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Product summary

Based on the ingredients included, "Medik8 - Advanced Night Ceramide Cream" works well for moisturizing the skin. To work well, any moisturizer needs to include a combination of water-binding and emollient ingredients. Medik8 - Advanced Night Ceramide Cream ticks this box. Acetyl glucosamine, glycerin and sorbitol in this product (humectants) attract water molecules to the upper layer of the skin (the water comes from the outside air or from the deeper layers of the skin if the air is dry). Emollients in this formulation (caprooyl phytosphingosine, ceramide eop, ceramide np, ceramide ns and linoleic acid) help to reduce the moisture loss from the skin. They also soften the skin surface and relieve the feeling of dryness and tightness.

Ingredient callouts

  • This product also contains vitamin C (Ascorbic Acid). It can be an effective active for anti-aging and evening out the skin tone, but in this moisturizer it is used for stabilizing other ingredients in the formulation. In this concentration (0.35% - 0.60%) it cannot have a noticeable benefit for the skin.
  • Another benefit is that this moisturizer contain ceramides (ceramide ns 0.35% - 0.65%, ceramide np 0.65% - 0.95%, ceramide eos 0.25% - 0.50%, ceramide eop 0.30% - 0.60%, caprooyl sphingosine 0.20% - 0.35%, caprooyl phytosphingosine 0.30% - 0.50% and phytosphingosine 0.45% - 0.65%). Ceramides are an important part of our natural skin barrier. The ceramides used in skincare are synthetic or come from plants. They help soften the skin and can help "fill the gaps" in the skin barrier, keeping the skin hydrated and resilient for longer.
  • This moistruizer also contains peptides (ferric hexapeptide-35 0.30% - 0.55%). Peptides is a very big group of ingredients. They all consist of a different combination of amino-acids. Our skin produces peptides naturally. Some of them work as natural anti-biotics, promote wound-healing and production of collagen. The scientists are still studying how effective the topical application of peptides is, but it is very likely that peptides in skincare are helpful. They might be able to support skin barrier restoration and even have an anti-aging benefit. At the very least, they certainly help attract water to the skin and support the hydration in this way.
  • Another helpful ingredient in this moisturizer is Linoleic Acid. It is one of the fatty acids naturally present in skin. It is part of the skin barrier. Preliminary research shows that it might be able to reduce clogged pores.

Irritation risk

This moisturizer contains a bunch of common irritants, including ingredients that do not provide any known benefit for the skin. It might not be the best choice if your skin is sensitive. We assess the overall irritancy of this moisturizer to be high. For a detailed overview of all potential irritants: click here

You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.


The product retails from 72.00$ up to 74.00$ in the United States and for 86.30CA$ in Canada.

For a detailed price comparison: click here.