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Perricone MD Smooth, Brighten & Protect Regimen
Perricone MD

Perricone MD Smooth, Brighten & Protect Regimen

SPF 30Efficacy60/100IrritancyHigh·2 UV filters
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Works for

3 of 4 advertised claims delivered

Sun protection
SPF 30 · 2 UV filters · Partial spectrum
Weak protectionLow filter dose
SPF 30Partial spectrumMineral filters

This product does not offer good protection against UVA rays.

This product can be considered "reef safe" because it does not contain the UV filters (oxybenzone and octinoxate) that can be harmful to coral reefs when present in the water in high concentrations.

UV spectrum
UVB290–320 nmUVA II320–340 nmUVA I340–400 nm
Titanium Dioxide
Benzophenone-4
FilterCoverageWhat it doesEst. amount
Titanium Dioxide Mineral UVBUVA2 Photo-stable Works as a UV filter when used in high concentrations. It is photostable and is effective mostly against the UVB light, with some protection in the UVA range. In small concentrations, used for its ability to improve the color of cosmetic products. Is usually well tolerated by the skin4.2%
Benzophenone-4UVBUVA Photo-stable Sulisobenzone. A UV filter. Is typically used to improve the product stability under exposure to UV light. It is effective against both UVA and UVB rays. It can be used is larger concentrations as a sun protection ingredient for the skin, but can be irritating~0.7–1.05%
~ marks concentrations estimated from label position and typical use levels
Reef-safe
No oxybenzone or octinoxate — the two filters banned in Hawaii, Florida Keys and Aruba.
Anti-aging
Glycolic acid, Astaxanthin + 5 more
Strong evidence
What the product description says
“What It Does Delivers firmer-looking skin while smoothing the appearance of lines and wrinkles.”
Source: Perricone MD

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains glycolic acid.

These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: astaxanthin.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

Glycolic acidKey activeEffect: HighAn alpha-hydroxy acid (AHA) that helps to remove the dead skin cells on the surface of the skin reveling a more even, smoother complexation. It is also able to stimulate collagen production with long-term use. Could help to reduce pore congestion. It can be irritating to the skin. Apply sunscreen daily if using products with glycolic acid~0.3–0.55%
AstaxanthinKey activeEffect: MediumHelps neutralize free radicals in skin and might help to calm down inflammation~0.05–0.15%
Thioctic acidEffect: Low~0.1–0.15%
Tetrahexyldecyl ascorbateUnder-dosedEffect: HighBeing a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.~0.25–0.5%
Copper gluconateEffect: Low, below effective doseTypically used to stabilize the product formulations. It is a salt of polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing~0.3–0.5%
Zinc gluconateEffect: Low, below effective doseTypically used to stabilize the product formulations. It is a salt of a polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing. Due to the zinc content, might help calm down inflammation in skin~0.3–0.5%
Ascorbyl palmitateEffect: Low, below effective doseBeing a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.~1.3–1.6%
Exfoliation
Glycolic acid, Copper gluconate + 1 more
Strong evidence
What the product description says
“One of our best wrinkle serums, it combines gentle micro-exfoliation with nourishing technology for noticeably radiant and firmer-looking skin.”
Source: Perricone MD

This product can help exfoliate the skin. In other words, it helps break down the bonds between dead cells on the surface of the skin and speed up the skin turnover. Skin often appears softer and brighter after exfoliation, but overdoing it can result in disrupted skin barrier. The following ingredient is doing the exfoliating job in this product: glycolic acid.

