Perricone MD

Perricone MD Repair & Restore Regimen

Name: Perricone MD - Repair & Restore Regimen
Brand: Perricone MD

Efficacy87/100IrritancyHigh

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Works for

2 of 2 advertised claims delivered

Moisturizing

Acetyl hexapeptide-8, Palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine + 33 more

Strong evidence

What the product description says

“A deeply hydrating, fast-absorbing, skin firming moisturizer that delivers the optimal nourishment to strengthen and replenish skin’s moisture barrier for plumper, firmer-looking skin.”

Source: Perricone MD

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: anhydroxylitol, glycerin.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: dimethicone, helianthus annuus seed oil.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: acetyl hexapeptide-8, palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine, palmitoyl tripeptide-38, palmitoyl tripeptide-5

Salvia hispanica seed oilKey active· EmollientEffect: HighChia seed oil. Helps to soften the upper layer of the skin and might be helpful in repairing skin barrier~0.4–0.65%

Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~0.3–0.55%

SqualaneKey active· Emollient, OcclusiveEffect: HighAn oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.~0.4–0.6%

Tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetateKey activeEffect: HighA peptide. It helps attract water to the upper layer of the skin, support skin's barrier function and might have some slight anti-aging effect through stimulating skin's own production of hyaluronic acid~0.3–0.55%

XylitylglucosideKey active· HumectantEffect: HighHelps attract water to the upper layer of the skin and repair the skin barrier function~0.3–0.55%

AnhydroxylitolKey active· HumectantEffect: HighHelps attract water to the upper layer of the skin and repair the skin barrir function~0.3–0.6%

Acetyl hexapeptide-8Hero· HumectantEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.55%

DimethiconeKey active· Emollient, OcclusiveEffect: HighA silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish~0.45–0.7%

GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~0.45–0.65%

Helianthus annuus seed oilKey active· Emollient, OcclusiveEffect: HighA great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function~0.4–0.65%

Palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonineHeroEffect: High~0.3–0.55%

Palmitoyl tripeptide-38HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~1.5–1.9%

Palmitoyl tripeptide-5HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.55%

PantethineKey active· EmollientEffect: HighHelps to hydrate the skin by improving its barrier funciton~4.7–5.7%

PhospholipidsKey activeEffect: MediumEmollients that are naturaly present in skin. In addition, they help water and oil mix together in the product~0.35–0.65%

Cetearyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture~0.45–0.65%

Magnesium aspartateKey activeEffect: MediumMight be helpful in restoring skin barrier function and calm down inflammation in skin~0.3–0.55%

Macadamia ternifolia seed oilKey active· EmollientEffect: MediumPlant oil from nuts that helps soften the upper layer of the skin. Contains a high concentration of oleic acid that can weaken skin's barrier function and increase water-loss while enhancing penetration of other ingredients~0.45–0.65%

Ethylhexyl palmitateKey active· EmollientEffect: MediumAn emollient that helps soften the skin and create a nice product texture~0.45–0.65%

GlucoseKey active· HumectantEffect: MediumHelps attract water to the upper layer of the skin. Could be helpful in restoring the skin barrier function~0.3–0.6%

Glyceryl stearate· EmollientEffect: LowAn emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together~0.45–0.7%

Hydrogenated polyisobutene· Emollient, OcclusiveEffect: LowUsed to improve the product consistency and soften the upper layer of the skin~0.35–0.6%

C13-14 isoparaffin· EmollientEffect: LowHelps soften the upper layer of the skin, dissolve other ingredients and create a thicker product consistency~0.3–0.6%

Linum usitatissimum seed oilEffect: Low~0.3–0.6%

Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~0.4–0.65%

Polysilicone-11Effect: LowA silicone that forms a light film on the skin surface helping to bind water and temporarily absorb oils creating a matt and powdery feel~0.35–0.6%

Polyglyceryl-10 stearateEffect: LowHelps water and oil mix together and softens the upper layer of the skin~0.35–0.65%

Hydroxypropyl cyclodextrin· EmollientEffect: LowUsed to stabilize product formulations and help soften the upper layer of the skin~0.35–0.65%

Zinc gluconateUnder-dosedEffect: HighTypically used to stabilize the product formulations. It is a salt of a polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing. Due to the zinc content, might help calm down inflammation in skin~0.3–0.55%

Avena sativa kernel extractUnder-dosedEffect: HighAn effective moisturizing and skin barrier repair ingredient. Helps calm down inflammation and has some anti-oxidant properties~1–1.3%

Caprylic/capric triglycerideUnder-dosedEffect: HighA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin~0.45–0.7%

Copper gluconateUnder-dosedEffect: HighTypically used to stabilize the product formulations. It is a salt of polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing~0.3–0.55%

Lactic acidUnder-dosedEffect: HighAn exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)~0.35–0.6%

Alaria esculenta extractUnder-dosedEffect: MediumWorks as a humectant helping to attract water to the upper layer of the skin and might be effective as an anti-oxidant.~0.3–0.6%

TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.35–0.65%

Anti-aging

Acetyl hexapeptide-8, Palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine + 9 more

Moderate evidence

What the product description says

“A highly potent serum with a silky, luxurious texture to smooth even the most stubborn, deep-set lines, wrinkles and creases, including marionette lines, frown lines, smile lines and nasolabial folds.”

