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Dermatica Daily Firming Multi-Peptide Serum
Dermatica

Dermatica Daily Firming Multi-Peptide Serum

Efficacy87/100IrritancyMedium
See all ingredients

Works for

Moisturizing
Urea, Palmitoyl tripeptide-5 + 23 more
Works well
What the product description says
“This hydrating serum is powered by Peptides and Plant Exosomes to target the signs of ageing and help support visibly smoother, firmer-looking skin.”
Source: Dermatica

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: arginine, carnosine.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: arginine, caprylyl glycol.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: acetyl hexapeptide-8, hexapeptide-9, palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine, palmitoyl tetrapeptide-7, palmitoyl tripeptide-1, palmitoyl tripeptide-38, palmitoyl tripeptide-5, urea

UreaHero· HumectantEffect: HighNaturally present in skin (urea makes up about 7% of natural moisturizing factors in skin). Attracts water to the upper layer of the skin. Also has a positive effect on the skin barrier beyond the humectant action. Can enhance penetration of other ingredients. Is an exfoliating ingredient when used in high concentrations~0.95–1.15%
Palmitoyl tripeptide-5HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.35%
Acetyl hexapeptide-8Hero· HumectantEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.35%
Palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonineHeroEffect: High~0.2–0.4%
Palmitoyl tripeptide-1Hero· EmollientEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.15–0.3%
Palmitoyl tetrapeptide-7Hero· EmollientEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.1–0.25%
Palmitoyl tripeptide-38HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.1–0.2%
Hexapeptide-9Hero· HumectantEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.05–0.15%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~4.9–6%
ArginineKey active· Humectant, OcclusiveEffect: HighAn amino acid that is naturally present in skin and helps keep it hydrated. When used together with AHAs, it can reduce their irritating effect on the skin~4–4.9%
EctoinKey activeEffect: HighSoftens the upper layer of the skin and can support skin barrier function~3.1–3.7%
Sodium pcaKey active· HumectantEffect: HighNaturally present in skin and helps to attract water to its upper layer~1.4–1.7%
DiglycerinKey active· HumectantEffect: HighHelps attract water to the upper layer of the skin~1.2–1.4%
CarnosineKey active· HumectantEffect: HighA type of peptide. It attracts water to the upper layer of the skin. It can help neutralize free radicals in skin combatting the sun damage~0.5–0.8%
Hydrolyzed rice proteinKey active· HumectantEffect: MediumHelps attract water to the upper layer of the skin. Might have some anti-oxidant properties~0.35–0.65%
PcaKey active· HumectantEffect: HighNaturally present in skin and helps to attract water to its upper layer~0.3–0.5%
LysineKey activeEffect: HighAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.3–0.55%
ErythritolKey active· HumectantEffect: HighHelps to attract water to the upper layer of the skin~0.2–0.4%
Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~1.6–2%
Sorbitol· HumectantEffect: LowHelps attract water to the upper layer of the skin and improves the product texture~0.25–0.5%
Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~0.25–0.5%
Hydroxypropyl cyclodextrin· EmollientEffect: LowUsed to stabilize product formulations and help soften the upper layer of the skin~0.25–0.5%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.15–0.25%
Lactic acidUnder-dosedAn exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)~0.35–0.6%
AllantoinUnder-dosedHelps calm down inflammation in skin and can help reduce itching. Helps to repair the skin barrier and keep skin hydrated~0.35–0.6%
Anti-aging
Carnosine, Lysine + 9 more
May help
What the product description says
“This hydrating serum is powered by Peptides and Plant Exosomes to target the signs of ageing and help support visibly smoother, firmer-looking skin.”
Source: Dermatica

This product contains acetyl hexapeptide-8, carnosine, hexapeptide-9, lysine, palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine, palmitoyl tetrapeptide-7, palmitoyl tripeptide-1, palmitoyl tripeptide-38, palmitoyl tripeptide-5. These ingredients might be able to help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness, but there is not enough evidence that it actually works.

