Dermaquest

Dermaquest Stem Cell 3D Active Retinol Repair Serum - 1%

Name: Dermaquest - Stem Cell 3D Active Retinol Repair Serum - 1%
Brand: Dermaquest

Efficacy100/100IrritancyHigh

See all ingredients

Works for

Anti-aging

Retinol, Retinyl retinoate + 8 more

Works well

What the product description says

“with consistent use, dermaquest stem cell 3d active retinol repair serum significantly improves the appearance of lines, wrinkles, uv damage, epidermal thickness, and tone and texture”

Source: N/A

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains retinal, retinol, retinyl retinoate, bakuchiol.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

RetinolHeroEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~0.45–0.65%

Retinyl retinoateHeroEffect: HighA "hybrid" of retinol and retinoic acid. It is more stable than retinol and is likely to be more effective based on the early research data available. Is as irritating as retinol~0.4–0.6%

RetinalHeroEffect: HighOne step removed from the biologically active in skin form of vitamin A. Once converted to the retinoic acid in the skin, retinal is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. Concentrations of 0.05% and 0.1% are shown to be effective. It can, however, be irritating~0.4–0.6%

BakuchiolKey activeEffect: HighA plant extract that is, though different in chemical structure, acts similar to retinoids. First studies show that it can help reduce fine lines and wrinkles, improve skin tone, reduce clogged pores and blemishes, and reduce inflammation. There is no conclusive evidence that bakuchiol is as effective as retinol however. The study that directly compared retinol with bakuchiol used bakuchiol applied twice daily compared to once per day for the retinol. According to this study, bakuchiol is less irritating than retinol. Bakuchiol is extracted from seeds of Babchi plant. Other parts of the plant contain coumarins that could cause allergic and irritant reactions. These compounds should be removed in the extraction process when bakuchiol is produced, but it is a good idea to be cautious and stay away from products that include the Babchi plant extracts other than purified bakuchiol to avoid irritation~0.25–0.45%

Aloe barbadensis leaf juiceEffect: Low, below effective doseTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin~1.8–2.2%

Camellia sinensis leaf extractEffect: Low, below effective doseCan contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation~0.25–0.4%

TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.2–0.4%

Laminaria digitata extractEffect: Low, below effective doseSeaweed extract that helps the skin to attract water and make it more smooth for touch. Also shows promise of anti-aging properties, but good research is lacking at the moment~0.2–0.4%

Retinyl linoleateUnder-dosedAn ester of a retinoid and linoleic acid. Three steps removed from the bioactive form of retinoid, retinoic acid. Once converted to retinoic acid in skin, it can help reduce wrinkles, stimulate collagen production, even out skin tone and reduce blemishes. The concentrations used in cosmetic products are often not high enough to have a positive effect in skin.~0.35–0.65%

NiacinamideUnder-dosedIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~0.2–0.4%

Evens skin tone

Retinol, Retinal + 7 more

Works well

What the product description says

“with consistent use, dermaquest stem cell 3d active retinol repair serum significantly improves the appearance of lines, wrinkles, uv damage, epidermal thickness, and tone and texture”

Source: N/A

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: retinal, retinol, retinyl retinoate.

In addition, this product contains bakuchiol, tranexamic acid. This ingredient (ingredients) might help reduce hyperpigmentation, but the effect, if any, is likely to be small.

The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually can help even out the skin tone: retinyl retinoate.

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

Retinyl retinoateHeroEffect: MediumA "hybrid" of retinol and retinoic acid. It is more stable than retinol and is likely to be more effective based on the early research data available. Is as irritating as retinol~0.4–0.6%

Tranexamic acidKey activeEffect: HighAn amino acid that is effective in reducing hyperpigmentation and evening out the skin tone. It can also help in skin barrier recovery. It is used to treat melasma, especially with injections and when taken orally~0.3–0.6%

Dipotassium glycyrrhizateEffect: Low, below effective doseA salt derived from licorice. Works as an emollient to soften the upper layer of the skin and can help calm down inflammation. Might be helpful for skin lightening~0.2–0.35%

Anti-blemish

Retinol, Retinyl retinoate + 6 more

Works well

This product can help reduce breakouts and clogged pores because it contains the following ingredient: retinal, retinol, retinyl retinoate. These ingredients is used for treating acne and can have a noticeable effect.