Source: Perricone MD

This product contains acetyl hexapeptide-8, palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine, palmitoyl tripeptide-38, palmitoyl tripeptide-5, tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetate. These ingredients might be able to help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness, but there is not enough evidence that it actually works.

Acetyl hexapeptide-8Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.55%

Palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonineKey activeEffect: Medium~0.3–0.55%

Palmitoyl tripeptide-38Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~1.5–1.9%

Palmitoyl tripeptide-5Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.55%

Tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetateKey activeEffect: MediumA peptide. It helps attract water to the upper layer of the skin, support skin's barrier function and might have some slight anti-aging effect through stimulating skin's own production of hyaluronic acid~0.3–0.55%

Tetrahexyldecyl ascorbateUnder-dosedEffect: HighBeing a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.~0.4–0.6%

Lactic acidUnder-dosedEffect: MediumAn exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)~0.35–0.6%

Copper gluconateEffect: Low, below effective doseTypically used to stabilize the product formulations. It is a salt of polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing~0.3–0.55%

Zinc gluconateEffect: Low, below effective doseTypically used to stabilize the product formulations. It is a salt of a polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing. Due to the zinc content, might help calm down inflammation in skin~0.3–0.55%

Alaria esculenta extractEffect: Low, below effective doseWorks as a humectant helping to attract water to the upper layer of the skin and might be effective as an anti-oxidant.~0.3–0.6%

Can it cause trouble?

Irritancy

6 strong irritants: Rosmarinus officinalis leaf extract, Parfum + 4 more — patch-test recommended

High risk

We flagged 23 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.

IngredientFunctionIrritationEst. amount

Rosmarinus officinalis leaf extractCan be helpful in reducing inflammation in skin, including inflamed acne. It can be irritatingHigh~0.4–0.6%est.

ParfumAn aromatic blend of unspecified and possibly irritating ingredientsHigh~0.35–0.6%est.

CitronellolA fragrance. Can be irritatingHigh~0.35–0.6%est.

HydroxycitronellalA fragrance. A likely allergen and can be irritatingHigh~0.35–0.6%est.

LimoneneA common frangrance that can easily irritate skin, especially if exposed to air, light or heatHigh~0.35–0.6%est.

LinaloolA fragrance. Can be irritatingHigh~0.35–0.6%est.

Tetrahexyldecyl ascorbateBeing a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.Medium~2.4–3%est.

Macadamia ternifolia seed oilPlant oil from nuts that helps soften the upper layer of the skin. Contains a high concentration of oleic acid that can weaken skin's barrier function and increase water-loss while enhancing penetration of other ingredientsMedium~0.7–1%est.

EthylhexylglycerinA preservativeMedium~0.5–0.75%est.

Acrylates/c10-30 alkyl acrylate crosspolymerMaintains the texture of skincare products. Allows the product to spread evenly. Helps oil and water mix togetherMedium~0.4–0.6%est.

Caprylyl glycolHelps preserve products and creates a nice product textureMedium~0.4–0.6%est.

Hydroxypropyl cyclodextrinUsed to stabilize product formulations and help soften the upper layer of the skinMedium~0.35–0.65%est.

Lactic acidAn exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)Medium~0.3–0.55%est.

Zinc gluconateTypically used to stabilize the product formulations. It is a salt of a polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing. Due to the zinc content, might help calm down inflammation in skinMedium~0.3–0.55%est.

Copper gluconateTypically used to stabilize the product formulations. It is a salt of polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missingMedium~0.3–0.55%est.

Caprylic/capric triglycerideA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerinMedium~0.45–0.7%est.

Caprylyl/capryl glucosideHelps oil and water mix together. Can be used as a cleansing agentMedium~0.45–0.7%est.

Potassium sorbateA preservativeMedium~0.4–0.6%est.

Polysorbate 60Helps oil and water mix togetherMedium~0.45–0.65%est.

Polyglyceryl-10 stearateHelps water and oil mix together and softens the upper layer of the skinMedium~0.35–0.65%est.

PolyacrylamideUsed to improve product texture and help oil and water mix togetherMedium~0.4–0.6%est.

