Perricone MD

Perricone MD Skincare Cold Plasma+ Sub-D Neck

Name: Perricone MD - Skincare Cold Plasma+ Sub-D Neck
Brand: Perricone MD

Efficacy100/100IrritancyHigh

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Works for

2 of 2 advertised claims delivered

Anti-aging

Glycolic acid, Niacinamide + 6 more

Strong evidence

What the product description says

“, Improves the appearance of wrinkles and redundant skin on the neck while providing essential hydration.”

Source: Allbeauty

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains glycolic acid, niacinamide.

These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: palmitoyl tripeptide-5, tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetate.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

Glycolic acidKey activeEffect: HighAn alpha-hydroxy acid (AHA) that helps to remove the dead skin cells on the surface of the skin reveling a more even, smoother complexation. It is also able to stimulate collagen production with long-term use. Could help to reduce pore congestion. It can be irritating to the skin. Apply sunscreen daily if using products with glycolic acid~0.5–0.75%

NiacinamideKey activeEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~1.2–1.4%

Palmitoyl tripeptide-5Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.6%

Tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetateKey activeEffect: MediumA peptide. It helps attract water to the upper layer of the skin, support skin's barrier function and might have some slight anti-aging effect through stimulating skin's own production of hyaluronic acid~0.25–0.4%

Tetrahexyldecyl ascorbateUnder-dosedEffect: HighBeing a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.~0.4–0.6%

Zinc gluconateEffect: Low, below effective doseTypically used to stabilize the product formulations. It is a salt of a polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing. Due to the zinc content, might help calm down inflammation in skin~0.25–0.4%

TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.25–0.45%

Copper gluconateEffect: Low, below effective doseTypically used to stabilize the product formulations. It is a salt of polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing~0.25–0.45%

Moisturizing

Niacinamide, Palmitoyl tripeptide-5 + 21 more

Strong evidence

What the product description says

“, Improves the appearance of wrinkles and redundant skin on the neck while providing essential hydration.”

Source: Allbeauty

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: glycerin, sodium hyaluronate.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: dimethicone, helianthus annuus seed oil.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: niacinamide, palmitoyl tripeptide-5

GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~3–3.7%

Glycine soja oilKey active· EmollientEffect: HighA good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.~0.25–0.45%

NiacinamideHeroEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~1.2–1.4%

Palmitoyl tripeptide-5HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.6%

Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~0.25–0.45%

SqualaneKey active· Emollient, OcclusiveEffect: HighAn oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.~0.3–0.55%

Tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetateKey activeEffect: HighA peptide. It helps attract water to the upper layer of the skin, support skin's barrier function and might have some slight anti-aging effect through stimulating skin's own production of hyaluronic acid~0.25–0.4%

Helianthus annuus seed oilKey active· Emollient, OcclusiveEffect: HighA great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function~0.25–0.5%

DimethiconeKey active· Emollient, OcclusiveEffect: HighA silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish~0.65–0.95%

Echium plantagineum seed oilKey activeEffect: HighA plant oil that because of its high content of alpha-linolenic acid help support skin barrier function and moisturize the skin~0.25–0.5%

Jojoba estersKey active· EmollientEffect: HighAn emollient made of jojoba oil. Helps soften the skin and support its barrier function~1–1.2%

Hydrogenated vegetable glyceridesKey active· EmollientEffect: MediumHelp soften the upper layer of the skin~0.7–1.05%

Acetyl carnitine hclKey activeEffect: MediumMight be helpful in decreasing sebum production making the skin less oily. Is claimed to be able to support ceramide production in skin that leads to better hydration, but evidence is lacking. Is able to attract water to the upper layer of the skin~1.9–2.3%

Magnesium aspartateKey activeEffect: MediumMight be helpful in restoring skin barrier function and calm down inflammation in skin~0.25–0.45%

Cetearyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture~1.5–1.8%

Glyceryl stearate· EmollientEffect: LowAn emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together~0.5–0.7%

Hydrogenated polyisobutene· Emollient, OcclusiveEffect: LowUsed to improve the product consistency and soften the upper layer of the skin~4.7–5.8%