In addition, this product contains bakuchiol. It can help in reducing blemishes, even though it is less effective.

Anti-oxidation

Side benefit · Retinol, Bakuchiol + 6 more

Works well

This product contains antioxidants (bakuchiol, retinol) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

RetinolKey activeEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~0.45–0.65%

Chlorella vulgaris extractEffect: LowA plant extract that can help to attract water to the upper layer of the skin and might have some anti-oxidant and anti-inflammatory properties~0.2–0.4%

Olea europaea leaf extractEffect: LowA plant extract that might have some anti-oxidant and anti-inflammatory properties but evidence for effectiveness in skin is missing~0.2–0.35%

Camellia sinensis leaf extractUnder-dosedCan contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation~0.25–0.4%

TocopherolUnder-dosedPure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.2–0.4%

Exfoliation

Side benefit · Retinol, Retinyl retinoate

Works well

This product can help exfoliate the skin. In other words, it helps break down the bonds between dead cells on the surface of the skin and speed up the skin turnover. Skin often appears softer and brighter after exfoliation, but overdoing it can result in disrupted skin barrier. The following ingredient is doing the exfoliating job in this product: retinol, retinyl retinoate.

Retinyl retinoateKey activeEffect: HighA "hybrid" of retinol and retinoic acid. It is more stable than retinol and is likely to be more effective based on the early research data available. Is as irritating as retinol~0.4–0.6%

Moisturizing

Side benefit · Glycerin, Squalane + 22 more

Works

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: glycerin, saccharide isomerate.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: caprylic/capric triglyceride, dimethicone.

GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~4.9–5.9%

SqualaneKey active· Emollient, OcclusiveEffect: HighAn oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.~4.1–5%

Caprylic/capric triglycerideKey active· Emollient, OcclusiveEffect: HighA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin~3.1–3.8%

C12-15 alkyl benzoateKey active· EmollientEffect: MediumEnhances the product texture and makes it more spreadable. Helps reduce water loss from the outer layer of skin. Extands the shelf life by preventing bacteria growth~2.3–2.8%

Cetearyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture~1.2–1.5%

DimethiconeKey active· Emollient, OcclusiveEffect: HighA silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish~0.7–1.05%

Cetyl palmitateKey active· EmollientEffect: MediumAn emollient that helps soften the skin and is used to improve product texture and stability~0.35–0.6%

Sodium hyaluronate crosspolymerKey active· HumectantEffect: HighAttracts water into the upper layer of the skin~0.25–0.45%

Ethylhexyl palmitateKey active· EmollientEffect: MediumAn emollient that helps soften the skin and create a nice product texture~0.25–0.45%

Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~0.2–0.4%

Saccharide isomerateKey active· HumectantEffect: HighHelps attract water to the upper layer of the skin~0.2–0.4%

Chlorella vulgaris extractKey activeEffect: MediumA plant extract that can help to attract water to the upper layer of the skin and might have some anti-oxidant and anti-inflammatory properties~0.2–0.4%

Dicaprylyl ether· EmollientEffect: LowHelps soften the upper layer of the skin while creating a non-greasy feel on the skin. Helps to dissolve other ingredients~0.55–0.8%

Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~0.25–0.45%

Pentylene glycol· EmollientEffect: LowUsed to preserve products, dissolve other ingredients and create a nice product texture~0.25–0.5%

C13-14 isoparaffin· EmollientEffect: LowHelps soften the upper layer of the skin, dissolve other ingredients and create a thicker product consistency~0.25–0.45%

Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~0.2–0.4%

Dipotassium glycyrrhizateUnder-dosedA salt derived from licorice. Works as an emollient to soften the upper layer of the skin and can help calm down inflammation. Might be helpful for skin lightening~0.2–0.35%

Laminaria digitata extractUnder-dosedSeaweed extract that helps the skin to attract water and make it more smooth for touch. Also shows promise of anti-aging properties, but good research is lacking at the moment~0.2–0.4%

Can it cause trouble?

Irritancy

25 flagged ingredients — patch-test recommended

High risk

We flagged 25 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.

IngredientFunctionIrritationEst. amount

RetinolTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritatingHigh~0.45–0.65%est.