Sodium acrylates copolymerUsed to create a thicker product consistencyMedium~0.3–0.55%est.

Laureth-7Helps oil and water mix togetherMedium~0.25–0.5%est.

Comedogenic

2 ingredients rated 2 or more on the 0–5 pore-clogging scale

2 flagged

These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.

IngredientFunctionRatingEst. amount

Ethylhexyl palmitateAn emollient that helps soften the skin and create a nice product texture3/5~0.45–0.65%est.

Cetearyl alcoholA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture2/5~0.45–0.65%est.

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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%

Formula

Irritation risk: Low

Plain old water

More about Water

Propanediol~5.2–6.4%

Formula

Irritation risk: Low

Acts as a solvent for other ingredients. Speeds up the absorption of other ingredients into the skin

More about Propanediol

Pantethine~4.7–5.7%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-inflammatoryReduces irritation

Helps to hydrate the skin by improving its barrier funciton

More about Pantethine

Glycerin~3.2–3.9%

Key active

Irritation risk: Low

Works for

Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin

Tetrahexyldecyl ascorbate~2.4–3%

Under-dosedIrritant · medium

Irritation risk: Medium

Works for

Anti-agingEvens skin toneAnti-oxidation

Being a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.

More about Tetrahexyldecyl ascorbate

S-palmitoylglutathione~2–2.4%

Formula

Irritation risk: Low

More about S-palmitoylglutathione

Dimethyl mea~1.8–2.2%

Formula

Irritation risk: Low

More about Dimethyl mea

Palmitoyl tripeptide-38~1.5–1.9%

Hero · Moisturizing

Irritation risk: Low

Works for

MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tripeptide-38

Acetyl tyrosine~1.3–1.6%

Formula

Irritation risk: Low

More about Acetyl tyrosine

Avena sativa kernel extract~1–1.3%

Under-dosed

Irritation risk: Low

Works for

Reduces irritationMoisturizingAnti-inflammatoryReduces rednessAnti-oxidation

An effective moisturizing and skin barrier repair ingredient. Helps calm down inflammation and has some anti-oxidant properties

More about Avena sativa kernel extract

Xanthan gum~0.75–1.1%

Formula

Irritation risk: Low

Works for

Cleansing

Used to create a thicker product consistency

More about Xanthan gum

Macadamia ternifolia seed oil~0.7–1%

Key activeIrritant · medium

Irritation risk: Medium

Works for

Moisturizing

Plant oil from nuts that helps soften the upper layer of the skin. Contains a high concentration of oleic acid that can weaken skin's barrier function and increase water-loss while enhancing penetration of other ingredients

More about Macadamia ternifolia seed oil

Linum usitatissimum seed oil~0.55–0.8%

Formula

Irritation risk: Low

Works for

Moisturizing

More about Linum usitatissimum seed oil

Salvia hispanica seed oil~0.55–0.85%

Key active

Irritation risk: Low

Works for

Moisturizing

Chia seed oil. Helps to soften the upper layer of the skin and might be helpful in repairing skin barrier

More about Salvia hispanica seed oil

Silica cetyl silylate~0.5–0.75%

Formula

Irritation risk: Low

More about Silica cetyl silylate

Ethylhexylglycerin~0.5–0.75%

Irritant · medium

Irritation risk: Medium

A preservative

More about Ethylhexylglycerin

Sodium hyaluronate~0.5–0.75%

Key active

Irritation risk: Low

Works for

Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate

Helianthus annuus seed oil~0.5–0.75%

Key active

Irritation risk: Low

Works for

Moisturizing

A great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function

More about Helianthus annuus seed oil

Rosmarinus officinalis leaf extract~0.4–0.6%

Irritant · high

Irritation risk: High

Works for

Anti-blemishAnti-oxidationAntibacterial

Can be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating

More about Rosmarinus officinalis leaf extract

Tetrasodium glutamate diacetate~0.4–0.6%

Formula

Irritation risk: Low

Helps stabilize the product formulation

More about Tetrasodium glutamate diacetate

Acrylates/c10-30 alkyl acrylate crosspolymer~0.4–0.6%

Irritant · medium

Irritation risk: Medium

Maintains the texture of skincare products. Allows the product to spread evenly. Helps oil and water mix together

More about Acrylates/c10-30 alkyl acrylate crosspolymer

Caprylyl glycol~0.4–0.6%

Irritant · medium

Irritation risk: Medium

Works for

Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol

Hydroxypropyl cyclodextrin~0.35–0.65%

Irritant · medium

Irritation risk: Medium

Works for

Moisturizing

Used to stabilize product formulations and help soften the upper layer of the skin

