysine hcl~0.25–0.5%

Key active

Irritation risk: Low

Works for

Moisturizing

More about Lysine hcl

Arginine hcl~0.25–0.5%

Key active

Irritation risk: Low

Works for

MoisturizingReduces irritation

An amino acid that is naturally present in skin and helps keep it hydrated. When used together with AHAs, it can reduce their irritating effect on the skin

More about Arginine hcl

Palmitoyl tripeptide-1~0.3–0.55%

Hero · Moisturizing

Irritation risk: Low

Works for

MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tripeptide-1

Alanine~0.25–0.5%

Key active

Irritation risk: Low

Works for

MoisturizingEvens skin tone

An amino-acid that helps to attract water to the upper layer of the skin and might help to lighten the skin, but solid evidence is lacking

More about Alanine

Histidine hcl~0.25–0.5%

Key active

Irritation risk: Low

Works for

Moisturizing

A salt of an amino-acid that helps attract water to the upper layer of the skin. Might be helpful in restoring the skin barrier function

More about Histidine hcl

Valine~0.25–0.45%

Formula

Irritation risk: Low

More about Valine

Leucine~0.25–0.5%

Formula

Irritation risk: Low

More about Leucine

Threonine~0.25–0.5%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-aging

An amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles

More about Threonine

Isoleucine~0.25–0.5%

Key active

Irritation risk: Low

Works for

Moisturizing

An amino acid that can help attract water to the upper layer of the skin and support skin's barrier function

More about Isoleucine

Palmitoyl tetrapeptide-7~0.3–0.55%

Hero · Moisturizing

Irritation risk: Low

Works for

MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tetrapeptide-7

Tryptophan~0.25–0.5%

Formula

Irritation risk: Low

More about Tryptophan

Phenylalanine~0.25–0.5%

Formula

Irritation risk: Low

More about Phenylalanine

Tyrosine~0.25–0.45%

Key active

Irritation risk: Low

Works for

Moisturizing

More about Tyrosine

Glycine~0.25–0.5%

Key active

Irritation risk: Low

Works for

Moisturizing

Helps to attract water to the upper layer of the skin and can help restore the skin barrier function

More about Glycine

Polysorbate 80~0.3–0.55%

Formula

Irritation risk: Low

Works for

Cleansing

Helps water and oil mix together

More about Polysorbate 80

Serine~0.25–0.45%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-aging

An amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles

More about Serine

Cystine~0.25–0.5%

Formula

Irritation risk: Low

More about Cystine

Cyanocobalamin~0.25–0.5%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-inflammatory

Can support skin barrier function and reduce inflammation in skin

More about Cyanocobalamin

Glutathione~0.25–0.5%

Key activeIrritant · medium

Irritation risk: Medium

Works for

Evens skin toneMoisturizingAnti-oxidation

A peptide that can help neutralize free radicals in skin and reduce melanin production resulting in skin lightening effect and reduction in hyperpigmentation. It can also help attract moisture to the upper layer of the skin

More about Glutathione

Asparagine~0.25–0.5%

Formula

Irritation risk: Low

More about Asparagine

Aspartic acid~0.25–0.5%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-aging

An amino-acid that helps increase skin hydration and might help to slightly improve skin firmness, potentially reducing lines and wrinkles

More about Aspartic acid

Ornithine hcl~0.25–0.5%

Formula

Irritation risk: Low

More about Ornithine hcl

Glutamic acid~0.25–0.5%

Key active

Irritation risk: Low

Works for

Moisturizing

An amino-acid that helps attract water to the upper layer of the skin

More about Glutamic acid

Nicotinamide adenine dinucleotide~0.25–0.5%

Formula

Irritation risk: Low

More about Nicotinamide adenine dinucleotide

Biotin~0.25–0.5%

Formula

Irritation risk: Low

Works for

Moisturizing

Might have some moisturising properties. Is not effective when applied topically beyond some moisturizing effect

More about Biotin

Proline~0.3–0.5%

Key active

Irritation risk: Low

Works for

Moisturizing

More about Proline

Methionine~0.25–0.5%

Formula

Irritation risk: Low

More about Methionine

Taurine~0.25–0.5%

Irritant · medium

Irritation risk: Medium

Works for

Anti-blemishAnti-inflammatoryAnti-oxidationEvens skin tone

Could be helpful in reducing inflammation in skin, evening out the skin tone and neutralizing free radicals, but more research is needed to confirm its effectiveness