Isononyl isononanoate· Emollient, OcclusiveEffect: LowForms a protective film on the surface of the skin to prevent moisture loss. Gives a velvety feel to products while reducing tackiness~4.2–5.1%

Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~0.25–0.5%

Zinc gluconateUnder-dosedEffect: HighTypically used to stabilize the product formulations. It is a salt of a polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing. Due to the zinc content, might help calm down inflammation in skin~0.25–0.4%

Copper gluconateUnder-dosedEffect: HighTypically used to stabilize the product formulations. It is a salt of polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing~0.25–0.45%

LecithinEffect: Low, below effective doseUsed mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin~0.3–0.5%

Evens skin tone

Not advertised by the brand · Glycolic acid, Niacinamide + 3 more

Strong evidence

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: glycolic acid, niacinamide

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

Anti-blemish

Not advertised by the brand · Niacinamide, Glycolic acid + 4 more

Strong evidence

This product can help reduce breakouts and clogged pores because it contains the following ingredient: niacinamide. This ingredient is used for treating acne and can have a noticeable effect.

The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually works: glycolic acid

Glycolic acidKey activeEffect: MediumAn alpha-hydroxy acid (AHA) that helps to remove the dead skin cells on the surface of the skin reveling a more even, smoother complexation. It is also able to stimulate collagen production with long-term use. Could help to reduce pore congestion. It can be irritating to the skin. Apply sunscreen daily if using products with glycolic acid~0.5–0.75%

Acetyl carnitine hclEffect: LowMight be helpful in decreasing sebum production making the skin less oily. Is claimed to be able to support ceramide production in skin that leads to better hydration, but evidence is lacking. Is able to attract water to the upper layer of the skin~1.9–2.3%

Rosmarinus officinalis leaf extractUnder-dosedEffect: MediumCan be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating~0.2–0.4%

Exfoliation

Not advertised by the brand · Glycolic acid, Zinc gluconate + 1 more

Strong evidence

This product can help exfoliate the skin. In other words, it helps break down the bonds between dead cells on the surface of the skin and speed up the skin turnover. Skin often appears softer and brighter after exfoliation, but overdoing it can result in disrupted skin barrier. The following ingredient is doing the exfoliating job in this product: glycolic acid.

Can it cause trouble?

Irritancy

4 strong irritants: Rosmarinus officinalis leaf extract, Parfum + 2 more — patch-test recommended

High risk

We flagged 23 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.

IngredientFunctionIrritationEst. amount

Glycolic acidAn alpha-hydroxy acid (AHA) that helps to remove the dead skin cells on the surface of the skin reveling a more even, smoother complexation. It is also able to stimulate collagen production with long-term use. Could help to reduce pore congestion. It can be irritating to the skin. Apply sunscreen daily if using products with glycolic acidHigh~0.5–0.75%est.

Rosmarinus officinalis leaf extractCan be helpful in reducing inflammation in skin, including inflamed acne. It can be irritatingHigh~0.2–0.4%est.

ParfumAn aromatic blend of unspecified and possibly irritating ingredientsHigh~0.2–0.35%est.

Benzyl benzoateFragrance with sweet balsamic smell. Help to preserve products and dissolve other ingredients. Could trigger allergic reactions and be irritatingHigh~0.05–0.15%est.

LimoneneA common frangrance that can easily irritate skin, especially if exposed to air, light or heatHigh~0.05–0.15%est.

Jojoba estersAn emollient made of jojoba oil. Helps soften the skin and support its barrier functionMedium~1–1.2%est.

PhosphatidylcholineUsed to enhance the delivery of other ingredientsMedium~0.45–0.65%est.

Tetrahexyldecyl ascorbateBeing a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.Medium~0.4–0.6%est.

Echium plantagineum seed oilA plant oil that because of its high content of alpha-linolenic acid help support skin barrier function and moisturize the skinMedium~0.25–0.5%est.

Phytic acidAn alpha-hydroxy acid (AHA), but is mostly used to stabilize product formulations in cosmeticsMedium~0.25–0.45%est.

EthylhexylglycerinA preservativeMedium~0.25–0.45%est.