More about Hydroxypropyl cyclodextrin

Phenoxyethanol~0.35–0.6%

Formula

Irritation risk: Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol

Silica~0.45–0.7%

Formula

Irritation risk: Low

Used to absorb oil and can temporarily mattify skin

More about Silica

Titanium dioxide~0.45–0.7%

Formula

Irritation risk: Low

Works for

Sun protection

Works as a UV filter when used in high concentrations. It is photostable and is effective mostly against the UVB light, with some protection in the UVA range. In small concentrations, used for its ability to improve the color of cosmetic products. Is usually well tolerated by the skin

More about Titanium dioxide

Iron oxides~0.3–0.55%

Formula

Irritation risk: Low

Works for

Sun protection

An umbrella term for the following three colorants: CI 77491, CI 77492, CI 77499. They might be able to offer some protection against visible light, but the degree of the protection is not clear

More about Iron oxides

Water~0.3–0.6%

Formula

Irritation risk: Low

Plain old water

More about Water

Propanediol~0.35–0.6%

Formula

Irritation risk: Low

Acts as a solvent for other ingredients. Speeds up the absorption of other ingredients into the skin

More about Propanediol

Squalane~0.4–0.6%

Key active

Irritation risk: Low

Works for

Moisturizing

An oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.

More about Squalane

Hydrogenated polyisobutene~0.35–0.65%

Formula

Irritation risk: Low

Works for

Moisturizing

Used to improve the product consistency and soften the upper layer of the skin

More about Hydrogenated polyisobutene

S-palmitoylglutathione~0.3–0.6%

Formula

Irritation risk: Low

More about S-palmitoylglutathione

Dimethicone~0.4–0.65%

Key active

Irritation risk: Low

Works for

MoisturizingMattifying

A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish

More about Dimethicone

Glycerin~0.35–0.65%

Key active

Irritation risk: Low

Works for

Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin

Macadamia ternifolia seed oil~0.35–0.65%

Key activeIrritant · medium

Irritation risk: Medium

Works for

Moisturizing

More about Macadamia ternifolia seed oil

Xylitylglucoside~0.3–0.55%

Key active

Irritation risk: Low

Works for

Moisturizing

Helps attract water to the upper layer of the skin and repair the skin barrier function

More about Xylitylglucoside

Tetrahexyldecyl ascorbate~0.3–0.6%

Under-dosedIrritant · medium

Irritation risk: Medium

Works for

Anti-oxidationEvens skin toneAnti-aging

More about Tetrahexyldecyl ascorbate

Dimethyl mea~0.3–0.6%

Formula

Irritation risk: Low

More about Dimethyl mea

Palmitoyl tripeptide-5~0.3–0.55%

Hero · Moisturizing

Irritation risk: Low

Works for

MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tripeptide-5

Acetyl hexapeptide-8~0.3–0.55%

Hero · Moisturizing

Irritation risk: Low

Works for

MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Acetyl hexapeptide-8

Anhydroxylitol~0.3–0.6%

Key active

Irritation risk: Low

Works for

Moisturizing

Helps attract water to the upper layer of the skin and repair the skin barrir function

More about Anhydroxylitol

Lactic acid~0.3–0.55%

Under-dosedIrritant · medium

Irritation risk: Medium

Works for

ExfoliationEvens skin toneMoisturizingAnti-aging

An exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)

More about Lactic acid

Xylitol~0.3–0.55%

Formula

Irritation risk: Low

Helps attract water to the upper layer of the skin and repair the skin barrier function

More about Xylitol

Xanthan gum~0.3–0.6%

Formula

Irritation risk: Low

Works for

Cleansing

Used to create a thicker product consistency

More about Xanthan gum

Linum usitatissimum seed oil~0.3–0.5%

Formula

Irritation risk: Low

Works for

Moisturizing

More about Linum usitatissimum seed oil

Salvia hispanica seed oil~0.35–0.6%

Key active

Irritation risk: Low

Works for

Moisturizing

Chia seed oil. Helps to soften the upper layer of the skin and might be helpful in repairing skin barrier

More about Salvia hispanica seed oil

Tocopherol~0.3–0.6%

Formula

Irritation risk: Low

Works for

Anti-oxidationMoisturizingAnti-inflammatoryAnti-aging

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol

Ethylhexylglycerin~0.3–0.6%

Irritant · medium

Irritation risk: Medium

A preservative

More about Ethylhexylglycerin

Magnesium aspartate~0.3–0.55%

Key active

Irritation risk: Low

Works for

Anti-inflammatoryMoisturizing

Might be helpful in restoring skin barrier function and calm down inflammation in skin

More about Magnesium aspartate

Zinc gluconate~0.3–0.55%

Under-dosedIrritant · medium

Irritation risk: Medium

Works for

MoisturizingAnti-blemishExfoliationEvens skin toneAnti-agingAnti-inflammatoryAnti-oxidation

Typically used to stabilize the product formulations. It is a salt of a polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing. Due to the zinc content, might help calm down inflammation in skin

More about Zinc gluconate

Alaria esculenta extract~0.3–0.6%

Under-dosed

Irritation risk: Low

Works for

MoisturizingAnti-oxidationAnti-aging

Works as a humectant helping to attract water to the upper layer of the skin and might be effective as an anti-oxidant.