CarnosineKey activeEffect: MediumA type of peptide. It attracts water to the upper layer of the skin. It can help neutralize free radicals in skin combatting the sun damage~0.5–0.8%
LysineKey activeEffect: MediumAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.3–0.55%
Palmitoyl tripeptide-5Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.35%
Palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonineKey activeEffect: Medium~0.2–0.4%
Acetyl hexapeptide-8Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.35%
Palmitoyl tripeptide-1Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.15–0.3%
Palmitoyl tripeptide-38Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.1–0.2%
Palmitoyl tetrapeptide-7Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.1–0.25%
Hexapeptide-9Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.05–0.15%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.15–0.25%
Lactic acidUnder-dosedAn exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)~0.35–0.6%
Anti-oxidation
Side benefit · Carnosine, Punica granatum extract + 2 more
Works well

This product contains antioxidants (carnosine) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

The following ingredients - punica granatum extract also can have an antioxidant effect, but there is less evidence to confirm their effectiveness in skin.

CarnosineKey activeEffect: HighA type of peptide. It attracts water to the upper layer of the skin. It can help neutralize free radicals in skin combatting the sun damage~0.5–0.8%
Punica granatum extractKey activeEffect: MediumA plant extract that can help neutralize free radicals in skin and even out the skin tone, but is typically used in products in a concentration that is too low to be effective~0.4–0.6%
Hydrolyzed rice proteinEffect: LowHelps attract water to the upper layer of the skin. Might have some anti-oxidant properties~0.35–0.65%
TocopherolUnder-dosedPure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.15–0.25%

Can it cause trouble?

Irritancy
11 flagged ingredients
Medium risk
We flagged 11 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Sodium polyacryloyldimethyl taurateHelps oil and water mix togetherMedium~2.3–2.8%est.
Levulinic acidHelps stabilize a product formulationMedium~1.8–2.2%est.
Benzoic acidA preservativeMedium~0.25–0.5%est.
Punica granatum extractA plant extract that can help neutralize free radicals in skin and even out the skin tone, but is typically used in products in a concentration that is too low to be effectiveMedium~0.4–0.6%est.
Lactic acidAn exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)Medium~0.35–0.6%est.
Trisodium ethylenediamine disuccinateUsed to improve stability of the formulationMedium~0.25–0.45%est.
Sorbic acidA preservativeMedium~0.25–0.45%est.
CarrageenanHelps thicken the product formula and create a nice product formulationMedium~0.25–0.45%est.
Hydroxypropyl cyclodextrinUsed to stabilize product formulations and help soften the upper layer of the skinMedium~0.25–0.5%est.
Caprylyl glycolHelps preserve products and creates a nice product textureMedium~0.25–0.5%est.
Potassium sorbateA preservativeMedium~0.25–0.4%est.
Comedogenic
1 ingredient rated 2 or more on the 0–5 pore-clogging scale
1 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
CarrageenanHelps thicken the product formula and create a nice product formulation3/5~0.25–0.45%est.

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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%
Formula
Irritation risk
Low

Plain old water

More about Water
Glycerin~4.9–6%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Arginine~4–4.9%
Key active
Irritation risk
Low
Works for
Moisturizing

An amino acid that is naturally present in skin and helps keep it hydrated. When used together with AHAs, it can reduce their irritating effect on the skin

More about Arginine
Ectoin~3.1–3.7%
Key active
Irritation risk
Low
Works for
Moisturizing

Softens the upper layer of the skin and can support skin barrier function

More about Ectoin
Sodium polyacryloyldimethyl taurate~2.3–2.8%
Irritant · medium
Irritation risk
Medium

Helps oil and water mix together

More about Sodium polyacryloyldimethyl taurate
Levulinic acid~1.8–2.2%
Irritant · medium
Irritation risk
Medium

Helps stabilize a product formulation

More about Levulinic acid
Butylene glycol~1.6–2%
Formula
Irritation risk
Low
Works for
Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol
Sodium pca~1.4–1.7%
Key active
Irritation risk
Low
Works for
Moisturizing

