PRODUCT REVIEW
Hand MD Daily Dual Repair
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What can the product work for?
Anti-aging
What does the product description say?
A clinically tested anti-aging treatment to prevent and reduce the appearance of wrinkles and fine lines.
retinol
29% -
35%
Irritation risk:
Concentration: Effectiveness: HIGH
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
hydroxypinacolone retinoate
0.25% -
0.5%
Irritation risk:
Concentration: Effectiveness: HIGH
A derivative of the most potent form of vitamin A, retinoic acid. The ingredient can be sold under name Granactive Retinoid. Note that if a skincare brand discloses the concentration of Granactive Retinoid in a product, the concentration refers to a diluted form of Hydroxypinacolone Retinoate: 1% of Granactive Retinoid corresponds to 0.1% of Hydroxypinacolone Retinoate. Hydroxypinacolone Retinoate (HPR) is a unique derivative of retinoic acid because it can directly work in the skin and does not require additional conversion steps. According to studies done by the manufacturer on models of human skin (not real people), this derivative is more effective than other cosmetic versions of retinoids (such as retinol, retinaldehyde, and retinyl palmitate), and, at the same time, causes less irritation. It has been also demonstrated to be more stable than retinol which makes formulating with easier and increases the chances that a product with it will maintain its effectiveness after opening. The packaging should still ideally be air-tight. HPR is available over the counter in the EU, UK, Asia, Australia and New Zealand, but is only with a prescription in Canada.
ferulic acid
6.3% -
7.7%
Irritation risk:
Concentration: Effectiveness:
MEDIUM
A potent anti-oxidant that has been shown to be effective in neutralizing free radicals in skin. There seem to have a synergetic effect of ferulic acid, vitamin E and C, meaning that when the ingredients are used together, they enhance each other's ability protect the skin against free radicals. Ferulic acid also helps to stabilize other ingredients - including vitamins C and E. It can help to even out the skin tone. Ferulic acid is approved for use as a sunscreen ingredient in Japan in concentrations up to 10%
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Moisturizing
What does the product description say?
The anti-aging serum rejuvenates with Retinol and powerful Peptides, while the antioxidant-rich moisturizer deeply hydrates and protects the upper layer of the skin against damage.
copernicia cerifera wax
0.45% -
0.65%
Irritation risk:
Concentration: Effectiveness: HIGH
Helps to soften the upper layer of the skin and create a nice product consistency
sodium hyaluronate
0.3% -
0.6%
Irritation risk:
Concentration: Effectiveness: HIGH
One of the best moisturizing ingredients. Attracts water into the upper layer of the skin
sodium pca
0.3% -
0.55%
Irritation risk:
Concentration: Effectiveness: HIGH
Naturally present in skin and helps to attract water to its upper layer
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Anti-blemish
retinol
29% -
35%
Irritation risk:
Concentration: Effectiveness: HIGH
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
hydroxypinacolone retinoate
0.25% -
0.5%
Irritation risk:
Concentration: Effectiveness: HIGH
A derivative of the most potent form of vitamin A, retinoic acid. The ingredient can be sold under name Granactive Retinoid. Note that if a skincare brand discloses the concentration of Granactive Retinoid in a product, the concentration refers to a diluted form of Hydroxypinacolone Retinoate: 1% of Granactive Retinoid corresponds to 0.1% of Hydroxypinacolone Retinoate. Hydroxypinacolone Retinoate (HPR) is a unique derivative of retinoic acid because it can directly work in the skin and does not require additional conversion steps. According to studies done by the manufacturer on models of human skin (not real people), this derivative is more effective than other cosmetic versions of retinoids (such as retinol, retinaldehyde, and retinyl palmitate), and, at the same time, causes less irritation. It has been also demonstrated to be more stable than retinol which makes formulating with easier and increases the chances that a product with it will maintain its effectiveness after opening. The packaging should still ideally be air-tight. HPR is available over the counter in the EU, UK, Asia, Australia and New Zealand, but is only with a prescription in Canada.
