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Noble Panacea The Exceptional RetiNAD+ Renewal Booster
Noble Panacea

Noble Panacea The Exceptional RetiNAD+ Renewal Booster

Efficacy100/100IrritancyMedium
See all ingredients

Works for

Anti-aging
Retinol, Retinal + 6 more
Works well
What the product description says
“A powerful complex of three retinoid forms and NAD+ help target fine lines and wrinkles, loss of firmness, and elasticity, for visibly renewed skin.”
Source: Dermstore

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains retinal, retinol, niacinamide.

These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: hexapeptide-9, resveratrol.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

RetinolHeroEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~0.3–0.5%
RetinalHeroEffect: HighOne step removed from the biologically active in skin form of vitamin A. Once converted to the retinoic acid in the skin, retinal is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. Concentrations of 0.05% and 0.1% are shown to be effective. It can, however, be irritating~0.3–0.55%
NiacinamideKey activeEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~0.7–1.05%
ResveratrolKey activeEffect: MediumHelps neutralize free radicals in skin and might help reduce fine lines and wrinkles, as well as even out the skin tone~0.45–0.65%
Hexapeptide-9Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.5%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.3–0.55%
GluconolactoneUnder-dosedA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals~0.25–0.45%
Lactic acidUnder-dosedAn exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)~0.25–0.5%
Moisturizing
Niacinamide, Hexapeptide-9 + 17 more
Works well
What the product description says
“RetiNAD+ Renewal Booster is proven to smooth, firm, and plump skin in just 10 days.”
Source: Dermstore

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: diglycerin, glycerin.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: helianthus annuus extract, caprylyl glycol.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: hexapeptide-9, niacinamide

NiacinamideHeroEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~0.7–1.05%
Hexapeptide-9Hero· HumectantEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.5%
DiglycerinKey active· HumectantEffect: HighHelps attract water to the upper layer of the skin~5.2–6.4%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~3.1–3.8%
Chlorella vulgaris extractKey activeEffect: MediumA plant extract that can help to attract water to the upper layer of the skin and might have some anti-oxidant and anti-inflammatory properties~1.9–2.4%
Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~0.45–0.7%
Helianthus annuus extractKey active· EmollientEffect: HighHelps soften the upper layer of the skin~0.3–0.55%
CollagenKey activeEffect: MediumCannot penetrate the skin barrier so is not particularly useful in skincare products~0.3–0.5%
Collagen amino acidsKey activeEffect: HighHelp attract water to the upper layer of the skin, soften it and support the skin barrier function~0.25–0.5%
PhospholipidsKey activeEffect: MediumEmollients that are naturaly present in skin. In addition, they help water and oil mix together in the product~0.25–0.45%
Calcium gluconate· HumectantEffect: LowHelps attract water to the upper layer of the skin and helps to improve appearance of the product~0.25–0.5%
Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~0.2–0.35%
Padina pavonica thallus extractEffect: Low, below effective doseMight help to soften the upper layer of the skin. Is claimed to have anti-oxidant properties, but evidence in missing~0.5–0.8%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.3–0.55%
LecithinEffect: Low, below effective doseUsed mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin~0.25–0.5%
Caprylic/capric triglycerideUnder-dosedA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin~0.35–0.6%
Dipentaerythrityl hexacaprylate/hexacaprateUnder-dosed~0.3–0.55%
GluconolactoneUnder-dosedA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals~0.25–0.45%
Lactic acidUnder-dosedAn exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)~0.25–0.5%
Anti-oxidation
Side benefit · Haematococcus pluvialis extract, Resveratrol + 5 more
Works well

This product contains antioxidants (resveratrol, retinol) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

The following ingredients - haematococcus pluvialis extract also can have an antioxidant effect, but there is less evidence to confirm their effectiveness in skin.

