PRODUCT REVIEW
Glowbiotics MD Retinol Anti-Aging and Brightening Treatment
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Price as of 12/25/2023 2:13 GMT.
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What can the product work for?
Anti-aging
What does the product description say?
Retinol Anti-Aging and Brightening Treatment
hydroxypinacolone retinoate
0.01% -
0.05%
Irritation risk:
Concentration: Effectiveness: HIGH
A derivative of the most potent form of vitamin A, retinoic acid. The ingredient can be sold under name Granactive Retinoid. Note that if a skincare brand discloses the concentration of Granactive Retinoid in a product, the concentration refers to a diluted form of Hydroxypinacolone Retinoate: 1% of Granactive Retinoid corresponds to 0.1% of Hydroxypinacolone Retinoate. Hydroxypinacolone Retinoate (HPR) is a unique derivative of retinoic acid because it can directly work in the skin and does not require additional conversion steps. According to studies done by the manufacturer on models of human skin (not real people), this derivative is more effective than other cosmetic versions of retinoids (such as retinol, retinaldehyde, and retinyl palmitate), and, at the same time, causes less irritation. It has been also demonstrated to be more stable than retinol which makes formulating with easier and increases the chances that a product with it will maintain its effectiveness after opening. The packaging should still ideally be air-tight. HPR is available over the counter in the EU, UK, Asia, Australia and New Zealand, but is only with a prescription in Canada.
retinol
0.25% -
0.5%
Irritation risk:
Concentration: Effectiveness: HIGH
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
bakuchiol
0.3% -
0.55%
Irritation risk:
Concentration: Effectiveness: HIGH
A plant extract that is, though different in chemical structure, acts similar to retinoids. First studies show that it can help reduce fine lines and wrinkles, improve skin tone, reduce clogged pores and blemishes, and reduce inflammation. There is no conclusive evidence that bakuchiol is as effective as retinol however. The study that directly compared retinol with bakuchiol used bakuchiol applied twice daily compared to once per day for the retinol. According to this study, bakuchiol is less irritating than retinol. Bakuchiol is extracted from seeds of Babchi plant. Other parts of the plant contain coumarins that could cause allergic and irritant reactions. These compounds should be removed in the extraction process when bakuchiol is produced, but it is a good idea to be cautious and stay away from products that include the Babchi plant extracts other than purified bakuchiol to avoid irritation
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Evens skin tone
What does the product description say?
An innovative Pigment Balancing Complex of botanicals and photo-protective actives brightens and clarifies skin; it helps to reduce dark spots, pigmentation and uneven tone to reveal a radiant, healthy complexion come morning.
niacinamide
4.2% -
5.1%
Irritation risk:
Concentration: Effectiveness: HIGH
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture.
The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
bakuchiol
0.3% -
0.55%
Irritation risk:
Concentration: Effectiveness: HIGH
A plant extract that is, though different in chemical structure, acts similar to retinoids. First studies show that it can help reduce fine lines and wrinkles, improve skin tone, reduce clogged pores and blemishes, and reduce inflammation. There is no conclusive evidence that bakuchiol is as effective as retinol however. The study that directly compared retinol with bakuchiol used bakuchiol applied twice daily compared to once per day for the retinol. According to this study, bakuchiol is less irritating than retinol. Bakuchiol is extracted from seeds of Babchi plant. Other parts of the plant contain coumarins that could cause allergic and irritant reactions. These compounds should be removed in the extraction process when bakuchiol is produced, but it is a good idea to be cautious and stay away from products that include the Babchi plant extracts other than purified bakuchiol to avoid irritation
gluconic acid
0.15% -
0.3%
Irritation risk:
Concentration: Effectiveness: HIGH
A polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in imporved hydration levels. It has been shown to be helpful against acne and clogged pores. Might help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals
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Moisturizing
What does the product description say?
Lightweight and quick-absorbing, it repairs and renews aging skin while you sleep.
myristoyl nonapeptide-3
0.25% -
0.45%
Irritation risk:
Concentration: Effectiveness: HIGH
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
polyglycerin-3
0.2% -
0.4%
Irritation risk:
Concentration: Effectiveness: HIGH
Helps to attract water to the upper layer of the skin
beta-glucan
0.25% -
0.45%
Irritation risk:
Concentration: Effectiveness: HIGH
Helps attract water to the upper layer of the skin, calm down inflammation and irritation, restore the barrier function and support wound healing. It can be helpful in reducing fine lines and wrinkles
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Anti-blemish
retinol
0.25% -
0.5%
Irritation risk:
Concentration: Effectiveness: HIGH
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
niacinamide
4.2% -
5.1%
Irritation risk:
Concentration: Effectiveness: HIGH
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture.
