Works for:
based on ingredients and %- Anti-blemish
- Anti-oxidation
- Exfoliation
- Anti-aging
Can it cause trouble?
- Irritation risk: high
- Comedogenic risk ingredients: 2
Key actives
Product Summary
"Perricone MD - Acne Relief Prebiotic Acne Therapy" is effective for: Anti-inflammatory, Exfoliation, Anti-blemish, Anti-aging and Evens skin tone
This product could be helpful for: Moisturizing, but its actives are not the most effective or are not well-studied.
Ingredient callouts
- this product contains an effective form of Retinoids (vitamin A): retinol 0.15% - 0.65%. Retinoids are potent multitasking actives. They work to improve and prevent early signs of aging, reduce hyperpigmentation (age spots and post-acne marks), and prevent inflamed blemishes and clogged pores. The downside of Retinoids is that they can be irritating. If you are not already using a Retinoid in your routine, it is best to start slowly and apply the Retinoid product only a few times per week. If your skin tolerates it well, you can gradually increase the frequency to daily.
- Humectants (arginine 0.10% - 0.45%, citrulline 0.10% - 0.50%, glycerin 0.15% - 0.60%, citrulline 0.15% - 0.55%, glycerin 0.30% - 0.70%, sucrose 2.40% - 3.60% and glycerin 22.00% - 34.00%). These ingredients help attract water to the upper layer of the skin and improve the skin hydration.
About the brand
According to Cruelty-Free Kitty "Perricone MD" is cruelty free and so is its parent company.
Price
The product retails for 89.00$ in the United States.
For a detailed price comparison: click here.
Anti-aging
This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains retinol.
Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
An exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)
Anti-blemish
What does the product description say?
Acne Relief Prebiotic Acne Therapy
Source: From product name
This product can help reduce breakouts and clogged pores because it contains the following ingredient: retinol, salicylic acid. These ingredients is used for treating acne and can have a noticeable effect.
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
Used for skin exfoliation. It has an anti-inflammatory and anti-bacterial effect, helps to unclog pores, prevent blemishes and speed up healing of the existing ones. Sometimes referred to as a BHA (beta-hydroxy acid)
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
Anti-oxidation
This product contains antioxidants (retinol) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
A more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.
Evens skin tone
This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: retinol.
In addition, this product contains salicylic acid. This ingredient (ingredients) might help reduce hyperpigmentation, but the effect, if any, is likely to be small.
Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
Used for skin exfoliation. It has an anti-inflammatory and anti-bacterial effect, helps to unclog pores, prevent blemishes and speed up healing of the existing ones. Sometimes referred to as a BHA (beta-hydroxy acid)
An exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
Exfoliation
This product can help exfoliate the skin. In other words, it helps break down the bonds between dead cells on the surface of the skin and speed up the skin turnover. Skin often appears softer and brighter after exfoliation, but overdoing it can result in disrupted skin barrier. The following ingredient is doing the exfoliating job in this product: retinol, salicylic acid.
Used for skin exfoliation. It has an anti-inflammatory and anti-bacterial effect, helps to unclog pores, prevent blemishes and speed up healing of the existing ones. Sometimes referred to as a BHA (beta-hydroxy acid)
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
An exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)
Moisturizing
This product can help improve hydration of the skin with the two types of ingredients.
The first type is called “humectants”:
these ingredients help attract water.
When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from
within deeper layers of the skin. The following ingredients in this product do the job:
arginine, citrulline.
This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: arginine, dimethicone.
Can help attract water to the upper layer of the skin. In crystal form, it can work as a gentle exfoliant, gentler than the salt scrub. Helps stabilize the emulsion
An amino acid that is naturally present in skin and helps keep it hydrated. When used together with AHAs, it can reduce their irritating effect on the skin
A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
An amino-acid that helps attract water to the upper layer of the skin
An oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.