RetinalOne step removed from the biologically active in skin form of vitamin A. Once converted to the retinoic acid in the skin, retinal is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. Concentrations of 0.05% and 0.1% are shown to be effective. It can, however, be irritatingHigh~0.4–0.6%est.

Retinyl retinoateA "hybrid" of retinol and retinoic acid. It is more stable than retinol and is likely to be more effective based on the early research data available. Is as irritating as retinolHigh~0.4–0.6%est.

Retinyl linoleateAn ester of a retinoid and linoleic acid. Three steps removed from the bioactive form of retinoid, retinoic acid. Once converted to retinoic acid in skin, it can help reduce wrinkles, stimulate collagen production, even out skin tone and reduce blemishes. The concentrations used in cosmetic products are often not high enough to have a positive effect in skin.High~0.35–0.65%est.

Symphytum officinale leaf extractA plant extract that has an anti-bacterial effectHigh~0.2–0.35%est.

Lavandula angustifolia oilAn essential oil. Potential allergen and can be irritating. It has some anti-bacterial propertiesHigh~0.1–0.15%est.

LinaloolA fragrance. Can be irritatingHigh~0.05–0.15%est.

Caprylic/capric triglycerideA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerinMedium~3.1–3.8%est.

Aloe barbadensis leaf juiceTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skinMedium~1.8–2.2%est.

Sorbitan palmitateHelps water and oil mix together and stabilize the product formulationMedium~0.3–0.55%est.

Sodium hyaluronate crosspolymerAttracts water into the upper layer of the skinMedium~0.25–0.45%est.

BakuchiolA plant extract that is, though different in chemical structure, acts similar to retinoids. First studies show that it can help reduce fine lines and wrinkles, improve skin tone, reduce clogged pores and blemishes, and reduce inflammation. There is no conclusive evidence that bakuchiol is as effective as retinol however. The study that directly compared retinol with bakuchiol used bakuchiol applied twice daily compared to once per day for the retinol. According to this study, bakuchiol is less irritating than retinol. Bakuchiol is extracted from seeds of Babchi plant. Other parts of the plant contain coumarins that could cause allergic and irritant reactions. These compounds should be removed in the extraction process when bakuchiol is produced, but it is a good idea to be cautious and stay away from products that include the Babchi plant extracts other than purified bakuchiol to avoid irritationMedium~0.25–0.45%est.

Olea europaea leaf extractA plant extract that might have some anti-oxidant and anti-inflammatory properties but evidence for effectiveness in skin is missingMedium~0.2–0.35%est.

Chlorella vulgaris extractA plant extract that can help to attract water to the upper layer of the skin and might have some anti-oxidant and anti-inflammatory propertiesMedium~0.2–0.4%est.

Disodium edtaStabilizes the product formulationMedium~0.2–0.4%est.

Pentylene glycolUsed to preserve products, dissolve other ingredients and create a nice product textureMedium~0.25–0.5%est.

Caprylyl glycolHelps preserve products and creates a nice product textureMedium~0.25–0.45%est.

EthylhexylglycerinA preservativeMedium~0.2–0.4%est.

Hexylene glycolHelps create a more spreadable product textureMedium~0.2–0.4%est.

PolyacrylamideUsed to improve product texture and help oil and water mix togetherMedium~0.25–0.45%est.

Laureth-7Helps oil and water mix togetherMedium~0.2–0.4%est.

BhtA preservativeMedium~0.15–0.3%est.

BhaHelps preserve the product formulationMedium~0.15–0.3%est.

Potassium sorbateA preservativeMedium~0.15–0.25%est.

Benzoic acidA preservativeMedium~0.15–0.25%est.

Comedogenic

4 ingredients rated 2 or more on the 0–5 pore-clogging scale

4 flagged

These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.

IngredientFunctionRatingEst. amount

Laminaria digitata extractSeaweed extract that helps the skin to attract water and make it more smooth for touch. Also shows promise of anti-aging properties, but good research is lacking at the moment3/5~0.2–0.4%est.

Chlorella vulgaris extractA plant extract that can help to attract water to the upper layer of the skin and might have some anti-oxidant and anti-inflammatory properties3/5~0.2–0.4%est.

Ethylhexyl palmitateAn emollient that helps soften the skin and create a nice product texture3/5~0.25–0.45%est.

Cetearyl alcoholA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture2/5~1.2–1.5%est.