sodium ascorbyl phosphate
0.45% -
0.65%
Irritation risk:
Concentration: Effectiveness:
MEDIUM
A stable derivative of vitamin C. It is oil-soluble which means it is more likely to penetrate the skin compared to the pure form of vitamin C (which is water-soluble), but it is less bio-available and is way less effective in stimulating collagen and reducing wrinkles compared to the pure form of vitamin C (L-ascorbic acid) and its other derivatives (for example, magnesium ascorbyl phosphate). At the same time, this vitamin C derivative has been shown in studies to be effective in reducing acne, blemishes and clogged pores. It is less irritating then the pure form of vitamin C
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Evens skin tone
retinol
29% -
35%
Irritation risk:
Concentration: Effectiveness: HIGH
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
hydroxypinacolone retinoate
0.25% -
0.5%
Irritation risk:
Concentration: Effectiveness: HIGH
A derivative of the most potent form of vitamin A, retinoic acid. The ingredient can be sold under name Granactive Retinoid. Note that if a skincare brand discloses the concentration of Granactive Retinoid in a product, the concentration refers to a diluted form of Hydroxypinacolone Retinoate: 1% of Granactive Retinoid corresponds to 0.1% of Hydroxypinacolone Retinoate. Hydroxypinacolone Retinoate (HPR) is a unique derivative of retinoic acid because it can directly work in the skin and does not require additional conversion steps. According to studies done by the manufacturer on models of human skin (not real people), this derivative is more effective than other cosmetic versions of retinoids (such as retinol, retinaldehyde, and retinyl palmitate), and, at the same time, causes less irritation. It has been also demonstrated to be more stable than retinol which makes formulating with easier and increases the chances that a product with it will maintain its effectiveness after opening. The packaging should still ideally be air-tight. HPR is available over the counter in the EU, UK, Asia, Australia and New Zealand, but is only with a prescription in Canada.
ferulic acid
6.3% -
7.7%
Irritation risk:
Concentration: Effectiveness:
MEDIUM
A potent anti-oxidant that has been shown to be effective in neutralizing free radicals in skin. There seem to have a synergetic effect of ferulic acid, vitamin E and C, meaning that when the ingredients are used together, they enhance each other's ability protect the skin against free radicals. Ferulic acid also helps to stabilize other ingredients - including vitamins C and E. It can help to even out the skin tone. Ferulic acid is approved for use as a sunscreen ingredient in Japan in concentrations up to 10%
Show more
Exfoliation
retinol
29% -
35%
Irritation risk:
Concentration: Effectiveness: HIGH
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
hydroxypinacolone retinoate
0.25% -
0.5%
Irritation risk:
Concentration: Effectiveness:
MEDIUM
A derivative of the most potent form of vitamin A, retinoic acid. The ingredient can be sold under name Granactive Retinoid. Note that if a skincare brand discloses the concentration of Granactive Retinoid in a product, the concentration refers to a diluted form of Hydroxypinacolone Retinoate: 1% of Granactive Retinoid corresponds to 0.1% of Hydroxypinacolone Retinoate. Hydroxypinacolone Retinoate (HPR) is a unique derivative of retinoic acid because it can directly work in the skin and does not require additional conversion steps. According to studies done by the manufacturer on models of human skin (not real people), this derivative is more effective than other cosmetic versions of retinoids (such as retinol, retinaldehyde, and retinyl palmitate), and, at the same time, causes less irritation. It has been also demonstrated to be more stable than retinol which makes formulating with easier and increases the chances that a product with it will maintain its effectiveness after opening. The packaging should still ideally be air-tight. HPR is available over the counter in the EU, UK, Asia, Australia and New Zealand, but is only with a prescription in Canada.
Anti-oxidation
ferulic acid
6.3% -
7.7%
Irritation risk:
Concentration: Effectiveness: HIGH
A potent anti-oxidant that has been shown to be effective in neutralizing free radicals in skin. There seem to have a synergetic effect of ferulic acid, vitamin E and C, meaning that when the ingredients are used together, they enhance each other's ability protect the skin against free radicals. Ferulic acid also helps to stabilize other ingredients - including vitamins C and E. It can help to even out the skin tone. Ferulic acid is approved for use as a sunscreen ingredient in Japan in concentrations up to 10%
retinol
29% -
35%
Irritation risk:
Concentration: Effectiveness: HIGH
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
sodium ascorbyl phosphate
0.45% -
0.65%
Irritation risk:
Concentration: Effectiveness:
MEDIUM
A stable derivative of vitamin C. It is oil-soluble which means it is more likely to penetrate the skin compared to the pure form of vitamin C (which is water-soluble), but it is less bio-available and is way less effective in stimulating collagen and reducing wrinkles compared to the pure form of vitamin C (L-ascorbic acid) and its other derivatives (for example, magnesium ascorbyl phosphate). At the same time, this vitamin C derivative has been shown in studies to be effective in reducing acne, blemishes and clogged pores. It is less irritating then the pure form of vitamin C
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Honesty check
How honest is this product?
| Promise | Can it deliver? |
|---|---|
| Anti-aging | |
| Moisturizing |
Total Promises Fulfilled score:
87/100.
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Can it cause trouble?