Glycolic acidKey activeEffect: HighAn alpha-hydroxy acid (AHA) that helps to remove the dead skin cells on the surface of the skin reveling a more even, smoother complexation. It is also able to stimulate collagen production with long-term use. Could help to reduce pore congestion. It can be irritating to the skin. Apply sunscreen daily if using products with glycolic acid~0.3–0.55%
Copper gluconateEffect: Low, below effective doseTypically used to stabilize the product formulations. It is a salt of polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing~0.3–0.5%
Zinc gluconateEffect: Low, below effective doseTypically used to stabilize the product formulations. It is a salt of a polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing. Due to the zinc content, might help calm down inflammation in skin~0.3–0.5%
Evens skin tone
Glycolic acid, Copper gluconate + 2 more
Strong evidence
What the product description says
“Photo-Brightening Moisturizer Broad Spectrum SPF 30 (2 fl oz / 59 mL) An oil-free moisturizer that visibly brightens, tightens and reduces the appearance of dark spots.”
Source: Perricone MD

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: glycolic acid

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

This product can also help with skin tone because it offers sun protection. Sun damage is the main factor causing age spots, darkening of post-acne marks and other discolorations. This is why sun protection is the best strategy for maintaining an even skin tone. We, however, do not recommend using this product as a sunscreen because the protection it offers is not strong enough).

Glycolic acidKey activeEffect: HighAn alpha-hydroxy acid (AHA) that helps to remove the dead skin cells on the surface of the skin reveling a more even, smoother complexation. It is also able to stimulate collagen production with long-term use. Could help to reduce pore congestion. It can be irritating to the skin. Apply sunscreen daily if using products with glycolic acid~0.3–0.55%
Tetrahexyldecyl ascorbateUnder-dosedEffect: HighBeing a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.~0.25–0.5%
Copper gluconateEffect: Low, below effective doseTypically used to stabilize the product formulations. It is a salt of polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing~0.3–0.5%
Zinc gluconateEffect: Low, below effective doseTypically used to stabilize the product formulations. It is a salt of a polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing. Due to the zinc content, might help calm down inflammation in skin~0.3–0.5%
Anti-oxidation
Not advertised by the brand · Thioctic acid, Astaxanthin + 5 more
Strong evidence

This product contains antioxidants (astaxanthin, thioctic acid) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

Thioctic acidKey activeEffect: High~0.1–0.15%
AstaxanthinKey activeEffect: HighHelps neutralize free radicals in skin and might help to calm down inflammation~0.05–0.15%
Tetrahexyldecyl ascorbateUnder-dosedEffect: HighBeing a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.~0.25–0.5%
Copper gluconateEffect: Low, below effective doseTypically used to stabilize the product formulations. It is a salt of polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing~0.3–0.5%
BisabololEffect: Low, below effective doseAn active component of chamomile plant that historically has been used to calm down irritated skin. A recent study shows that bisabolol indeed can have some anti-inflammatory effect on skin, even though conclusive data is lacking. Bisabolol has a sweet floral scent and can be added to products for its aromatic properties~0.25–0.4%
Zinc gluconateEffect: Low, below effective doseTypically used to stabilize the product formulations. It is a salt of a polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing. Due to the zinc content, might help calm down inflammation in skin~0.3–0.5%
Ascorbyl palmitateEffect: Low, below effective doseBeing a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.~1.3–1.6%
Moisturizing
Not advertised by the brand · Sodium hyaluronate, Glycerin + 14 more
Good evidence

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: glycerin, sodium hyaluronate.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: dimethicone, cetearyl alcohol.

Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~0.3–0.55%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~0.3–0.6%
TyrosineKey activeEffect: High~0.3–0.5%
DimethiconeKey active· Emollient, OcclusiveEffect: HighA silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish~0.35–0.65%
Magnesium aspartateKey activeEffect: MediumMight be helpful in restoring skin barrier function and calm down inflammation in skin~0.3–0.5%
Cetearyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture~0.35–0.6%
CyclopentasiloxaneKey active· EmollientEffect: MediumA silicone that helps improve the product texture and spreadability. Can absorb oil creating a short-term mattifying effect on the skin~0.3–0.6%
Isopropyl palmitate· EmollientEffect: LowHelps soften the upper layer of the skin and create a thicker product consistency~0.3–0.55%
Pentylene glycol· EmollientEffect: LowUsed to preserve products, dissolve other ingredients and create a nice product texture~0.35–0.6%
Polysilicone-11Effect: LowA silicone that forms a light film on the skin surface helping to bind water and temporarily absorb oils creating a matt and powdery feel~0.25–0.45%
Glyceryl stearate· EmollientEffect: LowAn emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together~0.35–0.65%
Isohexadecane· EmollientEffect: LowImproves the texture of the product and helps soften the skin. Helps oil and water mix together and can be used as a cleansing agent~0.4–0.6%
Zinc gluconateUnder-dosedEffect: HighTypically used to stabilize the product formulations. It is a salt of a polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing. Due to the zinc content, might help calm down inflammation in skin~0.3–0.5%
Copper gluconateUnder-dosedEffect: HighTypically used to stabilize the product formulations. It is a salt of polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing~0.3–0.5%
Caprylic/capric triglycerideUnder-dosedEffect: HighA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin~0.25–0.45%
Stearic acidEffect: Low, below effective doseHelps oil and water mix together and works as an emollient~0.45–0.65%