More about Taurine

Hydroxyproline~0.25–0.5%

Key active

Irritation risk: Low

Works for

CleansingMoisturizingAnti-aging

Is helpful in restoring skin barrier function supporting its moisture levels. Is claimed to stimulte collagen production in skin but evidence is lacking

More about Hydroxyproline

Glucosamine hcl~0.25–0.5%

Key active

Irritation risk: Low

Works for

MoisturizingAntibacterialEvens skin toneAnti-agingAnti-oxidation

Might be able to stimulate production of skin's natural moisturizing compounds such as hyaluronic acid. Could be helpful for evening the skin tone.

More about Glucosamine hcl

Coenzyme a~0.25–0.45%

Formula

Irritation risk: Low

Works for

Moisturizing

Helps soften the upper layer of the skin and dissolve other ingredients in a product

More about Coenzyme a

Sodium glucuronate~0.25–0.45%

Formula

Irritation risk: Low

More about Sodium glucuronate

Thiamine diphosphate~0.25–0.45%

Formula

Irritation risk: Low

More about Thiamine diphosphate

Retinyl acetate~0.25–0.45%

Key activeIrritant · high

Irritation risk: High

Works for

Anti-aging

More about Retinyl acetate

Inositol~0.2–0.4%

Key active

Irritation risk: Low

Works for

Moisturizing

More about Inositol

Niacin~0.2–0.4%

Under-dosedIrritant · high

Irritation risk: High

Works for

MoisturizingAnti-blemishAnti-agingEvens skin tone

A form of vitamin B3. It is similar in action to niacinamide, but is more likely to cause red flashes in skin as the side effect

More about Niacin

Niacinamide~0.2–0.35%

Under-dosed

Irritation risk: Low

Works for

Evens skin toneAnti-agingMoisturizingAnti-blemishReduces irritationAnti-inflammatoryAntibacterialReduces redness

Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production

More about Niacinamide

Pyridoxine hcl~0.15–0.3%

Irritant · medium

Irritation risk: Medium

Works for

Anti-oxidation

Might help neutralize free radicals in skin

More about Pyridoxine hcl

Calcium pantothenate~0.15–0.25%

Key active

Irritation risk: Low

Works for

Reduces irritationMoisturizing

Helps support skin barrier function improving skin hydration and reducing sensitivity

More about Calcium pantothenate

Riboflavin~0.15–0.3%

Formula

Irritation risk: Low

More about Riboflavin

Sodium tocopheryl phosphate~0.15–0.3%

Formula

Irritation risk: Low

Works for

Cleansing

More about Sodium tocopheryl phosphate

Thiamine hcl~0.1–0.15%

Irritant · medium

Irritation risk: Medium

Can help attract water to the upper layer of the skin. Is studied as a mosquito repellent

More about Thiamine hcl

Folic acid~0.1–0.15%

Key active

Irritation risk: Low

Works for

Anti-aging

Can help stimulate collagen production in skin. While available studies are promising, more research is needed to confirm the efficacy in skin

More about Folic acid

Ingredient list view

Water, Glycerin, Propylheptyl caprylate, Silica, Dicaprylyl carbonate, Squalane, Imperata cylindrica root extract, Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, Zinc pca, Sucrose palmitate, Polyacrylate crosspolymer-6, Phenoxyethanol, Butylene glycol, 1,2-hexanediol, Parfum, Cetyl alcohol, Glyceryl linoleate, Stearalkonium hectorite, Caprylic/capric triglyceride, Tocopheryl acetate, Propylene carbonate, Polysorbate 60, Sorbitan isostearate, Prunus amygdalus dulcis oil, Sodium chloride, Biosaccharide gum-1, Carbomer, Sodium phytate, Hydrogenated vegetable oil, Adenosine, Anigozanthos flavidus extract, Benzyl alcohol, Sodium hydroxide, Sodium lactate, Caprylyl glycol, Sodium hyaluronate, Citric acid, Levulinic acid, Glyceryl caprylate, Potassium sorbate, Polysorbate 20, Sodium citrate, Dipeptide diaminobutyroyl benzylamide diacetate, Crithmum maritimum extract, Glucose, Tocopherol, P-anisic acid, Potassium chloride, Calcium chloride, Acrylates/c10-30 alkyl acrylate crosspolymer, Magnesium sulfate, Glutamine, Sodium phosphate, Ascorbic acid, Sodium acetate, Lysine hcl, Arginine hcl, Palmitoyl tripeptide-1, Alanine, Histidine hcl, Valine, Leucine, Threonine, Isoleucine, Palmitoyl tetrapeptide-7, Tryptophan, Phenylalanine, Tyrosine, Glycine, Polysorbate 80, Serine, Cystine, Cyanocobalamin, Glutathione, Asparagine, Aspartic acid, Ornithine hcl, Glutamic acid, Nicotinamide adenine dinucleotide, Biotin, Proline, Methionine, Taurine, Hydroxyproline, Glucosamine hcl, Coenzyme a, Sodium glucuronate, Thiamine diphosphate, Retinyl acetate, Inositol, Niacin, Niacinamide, Pyridoxine hcl, Calcium pantothenate, Riboflavin, Sodium tocopheryl phosphate, Thiamine hcl, Folic acid