Zinc gluconateTypically used to stabilize the product formulations. It is a salt of a polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing. Due to the zinc content, might help calm down inflammation in skinMedium~0.25–0.4%est.

Glycine soja oilA good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.Medium~0.25–0.45%est.

CaffeineMight be helpful in neutralizing free radicals. Can have a dehydration effect that might somewhat decrease the look of puffy eyesMedium~0.25–0.45%est.

Copper gluconateTypically used to stabilize the product formulations. It is a salt of polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missingMedium~0.25–0.45%est.

CarrageenanHelps thicken the product formula and create a nice product formulationMedium~0.25–0.5%est.

Disodium edtaStabilizes the product formulationMedium~0.25–0.45%est.

Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymerA gelling agent that thickens the product consistency and leaves the skin with a velvety finishMedium~0.25–0.45%est.

Cetearyl glucosideHelps water and oil in the product mix well together and improves product textureMedium~0.25–0.45%est.

Caprylyl glycolHelps preserve products and creates a nice product textureMedium~0.25–0.5%est.

Polysorbate 60Helps oil and water mix togetherMedium~0.25–0.45%est.

Potassium sorbateA preservativeMedium~0.25–0.4%est.

Sodium metabisulfiteA preservativeMedium~0.1–0.2%est.

Comedogenic

3 ingredients rated 2 or more on the 0–5 pore-clogging scale

3 flagged

These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.

IngredientFunctionRatingEst. amount

CarrageenanHelps thicken the product formula and create a nice product formulation3/5~0.25–0.5%est.

Cetearyl alcoholA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture2/5~1.5–1.8%est.

Glycine soja oilA good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.2/5~0.25–0.45%est.

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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%

Formula

Irritation risk: Low

Plain old water

More about Water

Hydrogenated polyisobutene~4.7–5.8%

Formula

Irritation risk: Low

Works for

Moisturizing

Used to improve the product consistency and soften the upper layer of the skin

More about Hydrogenated polyisobutene

Isononyl isononanoate~4.2–5.1%

Formula

Irritation risk: Low

Works for

Moisturizing

Forms a protective film on the surface of the skin to prevent moisture loss. Gives a velvety feel to products while reducing tackiness

More about Isononyl isononanoate

Glycerin~3–3.7%

Key active

Irritation risk: Low

Works for

Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin

Propanediol~2.3–2.8%

Formula

Irritation risk: Low

Acts as a solvent for other ingredients. Speeds up the absorption of other ingredients into the skin

More about Propanediol

Acetyl carnitine hcl~1.9–2.3%

Key active

Irritation risk: Low

Works for

MattifyingMoisturizingAnti-blemish

Might be helpful in decreasing sebum production making the skin less oily. Is claimed to be able to support ceramide production in skin that leads to better hydration, but evidence is lacking. Is able to attract water to the upper layer of the skin

More about Acetyl carnitine hcl

Dimethyl mea~1.6–2%

Formula

Irritation risk: Low

More about Dimethyl mea

Cetearyl alcohol~1.5–1.8%

Key activeComedogenic 2/5

Irritation risk: Low
Comedogenicity: 2/5

Works for

CleansingMoisturizing

A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture

More about Cetearyl alcohol

Niacinamide~1.2–1.4%

Hero · Moisturizing, Anti-blemish

Irritation risk: Low

Works for

Anti-agingEvens skin toneMoisturizingAnti-blemishReduces irritationAntibacterialReduces rednessAnti-inflammatory

Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production

More about Niacinamide

Jojoba esters~1–1.2%

Key activeIrritant · medium

Irritation risk: Medium

Works for

Moisturizing

An emollient made of jojoba oil. Helps soften the skin and support its barrier function