Alternatives

The closest match we found

Medicube Deep Reviving Bakuchiol Retinol Serum

Closest match81% match

$20.08

View all alternatives

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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%

Formula

Irritation risk: Low

Plain old water

More about Water

Glycerin~4.9–5.9%

Key active

Irritation risk: Low

Works for

Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin

Squalane~4.1–5%

Key active

Irritation risk: Low

Works for

Moisturizing

An oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.

More about Squalane

Caprylic/capric triglyceride~3.1–3.8%

Key activeIrritant · medium

Irritation risk: Medium

Works for

Moisturizing

A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin

More about Caprylic/capric triglyceride

C12-15 alkyl benzoate~2.3–2.8%

Key active

Irritation risk: Low

Works for

Moisturizing

Enhances the product texture and makes it more spreadable. Helps reduce water loss from the outer layer of skin. Extands the shelf life by preventing bacteria growth

More about C12-15 alkyl benzoate

Aloe barbadensis leaf juice~1.8–2.2%

Irritant · medium

Irritation risk: Medium

Works for

MoisturizingAnti-inflammatoryAntibacterialReduces rednessReduces irritationAnti-blemishAnti-aging

Traditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin

More about Aloe barbadensis leaf juice

Cetearyl olivate~1.5–1.9%

Formula

Irritation risk: Low

Works for

Cleansing

Helps oil and water mix together

More about Cetearyl olivate

Sorbitan olivate~1.4–1.7%

Formula

Irritation risk: Low

Works for

Cleansing

Helps oil and water mix together

More about Sorbitan olivate

Cetearyl alcohol~1.2–1.5%

Key activeComedogenic 2/5

Irritation risk: Low
Comedogenicity: 2/5

Works for

CleansingMoisturizing

A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture

More about Cetearyl alcohol

Butyrospermum parkii nut extract~0.95–1.15%

Formula

Irritation risk: Low

More about Butyrospermum parkii nut extract

Dimethicone~0.7–1.05%

Key active

Irritation risk: Low

Works for

MoisturizingMattifying

A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish

More about Dimethicone

Dicaprylyl ether~0.55–0.8%

Formula

Irritation risk: Low

Works for

Moisturizing

Helps soften the upper layer of the skin while creating a non-greasy feel on the skin. Helps to dissolve other ingredients

More about Dicaprylyl ether

Safflower seed oil piperonyl esters~0.5–0.75%

Formula

Irritation risk: Low

More about Safflower seed oil piperonyl esters

Retinol~0.45–0.65%

Hero · Anti-aging, Evens skin tone, Anti-blemishIrritant · high

Irritation risk: High

Works for

Anti-agingEvens skin toneAnti-blemishMattifyingExfoliationAnti-oxidation

Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating

More about Retinol

Retinal~0.4–0.6%

Hero · Anti-aging, Evens skin tone, Anti-blemishIrritant · high

Irritation risk: High

Works for

Evens skin toneAnti-agingAnti-blemish

One step removed from the biologically active in skin form of vitamin A. Once converted to the retinoic acid in the skin, retinal is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. Concentrations of 0.05% and 0.1% are shown to be effective. It can, however, be irritating

More about Retinal

Retinyl retinoate~0.4–0.6%

Hero · Anti-aging, Evens skin tone, Anti-blemishIrritant · high

Irritation risk: High

Works for

Anti-agingAnti-blemishExfoliationEvens skin tone

A "hybrid" of retinol and retinoic acid. It is more stable than retinol and is likely to be more effective based on the early research data available. Is as irritating as retinol

More about Retinyl retinoate

Retinyl linoleate~0.35–0.65%

Under-dosedIrritant · high

Irritation risk: High

Works for

Anti-oxidationAnti-agingEvens skin toneAnti-blemish

An ester of a retinoid and linoleic acid. Three steps removed from the bioactive form of retinoid, retinoic acid. Once converted to retinoic acid in skin, it can help reduce wrinkles, stimulate collagen production, even out skin tone and reduce blemishes. The concentrations used in cosmetic products are often not high enough to have a positive effect in skin.

