Prequel BARRIER THERAPY SKIN PROTECTANT CREAM

Prequel BARRIER THERAPY SKIN PROTECTANT CREAM

Efficacy100/100IrritancyMedium
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Works for

1 of 1 advertised claim delivered

Moisturizing
Caprooyl phytosphingosine, Caprooyl sphingosine + 23 more
Strong evidence
What the product description says
“BARRIER THERAPY SKIN PROTECTANT CREAM”
From product name

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: allantoin, glycerin.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: butyrospermum parkii butter, caprylic/capric triglyceride.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: caprooyl phytosphingosine, caprooyl sphingosine, ceramide ap, ceramide eop, ceramide eos, ceramide np, ceramide ns, colloidal oatmeal

Caprooyl phytosphingosineHero· EmollientEffect: HighA component of ceramides. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin~0.5–0.8%
Caprooyl sphingosineHeroEffect: HighA component of ceramides. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin~0.45–0.7%
Caprylic/capric triglycerideKey active· Emollient, OcclusiveEffect: HighA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin~2.5–3%
CholesterolKey active· EmollientEffect: HighAn emollient that is naturally found in skin~0.6–0.85%
Colloidal oatmealHero· EmollientEffect: HighHelps to restore skin barrier function, soften the upper layer of the skin and calm down inflammation1%
DimethiconeKey active· Emollient, OcclusiveEffect: HighA silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish~2–2.4%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~3.8–4.6%
Glycine soja oilKey active· EmollientEffect: HighA good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.~0.4–0.6%
Glycine soja sterolsKey active· EmollientEffect: HighAn emollient that helps soften the skin~0.45–0.65%
AllantoinKey active· HumectantEffect: HighHelps calm down inflammation in skin and can help reduce itching. Helps to repair the skin barrier and keep skin hydrated~1.3–1.6%
Butyrospermum parkii butterKey active· Emollient, OcclusiveEffect: HighA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals~3.3–4%
Carthamus tinctorius seed oilKey active· EmollientEffect: HighAn emollient that helps soften the skin and might help calm down inflammation~5.9–7.2%
Ceramide apHeroEffect: HighA type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin~0.65–0.95%
Ceramide eopHero· EmollientEffect: HighA type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin~0.6–0.9%
Ceramide eosHeroEffect: HighA type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin~0.6–0.9%
Ceramide npHero· EmollientEffect: HighA type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin~0.6–0.9%
Ceramide nsHero· EmollientEffect: HighA type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin~0.6–0.85%
Cetyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together~4.5–5.5%
C10-18 triglyceridesKey active· EmollientEffect: MediumHelps soften the skin and attract water to its upper layer. Helps create nice product texture~1.6–2%
AdenosineKey activeEffect: MediumMight help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)~1.1–1.4%
PhospholipidsKey activeEffect: MediumEmollients that are naturaly present in skin. In addition, they help water and oil mix together in the product~0.45–0.65%
Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~0.35–0.65%
Glyceryl stearate· EmollientEffect: LowAn emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together~0.45–0.65%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.35–0.65%
LecithinEffect: Low, below effective doseUsed mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin~0.45–0.65%
Anti-aging
Not advertised by the brand · Adenosine, Butyrospermum parkii butter + 2 more
Strong evidence

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains adenosine.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

AdenosineKey activeEffect: HighMight help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)~1.1–1.4%
Butyrospermum parkii butterEffect: LowA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals~3.3–4%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.35–0.65%
Ascorbyl palmitateEffect: Low, below effective doseBeing a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.~0.4–0.6%

Can it cause trouble?

Irritancy
13 flagged ingredients
Medium risk
We flagged 13 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Glyceryl oleateHelps oil and water mix together. Can be irritatingHigh~0.35–0.65%est.
Caprylic/capric triglycerideA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerinMedium~2.5–3%est.
Sodium stearoyl glutamateHelps oil and water mix togetherMedium~0.5–0.7%est.
Behenic acidHelps water and oil mix togetherMedium~0.55–0.8%est.
Ceteareth-25Helps oil and water mix togetherMedium~0.5–0.75%est.
Glycine soja oilA good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.Medium~0.4–0.6%est.
Ascorbyl palmitateBeing a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.Medium~0.4–0.6%est.
Caprylyl glycolHelps preserve products and creates a nice product textureMedium~0.35–0.65%est.
HydroxyacetophenoneUsed to increase effectiveness of preservativesMedium~0.3–0.55%est.
EthylhexylglycerinA preservativeMedium~0.25–0.5%est.
1,2-hexanediolA preservativeMedium~0.2–0.35%est.
Tocopheryl acetateA more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.Medium~0.2–0.4%est.
Citric acidCan work as an exfoliant but is typically used to adjust the product pHMedium~0.1–0.2%est.
Comedogenic
2 ingredients rated 2 or more on the 0–5 pore-clogging scale
2 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Butyrospermum parkii butterA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals3/5~3.3–4%est.
Glycine soja oilA good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.2/5~0.4–0.6%est.
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Ingredients

Filter by role to see what each ingredient is doing.