Haematococcus pluvialis extractKey activeEffect: MediumGreen algae extract that might contain antioxidant astaxanthin~0.5–0.75%
ResveratrolKey activeEffect: HighHelps neutralize free radicals in skin and might help reduce fine lines and wrinkles, as well as even out the skin tone~0.45–0.65%
RetinolKey activeEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~0.3–0.5%
Chlorella vulgaris extractEffect: LowA plant extract that can help to attract water to the upper layer of the skin and might have some anti-oxidant and anti-inflammatory properties~1.9–2.4%
Padina pavonica thallus extractEffect: Low, below effective doseMight help to soften the upper layer of the skin. Is claimed to have anti-oxidant properties, but evidence in missing~0.5–0.8%
TocopherolUnder-dosedPure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.3–0.55%
GluconolactoneUnder-dosedA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals~0.25–0.45%
Evens skin tone
Side benefit · Retinal, Retinol + 4 more
Works well

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: retinal, retinol.

In addition, this product contains niacinamide. This ingredient (ingredients) might help reduce hyperpigmentation, but the effect, if any, is likely to be small.

The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually can help even out the skin tone: resveratrol.

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

RetinalHeroEffect: HighOne step removed from the biologically active in skin form of vitamin A. Once converted to the retinoic acid in the skin, retinal is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. Concentrations of 0.05% and 0.1% are shown to be effective. It can, however, be irritating~0.3–0.55%
RetinolHeroEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~0.3–0.5%
NiacinamideKey activeEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~0.7–1.05%
ResveratrolEffect: LowHelps neutralize free radicals in skin and might help reduce fine lines and wrinkles, as well as even out the skin tone~0.45–0.65%
Lactic acidUnder-dosedAn exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)~0.25–0.5%
GluconolactoneUnder-dosedA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals~0.25–0.45%
Anti-blemish
Side benefit · Niacinamide, Retinal + 2 more
Works well

This product can help reduce breakouts and clogged pores because it contains the following ingredient: niacinamide, retinal, retinol. These ingredients is used for treating acne and can have a noticeable effect.

NiacinamideHeroEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~0.7–1.05%
RetinalHeroEffect: HighOne step removed from the biologically active in skin form of vitamin A. Once converted to the retinoic acid in the skin, retinal is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. Concentrations of 0.05% and 0.1% are shown to be effective. It can, however, be irritating~0.3–0.55%
RetinolHeroEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~0.3–0.5%
GluconolactoneUnder-dosedA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals~0.25–0.45%
Exfoliation
Side benefit · Retinol, Microcrystalline cellulose + 2 more
Works well

This product can help exfoliate the skin. In other words, it helps break down the bonds between dead cells on the surface of the skin and speed up the skin turnover. Skin often appears softer and brighter after exfoliation, but overdoing it can result in disrupted skin barrier. The following ingredient is doing the exfoliating job in this product: retinol.

RetinolKey activeEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~0.3–0.5%
Microcrystalline celluloseEffect: Low~0.3–0.55%
Lactic acidUnder-dosedAn exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)~0.25–0.5%
GluconolactoneUnder-dosedA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals~0.25–0.45%

Can it cause trouble?

Irritancy
2 strong irritants: Retinal, Retinol
Medium risk
We flagged 18 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
RetinalOne step removed from the biologically active in skin form of vitamin A. Once converted to the retinoic acid in the skin, retinal is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. Concentrations of 0.05% and 0.1% are shown to be effective. It can, however, be irritatingHigh~0.3–0.55%est.
RetinolTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritatingHigh~0.3–0.5%est.
PullulanCreates a thin drying film on the skin resulting in a short-term tightening effectHigh~0.2–0.35%est.
Benzyl alcoholA preservative. Can be used to mask unpleasant smell. Can be irritatingHigh~0.1–0.25%est.
Ethyl macadamiateHelps water and oil mix togetherMedium~2.3–2.8%est.
Chlorella vulgaris extractA plant extract that can help to attract water to the upper layer of the skin and might have some anti-oxidant and anti-inflammatory propertiesMedium~1.9–2.4%est.
Dextrin palmitateHelps water and oil mix togetherMedium~1.7–2%est.
Haematococcus pluvialis extractGreen algae extract that might contain antioxidant astaxanthinMedium~0.5–0.75%est.
ResveratrolHelps neutralize free radicals in skin and might help reduce fine lines and wrinkles, as well as even out the skin toneMedium~0.45–0.65%est.
Caprylic/capric triglycerideA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerinMedium~0.35–0.6%est.
Polyglyceryl-3 cocoateHelps oil and water mix togetherMedium~0.3–0.55%est.
Polyglyceryl-6 caprylateHelps oil and water mix togetherMedium~0.3–0.55%est.
Polyglyceryl-6 ricinoleateHelps oil and water mix togetherMedium~0.3–0.55%est.
Lactic acidAn exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)Medium~0.25–0.5%est.
Citric acidCan work as an exfoliant but is typically used to adjust the product pHMedium~0.25–0.45%est.
GluconolactoneA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicalsMedium~0.25–0.45%est.
Caprylyl glycolHelps preserve products and creates a nice product textureMedium~0.2–0.35%est.
HydroxyacetophenoneUsed to increase effectiveness of preservativesMedium~0.1–0.2%est.
Comedogenic
2 ingredients rated 2 or more on the 0–5 pore-clogging scale
2 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Chlorella vulgaris extractA plant extract that can help to attract water to the upper layer of the skin and might have some anti-oxidant and anti-inflammatory properties3/5~1.9–2.4%est.
Padina pavonica thallus extractMight help to soften the upper layer of the skin. Is claimed to have anti-oxidant properties, but evidence in missing3/5~0.5–0.8%est.
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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%
Formula
Irritation risk
Low