Naturally present in skin and helps to attract water to its upper layer

More about Sodium pca
Diglycerin~1.2–1.4%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps attract water to the upper layer of the skin

More about Diglycerin
Urea~0.95–1.15%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingExfoliation

Naturally present in skin (urea makes up about 7% of natural moisturizing factors in skin). Attracts water to the upper layer of the skin. Also has a positive effect on the skin barrier beyond the humectant action. Can enhance penetration of other ingredients. Is an exfoliating ingredient when used in high concentrations

More about Urea
Microcrystalline cellulose~0.8–1.2%
Formula
Irritation risk
Low
Works for
Exfoliation
More about Microcrystalline cellulose
Carnosine~0.5–0.8%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-oxidationAnti-aging

A type of peptide. It attracts water to the upper layer of the skin. It can help neutralize free radicals in skin combatting the sun damage

More about Carnosine
Benzoic acid~0.25–0.5%
Irritant · medium
Irritation risk
Medium

A preservative

More about Benzoic acid
Punica granatum extract~0.4–0.6%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Anti-oxidationEvens skin tone

A plant extract that can help neutralize free radicals in skin and even out the skin tone, but is typically used in products in a concentration that is too low to be effective

More about Punica granatum extract
Allantoin~0.35–0.6%
Under-dosed
Irritation risk
Low
Works for
MoisturizingAnti-inflammatoryReduces irritationReduces rednessAnti-blemishExfoliation

Helps calm down inflammation in skin and can help reduce itching. Helps to repair the skin barrier and keep skin hydrated

More about Allantoin
Hydrolyzed rice protein~0.35–0.65%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-oxidation

Helps attract water to the upper layer of the skin. Might have some anti-oxidant properties

More about Hydrolyzed rice protein
Lactic acid~0.35–0.6%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
ExfoliationEvens skin toneMoisturizingAnti-aging

An exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)

More about Lactic acid
Lysine~0.3–0.55%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-aging

An amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles

More about Lysine
Pca~0.3–0.5%
Key active
Irritation risk
Low
Works for
Moisturizing

Naturally present in skin and helps to attract water to its upper layer

More about Pca
Sorbitol~0.25–0.5%
Formula
Irritation risk
Low
Works for
Moisturizing

Helps attract water to the upper layer of the skin and improves the product texture

More about Sorbitol
Trisodium ethylenediamine disuccinate~0.25–0.45%
Irritant · medium
Irritation risk
Medium

Used to improve stability of the formulation

More about Trisodium ethylenediamine disuccinate
Sorbic acid~0.25–0.45%
Irritant · medium
Irritation risk
Medium

A preservative

More about Sorbic acid
Erythritol~0.2–0.4%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps to attract water to the upper layer of the skin

More about Erythritol
Carrageenan~0.25–0.45%
Comedogenic 3/5Irritant · medium
Irritation risk
Medium
Comedogenicity
3/5

Helps thicken the product formula and create a nice product formulation

More about Carrageenan
Carbomer~0.25–0.4%
Formula
Irritation risk
Low
Works for
Cleansing

Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations

More about Carbomer
Hydroxypropyl cyclodextrin~0.25–0.5%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Used to stabilize product formulations and help soften the upper layer of the skin

More about Hydroxypropyl cyclodextrin
Sodium benzoate~0.2–0.4%
Formula
Irritation risk
Low

A preservative

More about Sodium benzoate
Xanthan gum~0.25–0.4%
Formula
Irritation risk
Low
Works for
Cleansing

Used to create a thicker product consistency

More about Xanthan gum
Polysorbate 20~0.25–0.5%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about Polysorbate 20
Caprylyl glycol~0.25–0.5%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol
Potassium sorbate~0.25–0.4%
Irritant · medium
Irritation risk
Medium

A preservative

More about Potassium sorbate
Tetrasodium glutamate diacetate~0.2–0.4%
Formula
Irritation risk
Low

