Works for:
based on ingredients and %- Anti-aging
- Moisturizing
- Evens skin tone
- Anti-blemish
Can it cause trouble?
- Irritation risk: high
- Comedogenic risk ingredients: 4
Key actives
Product Summary
Based on the ingredient list, "CKD Guaranteed - Retino Collagen Small Molecule 300 Guasha Neck Cream" can work well for skin moisturization. To work well, any moisturizer needs to include a combination of water-binding and emollient ingredients. CKD Guaranteed - Retino Collagen Small Molecule 300 Guasha Neck Cream ticks this box. Humectants in this product (alanine, arginine, aspartic acid, erythritol and fructooligosaccharides) help to increase the water content in the upper layer of the skin. (These ingredients do so by "capturing" water molecules from the outside air or from within the deeper layers of the skin). Emollients in this formulation (ceramide np, hydrolyzed collagen, vinyl dimethicone, arginine and caprylic/capric triglyceride) help to reduce the moisture loss from the skin. They also soften the skin surface and relieve the feeling of dryness and tightness.
Ingredient callouts
- We particularly like that there is a good concentration of Niacinamide (1.80% - 2.20%) in this moisturizer. Niacinamide is a well-studied multi-tasking active. It is a great ingredient to have in a moisturizer. It is stable, and can work well in almost any hydrating formulation. There is solid evidence that Niacinamide can help support skin barrier, regulate oil production and reduce acne and clogged pores. It also helps to fight photodamage and help improve the skin tone, reducing pigmentation marks.
- This moisturizer contains an effective form of Retinoids (vitamin A): retinal 0.25% - 0.45%. Retinoids are potent multitasking actives. They work to improve and prevent early signs of aging, reduce hyperpigmentation (age spots and post-acne marks), and prevent inflamed blemishes and clogged pores. The downside of Retinoids is that they can be irritating. If you are not already using a Retinoid in your routine, it is best to start slowly and apply the Retinoid product only a few times per week. If your skin tolerates it well, you can gradually increase the frequency to daily. Because of the irritation risk of Retinoids, we recommend to have another, retinoid-free moisturizer in your routine to use on the alternate days or when your skin feels dry.
- As a plus, this moisturizer also contains Ceramides (ceramide np 0.30% - 0.55%). Ceramides are a type of lipids that our skin produces itself. They are a building block of the skin's barrier. Ceramides used in skincare are synthetic or extracted from plants. They work well for softening the skin surface and "patch holes" in the skin's barrier.
- This moisturizer also contains Peptides (hexapeptide-2 0.15% - 0.25%). Peptides are a very big group of ingredients. They all consist of a different combination of aminoacids. Our skin produces Peptides naturally. Some of them work as natural antibiotics, promote wound-healing and production of collagen. The scientists are still studying how effective the topical application of Peptides is, but it is very likely that they are helpful. Peptides might be able to support skin barrier restoration and even have an anti-aging benefit. At the very least, they certainly help attract water to the skin and support the hydration in this way.
- Adenosine 0.25% - 0.45%. It is a chemical present inside our skin cells. A clinical trial confirmed that topical application of Adenosine in a low concentration can reduce dynamic wrinkles (these are the wrinkles that appear with age in a places where our mimic is the most active, for example, in the corners of the eyes or on the forehead).
Irritation risk
There are quite a few common irritants in this product, including ingredients without particular skin benefits. We would not recommend it for sensitive skin. We assess the overall irritancy of this moisturizer to be high. For a detailed overview of all potential irritants: click here
You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.
Price
The product retails for 29.25$ in the United States.
For a detailed price comparison: click here.
Anti-aging
What does the product description say?
Hydrolyzed Collagen Extract plumps and rejuvenates the neck, while Retinal reduces signs of aging.
Source: Soko Glam
This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains retinal, adenosine, niacinamide.
These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: aspartic acid, hexapeptide-2, lysine, serine, threonine.
Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.
One step removed from the biologically active in skin form of vitamin A. Once converted to the retinoic acid in the skin, retinal is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. Concentrations of 0.05% and 0.1% are shown to be effective. It can, however, be irritating
Might help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
An amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles
An amino-acid that helps increase skin hydration and might help to slightly improve skin firmness, potentially reducing lines and wrinkles
An amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles
An amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
One of the best moisturizing ingredients. Attracts water into the upper layer of the skin. Naturally present in skin. Typically has large molecule size unless advertised otherwise on the product label. Helps support skin's barrier function and may help to reduce inflammation
Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself
Anti-blemish
This product can help reduce breakouts and clogged pores because it contains the following ingredient: niacinamide, retinal. These ingredients is used for treating acne and can have a noticeable effect.
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
One step removed from the biologically active in skin form of vitamin A. Once converted to the retinoic acid in the skin, retinal is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. Concentrations of 0.05% and 0.1% are shown to be effective. It can, however, be irritating
A plant extract that has anti-bacterial properties. Can be used to preserve the product. Can be irritating
Evens skin tone
This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: retinal.