More about Jojoba esters

Hydrogenated vegetable glycerides~0.7–1.05%

Key active

Irritation risk: Low

Works for

CleansingMoisturizing

Help soften the upper layer of the skin

More about Hydrogenated vegetable glycerides

Dimethicone~0.65–0.95%

Key active

Irritation risk: Low

Works for

MoisturizingMattifying

A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish

More about Dimethicone

Glycolic acid~0.5–0.75%

Key activeIrritant · high

Irritation risk: High

Works for

Anti-agingEvens skin toneExfoliationAnti-blemish

An alpha-hydroxy acid (AHA) that helps to remove the dead skin cells on the surface of the skin reveling a more even, smoother complexation. It is also able to stimulate collagen production with long-term use. Could help to reduce pore congestion. It can be irritating to the skin. Apply sunscreen daily if using products with glycolic acid

More about Glycolic acid

Peg-100 stearate~0.55–0.85%

Formula

Irritation risk: Low

Works for

Cleansing

Helps oil and water mix togehter and creates a nice product texture

More about Peg-100 stearate

Glyceryl stearate~0.5–0.7%

Formula

Irritation risk: Low

Works for

CleansingMoisturizing

An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together

More about Glyceryl stearate

Phosphatidylcholine~0.45–0.65%

Irritant · medium

Irritation risk: Medium

Works for

Cleansing

Used to enhance the delivery of other ingredients

More about Phosphatidylcholine

Tetrahexyldecyl ascorbate~0.4–0.6%

Under-dosedIrritant · medium

Irritation risk: Medium

Works for

Anti-agingEvens skin toneAnti-oxidation

Being a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.

More about Tetrahexyldecyl ascorbate

Palmitoyl tripeptide-5~0.3–0.6%

Hero · Moisturizing

Irritation risk: Low

Works for

MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tripeptide-5

Xanthan gum~0.3–0.6%

Formula

Irritation risk: Low

Works for

Cleansing

Used to create a thicker product consistency

More about Xanthan gum

Echium plantagineum seed oil~0.25–0.5%

Key activeIrritant · medium

Irritation risk: Medium

Works for

MoisturizingAnti-inflammatory

A plant oil that because of its high content of alpha-linolenic acid help support skin barrier function and moisturize the skin

More about Echium plantagineum seed oil

Acetyl tyrosine~0.25–0.45%

Formula

Irritation risk: Low

More about Acetyl tyrosine

Squalane~0.3–0.55%

Key active

Irritation risk: Low

Works for

Moisturizing

An oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.

More about Squalane

Phytic acid~0.25–0.45%

Irritant · medium

Irritation risk: Medium

An alpha-hydroxy acid (AHA), but is mostly used to stabilize product formulations in cosmetics

More about Phytic acid

Ethylhexylglycerin~0.25–0.45%

Irritant · medium

Irritation risk: Medium

A preservative

More about Ethylhexylglycerin

Helianthus annuus seed oil~0.25–0.5%

Key active

Irritation risk: Low

Works for

Moisturizing

A great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function

More about Helianthus annuus seed oil

Tocopherol~0.25–0.45%

Formula

Irritation risk: Low

Works for

Anti-oxidationAnti-agingMoisturizingAnti-inflammatory

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol

Lecithin~0.3–0.5%

Formula

Irritation risk: Low

Works for

CleansingMoisturizing

Used mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin

More about Lecithin

Zinc gluconate~0.25–0.4%

Under-dosedIrritant · medium

Irritation risk: Medium

Works for

MoisturizingEvens skin toneAnti-oxidationAnti-agingAnti-blemishAnti-inflammatoryExfoliation

Typically used to stabilize the product formulations. It is a salt of a polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing. Due to the zinc content, might help calm down inflammation in skin

More about Zinc gluconate

Magnesium aspartate~0.25–0.45%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-inflammatory

Might be helpful in restoring skin barrier function and calm down inflammation in skin

More about Magnesium aspartate

Glycine soja oil~0.25–0.45%

Key activeComedogenic 2/5Irritant · medium

Irritation risk: Medium
Comedogenicity: 2/5

Works for

Moisturizing

A good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.