More about Alaria esculenta extract

Glucose~0.3–0.6%

Key active

Irritation risk: Low

Works for

Moisturizing

Helps attract water to the upper layer of the skin. Could be helpful in restoring the skin barrier function

More about Glucose

Sodium hyaluronate~0.3–0.55%

Key active

Irritation risk: Low

Works for

Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate

Copper gluconate~0.3–0.55%

Under-dosedIrritant · medium

Irritation risk: Medium

Works for

MoisturizingAnti-agingEvens skin toneAnti-blemishExfoliationAnti-oxidation

Typically used to stabilize the product formulations. It is a salt of polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing

More about Copper gluconate

Tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetate~0.3–0.55%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-aging

A peptide. It helps attract water to the upper layer of the skin, support skin's barrier function and might have some slight anti-aging effect through stimulating skin's own production of hyaluronic acid

More about Tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetate

Palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine~0.3–0.55%

Hero · Moisturizing

Irritation risk: Low

Works for

MoisturizingAnti-aging

More about Palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine

Helianthus annuus seed oil~0.35–0.65%

Key active

Irritation risk: Low

Works for

Moisturizing

A great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function

More about Helianthus annuus seed oil

Rosmarinus officinalis leaf extract~0.3–0.6%

Irritant · high

Irritation risk: High

Works for

Anti-blemishAntibacterialAnti-oxidation

Can be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating

More about Rosmarinus officinalis leaf extract

Tetrasodium glutamate diacetate~0.35–0.65%

Formula

Irritation risk: Low

Helps stabilize the product formulation

More about Tetrasodium glutamate diacetate

Magnesium chloride~0.35–0.65%

Formula

Irritation risk: Low

Helps thicken the product formulation

More about Magnesium chloride

Caprylic/capric triglyceride~0.45–0.7%

Under-dosedIrritant · medium

Irritation risk: Medium

Works for

Moisturizing

A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin

More about Caprylic/capric triglyceride

Acrylates/c10-30 alkyl acrylate crosspolymer~0.4–0.65%

Irritant · medium

Irritation risk: Medium

Maintains the texture of skincare products. Allows the product to spread evenly. Helps oil and water mix together

More about Acrylates/c10-30 alkyl acrylate crosspolymer

Caprylyl/capryl glucoside~0.45–0.7%

Irritant · medium

Irritation risk: Medium

Works for

Cleansing

Helps oil and water mix together. Can be used as a cleansing agent

More about Caprylyl/capryl glucoside

Caprylyl glycol~0.4–0.65%

Irritant · medium

Irritation risk: Medium

Works for

Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol

Potassium sorbate~0.4–0.6%

Irritant · medium

Irritation risk: Medium

A preservative

More about Potassium sorbate

Phenoxyethanol~0.4–0.6%

Formula

Irritation risk: Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol

Parfum~0.35–0.6%

Irritant · high

Irritation risk: High

An aromatic blend of unspecified and possibly irritating ingredients

More about Parfum

Citronellol~0.35–0.6%

Irritant · high

Irritation risk: High

A fragrance. Can be irritating

More about Citronellol

Hydroxycitronellal~0.35–0.6%

Irritant · high

Irritation risk: High

A fragrance. A likely allergen and can be irritating

More about Hydroxycitronellal

Limonene~0.35–0.6%

Irritant · high

Irritation risk: High

A common frangrance that can easily irritate skin, especially if exposed to air, light or heat