Plain old water

More about Water
Diglycerin~5.2–6.4%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps attract water to the upper layer of the skin

More about Diglycerin
Propanediol~4.2–5.2%
Formula
Irritation risk
Low

Acts as a solvent for other ingredients. Speeds up the absorption of other ingredients into the skin

More about Propanediol
Glycerin~3.1–3.8%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Ethyl macadamiate~2.3–2.8%
Irritant · medium
Irritation risk
Medium

Helps water and oil mix together

More about Ethyl macadamiate
Chlorella vulgaris extract~1.9–2.4%
Key activeComedogenic 3/5Irritant · medium
Irritation risk
Medium
Comedogenicity
3/5
Works for
MoisturizingAnti-oxidationAnti-inflammatory

A plant extract that can help to attract water to the upper layer of the skin and might have some anti-oxidant and anti-inflammatory properties

More about Chlorella vulgaris extract
Dextrin palmitate~1.7–2%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps water and oil mix together

More about Dextrin palmitate
Maltodextrin~1.5–1.8%
Formula
Irritation risk
Low
Works for
Mattifying

Used to stabilize the product formulation and can help absorb oil

More about Maltodextrin
Cyclodextrin~1.2–1.4%
Formula
Irritation risk
Low

A type of sugar that is used to support delivery of active ingredients and can enhance their penetration into the skin without disrupting the skin's barrier

More about Cyclodextrin
Potassium chloride~1–1.2%
Formula
Irritation risk
Low
More about Potassium chloride
Niacinamide~0.7–1.05%
Hero · Moisturizing, Anti-blemish
Irritation risk
Low
Works for
Anti-agingEvens skin toneMoisturizingAnti-blemishReduces irritationAntibacterialReduces rednessAnti-inflammatory

Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production

More about Niacinamide
Nicotinamide adenine dinucleotide~0.6–0.85%
Formula
Irritation risk
Low
More about Nicotinamide adenine dinucleotide
Padina pavonica thallus extract~0.5–0.8%
Comedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
MoisturizingAnti-oxidation

Might help to soften the upper layer of the skin. Is claimed to have anti-oxidant properties, but evidence in missing

More about Padina pavonica thallus extract
Haematococcus pluvialis extract~0.5–0.75%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Anti-oxidation

Green algae extract that might contain antioxidant astaxanthin

More about Haematococcus pluvialis extract
Tetrasodium glutamate diacetate~0.45–0.7%
Formula
Irritation risk
Low

Helps stabilize the product formulation

More about Tetrasodium glutamate diacetate
Sodium hyaluronate~0.45–0.7%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate
Sphingomonas ferment extract~0.45–0.65%
Formula
Irritation risk
Low
More about Sphingomonas ferment extract
Resveratrol~0.45–0.65%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Anti-oxidationAnti-agingEvens skin tone

Helps neutralize free radicals in skin and might help reduce fine lines and wrinkles, as well as even out the skin tone

