Works for
2 of 2 advertised claims delivered
Anti-agingAdenosine, Niacinamide + 5 moreStrong evidence
“This cream offers excellent protection and care for the skin barrier, while also being effective against wrinkles.”
This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains adenosine, niacinamide.
These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: sh-oligopeptide-1, sh-oligopeptide-2, sh-polypeptide-1, sh-polypeptide-11, sh-polypeptide-9.
Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.
MoisturizingNiacinamide, Panthenol + 18 moreStrong evidence
“Response synergy barrier cream”
This product can help improve hydration of the skin with the two types of ingredients.
The first type is called “humectants”:
these ingredients help attract water.
When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from
within deeper layers of the skin. The following ingredients in this product do the job:
betaine, glycerin.
This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: caprylic/capric triglyceride, dimethicone.
The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: niacinamide, panthenol, sh-oligopeptide-1, sh-oligopeptide-2, sh-polypeptide-1, sh-polypeptide-11, sh-polypeptide-9
Evens skin toneNot advertised by the brand · NiacinamideStrong evidence
This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: niacinamide
Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.
Anti-blemishNot advertised by the brand · NiacinamideStrong evidence
This product can help reduce breakouts and clogged pores because it contains the following ingredient: niacinamide. This ingredient is used for treating acne and can have a noticeable effect.
Can it cause trouble?
Irritancy6 flagged ingredientsLow risk
Comedogenic2 ingredients rated 2 or more on the 0–5 pore-clogging scale2 flagged
User reviews
Be the first — your take helps the next person decide.
Ingredients
Filter by role to see what each ingredient is doing.
Water~45–55%
Panthenol~5.6–6.8%
- Irritation risk
- Low
Helps attract water to the upper layer of the skin and can help improve skin barrier function
More about PanthenolGlycerin~4–4.9%
- Irritation risk
- Low
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
More about GlycerinCaprylic/capric triglyceride~3.2–3.9%
- Irritation risk
- Medium
A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin
More about Caprylic/capric triglycerideEthylhexyl palmitate~2.4–3%
- Irritation risk
- Low
- Comedogenicity
- 3/5
An emollient that helps soften the skin and create a nice product texture
More about Ethylhexyl palmitatePolyglyceryl-3 methylglucose distearate~2–2.4%
- Irritation risk
- Medium
Helps water and oil mix together
More about Polyglyceryl-3 methylglucose distearate1,2-hexanediol~0.8–1.2%
Niacinamide~1.5–1.8%
- Irritation risk
- Low
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
More about NiacinamideCetearyl alcohol~1.3–1.6%
- Irritation risk
- Low
- Comedogenicity
- 2/5
A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture
More about Cetearyl alcoholDimethicone~1.1–1.3%
- Irritation risk
- Low
A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish
More about DimethiconeCetearyl olivate~0.75–1.1%
Sorbitan olivate~0.65–0.95%
Glyceryl stearate~0.65–0.95%
- Irritation risk
- Low
An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together
More about Glyceryl stearateTromethamine~0.55–0.8%
Carbomer~0.5–0.8%
- Irritation risk
- Low
Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations
More about CarbomerBetaine~0.5–0.75%
- Irritation risk
- Low
Helps attract water to the upper layer of the skin and improves the product texture
More about BetaineAdenosine~0.5–0.7%
- Irritation risk
- Low
Might help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)
More about AdenosineDisodium edta~0.45–0.7%
Butylene glycol~0.4–0.65%
- Irritation risk
- Low
Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin
More about Butylene glycolLecithin~0.45–0.65%
- Irritation risk
- Low
Used mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin
More about LecithinAcetyl glutamine~0.3–0.6%
- Irritation risk
- Low
Lactococcus ferment extract~0.3–0.55%
- Irritation risk
- Low
Bifida ferment extract~0.25–0.5%
- Irritation risk
- Low
Lactobacillus ferment lysate~0.25–0.5%
- Irritation risk
- Low
A "broth" with parts of dead cells of lactobacteria. Might be helpful supporting diverse microbiome in skin, but evidence is lacking
More about Lactobacillus ferment lysateSodium hyaluronate~0.25–0.45%
- Irritation risk
- Low
One of the best moisturizing ingredients. Attracts water into the upper layer of the skin
More about Sodium hyaluronateCaprylyl glycol~0.25–0.5%
- Irritation risk
- Medium
Helps preserve products and creates a nice product texture
More about Caprylyl glycolSh-oligopeptide-1~0.2–0.4%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Sh-oligopeptide-1Sh-polypeptide-1~0.2–0.35%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Sh-polypeptide-1Sh-oligopeptide-2~0.15–0.3%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Sh-oligopeptide-2Sh-polypeptide-11~0.15–0.25%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Sh-polypeptide-11Sh-polypeptide-9~0.1–0.2%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Sh-polypeptide-9Bacillus/folic acid/soybean ferment extract~0.1–0.15%
- Irritation risk
- Low
Ethylhexylglycerin~0.05–0.15%
Ingredient list view
Water, Panthenol, Glycerin, Caprylic/capric triglyceride, Ethylhexyl palmitate, Polyglyceryl-3 methylglucose distearate, 1,2-hexanediol, Niacinamide, Cetearyl alcohol, Dimethicone, Cetearyl olivate, Sorbitan olivate, Glyceryl stearate, Tromethamine, Carbomer, Betaine, Adenosine, Disodium edta, Butylene glycol, Lecithin, Acetyl glutamine, Lactococcus ferment extract, Bifida ferment extract, Lactobacillus ferment lysate, Sodium hyaluronate, Caprylyl glycol, Sh-oligopeptide-1, Sh-polypeptide-1, Sh-oligopeptide-2, Sh-polypeptide-11, Sh-polypeptide-9, Bacillus/folic acid/soybean ferment extract, Ethylhexylglycerin
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Worth comparing, line by line.
Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.
| OrjenaResponse synergy barrier creamYOUR PRODUCT | Saturday SkinCarrot + Niacinamide Moisturizing Cream | LABIOTTEAesthe RX Collagen Cream | APLBPremium Mens Homme Moisture Cream | |
|---|---|---|---|---|
| Match | — | 76% | 76% | 75% |
| Price | $25.00 | $29.99+$4.99 | $59.99+$34.99 | $24.00−$1.00 |
| Shared key ingredients | — | 9 of 13 | 10 of 13 | 9 of 13 |
| Key difference | — | Sh-Polypeptide-8 | Hexapeptide-2 | Copper Tripeptide-1 |
| Irritancy | Low | Medium | High | High |
| Drying alcohol | — | — | Contains drying alcohol | — |
| View product | Shop | Shop | Shop |
Product summary
Based on the ingredient list, "Orjena - Response synergy barrier cream" can work well for skin moisturization. This moisturizer uses a good combo of humectants and emollients. These both types of ingredients are essentials for improving the skin hydration and keeping the skin barrier healthy. Panthenol, betaine, glycerin, sodium hyaluronate and butylene glycol in this product (humectants) attract water molecules to the upper layer of the skin (the water comes from the outside air or from the deeper layers of the skin if the air is dry). Caprylic/capric triglyceride, dimethicone, cetearyl alcohol, ethylhexyl palmitate and caprylyl glycol in this product help decrease the water evoporation from the skin, so that it stays hydrated for longer. These ingredients also soften the skin and take away the feeling of tightness and dryness.
Ingredient callouts
- We like that this moisturizer contains peptides (sh-polypeptide-9 0.10% - 0.20%, sh-polypeptide-11 0.15% - 0.25%, sh-oligopeptide-2 0.15% - 0.30%, sh-polypeptide-1 0.20% - 0.35% and sh-oligopeptide-1 0.20% - 0.40%). There are many different kind of Peptides and they are naturally present in our skin. They all are a combination of aminoacids. Some of them work as natural antibiotics, promote wound-healing and production of collagen. The science is still not settled on how effective Peptides are in skincare, but it is very likely that they have a benefit. Peptides might help restore the skin barrier and fight the signs of aging. At the very least, Peptides work as humectants: they attract water to the upper layer of the skin and improve its hydration.
- Adenosine 0.50% - 0.70%. It is a compound that in involved in many biological processes inside the skin cells. According one high-quality clinical trial, topical Adenosine in low concentrations can somewhat help improve "deep wrinkles" - the wrinkles that appear with age in places where our faces are most dynamic (for example, on the forehead or in the corners of the eyes).
- Panthenol (pro-vitamin B5) at about 5.60% - 6.80% concentration. In this concentration, Panthenol works effectively to improve the skin barrier and reduce inflammation.
Irritation risk
This product does not contain known common irritants and is suitable for sensitive skin. We assess the overall irritancy of this moisturizer to be low. For a detailed overview of all potential irritants: click here
You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.
Sources cited in this review
Every concentration estimate and effectiveness label is anchored to one of these 12 studies and safety reviews.
- 1Skin moisturizing effects of panthenol-based formulationspdfs.semanticscholar.org
- 2
- 3
- 4
- 5
- 6
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