More about Limonene

Linalool~0.35–0.6%

Irritant · high

Irritation risk: High

A fragrance. Can be irritating

More about Linalool

Water~0.35–0.65%

Formula

Irritation risk: Low

Plain old water

More about Water

Ethylhexyl palmitate~0.45–0.65%

Key activeComedogenic 3/5

Irritation risk: Low
Comedogenicity: 3/5

Works for

Moisturizing

An emollient that helps soften the skin and create a nice product texture

More about Ethylhexyl palmitate

Glycerin~0.45–0.65%

Key active

Irritation risk: Low

Works for

Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin

Dimethicone~0.45–0.7%

Key active

Irritation risk: Low

Works for

MoisturizingMattifying

A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish

More about Dimethicone

Cetearyl alcohol~0.45–0.65%

Key activeComedogenic 2/5

Irritation risk: Low
Comedogenicity: 2/5

Works for

CleansingMoisturizing

A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture

More about Cetearyl alcohol

Glyceryl stearate~0.45–0.7%

Formula

Irritation risk: Low

Works for

CleansingMoisturizing

An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together

More about Glyceryl stearate

Polysorbate 60~0.45–0.65%

Irritant · medium

Irritation risk: Medium

Works for

Cleansing

Helps oil and water mix together

More about Polysorbate 60

Palmitoyl glycine~0.45–0.7%

Formula

Irritation risk: Low

More about Palmitoyl glycine

S-palmitoylglutathione~0.4–0.6%

Formula

Irritation risk: Low

More about S-palmitoylglutathione

Tetrahexyldecyl ascorbate~0.4–0.6%

Under-dosedIrritant · medium

Irritation risk: Medium

Works for

Anti-oxidationEvens skin toneAnti-aging

More about Tetrahexyldecyl ascorbate

Peg-100 stearate~0.5–0.75%

Formula

Irritation risk: Low

Works for

Cleansing

Helps oil and water mix togehter and creates a nice product texture

More about Peg-100 stearate

Ribose~0.35–0.6%

Formula

Irritation risk: Low

More about Ribose

Lactic acid~0.35–0.6%

Under-dosedIrritant · medium

Irritation risk: Medium

Works for

ExfoliationEvens skin toneMoisturizingAnti-aging

More about Lactic acid

Linum usitatissimum seed oil~0.3–0.6%

Formula

Irritation risk: Low

Works for

Moisturizing

More about Linum usitatissimum seed oil

Macadamia ternifolia seed oil~0.45–0.65%

Key activeIrritant · medium

Irritation risk: Medium

Works for

Moisturizing

More about Macadamia ternifolia seed oil

Phospholipids~0.35–0.65%

Key active

Irritation risk: Low

Works for

Moisturizing

Emollients that are naturaly present in skin. In addition, they help water and oil mix together in the product

More about Phospholipids

Polyglyceryl-10 stearate~0.35–0.65%

Irritant · medium

Irritation risk: Medium

Works for

Moisturizing

Helps water and oil mix together and softens the upper layer of the skin

More about Polyglyceryl-10 stearate

Ethylhexylglycerin~0.35–0.65%

Irritant · medium

Irritation risk: Medium

A preservative

More about Ethylhexylglycerin

Salvia hispanica seed oil~0.4–0.65%

Key active

Irritation risk: Low

Works for

Moisturizing

Chia seed oil. Helps to soften the upper layer of the skin and might be helpful in repairing skin barrier

More about Salvia hispanica seed oil

Tocopherol~0.35–0.65%

Formula

Irritation risk: Low

Works for

Anti-oxidationAnti-inflammatoryAnti-agingMoisturizing

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol

Helianthus annuus seed oil~0.4–0.65%

Key active

Irritation risk: Low

Works for

Moisturizing

A great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function

More about Helianthus annuus seed oil

Rosmarinus officinalis leaf extract~0.3–0.6%

Irritant · high

Irritation risk: High

Works for

Anti-blemishAnti-oxidationAntibacterial

Can be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating

More about Rosmarinus officinalis leaf extract

Tetrasodium glutamate diacetate~0.35–0.65%

Formula

Irritation risk: Low

Helps stabilize the product formulation

More about Tetrasodium glutamate diacetate

Sodium hydroxide~0.35–0.6%

Formula

Irritation risk: Low

Used to adjust the product's pH

More about Sodium hydroxide

Polyacrylamide~0.4–0.6%

Irritant · medium

Irritation risk: Medium

Used to improve product texture and help oil and water mix together

More about Polyacrylamide

Sodium acrylates copolymer~0.3–0.55%

Irritant · medium

Irritation risk: Medium

Used to create a thicker product consistency

More about Sodium acrylates copolymer

Polysilicone-11~0.35–0.6%

Formula

Irritation risk: Low

Works for

MattifyingMoisturizing

A silicone that forms a light film on the skin surface helping to bind water and temporarily absorb oils creating a matt and powdery feel

More about Polysilicone-11

Hydrogenated polyisobutene~0.35–0.6%

Formula

Irritation risk: Low

Works for

Moisturizing

Used to improve the product consistency and soften the upper layer of the skin

More about Hydrogenated polyisobutene

C13-14 isoparaffin~0.3–0.6%

Formula

Irritation risk: Low

Works for

Moisturizing

Helps soften the upper layer of the skin, dissolve other ingredients and create a thicker product consistency