Can it cause trouble?

Irritancy
13 strong irritants: Benzophenone-4, Methylchloroisothiazolinone + 11 more — patch-test recommended
High risk
We flagged 36 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Sodium laureth sulfateWorks as a foaming cleansing agentHigh~10–12%est.
Decyl glucosideHelps oil and water mix together. Can be irritatingHigh~5.5–6.7%est.
Cocamidopropyl betaineHelps water and oil mix together. Used as a cleansing ingredient. Could be an allergenHigh~4.5–5.4%est.
Benzophenone-4Sulisobenzone. A UV filter. Is typically used to improve the product stability under exposure to UV light. It is effective against both UVA and UVB rays. It can be used is larger concentrations as a sun protection ingredient for the skin, but can be irritatingHigh~0.7–1.05%est.
MethylchloroisothiazolinoneA preservative. Is a frequent allergen in cosmeticsHigh~0.00075–0.0015%est.
MethylisothiazolinoneA preservative. Is a frequent allergenHigh~0.00075–0.0015%est.
ParfumAn aromatic blend of unspecified and possibly irritating ingredientsHigh~0.35–0.65%est.
LimoneneA common frangrance that can easily irritate skin, especially if exposed to air, light or heatHigh~0.3–0.6%est.
Glycolic acidAn alpha-hydroxy acid (AHA) that helps to remove the dead skin cells on the surface of the skin reveling a more even, smoother complexation. It is also able to stimulate collagen production with long-term use. Could help to reduce pore congestion. It can be irritating to the skin. Apply sunscreen daily if using products with glycolic acidHigh~0.3–0.55%est.
Benzyl alcoholA preservative. Can be used to mask unpleasant smell. Can be irritatingHigh~0.25–0.5%est.
Alpha-isomethyl iononeA fragrance. Potential allergen and can be irritatingHigh~0.25–0.5%est.
Benzyl benzoateFragrance with sweet balsamic smell. Help to preserve products and dissolve other ingredients. Could trigger allergic reactions and be irritatingHigh~0.25–0.5%est.
Benzyl salicylateA fragrance. Is a likely irritantHigh~0.25–0.5%est.
CitronellolA fragrance. Can be irritatingHigh~0.25–0.5%est.
EugenolA fragrance. Is a likely irritantHigh~0.25–0.5%est.
GeraniolA fragrance. Can be irritatingHigh~0.25–0.5%est.
Hexyl cinnamalA fragrance with jasmine smell. A likely irritantHigh~0.25–0.5%est.
LinaloolA fragrance. Can be irritatingHigh~0.25–0.5%est.
Ascorbyl palmitateBeing a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.Medium~1.3–1.6%est.
Zinc gluconateTypically used to stabilize the product formulations. It is a salt of a polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing. Due to the zinc content, might help calm down inflammation in skinMedium~0.8–1.2%est.
Copper gluconateTypically used to stabilize the product formulations. It is a salt of polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missingMedium~0.65–1%est.
Disodium edtaStabilizes the product formulationMedium~0.55–0.85%est.
Citric acidCan work as an exfoliant but is typically used to adjust the product pHMedium~0.5–0.75%est.
Isopropyl palmitateHelps soften the upper layer of the skin and create a thicker product consistencyMedium~0.3–0.55%est.
Tetrahexyldecyl ascorbateBeing a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.Medium~0.25–0.5%est.
Ceteareth-20Helps oil and water mix together. Has some emollient propertiesMedium~0.4–0.65%est.
Pentylene glycolUsed to preserve products, dissolve other ingredients and create a nice product textureMedium~0.35–0.6%est.
Ethylhexyl methoxycryleneHelps improve stability of sunscreen filters and boost their effectivenessMedium~0.3–0.5%est.
Polyester-8Used to stabilize product formulations and individual ingredients (for example, sunscreens). Can be an allergenMedium~0.3–0.55%est.
Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymerA gelling agent that thickens the product consistency and leaves the skin with a velvety finishMedium~0.3–0.55%est.
Diethylhexyl syringylidenemalonateUsed to stabilize the product formulationMedium~0.3–0.5%est.
Polysorbate 60Helps oil and water mix togetherMedium~0.25–0.4%est.
Caprylic/capric triglycerideA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerinMedium~0.25–0.45%est.
Potassium sorbateA preservativeMedium~0.1–0.2%est.
Hydrogenated phosphatidylcholineHelps oil and water mix togetherMedium~0.15–0.25%est.
AstaxanthinHelps neutralize free radicals in skin and might help to calm down inflammationMedium~0.05–0.15%est.
Comedogenic
4 ingredients rated 2 or more on the 0–5 pore-clogging scale
4 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Isopropyl palmitateHelps soften the upper layer of the skin and create a thicker product consistency3/5~0.3–0.55%est.
Sodium laureth sulfateWorks as a foaming cleansing agent2/5~10–12%est.
Cetearyl alcoholA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture2/5~0.35–0.6%est.
Ceteareth-20Helps oil and water mix together. Has some emollient properties2/5~0.4–0.65%est.
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Alternatives
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Light/Medium Tinted Sunscreen SPF 40 | Dr. Dennis Gross
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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%
Formula
Irritation risk
Low