More about Glycine soja oil

Caffeine~0.25–0.45%

Irritant · medium

Irritation risk: Medium

Works for

De-puffingAnti-oxidation

Might be helpful in neutralizing free radicals. Can have a dehydration effect that might somewhat decrease the look of puffy eyes

More about Caffeine

Tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetate~0.25–0.4%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-aging

A peptide. It helps attract water to the upper layer of the skin, support skin's barrier function and might have some slight anti-aging effect through stimulating skin's own production of hyaluronic acid

More about Tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetate

Sodium hyaluronate~0.25–0.45%

Key active

Irritation risk: Low

Works for

Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate

Palmitoyl carnitine~0.25–0.45%

Formula

Irritation risk: Low

More about Palmitoyl carnitine

Copper gluconate~0.25–0.45%

Under-dosedIrritant · medium

Irritation risk: Medium

Works for

MoisturizingAnti-agingEvens skin toneAnti-blemishExfoliationAnti-oxidation

Typically used to stabilize the product formulations. It is a salt of polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing

More about Copper gluconate

Rosmarinus officinalis leaf extract~0.2–0.4%

Under-dosedIrritant · high

Irritation risk: High

Works for

Anti-blemishAntibacterialAnti-oxidation

Can be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating

More about Rosmarinus officinalis leaf extract

Carrageenan~0.25–0.5%

Comedogenic 3/5Irritant · medium

Irritation risk: Medium
Comedogenicity: 3/5

Helps thicken the product formula and create a nice product formulation

More about Carrageenan

Disodium edta~0.25–0.45%

Irritant · medium

Irritation risk: Medium

Stabilizes the product formulation

More about Disodium edta

Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer~0.25–0.45%

Irritant · medium

Irritation risk: Medium

A gelling agent that thickens the product consistency and leaves the skin with a velvety finish

More about Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer

Cetearyl glucoside~0.25–0.45%

Irritant · medium

Irritation risk: Medium

Works for

Cleansing

Helps water and oil in the product mix well together and improves product texture

More about Cetearyl glucoside

Sclerotium gum~0.25–0.4%

Formula

Irritation risk: Low

Used to create gel-like formulas and stabilize emulsions

More about Sclerotium gum

Caprylyl glycol~0.25–0.5%

Irritant · medium

Irritation risk: Medium

Works for

Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol

Polysorbate 60~0.25–0.45%

Irritant · medium

Irritation risk: Medium

Works for

Cleansing

Helps oil and water mix together

More about Polysorbate 60

Phenoxyethanol~0.25–0.45%

Formula

Irritation risk: Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol

Potassium sorbate~0.25–0.4%

Irritant · medium

Irritation risk: Medium

A preservative

More about Potassium sorbate

Parfum~0.2–0.35%

Irritant · high

Irritation risk: High

An aromatic blend of unspecified and possibly irritating ingredients

More about Parfum

Silica~0.35–0.6%

Formula

Irritation risk: Low

Used to absorb oil and can temporarily mattify skin

More about Silica

Titanium dioxide~0.3–0.55%

Formula

Irritation risk: Low

Works for

Sun protection

Works as a UV filter when used in high concentrations. It is photostable and is effective mostly against the UVB light, with some protection in the UVA range. In small concentrations, used for its ability to improve the color of cosmetic products. Is usually well tolerated by the skin

More about Titanium dioxide

Ci 77891~0.15–0.3%

Formula

Irritation risk: Low

More about Ci 77891

Iron oxides~0.15–0.25%

Formula

Irritation risk: Low

Works for

Sun protection

An umbrella term for the following three colorants: CI 77491, CI 77492, CI 77499. They might be able to offer some protection against visible light, but the degree of the protection is not clear

More about Iron oxides

Ci 77491~0.15–0.25%

Formula

Irritation risk: Low

A red colorant made of iron oxide. Typically is not irritating

More about Ci 77491

Sodium benzoate~0.15–0.25%

Formula

Irritation risk: Low

A preservative

More about Sodium benzoate

Sodium metabisulfite~0.1–0.2%

Irritant · medium

Irritation risk: Medium

A preservative

More about Sodium metabisulfite

Benzyl benzoate~0.05–0.15%

Irritant · high

Irritation risk: High

Fragrance with sweet balsamic smell. Help to preserve products and dissolve other ingredients. Could trigger allergic reactions and be irritating

More about Benzyl benzoate

Limonene~0.05–0.15%

Irritant · high

Irritation risk: High

A common frangrance that can easily irritate skin, especially if exposed to air, light or heat