In addition, this product contains niacinamide. This ingredient (ingredients) might help reduce hyperpigmentation, but the effect, if any, is likely to be small.
The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually can help even out the skin tone: alanine, cysteine.
Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
One step removed from the biologically active in skin form of vitamin A. Once converted to the retinoic acid in the skin, retinal is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. Concentrations of 0.05% and 0.1% are shown to be effective. It can, however, be irritating
An amino-acid that helps to attract water to the upper layer of the skin and might help to lighten the skin, but solid evidence is lacking
Might help neutralize free radicals in skin and might be helpful against hyperpigmentation
A salt derived from licorice. Works as an emollient to soften the upper layer of the skin and can help calm down inflammation. Might be helpful for skin lightening
Moisturizing
What does the product description say?
Retino Collagen Small Molecule 300 Guasha Neck Cream
Source: From product name
This product can help improve hydration of the skin with the two types of ingredients.
The first type is called “humectants”:
these ingredients help attract water.
When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from
within deeper layers of the skin. The following ingredients in this product do the job:
alanine, arginine.
This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: arginine, caprylic/capric triglyceride.
The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: ceramide np, hexapeptide-2, niacinamide
One of the best moisturizing ingredients. Attracts water into the upper layer of the skin. Naturally present in skin. Typically has large molecule size unless advertised otherwise on the product label. Helps support skin's barrier function and may help to reduce inflammation
Help attract water to the upper layer of the skin
Helps attract water to the upper layer of the skin
Helps to attract water to the upper layer of the skin
A typically plant-derived compound that is supposed mimic human collagen. Cannot penetrate the skin barrier so is not particularly useful in skincare products beyond attracting water to the upper layer of the skin
An amino acid that can help attract water to the upper layer of the skin and support skin's barrier function
An amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
An amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles
An amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles
A type of silicone that helps to create a nice product texture and soften the upper layer of the skin
An amino-acid that helps to attract water to the upper layer of the skin and might help to lighten the skin, but solid evidence is lacking
An amino acid that is naturally present in skin and helps keep it hydrated. When used together with AHAs, it can reduce their irritating effect on the skin
An amino-acid that helps increase skin hydration and might help to slightly improve skin firmness, potentially reducing lines and wrinkles
A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin
A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin
Red algae extract that helps attract water to the upper layer of the skin and might contain antioxidants
Might help neutralize free radicals in skin and might be helpful against hyperpigmentation
An amino-acid that helps attract water to the upper layer of the skin
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
Helps to attract water to the upper layer of the skin and can help restore the skin barrier function
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
Helps to soften the upper layer of the skin
Might help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)
Helps attract water to the upper layer of the skin. Could be helpful in restoring the skin barrier function
A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture
A plant extract that can help to attract water to the upper layer of the skin and might have some anti-oxidant and anti-inflammatory properties
Used to improve the product consistency and soften the upper layer of the skin
An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together
A type of silicone that helps to soften the upper layer of the skin and create a nice product finish on the skin
A sugar that is used to stabilize the product formulation. Can help attract water to the upper layer of the skin
An emollient that is naturally present in skin and helps soften it
Might have some moisturising properties. Is not effective when applied topically beyond some moisturizing effect
Used to preserve products, dissolve other ingredients and create a nice product texture
Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin
A salt derived from licorice. Works as an emollient to soften the upper layer of the skin and can help calm down inflammation. Might be helpful for skin lightening
Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself
Helps oil and water mix together and works as an emollient
Anti-oxidation
This product contains antioxidants (cysteine) that might be able to help neutralize free radicals in skin to lessen the damage it gets from the UV light (sun). There is not enough evidence to confirm their effectiveness in skin though.
Might help neutralize free radicals in skin and might be helpful against hyperpigmentation
A plant extract that might be helpful to neutralize free radicals in skin
Red algae extract that helps attract water to the upper layer of the skin and might contain antioxidants
A plant extract that is rich in a fragrance compound eugenol that is a frequent allergen and can be irritating. It might also contain anti-oxidants to help neutralize free radicals
A plant extract that can help to attract water to the upper layer of the skin and might have some anti-oxidant and anti-inflammatory properties
Might help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)
Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself
How honest is this product?
| Promise | Can it deliver? |
|---|---|
| Anti-aging | |
| Moisturizing |
Total Promises Fulfilled score: 100/100.