Plain old water

More about Water
Sodium laureth sulfate~10–12%
Comedogenic 2/5Irritant · high
Irritation risk
High
Comedogenicity
2/5
Works for
Cleansing

Works as a foaming cleansing agent

More about Sodium laureth sulfate
Decyl glucoside~5.5–6.7%
Irritant · high
Irritation risk
High
Works for
Cleansing

Helps oil and water mix together. Can be irritating

More about Decyl glucoside
Cocamidopropyl betaine~4.5–5.4%
Irritant · high
Irritation risk
High
Works for
Cleansing

Helps water and oil mix together. Used as a cleansing ingredient. Could be an allergen

More about Cocamidopropyl betaine
Ppg-2 hydroxyethyl coco/isostearamide~2.3–2.8%
Formula
Irritation risk
Low
Works for
Cleansing
More about Ppg-2 hydroxyethyl coco/isostearamide
Sodium chloride~1.9–2.3%
Formula
Irritation risk
Low

Used to stabilize mixtures of oil and water, and create thicker, gel-like product textures

More about Sodium chloride
Dimethyl mea~1.6–1.9%
Formula
Irritation risk
Low
More about Dimethyl mea
Ascorbyl palmitate~1.3–1.6%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidationAnti-aging

Being a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.

More about Ascorbyl palmitate
Magnesium aspartate~1.1–1.4%
Key active
Irritation risk
Low
Works for
Anti-inflammatoryMoisturizing

Might be helpful in restoring skin barrier function and calm down inflammation in skin

More about Magnesium aspartate
Zinc gluconate~0.8–1.2%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
MoisturizingAnti-agingEvens skin toneAnti-inflammatoryExfoliationAnti-blemishAnti-oxidation

Typically used to stabilize the product formulations. It is a salt of a polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing. Due to the zinc content, might help calm down inflammation in skin

More about Zinc gluconate
Copper gluconate~0.65–1%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
MoisturizingAnti-agingAnti-oxidationExfoliationAnti-blemishEvens skin tone