Colloidal oatmeal1%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-oxidationAnti-inflammatoryReduces irritation

Helps to restore skin barrier function, soften the upper layer of the skin and calm down inflammation

More about Colloidal oatmeal
Water~45–55%
Formula
Irritation risk
Low

Plain old water

More about Water
Carthamus tinctorius seed oil~5.9–7.2%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-oxidation

An emollient that helps soften the skin and might help calm down inflammation

More about Carthamus tinctorius seed oil
Cetyl alcohol~4.5–5.5%
Key active
Irritation risk
Low
Works for
CleansingMoisturizing

A non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together

More about Cetyl alcohol
Glycerin~3.8–4.6%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Butyrospermum parkii butter~3.3–4%
Key activeComedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
MoisturizingAnti-oxidationAnti-aging

A great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals

More about Butyrospermum parkii butter
Caprylic/capric triglyceride~2.5–3%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin

More about Caprylic/capric triglyceride
Dimethicone~2–2.4%
Key active
Irritation risk
Low
Works for
MoisturizingMattifying

A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish

More about Dimethicone
C10-18 triglycerides~1.6–2%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps soften the skin and attract water to its upper layer. Helps create nice product texture

More about C10-18 triglycerides
Allantoin~1.3–1.6%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-inflammatoryReduces rednessReduces irritationAnti-blemishExfoliation

Helps calm down inflammation in skin and can help reduce itching. Helps to repair the skin barrier and keep skin hydrated

More about Allantoin
Adenosine~1.1–1.4%
Key active
Irritation risk
Low
Works for
Anti-agingMoisturizingAnti-oxidation

Might help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)

More about Adenosine
Cetearyl olivate~0.9–1.1%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about Cetearyl olivate
Sorbitan olivate~0.7–1.05%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about Sorbitan olivate
Ceramide ap~0.65–0.95%
Hero · Moisturizing
Irritation risk
Low
Works for
Reduces irritationMoisturizingAnti-inflammatory

A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin

More about Ceramide ap
Ceramide eos~0.6–0.9%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-inflammatory

A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin

More about Ceramide eos
Ceramide eop~0.6–0.9%
Hero · Moisturizing
Irritation risk
Low
Works for
Reduces irritationMoisturizingAnti-inflammatory

A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin

More about Ceramide eop
Ceramide np~0.6–0.9%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-inflammatoryReduces irritation

A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin

More about Ceramide np
Ceramide ns~0.6–0.85%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-inflammatory

A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin

More about Ceramide ns
Cholesterol~0.6–0.85%
Key active
Irritation risk
Low
Works for
MoisturizingCleansing

An emollient that is naturally found in skin

More about Cholesterol
Caprooyl phytosphingosine~0.5–0.8%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-inflammatory

A component of ceramides. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin

More about Caprooyl phytosphingosine
Caprooyl sphingosine~0.45–0.7%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-inflammatory

A component of ceramides. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin

More about Caprooyl sphingosine
Glycolipids~0.45–0.65%
Formula
Irritation risk
Low
More about Glycolipids
Phospholipids~0.45–0.65%
Key active
Irritation risk
Low
Works for
Moisturizing

Emollients that are naturaly present in skin. In addition, they help water and oil mix together in the product

More about Phospholipids
Sodium stearoyl glutamate~0.5–0.7%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps oil and water mix together

More about Sodium stearoyl glutamate
Behenic acid~0.55–0.8%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps water and oil mix together

More about Behenic acid
Ceteareth-25~0.5–0.75%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps oil and water mix together

More about Ceteareth-25
Glycine soja oil~0.4–0.6%
Key activeComedogenic 2/5Irritant · medium
Irritation risk
Medium
Comedogenicity
2/5
Works for
Moisturizing

A good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.

More about Glycine soja oil
Glycine soja sterols~0.45–0.65%
Key active
Irritation risk
Low
Works for
Moisturizing

An emollient that helps soften the skin

More about Glycine soja sterols
Ascorbyl palmitate~0.4–0.6%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidationAnti-aging

Being a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.

More about Ascorbyl palmitate
Tocopherol~0.35–0.65%
Formula
Irritation risk
Low
Works for
Anti-oxidationMoisturizingAnti-inflammatoryAnti-aging

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol
Lecithin~0.45–0.65%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

Used mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin

More about Lecithin
Glyceryl stearate~0.45–0.65%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together

More about Glyceryl stearate
Glyceryl oleate~0.35–0.65%
Irritant · high
Irritation risk
High
Works for
Cleansing

Helps oil and water mix together. Can be irritating

More about Glyceryl oleate
Carbomer~0.3–0.6%
Formula
Irritation risk
Low
Works for
Cleansing

Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations

More about Carbomer
Caprylyl glycol~0.35–0.65%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol
Hydroxyacetophenone~0.3–0.55%
Irritant · medium
Irritation risk
Medium

Used to increase effectiveness of preservatives

More about Hydroxyacetophenone
Phenoxyethanol~0.3–0.5%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Ethylhexylglycerin~0.25–0.5%
Irritant · medium
Irritation risk
Medium

A preservative

More about Ethylhexylglycerin
1,2-hexanediol~0.2–0.35%
Irritant · medium
Irritation risk
Medium

A preservative

More about 1,2-hexanediol
Tocopheryl acetate~0.2–0.4%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidation

A more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.