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Potential irritants
Comedogenic ingredients
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| Product | Similarity | Price | Irritancy |
|---|---|---|---|
 CKD Guaranteed Retino Collagen Small Molecule 300 Guasha Neck Cream | Current | $29.25 | |
 Dr. Different VITALIFT-A Eye & Neck | 74% | $30.00 | |
HSGN Retinally Liposomal Retinal Cream | 71% | $13.20 | |
TOSOWOONG Collagen Lifting Cream | 70% | $18.90 | |
 SCINIC Cicanoid Retinal Cream | 69% | $22.30 | |
 AHC Youth Focus Emulsion | 67% | $21.99 |
Key Actives
Potential irritants
Comedogenic ingredients
All ingredients
Ingredient list view
Water, Glycerin, Caprylic/capric triglyceride, Butylene glycol, Pentylene glycol, Niacinamide, 1,2-hexanediol, Cetearyl olivate, Hydrogenated polyisobutene, Sorbitan olivate, Polyglyceryl-3 methylglucose distearate, Vinyl dimethicone, Diisostearyl malate, Glyceryl stearate, Caprylyl methicone, Erythritol, Cetearyl alcohol, Glucose, Chlorella vulgaris extract, Carbomer, Ammonium acryloyldimethyltaurate/vp copolymer, Fructooligosaccharides, Fructose, Citrus aurantium bergamia fruit oil, Melia azadirachta flower extract, Ocimum sanctum leaf extract, Palmitic acid, Ethylhexylglycerin, Dipotassium glycyrrhizate, Stearic acid, Adenosine, Melia azadirachta leaf extract, Lavandula angustifolia oil, Hydrogenated lecithin, Sodium phytate, Retinal, Curcuma longa root extract, Corallina officinalis extract, Salvia sclarea oil, Hydrolyzed collagen, Ceramide np, Theobroma cacao seed extract, Dextrin, Glycine, Serine, Glutamic acid, Tromethamine, Dipropylene glycol, Cynanchum atratum extract, Aspartic acid, Leucine, Alanine, Lysine, Arginine, Tyrosine, Phenylalanine, Proline, Valine, Threonine, Isoleucine, Histidine, Methionine, Cysteine, Hyaluronic acid, Althaea rosea flower extract, Tocopherol, Caprylyl/capryl glucoside, Hexapeptide-2, Hydrolyzed elastin, Biotin, Limonene, Linalool
- Glycerol and the skin: holistic approach to its origin and functions
- Niacinamide - mechanisms of action and its topical use in dermatology
- Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology, 3(2), 88–93. doi:10.1111/j.1473-2130.2004.00115.x
- The influence of alkane chain length on the skin irritation potential of 1,2-alkanediols
- Final report of the cosmetic ingredient review expert panel on the safety assessment of Polyisobutene and Hydrogenated Polyisobutene as used in cosmetics
- Topical Glucose Induces Claudin-1 and Filaggrin Expression in a Mouse Model of Atopic Dermatitis and in Keratinocyte Culture, Exerting Anti-inflammatory Effects by Repairing Skin Barrier Function
- Safety Assessment of Citrus-Derived Peel Oils as Used in Cosmetics
- Oxidized citrus oil (R-limonene): A frequent skin sensitizer in Europe
- Air oxidation increases skin irritation from fragrance terpenes
- Ameliorating effect of dipotassium glycyrrhizinate on an IL-4- and IL-13-induced atopic dermatitis-like skin-equivalent model
- Final report on the safety assessment of Glycyrrhetinic Acid, Potassium Glycyrrhetinate, Disodium Succinoyl Glycyrrhetinate, Glyceryl Glycyrrhetinate, Glycyrrhetinyl Stearate, Stearyl Glycyrrhetinate, Glycyrrhizic Acid, Ammonium Glycyrrhizate, Dipotassium Glycyrrhizate, Disodium Glycyrrhizate, Trisodium Glycyrrhizate, Methyl Glycyrrhizate, and Potassium Glycyrrhizinate.
- Evaluation of anti-wrinkle efficacy of adenosine-containing products using the FOITS technique
- Melia azedarach
- Preliminary and Pharmacological Profile of Melia azedarach L.: An Overview
- Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety
- Vaughn, A. R., Branum, A., & Sivamani, R. K. (2016). Effects of Turmeric (Curcuma longa) on Skin Health: A Systematic Review of the Clinical Evidence. Phytotherapy Research, 30(8), 1243–1264. doi:10.1002/ptr.5640
- Skin hydration is significantly increased by a cream formulated to mimic the skin’s own natural moisturizing systems
- Topically Applied Ceramides Interact with the Stratum Corneum Lipid Matrix in Compromised Ex Vivo Skin
- Effect of Topical Application of Glycine and Proline on Recalcitrant Leg Ulcers of Prolidase Deficiency
- Functional glycine receptor in cultured human keratinocytes
- Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin
- Safety Assessment of Tromethamine as Used in Cosmetics
- Acetyl aspartic acid, a novel active ingredient, demonstrates potential to improve signs of skin ageing: from consumer need to clinical proof
- In vivo topical application of acetyl aspartic acid increases fibrillin-1 and collagen IV deposition leading to a significant improvement of skin firmness
- Combination of amino acids reduces pigmentation in B16F0 melanoma cells
- Local rhamnosoft, ceramides and L‐isoleucine in atopic eczema: a randomized, placebo controlled trial
- Histidine and/or Histidine Derivative for the Treatment of Inflammatory Skin Diseases
- Safety Assessment of α-Amino Acids as Used in Cosmetics
- The Potential Uses of N-acetylcysteine in Dermatology: A Review
- Efficacy of a New Topical Nano-hyaluronic Acid in Humans
- Physiochemical properties and application of hyaluronic acid: a systematic review
- Vitamin E in dermatology
- Vitamin E and Skin Health