ZO Skin Health Growth Factor Serum

ZO Skin Health Growth Factor Serum

Efficacy75/100IrritancyMedium·100% recommend (1 review)

Works for

Anti-aging
Sh-polypeptide-9, Dipeptide diaminobutyroyl benzylamide diacetate + 6 more
May help
What the product description says
“Skin looks 6 years younger in 8 weeks.”
Source: Zo Skin Health

This product contains dipeptide diaminobutyroyl benzylamide diacetate, sh-oligopeptide-1, sh-oligopeptide-2, sh-polypeptide-1, sh-polypeptide-11, sh-polypeptide-9. These ingredients might be able to help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness, but there is not enough evidence that it actually works.

Sh-polypeptide-9Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.35%
Dipeptide diaminobutyroyl benzylamide diacetateKey activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.4%
Sh-oligopeptide-1Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.4%
Sh-oligopeptide-2Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.4%
Sh-polypeptide-1Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.4%
Sh-polypeptide-11Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.35%
Beta-glucanEffect: LowHelps attract water to the upper layer of the skin, calm down inflammation and irritation, restore the barrier function and support wound healing. It can be helpful in reducing fine lines and wrinkles~0.2–0.4%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.25–0.45%
Moisturizing
Not advertised by the brand · Sh-oligopeptide-2, Sh-polypeptide-1 + 18 more
Works well

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: glycerin, lactobacillus ferment.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: dimethicone, caprylyl glycol.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: dipeptide diaminobutyroyl benzylamide diacetate, sh-oligopeptide-1, sh-oligopeptide-2, sh-polypeptide-1, sh-polypeptide-11, sh-polypeptide-9

Sh-oligopeptide-2HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.4%
Sh-polypeptide-1HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.4%
Sh-polypeptide-11HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.35%
Sh-polypeptide-9HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.35%
Sh-oligopeptide-1HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.4%
Dipeptide diaminobutyroyl benzylamide diacetateHeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.4%
DimethiconeKey active· Emollient, OcclusiveEffect: HighA silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish~5.6–6.8%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~3.2–3.9%
Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~0.7–1.05%
Dimethicone crosspolymerKey activeEffect: MediumUsed to create a thicker product texture. Helps soften the upper layer of the skin and might be able to prevent moisture loss from its surface~0.5–0.8%
Lactobacillus fermentKey active· HumectantEffect: HighA fermentation product created by bacteria Lactobacillus. The fermented product has anti-bacterial properties and might be helpful in calming down inflammation, but studies are lacking. Helps attract water to the upper layer of the skin. Can be used as a preservative~0.45–0.7%
PhospholipidsKey activeEffect: MediumEmollients that are naturaly present in skin. In addition, they help water and oil mix together in the product~0.35–0.6%
Beta-glucanKey activeEffect: HighHelps attract water to the upper layer of the skin, calm down inflammation and irritation, restore the barrier function and support wound healing. It can be helpful in reducing fine lines and wrinkles~0.2–0.4%
Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~4.1–5%
Caprylyl methiconeEffect: LowA type of silicone that helps to soften the upper layer of the skin and create a nice product finish on the skin~2.4–2.9%
Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~1–1.2%
Scutellaria baicalensis root extract· HumectantEffect: LowA plant extract that might contain a compound baicalin that could be helpful in neutralizing free radicals and reducing inflammation in skin. The baicalin concentration in skincare products is often too low for an effective action. Can be used for its fragrant properties~0.4–0.6%
Pentylene glycol· EmollientEffect: LowUsed to preserve products, dissolve other ingredients and create a nice product texture~0.3–0.5%
LecithinEffect: Low, below effective doseUsed mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin~0.3–0.6%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.25–0.45%

Can it cause trouble?

Irritancy
1 strong irritant: Parfum
Medium risk
We flagged 10 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Scutellaria baicalensis root extractA plant extract that might contain a compound baicalin that could be helpful in neutralizing free radicals and reducing inflammation in skin. The baicalin concentration in skincare products is often too low for an effective action. Can be used for its fragrant propertiesHigh~0.4–0.6%est.
ParfumAn aromatic blend of unspecified and possibly irritating ingredientsHigh~0.1–0.15%est.
Dimethicone/peg-10/15 crosspolymerHelps oil and water mix togetherMedium~1.9–2.3%est.
1,2-hexanediolA preservativeMedium~0.75–1.1%est.
Caprylyl glycolHelps preserve products and creates a nice product textureMedium~1–1.2%est.
Sodium citrateHelps to control the skin's pH level. Maintains the skin's natural film of amino-lactic acids and oils. Helps to preserve productsMedium~0.4–0.65%est.
Glycyrrhiza uralensis root extractLicorice root extract. Might be helpful in reducing hyperpigmentationMedium~0.25–0.4%est.
Pentylene glycolUsed to preserve products, dissolve other ingredients and create a nice product textureMedium~0.3–0.5%est.
Hexylene glycolHelps create a more spreadable product textureMedium~0.25–0.4%est.
Potassium sorbateA preservativeMedium~0.25–0.45%est.
Comedogenic
Clean of flagged comedogenic ingredients
None flagged

User reviews

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1 of 1 community members would buy it again.