More about C13-14 isoparaffin

Laureth-7~0.25–0.5%

Irritant · medium

Irritation risk: Medium

Works for

Cleansing

Helps oil and water mix together

More about Laureth-7

Phenoxyethanol~0.2–0.4%

Formula

Irritation risk: Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol

Parfum~0.2–0.35%

Irritant · high

Irritation risk: High

An aromatic blend of unspecified and possibly irritating ingredients

More about Parfum

Citronellol~0.2–0.35%

Irritant · high

Irritation risk: High

A fragrance. Can be irritating

More about Citronellol

Hydroxycitronellal~0.2–0.35%

Irritant · high

Irritation risk: High

A fragrance. A likely allergen and can be irritating

More about Hydroxycitronellal

Limonene~0.1–0.25%

Irritant · high

Irritation risk: High

A common frangrance that can easily irritate skin, especially if exposed to air, light or heat

More about Limonene

Linalool~0.1–0.2%

Irritant · high

Irritation risk: High

A fragrance. Can be irritating

More about Linalool

Ingredient list view

Water, Propanediol, Pantethine, Glycerin, Tetrahexyldecyl ascorbate, S-palmitoylglutathione, Dimethyl mea, Palmitoyl tripeptide-38, Acetyl tyrosine, Avena sativa kernel extract, Xanthan gum, Macadamia ternifolia seed oil, Linum usitatissimum seed oil, Salvia hispanica seed oil, Silica cetyl silylate, Ethylhexylglycerin, Sodium hyaluronate, Helianthus annuus seed oil, Rosmarinus officinalis leaf extract, Tetrasodium glutamate diacetate, Acrylates/c10-30 alkyl acrylate crosspolymer, Caprylyl glycol, Hydroxypropyl cyclodextrin, Phenoxyethanol, Silica, Titanium dioxide, Iron oxides, Water, Propanediol, Squalane, Hydrogenated polyisobutene, S-palmitoylglutathione, Dimethicone, Glycerin, Macadamia ternifolia seed oil, Xylitylglucoside, Tetrahexyldecyl ascorbate, Dimethyl mea, Palmitoyl tripeptide-5, Acetyl hexapeptide-8, Anhydroxylitol, Lactic acid, Xylitol, Xanthan gum, Linum usitatissimum seed oil, Salvia hispanica seed oil, Tocopherol, Ethylhexylglycerin, Magnesium aspartate, Zinc gluconate, Alaria esculenta extract, Glucose, Sodium hyaluronate, Copper gluconate, Tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetate, Palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine, Helianthus annuus seed oil, Rosmarinus officinalis leaf extract, Tetrasodium glutamate diacetate, Magnesium chloride, Caprylic/capric triglyceride, Acrylates/c10-30 alkyl acrylate crosspolymer, Caprylyl/capryl glucoside, Caprylyl glycol, Potassium sorbate, Phenoxyethanol, Parfum, Citronellol, Hydroxycitronellal, Limonene, Linalool, Water, Ethylhexyl palmitate, Glycerin, Dimethicone, Cetearyl alcohol, Glyceryl stearate, Polysorbate 60, Palmitoyl glycine, S-palmitoylglutathione, Tetrahexyldecyl ascorbate, Peg-100 stearate, Ribose, Lactic acid, Linum usitatissimum seed oil, Macadamia ternifolia seed oil, Phospholipids, Polyglyceryl-10 stearate, Ethylhexylglycerin, Salvia hispanica seed oil, Tocopherol, Helianthus annuus seed oil, Rosmarinus officinalis leaf extract, Tetrasodium glutamate diacetate, Sodium hydroxide, Polyacrylamide, Sodium acrylates copolymer, Polysilicone-11, Hydrogenated polyisobutene, C13-14 isoparaffin, Laureth-7, Phenoxyethanol, Parfum, Citronellol, Hydroxycitronellal, Limonene, Linalool

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Perricone MD

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Perricone MD

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Product summary

Judging from the ingredient list, "Perricone MD - Repair & Restore Regimen" works well for improving skin hydration To work well, any moisturizer needs to include a combination of water-binding and emollient ingredients. Perricone MD - Repair & Restore Regimen ticks this box. Humectants in this product (acetyl hexapeptide-8, anhydroxylitol, glycerin, sodium hyaluronate and xylitylglucoside) help to increase the water content in the upper layer of the skin. (These ingredients do so by "capturing" water molecules from the outside air or from within the deeper layers of the skin). Emollients in this formulation (pantethine, salvia hispanica seed oil, dimethicone, helianthus annuus seed oil and squalane) help to reduce the moisture loss from the skin. They also soften the skin surface and relieve the feeling of dryness and tightness.