Typically used to stabilize the product formulations. It is a salt of polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing

More about Copper gluconate
Disodium edta~0.55–0.85%
Irritant · medium
Irritation risk
Medium

Stabilizes the product formulation

More about Disodium edta
Citric acid~0.5–0.75%
Irritant · medium
Irritation risk
Medium

Can work as an exfoliant but is typically used to adjust the product pH

More about Citric acid
Benzophenone-4~0.7–1.05%
UV filterUnder-dosedIrritant · high
Irritation risk
High
Works for
Sun protection

Sulisobenzone. A UV filter. Is typically used to improve the product stability under exposure to UV light. It is effective against both UVA and UVB rays. It can be used is larger concentrations as a sun protection ingredient for the skin, but can be irritating

More about Benzophenone-4
Methylchloroisothiazolinone~0.00075–0.0015%
Irritant · high
Irritation risk
High

A preservative. Is a frequent allergen in cosmetics

More about Methylchloroisothiazolinone
Methylisothiazolinone~0.00075–0.0015%
Irritant · high
Irritation risk
High

A preservative. Is a frequent allergen

More about Methylisothiazolinone
Parfum~0.35–0.65%
Irritant · high
Irritation risk
High

An aromatic blend of unspecified and possibly irritating ingredients

More about Parfum
Limonene~0.3–0.6%
Irritant · high
Irritation risk
High

A common frangrance that can easily irritate skin, especially if exposed to air, light or heat

More about Limonene
Water~0.3–0.6%
Formula
Irritation risk
Low

Plain old water

More about Water
Glycolic acid~0.3–0.55%
Key activeIrritant · high
Irritation risk
High
Works for
Evens skin toneExfoliationAnti-agingAnti-blemish

An alpha-hydroxy acid (AHA) that helps to remove the dead skin cells on the surface of the skin reveling a more even, smoother complexation. It is also able to stimulate collagen production with long-term use. Could help to reduce pore congestion. It can be irritating to the skin. Apply sunscreen daily if using products with glycolic acid

More about Glycolic acid
Dimethyl mea~0.3–0.55%
Formula
Irritation risk
Low
More about Dimethyl mea
Isopropyl palmitate~0.3–0.55%
Comedogenic 3/5Irritant · medium
Irritation risk
Medium
Comedogenicity
3/5
Works for
Moisturizing

Helps soften the upper layer of the skin and create a thicker product consistency

More about Isopropyl palmitate
Tetrahexyldecyl ascorbate~0.25–0.5%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
Anti-oxidationEvens skin toneAnti-aging

Being a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.

More about Tetrahexyldecyl ascorbate
Tyrosine~0.3–0.5%
Key active
Irritation risk
Low
Works for
Moisturizing
More about Tyrosine
Glyceryl stearate~0.35–0.65%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together

More about Glyceryl stearate
Peg-100 stearate~0.4–0.65%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix togehter and creates a nice product texture

More about Peg-100 stearate
Cetearyl alcohol~0.35–0.6%
Key activeComedogenic 2/5
Irritation risk
Low
Comedogenicity
2/5
Works for
CleansingMoisturizing

A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture

More about Cetearyl alcohol
Benzyl alcohol~0.25–0.5%
Irritant · high
Irritation risk
High

A preservative. Can be used to mask unpleasant smell. Can be irritating

More about Benzyl alcohol
Hydrogenated lecithin~0.3–0.55%
Formula
Irritation risk
Low
Works for
Cleansing

Helps to retain moisture by creating a protective barrier on the skin. Rich in fatty acids. Improves product texture and helps with the penetration of other ingredients.