The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
hydroxypinacolone retinoate
0.01% -
0.05%
Irritation risk:
Concentration: Effectiveness: HIGH
A derivative of the most potent form of vitamin A, retinoic acid. The ingredient can be sold under name Granactive Retinoid. Note that if a skincare brand discloses the concentration of Granactive Retinoid in a product, the concentration refers to a diluted form of Hydroxypinacolone Retinoate: 1% of Granactive Retinoid corresponds to 0.1% of Hydroxypinacolone Retinoate. Hydroxypinacolone Retinoate (HPR) is a unique derivative of retinoic acid because it can directly work in the skin and does not require additional conversion steps. According to studies done by the manufacturer on models of human skin (not real people), this derivative is more effective than other cosmetic versions of retinoids (such as retinol, retinaldehyde, and retinyl palmitate), and, at the same time, causes less irritation. It has been also demonstrated to be more stable than retinol which makes formulating with easier and increases the chances that a product with it will maintain its effectiveness after opening. The packaging should still ideally be air-tight. HPR is available over the counter in the EU, UK, Asia, Australia and New Zealand, but is only with a prescription in Canada.
Show more
Exfoliation
gluconic acid
0.15% -
0.3%
Irritation risk:
Concentration: Effectiveness: HIGH
A polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in imporved hydration levels. It has been shown to be helpful against acne and clogged pores. Might help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals
retinol
0.25% -
0.5%
Irritation risk:
Concentration: Effectiveness: HIGH
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
hydroxypinacolone retinoate
0.01% -
0.05%
Irritation risk:
Concentration: Effectiveness:
MEDIUM
A derivative of the most potent form of vitamin A, retinoic acid. The ingredient can be sold under name Granactive Retinoid. Note that if a skincare brand discloses the concentration of Granactive Retinoid in a product, the concentration refers to a diluted form of Hydroxypinacolone Retinoate: 1% of Granactive Retinoid corresponds to 0.1% of Hydroxypinacolone Retinoate. Hydroxypinacolone Retinoate (HPR) is a unique derivative of retinoic acid because it can directly work in the skin and does not require additional conversion steps. According to studies done by the manufacturer on models of human skin (not real people), this derivative is more effective than other cosmetic versions of retinoids (such as retinol, retinaldehyde, and retinyl palmitate), and, at the same time, causes less irritation. It has been also demonstrated to be more stable than retinol which makes formulating with easier and increases the chances that a product with it will maintain its effectiveness after opening. The packaging should still ideally be air-tight. HPR is available over the counter in the EU, UK, Asia, Australia and New Zealand, but is only with a prescription in Canada.
Anti-oxidation
retinol
0.25% -
0.5%
Irritation risk:
Concentration: Effectiveness: HIGH
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
gluconic acid
0.15% -
0.3%
Irritation risk:
Concentration: Effectiveness: HIGH
A polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in imporved hydration levels. It has been shown to be helpful against acne and clogged pores. Might help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals
bakuchiol
0.3% -
0.55%
Irritation risk:
Concentration: Effectiveness: HIGH
A plant extract that is, though different in chemical structure, acts similar to retinoids. First studies show that it can help reduce fine lines and wrinkles, improve skin tone, reduce clogged pores and blemishes, and reduce inflammation. There is no conclusive evidence that bakuchiol is as effective as retinol however. The study that directly compared retinol with bakuchiol used bakuchiol applied twice daily compared to once per day for the retinol. According to this study, bakuchiol is less irritating than retinol. Bakuchiol is extracted from seeds of Babchi plant. Other parts of the plant contain coumarins that could cause allergic and irritant reactions. These compounds should be removed in the extraction process when bakuchiol is produced, but it is a good idea to be cautious and stay away from products that include the Babchi plant extracts other than purified bakuchiol to avoid irritation
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Honesty check
How honest is this product?
| Promise | Can it deliver? |
|---|---|
| Anti-aging | |
| Moisturizing | |
| Evens skin tone |
Total Promises Fulfilled score:
100/100.