Ingredient callouts

This moistruizer also contains peptides (palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine 0.30% - 0.55%, acetyl hexapeptide-8 0.30% - 0.55%, palmitoyl tripeptide-5 0.30% - 0.55% and palmitoyl tripeptide-38 1.50% - 1.90%). Peptides is a very big group of ingredients. They all consist of a different combination of amino-acids. Our skin produces peptides naturally. Some of them work as natural anti-biotics, promote wound-healing and production of collagen. The scientists are still studying how effective the topical application of peptides is, but it is very likely that peptides in skincare are helpful. They might be able to support skin barrier restoration and even have an anti-aging benefit. At the very least, they certainly help attract water to the skin and support the hydration in this way.

Irritation risk

This moisturizer contains a bunch of common irritants, including ingredients that do not provide any known benefit for the skin. It might not be the best choice if your skin is sensitive. We assess the overall irritancy of this moisturizer to be high. For a detailed overview of all potential irritants: click here

You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.

About the brand

According to Cruelty-Free Kitty "Perricone MD" is cruelty free and so is its parent company.

Price

The product retails from 275.00$ up to 329.00$ in the United States.

For a detailed price comparison: click here.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 32 studies and safety reviews.

1
Topical use of dexpanthenol in skin disordersncbi.nlm.nih.gov
2
Glycerol and the skin: holistic approach to its origin and functionsncbi.nlm.nih.gov
3
Double-blind, half-face study comparing topical vitamin C and vehicle for rejuvenation of photodamagencbi.nlm.nih.gov
4
Application of tetra-isopalmitoyl ascorbic acid in cosmetic formulations: Stability studies and in vivo efficacysciencedirect.com
5
Fatty acids profile of oil from nine varieties of Macadamia nuttandfonline.com
6
Hyaluronic acid: A key molecule in skin agingncbi.nlm.nih.gov
7
Hyaluronan (Hyaluronic Acid): a natural moisturizer for skin careresearchgate.net
8
Effect of Olive and Sunflower Seed Oil on the Adult Skin Barrier: Implications for Neonatal Skin Careonlinelibrary.wiley.com
9
Topically Applied Sunflower Seed Oil Prevents Invasive Bacterial Infections in Preterm Infants in Egyptjournals.lww.com
10
Effect of topically applied lipids on surfactant-irritated skinonlinelibrary.wiley.com
11
Impact of topical oils on the skin barrier: possible implications for neonatal health in developing countriesonlinelibrary.wiley.com
12
Allergic contact dermatitis induced by rosemary leaf extract in a cleansing gelpubmed.ncbi.nlm.nih.gov
13
Safety Assessment of Rosmarinus officinalis (Rosemary)-Derived Ingredients as Used in Cosmeticsjournals.sagepub.com
14
Rosmarinus officinalis Extract Suppresses Propionibacterium acnes–Induced Inflammatory Responsesliebertpub.com
15
Final report of the cosmetic ingredient review expert panel on the safety assessment of Polyisobutene and Hydrogenated Polyisobutene as used in cosmeticssemanticscholar.org
16
Dimethicone as a protective ingredient in topical medicationsjaad.org
17
Final Report on the Safety Assessment of Dimethicone Copolyoljournals.sagepub.com
18
Epidermal and dermal effects of topical lactic acidncbi.nlm.nih.gov
19
Dual Effects of Alpha-Hydroxy Acids on the Skinpdfs.semanticscholar.org
20
Vitamin E in dermatologyncbi.nlm.nih.gov
21
Vitamin E and Skin Healthlpi.oregonstate.edu
22
Magnesium ions inhibit the antigen-presenting function of human epidermal Langerhans cells in vivo and in vitro. Involvement of ATPase, HLA-DR, B7 molecules, and cytokinesncbi.nlm.nih.gov
23
Zinc salts in dermatologyncbi.nlm.nih.gov
24
An overview of zinc and its importance in dermatology-Part II: The association of zinc with some dermatologic disordersoatext.com
25
Zinc, copper and manganese enhanced keratinocyte migration through a functional modulation of keratinocyte integrinsncbi.nlm.nih.gov
26
Evaluation of the effects of topical zinc gluconate in wound healingncbi.nlm.nih.gov
27
A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimenncbi.nlm.nih.gov
28
Applications of hydroxy acids: classification, mechanisms, and photoactivityncbi.nlm.nih.gov
29
Topical Glucose Induces Claudin-1 and Filaggrin Expression in a Mouse Model of Atopic Dermatitis and in Keratinocyte Culture, Exerting Anti-inflammatory Effects by Repairing Skin Barrier Functionncbi.nlm.nih.gov
30
Safety Assessment of Polyglyceryl Fatty Acid Esters as Used in Cosmeticscir-safety.org
31
Final Report on the Safety Assessment of Acrylates Copolymer and 33 Related Cosmetic Ingredientsjournals.sagepub.com
32
Safety Assessment of Isoparaffins as Used in Cosmeticsjournals.sagepub.com

Perricone MDRepair & Restore Regimen

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