More about Retinyl linoleate

Tranexamic acid~0.3–0.6%

Key active

Irritation risk: Low

Works for

MoisturizingEvens skin tone

An amino acid that is effective in reducing hyperpigmentation and evening out the skin tone. It can also help in skin barrier recovery. It is used to treat melasma, especially with injections and when taken orally

More about Tranexamic acid

Cetyl palmitate~0.35–0.6%

Key active

Irritation risk: Low

Works for

Moisturizing

An emollient that helps soften the skin and is used to improve product texture and stability

More about Cetyl palmitate

Sorbitan palmitate~0.3–0.55%

Irritant · medium

Irritation risk: Medium

Works for

Cleansing

Helps water and oil mix together and stabilize the product formulation

More about Sorbitan palmitate

Sodium hyaluronate crosspolymer~0.25–0.45%

Key activeIrritant · medium

Irritation risk: Medium

Works for

Moisturizing

Attracts water into the upper layer of the skin

More about Sodium hyaluronate crosspolymer

Carbomer~0.25–0.45%

Formula

Irritation risk: Low

Works for

Cleansing

Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations

More about Carbomer

Tocopherol~0.2–0.4%

Under-dosed

Irritation risk: Low

Works for

Anti-oxidationMoisturizingAnti-inflammatoryAnti-aging

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol

Cellulose~0.2–0.4%

Formula

Irritation risk: Low

Works for

Mattifying

Can be used to help absorb oil as well as add volume and imporve texture of products.

More about Cellulose

Bakuchiol~0.25–0.45%

Key activeIrritant · medium

Irritation risk: Medium

Works for

Anti-oxidationAnti-inflammatoryAnti-blemishEvens skin toneAnti-aging

A plant extract that is, though different in chemical structure, acts similar to retinoids. First studies show that it can help reduce fine lines and wrinkles, improve skin tone, reduce clogged pores and blemishes, and reduce inflammation. There is no conclusive evidence that bakuchiol is as effective as retinol however. The study that directly compared retinol with bakuchiol used bakuchiol applied twice daily compared to once per day for the retinol. According to this study, bakuchiol is less irritating than retinol. Bakuchiol is extracted from seeds of Babchi plant. Other parts of the plant contain coumarins that could cause allergic and irritant reactions. These compounds should be removed in the extraction process when bakuchiol is produced, but it is a good idea to be cautious and stay away from products that include the Babchi plant extracts other than purified bakuchiol to avoid irritation

More about Bakuchiol

Sodium hyaluronate~0.2–0.4%

Key active

Irritation risk: Low

Works for

Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate

Hydroxyapatite~0.3–0.55%

Formula

Irritation risk: Low

More about Hydroxyapatite

Olea europaea leaf extract~0.2–0.35%

Irritant · medium

Irritation risk: Medium

Works for

Anti-oxidation

A plant extract that might have some anti-oxidant and anti-inflammatory properties but evidence for effectiveness in skin is missing

More about Olea europaea leaf extract

Camellia sinensis leaf extract~0.25–0.4%

Under-dosed

Irritation risk: Low

Works for

Anti-oxidationAntibacterialAnti-agingEvens skin toneMoisturizingAnti-blemish

Can contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation

More about Camellia sinensis leaf extract

Sodium palmitoyl proline~0.2–0.35%

Formula

Irritation risk: Low

More about Sodium palmitoyl proline

Nymphaea alba flower extract~0.2–0.35%

Formula

Irritation risk: Low

More about Nymphaea alba flower extract

Laminaria digitata extract~0.2–0.4%

Under-dosedComedogenic 3/5

Irritation risk: Low
Comedogenicity: 3/5

Works for

MoisturizingAnti-oxidationAnti-aging

Seaweed extract that helps the skin to attract water and make it more smooth for touch. Also shows promise of anti-aging properties, but good research is lacking at the moment

More about Laminaria digitata extract

Chlorella vulgaris extract~0.2–0.4%

Key activeComedogenic 3/5Irritant · medium

Irritation risk: Medium
Comedogenicity: 3/5

Works for

MoisturizingAnti-oxidationAnti-inflammatory

A plant extract that can help to attract water to the upper layer of the skin and might have some anti-oxidant and anti-inflammatory properties