An emollient that helps soften the skin and create a nice product texture
Helps attract water to the upper layer of the skin and soften it
A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture
Helps soften the upper layer of the skin, dissolve other ingredients and create a thicker product consistency
Helps preserve products and creates a nice product texture
An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together
Helps soften the upper layer of the skin while creating a non-greasy feel on the skin. Helps to dissolve other ingredients
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
An exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)
How honest is this product?
| Promise | Can it deliver? |
|---|---|
| Anti-blemish |
Total Promises Fulfilled score: 100/100.
We receive a small commission for purchases made through these links at no cost for you. Thank you for your support! Learn more
Potential irritants
Comedogenic ingredients
User reviews (0)
Averages from community submissions.
No reviews yet for this product.
Be the first to share your experience!
Tried this product?
Help capture what the ingredient list can't—texture, finish, pilling, scent, and more. Answer what you can, skip the rest.
Takes ~30 seconds.
Reviews are shown in aggregate. No personal details.
| Product | Similarity | Price | Irritancy |
|---|---|---|---|
 Perricone MD Acne Relief Prebiotic Acne Therapy | Current | $89.00 | |
Remedy for pore size | 83% | $32.00 | |
 innisfree Gentle Retinol Salicylic Anti-Blemish Sérum Anti-Imperfections Doux | 80% | $37.00 | |
 Honest Beauty Clearing Night Serum With Honestly Pure Retinol | 78% | - | |
InstaNatural Age Defying & Skin Clearing Serum & Hyaluronic Oil Free Moisturizer Duo | 78% | - | |
 Eva Naturals Vitamin C Plus Skin Clearing Serum | 78% | $16.99 |
Key Actives
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
Used for skin exfoliation. It has an anti-inflammatory and anti-bacterial effect, helps to unclog pores, prevent blemishes and speed up healing of the existing ones. Sometimes referred to as a BHA (beta-hydroxy acid)
A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
Can help attract water to the upper layer of the skin. In crystal form, it can work as a gentle exfoliant, gentler than the salt scrub. Helps stabilize the emulsion
An oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
An amino-acid that helps attract water to the upper layer of the skin
An oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
An amino-acid that helps attract water to the upper layer of the skin
An amino acid that is naturally present in skin and helps keep it hydrated. When used together with AHAs, it can reduce their irritating effect on the skin
Potential irritants
Can be drying and contribute to skin irritation. Used in formulars to dissolve other ingredients, create a thinner product consistency or for its antibacterial properties
Used for skin exfoliation. It has an anti-inflammatory and anti-bacterial effect, helps to unclog pores, prevent blemishes and speed up healing of the existing ones. Sometimes referred to as a BHA (beta-hydroxy acid)
Can be drying and contribute to skin irritation. Used in formulars to dissolve other ingredients, create a thinner product consistency or for its antibacterial properties
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
Helps water and oil mix together. Can be used as a cleansing agent
Used to improve product texture and help oil and water mix together
Helps evenly disperse other ingredients in a formulation and create an even layer on the surface of the skin
An exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)
Used to improve product texture and help oil and water mix together
A more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.
Can work as an exfoliant but is typically used to adjust the product pH
Comedogenic ingredients
An emollient that helps soften the skin and create a nice product texture
A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture
All ingredients
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
Helps water and oil mix together. Can be used as a cleansing agent
An emollient that helps soften the skin and create a nice product texture
Can help attract water to the upper layer of the skin. In crystal form, it can work as a gentle exfoliant, gentler than the salt scrub. Helps stabilize the emulsion
An oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.
Used to improve product texture and help oil and water mix together
Helps soften the upper layer of the skin, dissolve other ingredients and create a thicker product consistency
A preservative. It helps prevent bacterial growth in cosmetic products
Can be drying and contribute to skin irritation. Used in formulars to dissolve other ingredients, create a thinner product consistency or for its antibacterial properties
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
Helps evenly disperse other ingredients in a formulation and create an even layer on the surface of the skin
A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish
An amino-acid that helps attract water to the upper layer of the skin
An oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.
An exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)
Used to improve product texture and help oil and water mix together
Used to stabilize product formulations and create a nice product texture
Helps soften the upper layer of the skin, dissolve other ingredients and create a thicker product consistency
A preservative. It helps prevent bacterial growth in cosmetic products
Used for skin exfoliation. It has an anti-inflammatory and anti-bacterial effect, helps to unclog pores, prevent blemishes and speed up healing of the existing ones. Sometimes referred to as a BHA (beta-hydroxy acid)
Can be drying and contribute to skin irritation. Used in formulars to dissolve other ingredients, create a thinner product consistency or for its antibacterial properties
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
Helps soften the upper layer of the skin while creating a non-greasy feel on the skin. Helps to dissolve other ingredients
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
An amino-acid that helps attract water to the upper layer of the skin
An amino acid that is naturally present in skin and helps keep it hydrated. When used together with AHAs, it can reduce their irritating effect on the skin
Helps attract water to the upper layer of the skin and soften it
A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture
Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations
A more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
Can work as an exfoliant but is typically used to adjust the product pH
Helps oil and water mix togehter and creates a nice product texture
An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together
A preservative. It helps prevent bacterial growth in cosmetic products
Ingredient list view
Glycerin, Sodium cocoyl isethionate, Ethylhexyl palmitate, Silica cetyl silylate, Sucrose, Squalane, Polyacrylamide, Water, Caprylyl glycol, C13-14 isoparaffin, Laureth-7, Phenoxyethanol, Water, Sd alcohol 40-b, Glycerin, C12-15 alkyl lactate, Pvp, Dimethicone, Polysorbate 20, Citrulline, Squalane, Lactic acid, Succinic acid, Polyacrylamide, Dimethicone/vinyl dimethicone crosspolymer, C13-14 isoparaffin, Laureth-7, Phenoxyethanol, Sodium benzoate, Potassium sorbate, Salicylic acid, Water, Sd alcohol 40-b, Glycerin, Dicaprylyl ether, Niacinamide, Citrulline, Arginine, Methyl gluceth-20, Cetearyl alcohol, Carbomer, Xanthan gum, Tocopheryl acetate, Retinol, Citric acid, Sodium hydroxide, Disodium edta, Peg-20 methyl glucose sesquistearate, Peg-100 stearate, Glyceryl stearate, Methyl glucose sesquistearate, Polysorbate 20, Phenoxyethanol, Sodium benzoate, Potassium sorbate
- Glycerol and the skin: holistic approach to its origin and functions
- Final Report on the Safety Assessment of Sodium Cocoyl Isethionate
- Safety Assessment of Isoparaffins as Used in Cosmetics
- Dimethicone as a protective ingredient in topical medications
- Final Report on the Safety Assessment of Dimethicone Copolyol
- Dermatologic compositions comprising pyrrolidone-5-carboxylic acid and at least one entity chosen from citrulline, arginine and asparagine, and uses thereof in the treatment of atopic dermatitis
- Epidermal and dermal effects of topical lactic acid
- Dual Effects of Alpha-Hydroxy Acids on the Skin
- Salicylic acid as a peeling agent: a comprehensive review
- Beta Hydroxy Acids
- A review of toxicity from topical salicylic acid preparations
- Glycolic Acid Peels Versus Salicylic–Mandelic Acid Peels in Active Acne Vulgaris and Post‐Acne Scarring and Hyperpigmentation: A Comparative Study
- Niacinamide - mechanisms of action and its topical use in dermatology
- Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology, 3(2), 88–93. doi:10.1111/j.1473-2130.2004.00115.x
- Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety
- Improvement of naturally aged skin with vitamin A (retinol)
- A comparative study of the effects of retinol and retinoic acid on histological, molecular, and clinical properties of human skin