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
	FilorgaTime-Filler 5xp Gel CreamYOUR PRODUCT	NEOGEN X SUR.MEDICSurmedic 24K Gold Caviar Repair Vital Cream	JuneCellRejuvenation Lifting Skin Emulsion	kineffDermacycle 102 Night Renewal Cream
Match	—	81%	81%	79%
Price	$64.00	$39.59−$24.41	$66.10+$2.10	$12.99−$51.01
Shared key ingredients	—	12 of 33	24 of 33	17 of 33
Key difference	—	Copper Tripeptide-1	Copper Tripeptide-1	Copper Tripeptide-1
Irritancy	High	Medium	High	Medium
Drying alcohol	—	—	Contains drying alcohol	—
	View product	Shop	Shop	Shop

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Product summary

Based on the ingredients included, "Filorga - Time-Filler 5xp Gel Cream" works well for moisturizing the skin. To work well, any moisturizer needs to include a combination of water-binding and emollient ingredients. Filorga - Time-Filler 5xp Gel Cream ticks this box. Humectants in this product (alanine, aspartic acid, biosaccharide gum-1, glucosamine hcl and glutamic acid) help to increase the water content in the upper layer of the skin. (These ingredients do so by "capturing" water molecules from the outside air or from within the deeper layers of the skin). Palmitoyl tetrapeptide-7, palmitoyl tripeptide-1, squalane, cetyl alcohol and hydrogenated vegetable oil in this product help decrease the water evoporation from the skin, so that it stays hydrated for longer. These ingredients also soften the skin and take away the feeling of tightness and dryness.

Ingredient callouts

This product also contains Vitamin C (Ascorbic Acid). It can be an effective active for anti-aging and evening out the skin tone, but in this moisturizer it is used for stabilizing other ingredients in the formulation. In this concentration (0.25% - 0.50%) it cannot have a noticeable benefit for the skin.
This moisturizer includes a form of Retinoids (vitamin A) - retinyl acetate 0.25% - 0.45%, but this type of vitamin A is not very effective. It could in theory help with fine lines and wrinkles, but the effect is most likely minimal.
We like that this moisturizer contains peptides (palmitoyl tripeptide-1 0.30% - 0.55%, palmitoyl tetrapeptide-7 0.30% - 0.55% and dipeptide diaminobutyroyl benzylamide diacetate 0.25% - 0.50%). There are many different kind of Peptides and they are naturally present in our skin. They all are a combination of aminoacids. Some of them work as natural antibiotics, promote wound-healing and production of collagen. The science is still not settled on how effective Peptides are in skincare, but it is very likely that they have a benefit. Peptides might help restore the skin barrier and fight the signs of aging. At the very least, Peptides work as humectants: they attract water to the upper layer of the skin and improve its hydration.
Adenosine 0.25% - 0.50%. It is a chemical present inside our skin cells. A clinical trial confirmed that topical application of Adenosine in a low concentration can reduce dynamic wrinkles (these are the wrinkles that appear with age in a places where our mimic is the most active, for example, in the corners of the eyes or on the forehead).

This product contains ingredients that could be beneficial, but their concentrations are too low in this formulation: niacinamide, niacin, caprylic/capric triglyceride, vitamin c and vitamin e

Irritation risk

We assess the overall irritancy of this moisturizer to be high. For a detailed overview of all potential irritants: click here

You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.

Price

The product retails for 64.00$ in the United States and for 64.00£ in the United Kingdom.

For a detailed price comparison: click here.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 37 studies and safety reviews.