More about Chlorella vulgaris extract

Saccharide isomerate~0.2–0.4%

Key active

Irritation risk: Low

Works for

Moisturizing

Helps attract water to the upper layer of the skin

More about Saccharide isomerate

Symphytum officinale leaf extract~0.2–0.35%

Irritant · high

Irritation risk: High

Works for

Antibacterial

A plant extract that has an anti-bacterial effect

More about Symphytum officinale leaf extract

Buddleja davidii meristem cell culture~0.2–0.4%

Formula

Irritation risk: Low

More about Buddleja davidii meristem cell culture

Cyperus papyrus leaf cell extract~0.2–0.4%

Formula

Irritation risk: Low

More about Cyperus papyrus leaf cell extract

Niacinamide~0.2–0.4%

Under-dosed

Irritation risk: Low

Works for

Evens skin toneAnti-blemishAnti-agingMoisturizingReduces irritationAnti-inflammatoryReduces rednessAntibacterial

Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production

More about Niacinamide

Dipotassium glycyrrhizate~0.2–0.35%

Under-dosed

Irritation risk: Low

Works for

MoisturizingAnti-inflammatoryEvens skin tone

A salt derived from licorice. Works as an emollient to soften the upper layer of the skin and can help calm down inflammation. Might be helpful for skin lightening

More about Dipotassium glycyrrhizate

Disodium edta~0.2–0.4%

Irritant · medium

Irritation risk: Medium

Stabilizes the product formulation

More about Disodium edta

Ethylhexyl palmitate~0.25–0.45%

Key activeComedogenic 3/5

Irritation risk: Low
Comedogenicity: 3/5

Works for

Moisturizing

An emollient that helps soften the skin and create a nice product texture

More about Ethylhexyl palmitate

Silica dimethyl silylate~0.25–0.45%

Formula

Irritation risk: Low

Used to create a thicker product consistency

More about Silica dimethyl silylate

Butylene glycol~0.2–0.4%

Formula

Irritation risk: Low

Works for

Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol

Pentylene glycol~0.25–0.5%

Irritant · medium

Irritation risk: Medium

Works for

Moisturizing

Used to preserve products, dissolve other ingredients and create a nice product texture

More about Pentylene glycol

Phenoxyethanol~0.2–0.4%

Formula

Irritation risk: Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol

Caprylyl glycol~0.25–0.45%

Irritant · medium

Irritation risk: Medium

Works for

Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol

Ethylhexylglycerin~0.2–0.4%

Irritant · medium

Irritation risk: Medium

A preservative

More about Ethylhexylglycerin

Hexylene glycol~0.2–0.4%

Irritant · medium

Irritation risk: Medium

Works for

Cleansing

Helps create a more spreadable product texture

More about Hexylene glycol

Polyacrylamide~0.25–0.45%

Irritant · medium

Irritation risk: Medium

Used to improve product texture and help oil and water mix together

More about Polyacrylamide

C13-14 isoparaffin~0.25–0.45%

Formula

Irritation risk: Low

Works for

Moisturizing

Helps soften the upper layer of the skin, dissolve other ingredients and create a thicker product consistency

More about C13-14 isoparaffin

Laureth-7~0.2–0.4%

Irritant · medium

Irritation risk: Medium

Works for

Cleansing

Helps oil and water mix together

More about Laureth-7

Dipropylene glycol~0.2–0.35%

Formula

Irritation risk: Low

Helps to dissolve other ingredients in a formulation. Slows down the rate of product drying

More about Dipropylene glycol

Sea water~0.2–0.35%

Formula

Irritation risk: Low

Dissolves other ingredients. It does not have additional skin benefits compared to plain water

More about Sea water

Polysorbate 20~0.2–0.4%

Formula

Irritation risk: Low

Works for

Cleansing

Helps oil and water mix together

More about Polysorbate 20

Xanthan gum~0.2–0.35%

Formula

Irritation risk: Low

Works for

Cleansing

Used to create a thicker product consistency

More about Xanthan gum

Bht~0.15–0.3%

Irritant · medium

Irritation risk: Medium

A preservative

More about Bht

Bha~0.15–0.3%

Irritant · medium

Irritation risk: Medium

Helps preserve the product formulation

More about Bha

Potassium sorbate~0.15–0.25%

Irritant · medium

Irritation risk: Medium

A preservative

More about Potassium sorbate

Sodium benzoate~0.1–0.2%

Formula

Irritation risk: Low

A preservative

More about Sodium benzoate

Benzoic acid~0.15–0.25%

Irritant · medium

Irritation risk: Medium

A preservative

More about Benzoic acid

Sodium hydroxide~0.15–0.25%

Formula

Irritation risk: Low

Used to adjust the product's pH

More about Sodium hydroxide

Lavandula angustifolia oil~0.1–0.15%

Irritant · high

Irritation risk: High

An essential oil. Potential allergen and can be irritating. It has some anti-bacterial properties