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Can it cause trouble?
- Overall product irritation risk
- Acne & comedogenic risk ingredients: 2
Potential irritants
retinol
0.25% -
0.5%
Irritation risk:
Works for:
Evens skin tone,
Mattifying,
Anti-aging,
Anti-oxidation,
Exfoliation,
Anti-blemish
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
hydroxypinacolone retinoate
0.01% -
0.05%
Irritation risk:
Works for:
Anti-blemish,
Evens skin tone,
Anti-aging,
Exfoliation
A derivative of the most potent form of vitamin A, retinoic acid. The ingredient can be sold under name Granactive Retinoid. Note that if a skincare brand discloses the concentration of Granactive Retinoid in a product, the concentration refers to a diluted form of Hydroxypinacolone Retinoate: 1% of Granactive Retinoid corresponds to 0.1% of Hydroxypinacolone Retinoate. Hydroxypinacolone Retinoate (HPR) is a unique derivative of retinoic acid because it can directly work in the skin and does not require additional conversion steps. According to studies done by the manufacturer on models of human skin (not real people), this derivative is more effective than other cosmetic versions of retinoids (such as retinol, retinaldehyde, and retinyl palmitate), and, at the same time, causes less irritation. It has been also demonstrated to be more stable than retinol which makes formulating with easier and increases the chances that a product with it will maintain its effectiveness after opening. The packaging should still ideally be air-tight. HPR is available over the counter in the EU, UK, Asia, Australia and New Zealand, but is only with a prescription in Canada.
Show more
Comodogenic ingredients
cetearyl alcohol
0.55% -
0.85%
Irritation risk: Comedogenicity: Medium
Works for:
Cleansing,
Moisturizing
A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture
ethylhexyl palmitate
0.4% -
0.6%
Irritation risk: Comedogenicity: High
Works for:
Moisturizing
An emollient that helps soften the skin and create a nice product texture
User reviews (0)
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55%
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| Irritancy | IRRITANCY
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HIGH
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Ingredients & concentrations
All ingredients
Key Actives
niacinamide
4.2% -
5.1%
Irritation risk:
Works for:
Evens skin tone,
Moisturizing,
Anti-blemish,
Anti-aging,
Reduces irritation,
Anti-inflammatory,
Reduces redness,
Antibacterial
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture.
The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
retinol
0.25% -
0.5%
Irritation risk:
Works for:
Evens skin tone,
Mattifying,
Anti-aging,
Anti-oxidation,
Exfoliation,
Anti-blemish
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
Show more
Potential irritants
retinol
0.25% -
0.5%
Irritation risk:
Works for:
Evens skin tone,
Mattifying,
Anti-aging,
Anti-oxidation,
Exfoliation,
Anti-blemish
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
hydroxypinacolone retinoate
0.01% -
0.05%
Irritation risk:
Works for:
Anti-blemish,
Evens skin tone,
Anti-aging,
Exfoliation
A derivative of the most potent form of vitamin A, retinoic acid. The ingredient can be sold under name Granactive Retinoid. Note that if a skincare brand discloses the concentration of Granactive Retinoid in a product, the concentration refers to a diluted form of Hydroxypinacolone Retinoate: 1% of Granactive Retinoid corresponds to 0.1% of Hydroxypinacolone Retinoate. Hydroxypinacolone Retinoate (HPR) is a unique derivative of retinoic acid because it can directly work in the skin and does not require additional conversion steps. According to studies done by the manufacturer on models of human skin (not real people), this derivative is more effective than other cosmetic versions of retinoids (such as retinol, retinaldehyde, and retinyl palmitate), and, at the same time, causes less irritation. It has been also demonstrated to be more stable than retinol which makes formulating with easier and increases the chances that a product with it will maintain its effectiveness after opening. The packaging should still ideally be air-tight. HPR is available over the counter in the EU, UK, Asia, Australia and New Zealand, but is only with a prescription in Canada.
Show more
Comodogenic ingredients
cetearyl alcohol
0.55% -
0.85%
Irritation risk: Comedogenicity: Medium
Works for:
Cleansing,
Moisturizing
A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture
ethylhexyl palmitate
0.4% -
0.6%
Irritation risk: Comedogenicity: High
Works for:
Moisturizing
An emollient that helps soften the skin and create a nice product texture
All ingredients
glycerin
4.7% -
5.7%
Irritation risk:
Works for:
Moisturizing
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
niacinamide
4.2% -
5.1%
Irritation risk:
Works for:
Evens skin tone,
Moisturizing,
Anti-blemish,
Anti-aging,
Reduces irritation,
Anti-inflammatory,
Reduces redness,
Antibacterial
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture.