- Overall product irritation risk
- Acne & comedogenic risk ingredients: 2
Potential irritants
retinol
29% -
35%
Irritation risk:
Works for:
Anti-blemish,
Mattifying,
Exfoliation,
Anti-oxidation,
Anti-aging,
Evens skin tone
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
hydroxypinacolone retinoate
0.25% -
0.5%
Irritation risk:
Works for:
Anti-blemish,
Evens skin tone,
Anti-aging,
Exfoliation
A derivative of the most potent form of vitamin A, retinoic acid. The ingredient can be sold under name Granactive Retinoid. Note that if a skincare brand discloses the concentration of Granactive Retinoid in a product, the concentration refers to a diluted form of Hydroxypinacolone Retinoate: 1% of Granactive Retinoid corresponds to 0.1% of Hydroxypinacolone Retinoate. Hydroxypinacolone Retinoate (HPR) is a unique derivative of retinoic acid because it can directly work in the skin and does not require additional conversion steps. According to studies done by the manufacturer on models of human skin (not real people), this derivative is more effective than other cosmetic versions of retinoids (such as retinol, retinaldehyde, and retinyl palmitate), and, at the same time, causes less irritation. It has been also demonstrated to be more stable than retinol which makes formulating with easier and increases the chances that a product with it will maintain its effectiveness after opening. The packaging should still ideally be air-tight. HPR is available over the counter in the EU, UK, Asia, Australia and New Zealand, but is only with a prescription in Canada.
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Comodogenic ingredients
carrageenan
0.3% -
0.6%
Irritation risk: Comedogenicity: High
Helps thicken the product formula and create a nice product formulation
cetearyl alcohol
0.4% -
0.6%
Irritation risk: Comedogenicity: Medium
Works for:
Cleansing,
Moisturizing
A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture
User reviews (0)
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| Hand MD - Daily Dual Repair |  Biopelle - KNR Serum |  Glowbiotics MD - Retinol Anti-Aging and Brightening Treatment |  NeoRetin - Serum Booster Fluid |  DermExcel - Acne Repair serum |  MDSolarSciences - Revitalize Retinol Serum |  InstaNatural - Day & Night Skin Duo - Retinol and Vitamin C Serum |  NourishMax - VITAMIN C + B + E + FERULIC & RETINOL SERUM |  TONYMOLY - Vital Vita 12 Firming Ampoule |  Dr Dennis Gross - Ferulic Acid + Retinol Brightening Solution |  Beauty Pie - Super Retinol High Dose Booster Treatment | |
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| WIMJ similarity score |
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Other:
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| Irritancy | IRRITANCY
HIGH
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HIGH
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HIGH
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HIGH
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HIGH
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HIGH
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HIGH
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LOW
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HIGH
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HIGH
| IRRITANCY
MEDIUM
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Ingredients & concentrations
All ingredients
Key Actives
niacinamide
0.3% -
0.55%
Irritation risk:
Works for:
Evens skin tone,
Anti-blemish,
Moisturizing,
Anti-aging,
Reduces irritation,
Anti-inflammatory,
Antibacterial,
Reduces redness
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture.
The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
retinol
29% -
35%
Irritation risk:
Works for:
Anti-blemish,
Mattifying,
Exfoliation,
Anti-oxidation,
Anti-aging,
Evens skin tone
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
Show more
Potential irritants
retinol
29% -
35%
Irritation risk:
Works for:
Anti-blemish,
Mattifying,
Exfoliation,
Anti-oxidation,
Anti-aging,
Evens skin tone
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
hydroxypinacolone retinoate
0.25% -
0.5%
Irritation risk:
Works for:
Anti-blemish,
Evens skin tone,
Anti-aging,
Exfoliation
A derivative of the most potent form of vitamin A, retinoic acid. The ingredient can be sold under name Granactive Retinoid. Note that if a skincare brand discloses the concentration of Granactive Retinoid in a product, the concentration refers to a diluted form of Hydroxypinacolone Retinoate: 1% of Granactive Retinoid corresponds to 0.1% of Hydroxypinacolone Retinoate. Hydroxypinacolone Retinoate (HPR) is a unique derivative of retinoic acid because it can directly work in the skin and does not require additional conversion steps. According to studies done by the manufacturer on models of human skin (not real people), this derivative is more effective than other cosmetic versions of retinoids (such as retinol, retinaldehyde, and retinyl palmitate), and, at the same time, causes less irritation. It has been also demonstrated to be more stable than retinol which makes formulating with easier and increases the chances that a product with it will maintain its effectiveness after opening. The packaging should still ideally be air-tight. HPR is available over the counter in the EU, UK, Asia, Australia and New Zealand, but is only with a prescription in Canada.