More about Tocopheryl acetate
Tetrasodium glutamate diacetate~0.2–0.35%
Formula
Irritation risk
Low

Helps stabilize the product formulation

More about Tetrasodium glutamate diacetate
Sodium hydroxide~0.2–0.35%
Formula
Irritation risk
Low

Used to adjust the product's pH

More about Sodium hydroxide
Citric acid~0.1–0.2%
Irritant · medium
Irritation risk
Medium

Can work as an exfoliant but is typically used to adjust the product pH

More about Citric acid
Ingredient list view

Colloidal oatmeal, Water, Carthamus tinctorius seed oil, Cetyl alcohol, Glycerin, Butyrospermum parkii butter, Caprylic/capric triglyceride, Dimethicone, C10-18 triglycerides, Allantoin, Adenosine, Cetearyl olivate, Sorbitan olivate, Ceramide ap, Ceramide eos, Ceramide eop, Ceramide np, Ceramide ns, Cholesterol, Caprooyl phytosphingosine, Caprooyl sphingosine, Glycolipids, Phospholipids, Sodium stearoyl glutamate, Behenic acid, Ceteareth-25, Glycine soja oil, Glycine soja sterols, Ascorbyl palmitate, Tocopherol, Lecithin, Glyceryl stearate, Glyceryl oleate, Carbomer, Caprylyl glycol, Hydroxyacetophenone, Phenoxyethanol, Ethylhexylglycerin, 1,2-hexanediol, Tocopheryl acetate, Tetrasodium glutamate diacetate, Sodium hydroxide, Citric acid

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Amazon USPrice as of 10/26/2026 16:49 GMT
$35.98
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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
PrequelBARRIER THERAPY SKIN PROTECTANT CREAMYOUR PRODUCTREVOLUTION SKINCARECeramides Moisture CreamRevolutionCeramides Moisture CreamMedik8ADVANCED PRO COLLAGEN+ PEPTIDE CREAM
Match—59%59%55%
Price$18.00$11.95−$6.05$12.00−$6.00$99.00+$81.00
Shared key ingredients—12 of 1912 of 1912 of 19
Key difference—Sodium HyaluronateSodium HyaluronateOligopeptide-1
Irritancy Medium Low Low Medium
Drying alcohol————
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Product summary

Based on the ingredients included, "Prequel - BARRIER THERAPY SKIN PROTECTANT CREAM" works well for moisturizing the skin. To work well, any moisturizer needs to include a combination of water-binding and emollient ingredients. Prequel - BARRIER THERAPY SKIN PROTECTANT CREAM ticks this box. Humectants in this product (allantoin, glycerin and caprylyl glycol) help to increase the water content in the upper layer of the skin. (These ingredients do so by "capturing" water molecules from the outside air or from within the deeper layers of the skin). Caprooyl phytosphingosine, ceramide eop, ceramide np, ceramide ns and colloidal oatmeal in this product help decrease the water evoporation from the skin, so that it stays hydrated for longer. These ingredients also soften the skin and take away the feeling of tightness and dryness.

Ingredient callouts

  • Another benefit is that this moisturizer contain ceramides (caprooyl sphingosine 0.45% - 0.70%, caprooyl phytosphingosine 0.50% - 0.80%, ceramide ns 0.60% - 0.85%, ceramide np 0.60% - 0.90%, ceramide eop 0.60% - 0.90%, ceramide eos 0.60% - 0.90% and ceramide ap 0.65% - 0.95%). Ceramides are an important part of our natural skin barrier. The Ceramides used in skincare are synthetic or come from plants. They help soften the skin and can help "fill the gaps" in the skin barrier, keeping the skin hydrated and resilient for longer.
  • Adenosine 1.10% - 1.40%. It is a compound that in involved in many biological processes inside the skin cells. According one high-quality clinical trial, topical Adenosine in low concentrations can somewhat help improve "deep wrinkles" - the wrinkles that appear with age in places where our faces are most dynamic (for example, on the forehead or in the corners of the eyes).
  • In addition, this moisturizer contains Allantoin (1.30% - 1.60%). Allantoin is helpful in wound-healing and can help restore the skin barrier faster. It might also be able to improve scars, but the evidence is not very strong for this.
This product contains ingredients that could be beneficial, but their concentrations are too low in this formulation: lecithin, vitamin e and colloidal oatmeal

Irritation risk

There are actives in this product that can be irritating. We assess the overall irritancy of this moisturizer to be medium. For a detailed overview of all potential irritants: click here

You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 15 studies and safety reviews.

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Prequel BARRIER THERAPY SKIN PROTECTANT CREAM
PrequelBARRIER THERAPY SKIN PROTECTANT CREAM

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