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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%
Formula
Irritation risk
Low

Plain old water

More about Water
Dimethicone~5.6–6.8%
Key active
Irritation risk
Low
Works for
MoisturizingMattifying

A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish

More about Dimethicone
Butylene glycol~4.1–5%
Formula
Irritation risk
Low
Works for
Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol
Glycerin~3.2–3.9%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Caprylyl methicone~2.4–2.9%
Formula
Irritation risk
Low
Works for
Moisturizing

A type of silicone that helps to soften the upper layer of the skin and create a nice product finish on the skin

More about Caprylyl methicone
Dimethicone/peg-10/15 crosspolymer~1.9–2.3%
Irritant · medium
Irritation risk
Medium

Helps oil and water mix together

More about Dimethicone/peg-10/15 crosspolymer
Peg-12 dimethicone/ppg-20 crosspolymer~1.7–2.1%
Formula
Irritation risk
Low

Helps water and oil mix together

More about Peg-12 dimethicone/ppg-20 crosspolymer
Dimethicone/vinyl dimethicone crosspolymer~1.5–1.8%
Formula
Irritation risk
Low

Used to stabilize product formulations and create a nice product texture

More about Dimethicone/vinyl dimethicone crosspolymer
1,2-hexanediol~0.75–1.1%
Irritant · medium
Irritation risk
Medium

A preservative

More about 1,2-hexanediol
Caprylyl glycol~1–1.2%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol
Sodium hyaluronate~0.7–1.05%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate
Sodium chloride~0.65–0.95%
Formula
Irritation risk
Low

Used to stabilize mixtures of oil and water, and create thicker, gel-like product textures

More about Sodium chloride
Dimethicone crosspolymer~0.5–0.8%
Key active
Irritation risk
Low
Works for
Moisturizing

Used to create a thicker product texture. Helps soften the upper layer of the skin and might be able to prevent moisture loss from its surface

More about Dimethicone crosspolymer
Lactobacillus ferment~0.45–0.7%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-inflammatoryAnti-oxidationReduces irritation

A fermentation product created by bacteria Lactobacillus. The fermented product has anti-bacterial properties and might be helpful in calming down inflammation, but studies are lacking. Helps attract water to the upper layer of the skin. Can be used as a preservative

More about Lactobacillus ferment
Scutellaria baicalensis root extract~0.4–0.6%
Irritant · high
Irritation risk
High
Works for
Anti-inflammatoryAnti-oxidationMoisturizingReduces irritationAntibacterial

A plant extract that might contain a compound baicalin that could be helpful in neutralizing free radicals and reducing inflammation in skin. The baicalin concentration in skincare products is often too low for an effective action. Can be used for its fragrant properties

More about Scutellaria baicalensis root extract
Sodium citrate~0.4–0.65%
Irritant · medium
Irritation risk
Medium

Helps to control the skin's pH level. Maintains the skin's natural film of amino-lactic acids and oils. Helps to preserve products

More about Sodium citrate
Hydrolyzed sericin~0.4–0.6%
Formula
Phospholipids~0.35–0.6%
Key active
Irritation risk
Low
Works for
Moisturizing

Emollients that are naturaly present in skin. In addition, they help water and oil mix together in the product

More about Phospholipids
Acetyl glutamine~0.3–0.55%
Formula
Lecithin~0.3–0.6%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

Used mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin

More about Lecithin
Buddleja davidii meristem cell culture~0.25–0.5%
Formula
Cordyceps militaris mycelium extract~0.25–0.45%
Formula
Glycyrrhiza uralensis root extract~0.25–0.4%
Irritant · medium
Irritation risk
Medium
Works for
Evens skin tone

Licorice root extract. Might be helpful in reducing hyperpigmentation

More about Glycyrrhiza uralensis root extract
Dipropylene glycol~0.2–0.4%
Formula
Irritation risk
Low

Helps to dissolve other ingredients in a formulation. Slows down the rate of product drying

More about Dipropylene glycol
Pentylene glycol~0.3–0.5%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Used to preserve products, dissolve other ingredients and create a nice product texture

More about Pentylene glycol
Xanthan gum~0.25–0.45%
Formula
Irritation risk
Low
Works for
Cleansing

Used to create a thicker product consistency

More about Xanthan gum
Beta-glucan~0.2–0.4%
Key active
Irritation risk
Low
Works for
MoisturizingReduces irritationAnti-inflammatoryAnti-agingAnti-blemishAnti-oxidation

Helps attract water to the upper layer of the skin, calm down inflammation and irritation, restore the barrier function and support wound healing. It can be helpful in reducing fine lines and wrinkles

More about Beta-glucan
Dipeptide diaminobutyroyl benzylamide diacetate~0.2–0.4%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Dipeptide diaminobutyroyl benzylamide diacetate
Lactobacillus/panax ginseng root ferment filtrate~0.2–0.4%
Formula
Hexylene glycol~0.25–0.4%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps create a more spreadable product texture

More about Hexylene glycol
Phenoxyethanol~0.25–0.45%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Potassium sorbate~0.25–0.45%
Irritant · medium
Irritation risk
Medium