More about Limonene

Ingredient list view

Water, Hydrogenated polyisobutene, Isononyl isononanoate, Glycerin, Propanediol, Acetyl carnitine hcl, Dimethyl mea, Cetearyl alcohol, Niacinamide, Jojoba esters, Hydrogenated vegetable glycerides, Dimethicone, Glycolic acid, Peg-100 stearate, Glyceryl stearate, Phosphatidylcholine, Tetrahexyldecyl ascorbate, Palmitoyl tripeptide-5, Xanthan gum, Echium plantagineum seed oil, Acetyl tyrosine, Squalane, Phytic acid, Ethylhexylglycerin, Helianthus annuus seed oil, Tocopherol, Lecithin, Zinc gluconate, Magnesium aspartate, Glycine soja oil, Caffeine, Tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetate, Sodium hyaluronate, Palmitoyl carnitine, Copper gluconate, Rosmarinus officinalis leaf extract, Carrageenan, Disodium edta, Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, Cetearyl glucoside, Sclerotium gum, Caprylyl glycol, Polysorbate 60, Phenoxyethanol, Potassium sorbate, Parfum, Silica, Titanium dioxide, Ci 77891, Iron oxides, Ci 77491, Sodium benzoate, Sodium metabisulfite, Benzyl benzoate, Limonene

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Amazon UKPrice as of 10/24/2026 00:00 GMT

≈ $158.51

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
	Perricone MDSkincare Cold Plasma+ Sub-D NeckYOUR PRODUCT	BABORLIFTING RX Dual Eye Solution	Kerstin FlorianCaviar Eye Creme	PCA SKINPerfecting Neck and Decollete
Match	—	73%	71%	69%
Price	$158.51	$110.00−$48.51	$127.32−$31.19	$104.00−$54.51
Shared key ingredients	—	7 of 20	7 of 20	5 of 20
Key difference	—	Panthenol	Caprylic/Capric Triglyceride	Retinol
Irritancy	High	Medium	Medium	High
Drying alcohol	—	—	Contains drying alcohol	—
	View product	Shop	Shop	Shop

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Product summary

Based on the ingredients included, "Perricone MD - Skincare Cold Plasma+ Sub-D Neck" works well for moisturizing the skin. This moisturizer uses a good combo of humectants and emollients. These both types of ingredients are essentials for improving the skin hydration and keeping the skin barrier healthy. Glycerin, sodium hyaluronate and caprylyl glycol in this product (humectants) attract water molecules to the upper layer of the skin (the water comes from the outside air or from the deeper layers of the skin if the air is dry). Emollients in this formulation (glycine soja oil, jojoba esters, dimethicone, helianthus annuus seed oil and squalane) help to reduce the moisture loss from the skin. They also soften the skin surface and relieve the feeling of dryness and tightness.

Ingredient callouts

This moisturizer also contains Peptides (palmitoyl tripeptide-5 0.30% - 0.60%). Peptides are a very big group of ingredients. They all consist of a different combination of aminoacids. Our skin produces Peptides naturally. Some of them work as natural antibiotics, promote wound-healing and production of collagen. The scientists are still studying how effective the topical application of Peptides is, but it is very likely that they are helpful. Peptides might be able to support skin barrier restoration and even have an anti-aging benefit. At the very least, they certainly help attract water to the skin and support the hydration in this way.

This product contains ingredients that could be beneficial, but their concentrations are too low in this formulation: titanium dioxide, copper gluconate, zinc gluconate, lecithin, vitamin e and tetrahexyldecyl ascorbate

Irritation risk

This formulation includes some common irritants, including ingredients that do not provide a benefit for the skin. We assess the overall irritancy of this moisturizer to be high. For a detailed overview of all potential irritants: click here

You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.

About the brand

According to Cruelty-Free Kitty "Perricone MD" is cruelty free and so is its parent company.

Price

The product retails from 105.45£ up to 2920.00£ in the United Kingdom.

For a detailed price comparison: click here.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 34 studies and safety reviews.