More about Lavandula angustifolia oil

Linalool~0.05–0.15%

Irritant · high

Irritation risk: High

A fragrance. Can be irritating

More about Linalool

Ingredient list view

Water, Glycerin, Squalane, Caprylic/capric triglyceride, C12-15 alkyl benzoate, Aloe barbadensis leaf juice, Cetearyl olivate, Sorbitan olivate, Cetearyl alcohol, Butyrospermum parkii nut extract, Dimethicone, Dicaprylyl ether, Safflower seed oil piperonyl esters, Retinol, Retinal, Retinyl retinoate, Retinyl linoleate, Tranexamic acid, Cetyl palmitate, Sorbitan palmitate, Sodium hyaluronate crosspolymer, Carbomer, Tocopherol, Cellulose, Bakuchiol, Sodium hyaluronate, Hydroxyapatite, Olea europaea leaf extract, Camellia sinensis leaf extract, Sodium palmitoyl proline, Nymphaea alba flower extract, Laminaria digitata extract, Chlorella vulgaris extract, Saccharide isomerate, Symphytum officinale leaf extract, Buddleja davidii meristem cell culture, Cyperus papyrus leaf cell extract, Niacinamide, Dipotassium glycyrrhizate, Disodium edta, Ethylhexyl palmitate, Silica dimethyl silylate, Butylene glycol, Pentylene glycol, Phenoxyethanol, Caprylyl glycol, Ethylhexylglycerin, Hexylene glycol, Polyacrylamide, C13-14 isoparaffin, Laureth-7, Dipropylene glycol, Sea water, Polysorbate 20, Xanthan gum, Bht, Bha, Potassium sorbate, Sodium benzoate, Benzoic acid, Sodium hydroxide, Lavandula angustifolia oil, Linalool

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
	DermaquestStem Cell 3D Active Retinol Repair Serum - 1%YOUR PRODUCT	MedicubeDeep Reviving Bakuchiol Retinol Serum	colibri skincareVitamin A Serum	Some By MiRetinol Intense Reactivating Serum Large Size
Match	—	81%	69%	68%
Price	—	$20.08	$17.16	$34.48
Shared key ingredients	—	12 of 17	5 of 17	7 of 17
Key difference	—	Hydroxypinacolone Retinoate	Hydroxypinacolone Retinoate	Madecassoside
Irritancy	High	High	High	High
Drying alcohol	—	—	—	—
	View product	Shop	Shop	Shop

More alternatives: REMEDY SCIENCE REMEDY for healthy aging InstaNatural 2.5% Retinol Bakuchiol Serum

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Product summary

"Dermaquest - Stem Cell 3D Active Retinol Repair Serum - 1%" is effective for: Anti-aging, Evens skin tone, Anti-blemish and Exfoliation

This product could be helpful for: Moisturizing, but its actives are not the most effective or are not well-studied.

Ingredient callouts

Bakuchiol in this product (the concentration is about 0.25% - 0.45%). Helps fight photodamage (wrinkles, elasticity loss and pigmentation) and can reduce clogged pores and blemishes. Bakuchiol is a compound extracted from a plant Babchi. It acts similar to retinoids, but with less irritation risk.
This product contains an effective form of Retinoids (vitamin A): retinyl linoleate 0.35% - 0.65%, retinyl retinoate 0.40% - 0.60%, retinal 0.40% - 0.60% and retinol 0.45% - 0.65%. Retinoids are potent multitasking actives. They work to improve and prevent early signs of aging, reduce hyperpigmentation (age spots and post-acne marks), and prevent inflamed blemishes and clogged pores. The downside of Retinoids is that they can be irritating. If you are not already using a Retinoid in your routine, it is best to start slowly and apply the Retinoid product only a few times per week. If your skin tolerates it well, you can gradually increase the frequency to daily.
Humectants (saccharide isomerate 0.20% - 0.40%, sodium hyaluronate 0.20% - 0.40%, sodium hyaluronate crosspolymer 0.25% - 0.45% and glycerin 4.90% - 5.90%). These ingredients help attract water to the upper layer of the skin and improve the skin hydration.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 28 studies and safety reviews.