The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
Show more
Ingredient list view
Water, Glycerin, Niacinamide, Pentylene glycol, Lactococcus ferment lysate, Carthamus tinctorius oleosomes, Cetearyl olivate, Potassium cetyl phosphate, Behenyl alcohol, Sorbitan olivate, Glyceryl cocoate, Lauryl lactate, Hexylresorcinol, Cetearyl alcohol, Maltodextrin, Jojoba esters, Caprylic/capric triglyceride, Ethylhexyl palmitate, Retinol, Hydroxypinacolone retinoate, Bakuchiol, Terminalia ferdinandiana fruit extract, Terminalia chebula fruit extract, Beta-glucan, Myristoyl nonapeptide-3, Pisum sativum extract, Acacia decurrens flower wax, Helianthus annuus seed wax, Dimethyl isosorbide, Caprylyl glycol, Sucrose dilaurate, Xanthan gum, Hydroxyethylcellulose, Polysorbate 20, Caprylhydroxamic acid, Sodium cocoyl glutamate, Alcohol denat., Disodium edta, Polyglycerin-3, Gluconic acid, Sodium benzoate, Sodium acetate, 1,2-hexanediol, Bht, Cellulose, Benzoic acid, Bha
Sources
- Glycerol and the skin: holistic approach to its origin and functions
- Niacinamide - mechanisms of action and its topical use in dermatology
- Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology, 3(2), 88–93. doi:10.1111/j.1473-2130.2004.00115.x
- Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety
- Improvement of naturally aged skin with vitamin A (retinol)
- A comparative study of the effects of retinol and retinoic acid on histological, molecular, and clinical properties of human skin
- Antiaging effects of retinoid hydroxypinacolone retinoate on skin models. (2018). Journal of the American Academy of Dermatology, 79(3), AB44. doi:10.1016/j.jaad.2018.05.215
- Treatment of mild to moderate acne with a fixed combination of hydroxypinacolone retinoate, retinol glycospheres and papain glycospheres
- Bakuchiol in the Management of Acne-affected Skin
- Prospective, randomized, double‐blind assessment of topical bakuchiol and retinol for facial photoageing
- A dermocosmetic containing bakuchiol, Ginkgo biloba extract and mannitol improves the efficacy of adapalene in patients with acne vulgaris: result from a controlled randomized trial
- The chemotherapeutic potential of Terminalia ferdinandiana: Phytochemistry and bioactivity
- β-Glucans: Multi-Functional Modulator of Wound Healing
- Anti-Wrinkle Therapy: Significant New Findings in the Non-Invasive Cosmetic Treatment of Skin Wrinkles with Beta-Glucan
- Skin Health Promotion Effects of Natural Beta-Glucan Derived from Cereals and Microorganisms: A Review
- Anticancer properties of low molecular weight oat beta-glucan – An in vitro study
- A critical review on production and industrial applications 2 of beta-glucans
- Improving skin function with CM-glucan, a biological response modifier from yeast
- Preparation, characterization, and biological properties of β-glucans
- Characterization of a new beta(1-3)-glucan branching activity of Aspergillus fumigatus
- Final Report of the Safety Assessment of Acacia Catechu Gum, Acacia Concinna Fruit Extract, Acacia Dealbata Leaf Extract, Acacia Dealbata Leaf Wax, Acacia Decurrens Extract, Acacia Farnesiana Extract, Acacia Farnesiana Flower Wax, Acacia Farnesiana Gum, Acacia Senegal Extract, Acacia Senegal Gum, and Acacia Senegal Gum Extract1
- Effect of Olive and Sunflower Seed Oil on the Adult Skin Barrier: Implications for Neonatal Skin Care
- Activity enhancement of ferulic acid with dimethyl isosorbride in cosmetic compositions
- Safety Assessment of Amino Acid Alkyl Amides as Used in Cosmetics
- Irritant and sensitizing potential of eight surfactants commonly used in skin cleansers: an evaluation of 105 patients
- Alpha-hydroxyacids and carboxylic acids