1
Final report of the cosmetic ingredient review expert panel on the safety assessment of Polyisobutene and Hydrogenated Polyisobutene as used in cosmeticssemanticscholar.org
2
Glycerol and the skin: holistic approach to its origin and functionsncbi.nlm.nih.gov
3
Topically applied L-carnitine effectively reduces sebum secretion in human skinonlinelibrary.wiley.com
4
Niacinamide - mechanisms of action and its topical use in dermatologyncbi.nlm.nih.gov
5
Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology, 3(2), 88–93. doi:10.1111/j.1473-2130.2004.00115.x ncbi.nlm.nih.gov
6
Dimethicone as a protective ingredient in topical medicationsjaad.org
7
Final Report on the Safety Assessment of Dimethicone Copolyoljournals.sagepub.com
8
Photoprotective and antiinflammatory effects of topical glycolic acidncbi.nlm.nih.gov
9
Glycolic acid peel therapy – a current reviewncbi.nlm.nih.gov
10
Dual Effects of Alpha-Hydroxy Acids on the Skinmdpi.com
11
Double-blind, half-face study comparing topical vitamin C and vehicle for rejuvenation of photodamagencbi.nlm.nih.gov
12
Application of tetra-isopalmitoyl ascorbic acid in cosmetic formulations: Stability studies and in vivo efficacysciencedirect.com
13
Healing fats of the skin: the structural and immunologic roles of the omega-6 and omega-3 fatty acidsncbi.nlm.nih.gov
14
Cosmetic and dermatologic use of alpha hydroxy acidsonlinelibrary.wiley.com
15
Comparative Evaluation of Efficacy and Tolerability of Glycolic Acid, Salicylic Mandelic Acid, and Phytic Acid Combination Peels in Melasmancbi.nlm.nih.gov
16
Effect of Olive and Sunflower Seed Oil on the Adult Skin Barrier: Implications for Neonatal Skin Careonlinelibrary.wiley.com
17
Topically Applied Sunflower Seed Oil Prevents Invasive Bacterial Infections in Preterm Infants in Egyptjournals.lww.com
18
Effect of topically applied lipids on surfactant-irritated skinonlinelibrary.wiley.com
19
Impact of topical oils on the skin barrier: possible implications for neonatal health in developing countriesonlinelibrary.wiley.com
20
Vitamin E in dermatologyncbi.nlm.nih.gov
21
Vitamin E and Skin Healthlpi.oregonstate.edu
22
Zinc salts in dermatologyncbi.nlm.nih.gov
23
An overview of zinc and its importance in dermatology-Part II: The association of zinc with some dermatologic disordersoatext.com
24
Zinc, copper and manganese enhanced keratinocyte migration through a functional modulation of keratinocyte integrinsncbi.nlm.nih.gov
25
Evaluation of the effects of topical zinc gluconate in wound healingncbi.nlm.nih.gov
26
A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimenncbi.nlm.nih.gov
27
Applications of hydroxy acids: classification, mechanisms, and photoactivityncbi.nlm.nih.gov
28
Magnesium ions inhibit the antigen-presenting function of human epidermal Langerhans cells in vivo and in vitro. Involvement of ATPase, HLA-DR, B7 molecules, and cytokinesncbi.nlm.nih.gov
29
Hyaluronic acid: A key molecule in skin agingncbi.nlm.nih.gov
30
Hyaluronan (Hyaluronic Acid): a natural moisturizer for skin careresearchgate.net
31
Allergic contact dermatitis induced by rosemary leaf extract in a cleansing gelpubmed.ncbi.nlm.nih.gov
32
Safety Assessment of Rosmarinus officinalis (Rosemary)-Derived Ingredients as Used in Cosmeticsjournals.sagepub.com
33
Rosmarinus officinalis Extract Suppresses Propionibacterium acnes–Induced Inflammatory Responsesliebertpub.com
34
Final report on the safety assessment of sodium sulfite, potassium sulfite, ammonium sulfite, sodium bisulfite, ammonium bisulfite, sodium metabisulfite and potassium metabisulfitencbi.nlm.nih.gov

Perricone MDSkincare Cold Plasma+ Sub-D Neck

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As an Amazon Associate, WIMJ earns from qualifying purchases.