A preservative

More about Potassium sorbate
Tocopherol~0.25–0.45%
Formula
Irritation risk
Low
Works for
Anti-oxidationMoisturizingAnti-inflammatoryAnti-aging

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol
Disodium acetyl glucosamine phosphate~0.2–0.4%
Formula
Sh-oligopeptide-1~0.2–0.4%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Sh-oligopeptide-1
Sh-oligopeptide-2~0.2–0.4%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Sh-oligopeptide-2
Sh-polypeptide-1~0.2–0.4%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Sh-polypeptide-1
Sh-polypeptide-11~0.2–0.35%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Sh-polypeptide-11
Sh-polypeptide-9~0.2–0.35%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Sh-polypeptide-9
Bacillus/folic acid ferment filtrate extract~0.15–0.3%
Formula
Hexamethylindanopyran~0.15–0.3%
Formula
Terpineol~0.15–0.25%
Formula
Irritation risk
Low
More about Terpineol
Tetramethyl acetyloctahydronaphthalenes~0.1–0.2%
Formula
Parfum~0.1–0.15%
Irritant · high
Irritation risk
High

An aromatic blend of unspecified and possibly irritating ingredients

More about Parfum
Ingredient list view

Water, Dimethicone, Butylene glycol, Glycerin, Caprylyl methicone, Dimethicone/peg-10/15 crosspolymer, Peg-12 dimethicone/ppg-20 crosspolymer, Dimethicone/vinyl dimethicone crosspolymer, 1,2-hexanediol, Caprylyl glycol, Sodium hyaluronate, Sodium chloride, Dimethicone crosspolymer, Lactobacillus ferment, Scutellaria baicalensis root extract, Sodium citrate, Hydrolyzed sericin, Phospholipids, Acetyl glutamine, Lecithin, Buddleja davidii meristem cell culture, Cordyceps militaris mycelium extract, Glycyrrhiza uralensis root extract, Dipropylene glycol, Pentylene glycol, Xanthan gum, Beta-glucan, Dipeptide diaminobutyroyl benzylamide diacetate, Lactobacillus/panax ginseng root ferment filtrate, Hexylene glycol, Phenoxyethanol, Potassium sorbate, Tocopherol, Disodium acetyl glucosamine phosphate, Sh-oligopeptide-1, Sh-oligopeptide-2, Sh-polypeptide-1, Sh-polypeptide-11, Sh-polypeptide-9, Bacillus/folic acid ferment filtrate extract, Hexamethylindanopyran, Terpineol, Tetramethyl acetyloctahydronaphthalenes, Parfum

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Zo Skin Health30 mL
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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
ZO Skin HealthGrowth Factor SerumYOUR PRODUCTBe MinimalistMulti Peptides 10% Anti Aging Face Serum, Reduces Fine Lines & WrinklesDr. Diamond's MetacineINSTAFACIAL PLASMA BIOACTIVE GROWTH FACTOR SERUMFormulystUltimate Youth Concentrate
Match—60%58%58%
Price$200.00$12.99−$187.01$110.00−$90.00—
Shared key ingredients—7 of 127 of 127 of 12
Key difference—Palmitoyl Tripeptide-1Copper Tripeptide-1Acetyl Hexapeptide-30
Irritancy Medium Low Low Low
Drying alcohol————
View product Shop Shop Shop

More alternatives: Miamo GF5-Glutathione Rejuvenating SerumTheramid DERMA - PEPTIDES 35%

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Product summary

"ZO Skin Health - Growth Factor Serum" is effective for: Anti-inflammatory and Moisturizing

This product could be helpful for: Anti-aging and Anti-blemish, but its actives are not the most effective or are not well-studied.

Ingredient callouts

  • Peptides (dipeptide diaminobutyroyl benzylamide diacetate 0.30% - 0.55%). Peptides are a very big group of ingredients. They all consist of a different combination of aminoacids. Our skin produces Peptides naturally. Some of them work as natural antibiotics, promote wound-healing and production of collagen. The scientists are still studying how effective the topical application of Peptides is, but it is very likely that theynare helpful. Peptides might be able to support skin barrier restoration and even have an anti-aging benefit. At the very least, they certainly help attract water to the skin and support the hydration in this way.
  • Humectants (glycerin 2.10% - 2.50%). These ingredients help attract water to the upper layer of the skin and improve the skin hydration.

What our users say

Based on 1 review 100% recommend this product
  • When it comes to comedogenicity, the reviewer found that it does not clog pores.
  • When it comes to using this sunscreen under makeup, the user found that it pills under a foundation.
They find the product's texture to be heavy - light and In terms of the smell, our users report that no smell.

Price

The product retails for 109.99£ in the United Kingdom and for 180.00$ in the United States.

For a detailed price comparison: click here.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 23 studies and safety reviews.

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ZO Skin Health Growth Factor Serum
ZO Skin HealthGrowth Factor Serum

Affiliate links · As an Amazon Associate, WIMJ earns from qualifying purchases.

As an Amazon Associate, WIMJ earns from qualifying purchases.