More about Hydrogenated lecithin
Zinc gluconate~0.3–0.5%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
MoisturizingAnti-blemishAnti-inflammatoryAnti-oxidationEvens skin toneAnti-agingExfoliation

Typically used to stabilize the product formulations. It is a salt of a polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing. Due to the zinc content, might help calm down inflammation in skin

More about Zinc gluconate
Magnesium aspartate~0.3–0.5%
Key active
Irritation risk
Low
Works for
Anti-inflammatoryMoisturizing

Might be helpful in restoring skin barrier function and calm down inflammation in skin

More about Magnesium aspartate
Copper gluconate~0.3–0.5%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
MoisturizingEvens skin toneAnti-agingAnti-oxidationExfoliationAnti-blemish

Typically used to stabilize the product formulations. It is a salt of polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing

More about Copper gluconate
Sodium hyaluronate~0.3–0.55%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate
Disodium edta~0.3–0.55%
Irritant · medium
Irritation risk
Medium

Stabilizes the product formulation

More about Disodium edta
Ceteareth-20~0.4–0.65%
Comedogenic 2/5Irritant · medium
Irritation risk
Medium
Comedogenicity
2/5
Works for
Cleansing

Helps oil and water mix together. Has some emollient properties

More about Ceteareth-20
Dimethicone~0.35–0.65%
Key active
Irritation risk
Low
Works for
MoisturizingMattifying

A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish

More about Dimethicone
Phenoxyethanol~0.3–0.55%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Parfum~0.25–0.5%
Irritant · high
Irritation risk
High

An aromatic blend of unspecified and possibly irritating ingredients

More about Parfum
Alpha-isomethyl ionone~0.25–0.5%
Irritant · high
Irritation risk
High

A fragrance. Potential allergen and can be irritating

More about Alpha-isomethyl ionone
Benzyl benzoate~0.25–0.5%
Irritant · high
Irritation risk
High

Fragrance with sweet balsamic smell. Help to preserve products and dissolve other ingredients. Could trigger allergic reactions and be irritating

More about Benzyl benzoate
Benzyl salicylate~0.25–0.5%
Irritant · high
Irritation risk
High

A fragrance. Is a likely irritant

More about Benzyl salicylate
Citronellol~0.25–0.5%
Irritant · high
Irritation risk
High

A fragrance. Can be irritating

More about Citronellol
Eugenol~0.25–0.5%
Irritant · high
Irritation risk
High

A fragrance. Is a likely irritant

More about Eugenol
Geraniol~0.25–0.5%
Irritant · high
Irritation risk
High

A fragrance. Can be irritating

More about Geraniol
Hexyl cinnamal~0.25–0.5%
Irritant · high
Irritation risk
High

A fragrance with jasmine smell. A likely irritant

More about Hexyl cinnamal
Linalool~0.25–0.5%
Irritant · high
Irritation risk
High

A fragrance. Can be irritating

More about Linalool
Titanium dioxide4.2%
UV filterKey active
Irritation risk
Low
Works for
Sun protection

Works as a UV filter when used in high concentrations. It is photostable and is effective mostly against the UVB light, with some protection in the UVA range. In small concentrations, used for its ability to improve the color of cosmetic products. Is usually well tolerated by the skin

More about Titanium dioxide
Water~0.3–0.55%
Formula
Irritation risk
Low

Plain old water

More about Water
Glycerin~0.3–0.6%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Cyclopentasiloxane~0.3–0.6%
Key active
Irritation risk
Low
Works for
MoisturizingMattifying

A silicone that helps improve the product texture and spreadability. Can absorb oil creating a short-term mattifying effect on the skin

More about Cyclopentasiloxane
Dimethicone~0.35–0.65%
Key active
Irritation risk
Low
Works for
MoisturizingMattifying

A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish

More about Dimethicone
Pentylene glycol~0.35–0.6%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Used to preserve products, dissolve other ingredients and create a nice product texture

More about Pentylene glycol
Ethylhexyl methoxycrylene~0.3–0.5%
Irritant · medium
Irritation risk
Medium

Helps improve stability of sunscreen filters and boost their effectiveness

More about Ethylhexyl methoxycrylene
Polyester-8~0.3–0.55%
Irritant · medium
Irritation risk
Medium

Used to stabilize product formulations and individual ingredients (for example, sunscreens). Can be an allergen