More about Resveratrol
Calanthe discolor extract~0.35–0.6%
Formula
Irritation risk
Low
More about Calanthe discolor extract
Retinal~0.3–0.55%
Hero · Anti-aging, Evens skin tone, Anti-blemishIrritant · high
Irritation risk
High
Works for
Anti-blemishAnti-agingEvens skin tone

One step removed from the biologically active in skin form of vitamin A. Once converted to the retinoic acid in the skin, retinal is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. Concentrations of 0.05% and 0.1% are shown to be effective. It can, however, be irritating

More about Retinal
Retinol~0.3–0.5%
Hero · Anti-aging, Evens skin tone, Anti-blemishIrritant · high
Irritation risk
High
Works for
Anti-oxidationEvens skin toneAnti-blemishMattifyingExfoliationAnti-aging

Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating

More about Retinol
Collagen~0.3–0.5%
Key active
Irritation risk
Low
Works for
Moisturizing

Cannot penetrate the skin barrier so is not particularly useful in skincare products

More about Collagen
Tocopherol~0.3–0.55%
Under-dosed
Irritation risk
Low
Works for
Anti-oxidationAnti-agingAnti-inflammatoryMoisturizing

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol
Helianthus annuus extract~0.3–0.55%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps soften the upper layer of the skin

More about Helianthus annuus extract
Pinus strobus bark extract~0.3–0.5%
Formula
Irritation risk
Low
More about Pinus strobus bark extract
Nannochloropsis oculata extract~0.25–0.5%
Formula
Irritation risk
Low

A microalgae extract that helps to attact water to the upper layer of the skin

More about Nannochloropsis oculata extract
Hexapeptide-9~0.25–0.5%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Hexapeptide-9
Collagen amino acids~0.25–0.5%
Key active
Irritation risk
Low
Works for
Moisturizing

Help attract water to the upper layer of the skin, soften it and support the skin barrier function

More about Collagen amino acids
Dipentaerythrityl hexacaprylate/hexacaprate~0.3–0.55%
Under-dosed
Irritation risk
Low
Works for
CleansingMoisturizing
More about Dipentaerythrityl hexacaprylate/hexacaprate
Caprylic/capric triglyceride~0.35–0.6%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin

More about Caprylic/capric triglyceride
Polyglyceryl-3 cocoate~0.3–0.55%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps oil and water mix together

More about Polyglyceryl-3 cocoate
Polyglyceryl-4 caprate~0.3–0.55%
Formula
Irritation risk
Low
Works for
Cleansing
More about Polyglyceryl-4 caprate
Polyglyceryl-6 caprylate~0.3–0.55%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps oil and water mix together

More about Polyglyceryl-6 caprylate
Polyglyceryl-6 ricinoleate~0.3–0.55%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps oil and water mix together

More about Polyglyceryl-6 ricinoleate
Cellulose~0.3–0.55%
Formula
Irritation risk
Low
Works for
Mattifying

Can be used to help absorb oil as well as add volume and imporve texture of products.

More about Cellulose
Microcrystalline cellulose~0.3–0.55%
Formula
Irritation risk
Low
Works for
Exfoliation
More about Microcrystalline cellulose
Lactic acid~0.25–0.5%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
Evens skin toneMoisturizingExfoliationAnti-aging

An exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)

More about Lactic acid
Citric acid~0.25–0.45%
Irritant · medium
Irritation risk
Medium

Can work as an exfoliant but is typically used to adjust the product pH

More about Citric acid
Malic acid~0.25–0.45%
Formula
Irritation risk
Low

Helps adjust the product pH

More about Malic acid
Gluconolactone~0.25–0.45%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
MoisturizingAnti-agingEvens skin toneExfoliationAnti-blemishAnti-oxidation

A polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals

More about Gluconolactone
Calcium gluconate~0.25–0.5%
Formula
Irritation risk
Low
Works for
Moisturizing

Helps attract water to the upper layer of the skin and helps to improve appearance of the product

More about Calcium gluconate
Phospholipids~0.25–0.45%
Key active
Irritation risk
Low
Works for
Moisturizing

Emollients that are naturaly present in skin. In addition, they help water and oil mix together in the product