1
Glycerol and the skin: holistic approach to its origin and functionsncbi.nlm.nih.gov
2
Dimethicone as a protective ingredient in topical medicationsjaad.org
3
Final Report on the Safety Assessment of Dimethicone Copolyoljournals.sagepub.com
4
Retinoids in the treatment of skin aging: an overview of clinical efficacy and safetyncbi.nlm.nih.gov
5
Improvement of naturally aged skin with vitamin A (retinol)ncbi.nlm.nih.gov
6
A comparative study of the effects of retinol and retinoic acid on histological, molecular, and clinical properties of human skinonlinelibrary.wiley.com
7
Retinyl retinoate, a novel hybrid vitamin derivative, improves photoaged skin: a double-blind, randomized-controlled trialpubmed.ncbi.nlm.nih.gov
8
Improvement in skin wrinkles from the use of photostable retinyl retinoate: a randomized controlled trialpubmed.ncbi.nlm.nih.gov
9
Metabolism of topical retinaldehyde and retinol by mouse skin in vivo: predominant formation of retinyl esters and identification of 14‐hydroxy‐4, 14‐retro‐retinolonlinelibrary.wiley.com
10
Auto-regulation of Retinoic Acid Biosynthesis through Regulation of Retinol Esterification in Human Keratinocytesjbc.org
11
Effect of tranexamic acid on melasma: a clinical trial with histological evaluationonlinelibrary.wiley.com
12
Tranexamic acid accelerates skin barrier recovery and upregulates occludin in damaged skinonlinelibrary.wiley.com
13
The amelioration effect of tranexamic acid in wrinkles induced by skin drynesssciencedirect.com
14
Efficacy and possible mechanisms of topical tranexamic acid in melasmaonlinelibrary.wiley.com
15
Vitamin E in dermatologyncbi.nlm.nih.gov
16
Vitamin E and Skin Healthlpi.oregonstate.edu
17
Bakuchiol in the Management of Acne-affected Skinresearchgate.net
18
Prospective, randomized, double‐blind assessment of topical bakuchiol and retinol for facial photoageingonlinelibrary.wiley.com
19
A dermocosmetic containing bakuchiol, Ginkgo biloba extract and mannitol improves the efficacy of adapalene in patients with acne vulgaris: result from a controlled randomized trialncbi.nlm.nih.gov
20
Hyaluronic acid: A key molecule in skin agingncbi.nlm.nih.gov
21
Hyaluronan (Hyaluronic Acid): a natural moisturizer for skin careresearchgate.net
22
Wound Repair Potential of Olea europaea L. Leaf Extracts Revealed by In Vivo Experimental Models and Comparative Evaluation of the Extracts' Antioxidant Activityresearchgate.net
23
Symphytum Species: A Comprehensive Review on Chemical Composition, Food Applications and Phytopharmacologyncbi.nlm.nih.gov
24
Niacinamide - mechanisms of action and its topical use in dermatologyncbi.nlm.nih.gov
25
Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology, 3(2), 88–93. doi:10.1111/j.1473-2130.2004.00115.x ncbi.nlm.nih.gov
26
Ameliorating effect of dipotassium glycyrrhizinate on an IL-4- and IL-13-induced atopic dermatitis-like skin-equivalent modelresearchgate.net
27
Final report on the safety assessment of Glycyrrhetinic Acid, Potassium Glycyrrhetinate, Disodium Succinoyl Glycyrrhetinate, Glyceryl Glycyrrhetinate, Glycyrrhetinyl Stearate, Stearyl Glycyrrhetinate, Glycyrrhizic Acid, Ammonium Glycyrrhizate, Dipotassium Glycyrrhizate, Disodium Glycyrrhizate, Trisodium Glycyrrhizate, Methyl Glycyrrhizate, and Potassium Glycyrrhizinate.ncbi.nlm.nih.gov
28
Safety Assessment of Isoparaffins as Used in Cosmeticsjournals.sagepub.com

DermaquestStem Cell 3D Active Retinol Repair Serum - 1%

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