Show more
Comodogenic ingredients
carrageenan
0.3% -
0.6%
Irritation risk: Comedogenicity: High
Helps thicken the product formula and create a nice product formulation
cetearyl alcohol
0.4% -
0.6%
Irritation risk: Comedogenicity: Medium
Works for:
Cleansing,
Moisturizing
A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture
All ingredients
retinol
29% -
35%
Irritation risk:
Works for:
Anti-blemish,
Mattifying,
Exfoliation,
Anti-oxidation,
Anti-aging,
Evens skin tone
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
Show more
Ingredient list view
Retinol, Unspecified form of vitamin c, Unknown, Ferulic acid, Caffeine, Unknown, Water, Olea europaea fruit oil, Glycerin, Potassium cetyl phosphate, Isododecane, Dimethicone/bis-isobutyl ppg-20 crosspolymer, Phenoxyethanol, Benzoic acid, Ethylhexylglycerin, Glycereth-2 cocoate, Butylene glycol, Carbomer, Sodium ascorbyl phosphate, Lecithin, Methyl gluceth-20, Propanediol, Sodium hyaluronate, Euterpe oleracea seed powder, Dimethyl isosorbide, Hydroxypinacolone retinoate, Xanthan gum, Carrageenan, Ferulic acid, Caffeine, Tocopherol, Water, Olea europaea fruit oil, Dimethicone, Isodecyl neopentanoate, Dimethicone/bis-isobutyl ppg-20 crosspolymer, Niacinamide, Isododecane, Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, Squalane, Polysorbate 60, Glycerin, Cera alba, Carthamus tinctorius seed oil, Caprylic/capric triglyceride, Cetearyl alcohol, Glyceryl stearate, Dicaprylyl ether, Sodium pca, Microcrystalline wax, Diazolidinyl urea, Copernicia cerifera wax, Phenoxyethanol, Benzoic acid, Ethylhexylglycerin, Glycereth-2 cocoate, Sodium ascorbyl phosphate, Microcrystalline cellulose, Cellulose gum, Sodium hyaluronate, Dimethyl isosorbide, Hydroxypinacolone retinoate, Silica silylate, Xanthan gum, Titanium dioxide, C10-18 triglycerides, Sorbic acid, Tocopherol
Sources
- Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety
- Improvement of naturally aged skin with vitamin A (retinol)
- A comparative study of the effects of retinol and retinoic acid on histological, molecular, and clinical properties of human skin
- Ferulic Acid: Therapeutic Potential Through Its Antioxidant Property
- Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin
- Antioxidant Properties of Ferulic Acid and Its Possible Application
- Use of “natural” oils for moisturization: Review of olive, coconut, and sunflower seed oil
- Glycerol and the skin: holistic approach to its origin and functions
- Sodium ascorbyl phosphate shows in vitro and in vivo efficacy in the prevention and treatment of acne vulgaris
- Sodium ascorbyl phosphate in topical microemulsions
- Final report of the safety assessment of L-Ascorbic Acid, Calcium Ascorbate, Magnesium Ascorbate, Magnesium Ascorbyl Phosphate, Sodium Ascorbate, and Sodium Ascorbyl Phosphate as used in cosmetics
- Regulation of collagen synthesis in human dermal fibroblasts by the sodium and magnesium salts of ascorbyl-2-phosphate
- Comparison of clinical efficacies of sodium ascorbyl phosphate, retinol and their combination in acne treatment
- Application of l-ascorbic acid and its derivatives (sodium ascorbyl phosphate and magnesium ascorbyl phosphate) in topical cosmetic formulations: stability studies
- Sodium L-ascorbyl-2-phosphate 5% lotion for the treatment of acne vulgaris: a randomized, double-blind, controlled trial
- Hyaluronic acid: A key molecule in skin aging
- Hyaluronan (Hyaluronic Acid): a natural moisturizer for skin care
- Activity enhancement of ferulic acid with dimethyl isosorbride in cosmetic compositions
- Antiaging effects of retinoid hydroxypinacolone retinoate on skin models. (2018). Journal of the American Academy of Dermatology, 79(3), AB44. doi:10.1016/j.jaad.2018.05.215
- Treatment of mild to moderate acne with a fixed combination of hydroxypinacolone retinoate, retinol glycospheres and papain glycospheres
- Vitamin E in dermatology
- Vitamin E and Skin Health
- Dimethicone as a protective ingredient in topical medications
- Final Report on the Safety Assessment of Dimethicone Copolyol
- Niacinamide - mechanisms of action and its topical use in dermatology
- Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology, 3(2), 88–93. doi:10.1111/j.1473-2130.2004.00115.x