Perricone MD High Potency Hyaluronic Intensive Serum
- Anti-aging
- Moisturizing
- Evens skin tone
- Anti-blemish
- acetyl tetrapeptide-11
- niacinamide
- acetyl tetrapeptide-9
- acetyl glucosamine
- +11 more

Price comparison
Can the product deliver on its promises?
Promise
What does the product description say?WIMJ summary for anti-aging
This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains acetyl glucosamine, niacinamide.
These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: acetyl tetrapeptide-11, acetyl tetrapeptide-9.
Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.
Ingredient | Effectiveness | Concentration | Irritancy |
---|---|---|---|
HIGH | |||
HIGH | |||
MEDIUM
|
Promise
What does the product description say?WIMJ summary for moisturizing
This product can help improve hydration of the skin with the two types of ingredients.
The first type is called “humectants”:
these ingredients help attract water.
When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from
within deeper layers of the skin. The following ingredients in this product do the job:
glycerin, sodium acetylated hyaluronate.
This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: dimethicone, squalane.
The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: acetyl glucosamine, acetyl tetrapeptide-11, acetyl tetrapeptide-9, ceramide np, niacinamide, phytosphingosine
Ingredient | Effectiveness | Concentration | Irritancy |
---|---|---|---|
HIGH | |||
HIGH | |||
HIGH |
WIMJ summary for anti-blemish
This product might be able to help reduce blemishes and clogged pores because it contains niacinamide.
Ingredient | Effectiveness | Concentration | Irritancy |
---|---|---|---|
HIGH | |||
LOW
|
WIMJ summary for evens skin tone
This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: acetyl glucosamine, niacinamide
Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.
Ingredient | Effectiveness | Concentration | Irritancy |
---|---|---|---|
HIGH | |||
HIGH |
How honest is this product?
Promise | Can it deliver? |
---|---|
Anti-aging | |
Moisturizing | |
Evens skin tone | |
Anti-blemish |
Potential irritants

Ingredient | Irritancy | Skin Benefit |
---|---|---|
1,2-hexanediol | ||
caprylyl glycol | ||
hydroxyacetophenone |
Ingredients by volume
Ingredient | Estimated concentration |
---|---|
Plain old water
| 40% - 60% |
A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish
| 4.7% - 7% |
Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin
| 3.4% - 5.1% |
Show more |
Questions
Skincare resources
Scientific Sources
- Dimethicone as a protective ingredient in topical medications
- Final Report on the Safety Assessment of Dimethicone Copolyol
- Niacinamide - mechanisms of action and its topical use in dermatology
- Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology, 3(2), 88–93. doi:10.1111/j.1473-2130.2004.00115.x
- The effect of N-acetyl-glucosamine on stratum corneum desquamation and water content in human skin
- Glucosamine: an ingredient with skin and other benefits
- Genomic expression changes induced by topical N-acetyl glucosamine in skin equivalent cultures in vitro
- Incorporation of D-(^H)glucosamine into normal and psoriatic epidermal glycoconjugates
- Reduction in the appearance of facial hyperpigmentation by topical N-acetyl glucosamine
- Public Report: 2-Butenedioic acid (2E)-, di-C12-15-alkyl esters (INCI Name: Di-C12-15 Alkyl Fumarate)
- Final report of the cosmetic ingredient review expert panel on the safety assessment of Polyisobutene and Hydrogenated Polyisobutene as used in cosmetics
- Activity enhancement of ferulic acid with dimethyl isosorbride in cosmetic compositions
- The influence of alkane chain length on the skin irritation potential of 1,2-alkanediols
- Skin hydration is significantly increased by a cream formulated to mimic the skin’s own natural moisturizing systems
- Topically Applied Ceramides Interact with the Stratum Corneum Lipid Matrix in Compromised Ex Vivo Skin
- Surfactants and experimental irritant contact dermatitis
- Acetylated Hyaluronic Acid: Enhanced Bioavailability and Biological Studies
- Hyaluronic acid: A key molecule in skin aging
- Hyaluronan (Hyaluronic Acid): a natural moisturizer for skin care
- Efficacy of a New Topical Nano-hyaluronic Acid in Humans
- Physiochemical properties and application of hyaluronic acid: a systematic review
- Glycerol and the skin: holistic approach to its origin and functions