Helps stabilize the product formulation

More about Tetrasodium glutamate diacetate
Magnesium chloride~0.2–0.4%
Formula
Irritation risk
Low

Helps thicken the product formulation

More about Magnesium chloride
Palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine~0.2–0.4%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging
More about Palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine
Palmitoyl tripeptide-5~0.2–0.35%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tripeptide-5
Tetradecyl aminobutyroylvalylaminobutyric urea acetate
Not recognized
Acetyl hexapeptide-8~0.2–0.35%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Acetyl hexapeptide-8
Tetrapeptide-1~0.15–0.3%
Formula
Irritation risk
Low
More about Tetrapeptide-1
Tocopherol~0.15–0.25%
Under-dosed
Irritation risk
Low
Works for
Anti-oxidationAnti-agingAnti-inflammatoryMoisturizing

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol
Palmitoyl tripeptide-38~0.1–0.2%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tripeptide-38
Palmitoyl tripeptide-1~0.15–0.3%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tripeptide-1
Palmitoyl tetrapeptide-7~0.1–0.25%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tetrapeptide-7
Hexapeptide-9~0.05–0.15%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Hexapeptide-9
Ingredient list view

Water, Glycerin, Arginine, Ectoin, Sodium polyacryloyldimethyl taurate, Levulinic acid, Butylene glycol, Sodium pca, Diglycerin, Urea, Microcrystalline cellulose, Carnosine, Benzoic acid, Punica granatum extract, Allantoin, Hydrolyzed rice protein, Lactic acid, Lysine, Pca, Sorbitol, Trisodium ethylenediamine disuccinate, Sorbic acid, Erythritol, Carrageenan, Carbomer, Hydroxypropyl cyclodextrin, Sodium benzoate, Xanthan gum, Polysorbate 20, Caprylyl glycol, Potassium sorbate, Tetrasodium glutamate diacetate, Magnesium chloride, Palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine, Palmitoyl tripeptide-5, Unknown, Acetyl hexapeptide-8, Tetrapeptide-1, Tocopherol, Palmitoyl tripeptide-38, Palmitoyl tripeptide-1, Palmitoyl tetrapeptide-7, Hexapeptide-9

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Amazon USPrice as of 11/13 12:22 GMT
$28.99
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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
DermaticaDaily Firming Multi-Peptide SerumYOUR PRODUCTMedik8Liquid PeptidesBlissPro Youth SerumThe OrdinaryBuffet + Copper Peptides 1%
Match—49%47%47%
Price$28.99$68.00+$39.01—$28.90
Shared key ingredients—7 of 208 of 209 of 20
Key difference—Copper Palmitoyl Heptapeptide-14PanthenolCopper Tripeptide-1
Irritancy Medium Low Medium Medium
Drying alcohol————
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Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 14 studies and safety reviews.

  1. 1
    Glycerol and the skin: holistic approach to its origin and functionsncbi.nlm.nih.gov
  2. 2
    Topical urea in skincare: A reviewpubmed.ncbi.nlm.nih.gov
  3. 3
    Biological activities of the natural imidazole-containing peptidomimetics n-acetylcarnosine, carcinine and l-carnosine in ophthalmic and skin care productssciencedirect.com
  4. 4
    Extract of Punica granatum inhibits skin photoaging induced by UVB irradiationncbi.nlm.nih.gov
  5. 5
    Topical microemulsion containing Punica granatum extract: its control over skin erythema and melanin in healthy Asian subjectsncbi.nlm.nih.gov
  6. 6
    Safety Assessment of Punica granatum -Derived Ingredients as Used in Cosmeticscir-safety.org
Dermatica Daily Firming Multi-Peptide Serum
DermaticaDaily Firming Multi-Peptide Serum
Buy on Amazon$28.99 · as of 11/13 12:22 GMT

Affiliate links · As an Amazon Associate, WIMJ earns from qualifying purchases.

Buy on Amazon$28.99 · as of 11/13 12:22 GMT

As an Amazon Associate, WIMJ earns from qualifying purchases.