More about Polyester-8
Polyglyceryl-3 polydimethylsiloxyethyl dimethicone~0.3–0.55%
Formula
Irritation risk
Low
More about Polyglyceryl-3 polydimethylsiloxyethyl dimethicone
Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer~0.3–0.55%
Irritant · medium
Irritation risk
Medium

A gelling agent that thickens the product consistency and leaves the skin with a velvety finish

More about Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer
Benzyl alcohol~0.25–0.5%
Irritant · high
Irritation risk
High

A preservative. Can be used to mask unpleasant smell. Can be irritating

More about Benzyl alcohol
Aluminum hydroxide~0.3–0.6%
Formula
Irritation risk
Low

Is used to add opaque (non-transparent) appearance to formulations. Can be used to coat other ingredients for even dispersion. This is a different ingredient compared to the ones used in antipersperants (aluminium chloride and aluminium chlorohydrate)

More about Aluminum hydroxide
Stearic acid~0.45–0.65%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

Helps oil and water mix together and works as an emollient

More about Stearic acid
Diethylhexyl syringylidenemalonate~0.3–0.5%
Irritant · medium
Irritation risk
Medium

Used to stabilize the product formulation

More about Diethylhexyl syringylidenemalonate
Hydrogenated lecithin~0.3–0.55%
Formula
Irritation risk
Low
Works for
Cleansing

Helps to retain moisture by creating a protective barrier on the skin. Rich in fatty acids. Improves product texture and helps with the penetration of other ingredients.

More about Hydrogenated lecithin
Isohexadecane~0.4–0.6%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

Improves the texture of the product and helps soften the skin. Helps oil and water mix together and can be used as a cleansing agent

More about Isohexadecane
Bisabolol~0.25–0.4%
Formula
Irritation risk
Low
Works for
Reduces irritationAnti-inflammatoryAnti-oxidation

An active component of chamomile plant that historically has been used to calm down irritated skin. A recent study shows that bisabolol indeed can have some anti-inflammatory effect on skin, even though conclusive data is lacking. Bisabolol has a sweet floral scent and can be added to products for its aromatic properties

More about Bisabolol
Tetrahexyldecyl ascorbate~0.25–0.5%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
Evens skin toneAnti-agingAnti-oxidation

Being a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.

More about Tetrahexyldecyl ascorbate
Phenoxyethanol~0.25–0.45%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Polysilicone-11~0.25–0.45%
Formula
Irritation risk
Low
Works for
MattifyingMoisturizing

A silicone that forms a light film on the skin surface helping to bind water and temporarily absorb oils creating a matt and powdery feel

More about Polysilicone-11
Polysorbate 60~0.25–0.4%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps oil and water mix together

More about Polysorbate 60
Caprylic/capric triglyceride~0.25–0.45%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin

More about Caprylic/capric triglyceride
Sodium benzoate~0.1–0.2%
Formula
Irritation risk
Low

A preservative

More about Sodium benzoate
Potassium sorbate~0.1–0.2%
Irritant · medium
Irritation risk
Medium

A preservative

More about Potassium sorbate
Xanthan gum~0.15–0.25%
Formula
Irritation risk
Low
Works for
Cleansing

Used to create a thicker product consistency

More about Xanthan gum
Hydrogenated phosphatidylcholine~0.15–0.25%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps oil and water mix together

More about Hydrogenated phosphatidylcholine
Thioctic acid~0.1–0.15%
Key active
Irritation risk
Low
Works for
Anti-oxidationAnti-aging
More about Thioctic acid
Astaxanthin~0.05–0.15%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Anti-oxidationAnti-inflammatoryAnti-aging