1
Glycerol and the skin: holistic approach to its origin and functionsncbi.nlm.nih.gov
2
Allergic contact dermatitis from grassespubmed.ncbi.nlm.nih.gov
3
Zinc L-pyrrolidone carboxylate inhibits the UVA-induced production of matrix metalloproteinase-1 by in vitro cultured skin fibroblasts, whereas it enhances their collagen synthesisonlinelibrary.wiley.com
4
Zinc Therapy in Dermatology: A Review hindawi.com
5
The influence of alkane chain length on the skin irritation potential of 1,2-alkanediolsncbi.nlm.nih.gov
6
Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oilsmdpi.com
7
Evaluation of anti-wrinkle efficacy of adenosine-containing products using the FOITS techniquencbi.nlm.nih.gov
8
Hyaluronic acid: A key molecule in skin agingncbi.nlm.nih.gov
9
Hyaluronan (Hyaluronic Acid): a natural moisturizer for skin careresearchgate.net
10
Topical Glucose Induces Claudin-1 and Filaggrin Expression in a Mouse Model of Atopic Dermatitis and in Keratinocyte Culture, Exerting Anti-inflammatory Effects by Repairing Skin Barrier Functionncbi.nlm.nih.gov
11
Vitamin E in dermatologyncbi.nlm.nih.gov
12
Vitamin E and Skin Healthlpi.oregonstate.edu
13
Sodium anisateecha.europa.eu
14
Safety Assessment of Magnesium Sulfate as Used in Cosmeticsncbi.nlm.nih.gov
15
Combination of amino acids reduces pigmentation in B16F0 melanoma cellsncbi.nlm.nih.gov
16
Safety Assessment of α-Amino Acids as Used in Cosmeticsciteseerx.ist.psu.edu
17
Histidine and/or Histidine Derivative for the Treatment of Inflammatory Skin Diseasespatents.google.com
18
Topical palmitoyl pentapeptide provides improvement in photoaged human facial skinonlinelibrary.wiley.com
19
Local rhamnosoft, ceramides and L‐isoleucine in atopic eczema: a randomized, placebo controlled trialonlinelibrary.wiley.com
20
Effect of Topical Application of Glycine and Proline on Recalcitrant Leg Ulcers of Prolidase Deficiencyjamanetwork.com
21
Functional glycine receptor in cultured human keratinocytesonlinelibrary.wiley.com
22
Topical vitamin B12--a new therapeutic approach in atopic dermatitis-evaluation of efficacy and tolerability in a randomized placebo-controlled multicentre clinical trialpubmed.ncbi.nlm.nih.gov
23
Superiority of a vitamin B12-containing emollient compared to a standard emollient in the maintenance treatment of mild-to-moderate plaque psoriasisncbi.nlm.nih.gov
24
Glutathione as a skin whitening agent: Facts, myths, evidence and controversiesijdvl.com
25
Glutathione for skin lightening: a regnant myth or evidence-based verity?ncbi.nlm.nih.gov
26
Glutathione for skin lightening for dermatologists and cosmetologistsijord.com
27
Acetyl aspartic acid, a novel active ingredient, demonstrates potential to improve signs of skin ageing: from consumer need to clinical proofncbi.nlm.nih.gov
28
In vivo topical application of acetyl aspartic acid increases fibrillin-1 and collagen IV deposition leading to a significant improvement of skin firmnessncbi.nlm.nih.gov
29
Cosmeceuttical Critigue: Taurinemdedge.com
30
Topical effects of N-acetyl-L-hydroxyproline on ceramide synthesis and alleviation of pruritusncbi.nlm.nih.gov
31
Glucosamine: an ingredient with skin and other benefitsncbi.nlm.nih.gov
32
Niacinamide - mechanisms of action and its topical use in dermatologyncbi.nlm.nih.gov
33
Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology, 3(2), 88–93. doi:10.1111/j.1473-2130.2004.00115.x ncbi.nlm.nih.gov
34
Calcium pantothenate modulates gene expression in proliferating human dermal fibroblastsonlinelibrary.wiley.com
35
Dexpanthenol Modulates Gene Expression in Skin Wound Healing in vivokarger.com
36
Dexapanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate-induced irritationtandfonline.com
37
Folic acid and creatine improve the firmness of human skin in vivopubmed.ncbi.nlm.nih.gov

FilorgaTime-Filler 5xp Gel Cream

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