More about Phospholipids
Lecithin~0.25–0.5%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

Used mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin

More about Lecithin
Pullulan~0.2–0.35%
Irritant · high
Irritation risk
High
Works for
Mattifying

Creates a thin drying film on the skin resulting in a short-term tightening effect

More about Pullulan
Cellulose gum~0.15–0.3%
Formula
Irritation risk
Low

Used to create thicker product consistency and stabilize emulsions

More about Cellulose gum
Xanthan gum~0.15–0.3%
Formula
Irritation risk
Low
Works for
Cleansing

Used to create a thicker product consistency

More about Xanthan gum
Caprylyl glycol~0.2–0.35%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol
Benzyl alcohol~0.1–0.25%
Irritant · high
Irritation risk
High

A preservative. Can be used to mask unpleasant smell. Can be irritating

More about Benzyl alcohol
Hydroxyacetophenone~0.1–0.2%
Irritant · medium
Irritation risk
Medium

Used to increase effectiveness of preservatives

More about Hydroxyacetophenone
Ingredient list view

Water, Diglycerin, Propanediol, Glycerin, Ethyl macadamiate, Chlorella vulgaris extract, Dextrin palmitate, Maltodextrin, Cyclodextrin, Potassium chloride, Niacinamide, Nicotinamide adenine dinucleotide, Padina pavonica thallus extract, Haematococcus pluvialis extract, Tetrasodium glutamate diacetate, Sodium hyaluronate, Sphingomonas ferment extract, Resveratrol, Calanthe discolor extract, Retinal, Retinol, Collagen, Tocopherol, Helianthus annuus extract, Pinus strobus bark extract, Nannochloropsis oculata extract, Hexapeptide-9, Collagen amino acids, Dipentaerythrityl hexacaprylate/hexacaprate, Caprylic/capric triglyceride, Polyglyceryl-3 cocoate, Polyglyceryl-4 caprate, Polyglyceryl-6 caprylate, Polyglyceryl-6 ricinoleate, Cellulose, Microcrystalline cellulose, Lactic acid, Citric acid, Malic acid, Gluconolactone, Calcium gluconate, Phospholipids, Lecithin, Pullulan, Cellulose gum, Xanthan gum, Caprylyl glycol, Benzyl alcohol, Hydroxyacetophenone

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
Noble PanaceaThe Exceptional RetiNAD+ Renewal BoosterYOUR PRODUCTREMEDY SCIENCEREMEDY for healthy agingProtocolEnzyme-Active Retinol SerumMedicubeDeep Reviving Bakuchiol Retinol Serum
Match—75%64%63%
Price$240.00$35.00−$205.00—$19.78−$220.22
Shared key ingredients—9 of 166 of 167 of 16
Key difference—Glycolic AcidPhenylethyl ResorcinolHydroxypinacolone Retinoate
Irritancy Medium Medium High High
Drying alcohol—— Contains drying alcohol —
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Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 35 studies and safety reviews.

  1. 1
    Glycerol and the skin: holistic approach to its origin and functionsncbi.nlm.nih.gov
  2. 2
    Safety Assessment of Polysaccharide Gums as Used in Cosmeticscir-safety.org
  3. 3
    Cyclodextrins: new drug delivery systems in dermatologydoi.org
  4. 4
    Niacinamide - mechanisms of action and its topical use in dermatologyncbi.nlm.nih.gov
  5. 5
    Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology, 3(2), 88–93. doi:10.1111/j.1473-2130.2004.00115.x ncbi.nlm.nih.gov
  6. 6
    Effective Inhibition of Skin Cancer, Tyrosinase, and Antioxidative Properties by Astaxanthin and Astaxanthin Esters from the Green Alga Haematococcus pluvialispubs.acs.org
Noble Panacea The Exceptional RetiNAD+ Renewal Booster
Noble PanaceaThe Exceptional RetiNAD+ Renewal Booster
Buy at Dermstore$240.00Amazon

Affiliate links · As an Amazon Associate, WIMJ earns from qualifying purchases.

Buy at Dermstore$240.00Amazon

As an Amazon Associate, WIMJ earns from qualifying purchases.