Helps neutralize free radicals in skin and might help to calm down inflammation

More about Astaxanthin
Ingredient list view

Water, Sodium laureth sulfate, Decyl glucoside, Cocamidopropyl betaine, Ppg-2 hydroxyethyl coco/isostearamide, Sodium chloride, Dimethyl mea, Ascorbyl palmitate, Magnesium aspartate, Zinc gluconate, Copper gluconate, Disodium edta, Citric acid, Benzophenone-4, Methylchloroisothiazolinone, Methylisothiazolinone, Parfum, Limonene, Water, Glycolic acid, Dimethyl mea, Isopropyl palmitate, Tetrahexyldecyl ascorbate, Tyrosine, Glyceryl stearate, Peg-100 stearate, Cetearyl alcohol, Benzyl alcohol, Hydrogenated lecithin, Zinc gluconate, Magnesium aspartate, Copper gluconate, Sodium hyaluronate, Disodium edta, Ceteareth-20, Dimethicone, Phenoxyethanol, Parfum, Alpha-isomethyl ionone, Benzyl benzoate, Benzyl salicylate, Citronellol, Eugenol, Geraniol, Hexyl cinnamal, Linalool, Titanium dioxide, Water, Glycerin, Cyclopentasiloxane, Dimethicone, Pentylene glycol, Ethylhexyl methoxycrylene, Polyester-8, Polyglyceryl-3 polydimethylsiloxyethyl dimethicone, Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, Benzyl alcohol, Aluminum hydroxide, Stearic acid, Diethylhexyl syringylidenemalonate, Hydrogenated lecithin, Isohexadecane, Bisabolol, Tetrahexyldecyl ascorbate, Phenoxyethanol, Polysilicone-11, Polysorbate 60, Caprylic/capric triglyceride, Sodium benzoate, Potassium sorbate, Xanthan gum, Hydrogenated phosphatidylcholine, Thioctic acid, Astaxanthin

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Perricone MD
$149.00
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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
Perricone MDSmooth, Brighten & Protect RegimenYOUR PRODUCTDr Dennis GrossLight/Medium Tinted Sunscreen SPF 40 | Dr. Dennis Gross
Match—50%
Price$149.00$20.00−$129.00
Shared key ingredients—4 of 16
Key difference—Tetrahexyldecyl Ascorbate
Irritancy High Medium
SPFSPF 30SPF 40
Drying alcohol——
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Product summary

We do not recommend "Perricone MD - Smooth, Brighten & Protect Regimen" because it does not provide good UVA protection. UVA sun rays don't burn the skin, but they still lead to photoaging and hyperpigmentation.

It contains good moisturizing ingredients and can double as a hydrating day cream. This product prevents early signs of aging by protecting against sun damage (all broad spectrum sunscreens do that).

Sunscreen filters

This is a "mixed" sunscreen in the sense that it uses both mineral and organic (so-called "chemical") sun filters. Here are the organic filters this product uses: benzophenone-4. As for the mineral filters, this sunscreen uses titanium dioxide.

Irritation risk

It contains a bunch of common irritants, including ingredients that do not provide any known benefit for the skin. It might not be the best choice if your skin is sensitive. We assess the overall irritancy of this sunscreen to be high. For a detailed overview of all potential irritants: click here

You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.

About the brand

According to Cruelty-Free Kitty "Perricone MD" is cruelty free and so is its parent company.

Price

The product retails for 149.00$ in the United States.

For a detailed price comparison: click here.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 29 studies and safety reviews.

  1. 1
    Surfactants and experimental irritant contact dermatitisncbi.nlm.nih.gov
  2. 2
    Ecofriendly surfactant is allergen of the yearmdedge.com
  3. 3
    Magnesium ions inhibit the antigen-presenting function of human epidermal Langerhans cells in vivo and in vitro. Involvement of ATPase, HLA-DR, B7 molecules, and cytokinesncbi.nlm.nih.gov
  4. 4
    Zinc salts in dermatologyncbi.nlm.nih.gov
  5. 5
    An overview of zinc and its importance in dermatology-Part II: The association of zinc with some dermatologic disordersoatext.com
  6. 6
    Zinc, copper and manganese enhanced keratinocyte migration through a functional modulation of keratinocyte integrinsncbi.nlm.nih.gov
Perricone MD Smooth, Brighten & Protect Regimen
Perricone MDSmooth, Brighten & Protect Regimen
Buy at Perricone MD$149.00Amazon

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Buy at Perricone MD$149.00Amazon

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