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Obagi RETINOL + PHA
Obagi

Obagi RETINOL + PHA

Efficacy95/100IrritancyMedium
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Works for

5 of 5 advertised claims delivered

Anti-aging
Retinol, Gluconolactone + 1 more
Strong evidence
What the product description says
“Retinol + PHA Refining Night Cream works overnight to help refine skin texture and tone while reducing the appearance of blemishes, fine lines, and wrinkles for a visibly resurfaced, smoother, clearer, and more even-looking complexion in just 4 weeks*.”
Source: Obagi Medical

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains retinol, gluconolactone.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

GluconolactoneKey activeEffect: HighA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals~4.2–5.2%
RetinolHeroEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~0.5–0.75%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.4–0.6%
Exfoliation
Gluconolactone, Retinol
Strong evidence
What the product description says
“Formulated with Entrapped Retinol powered by slow-release technology for optimized delivery into deeper layers of the skin to encourage skin cell turnover, and Polyhydroxy Acid (Gluconolactone) to provide gentle yet effective exfoliation on the surface of the skin, plus eight nourishing ingredients to keep skin hydrated, this overnight cream has the unique ability to help renew and enhance the appearance of your complexion.”
Source: Obagi Medical

This product can help exfoliate the skin. In other words, it helps break down the bonds between dead cells on the surface of the skin and speed up the skin turnover. Skin often appears softer and brighter after exfoliation, but overdoing it can result in disrupted skin barrier. The following ingredient is doing the exfoliating job in this product: gluconolactone, retinol.

GluconolactoneKey activeEffect: HighA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals~4.2–5.2%
RetinolKey activeEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~0.5–0.75%
Evens skin tone
Retinol, Gluconolactone
Strong evidence
What the product description says
“Visibly improve skin tone evenness by 10%.*”
Source: Obagi Medical

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: retinol.

In addition, this product contains gluconolactone. This ingredient (ingredients) might help reduce hyperpigmentation, but the effect, if any, is likely to be small.

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

GluconolactoneKey activeEffect: HighA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals~4.2–5.2%
RetinolHeroEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~0.5–0.75%
Anti-blemish
Retinol, Gluconolactone
Strong evidence
What the product description says
“Retinol + PHA Refining Night Cream works overnight to help refine skin texture and tone while reducing the appearance of blemishes, fine lines, and wrinkles for a visibly resurfaced, smoother, clearer, and more even-looking complexion in just 4 weeks*.”
Source: Obagi Medical

This product can help reduce breakouts and clogged pores because it contains the following ingredient: retinol. This ingredient is used for treating acne and can have a noticeable effect.

The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually works: gluconolactone

RetinolHeroEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~0.5–0.75%
GluconolactoneKey activeEffect: MediumA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals~4.2–5.2%
Moisturizing
Helianthus annuus seed oil, Jojoba esters + 11 more
Good evidence
What the product description says
“Formulated with Entrapped Retinol powered by slow-release technology for optimized delivery into deeper layers of the skin to encourage skin cell turnover, and Polyhydroxy Acid (Gluconolactone) to provide gentle yet effective exfoliation on the surface of the skin, plus eight nourishing ingredients to keep skin hydrated, this overnight cream has the unique ability to help renew and enhance the appearance of your complexion.”
Source: Obagi Medical

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: glycerin, sodium hyaluronate.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: caprylic/capric triglyceride, dimethicone.

Helianthus annuus seed oilKey active· Emollient, OcclusiveEffect: HighA great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function~2.1–2.6%
Jojoba estersKey active· EmollientEffect: HighAn emollient made of jojoba oil. Helps soften the skin and support its barrier function~0.5–0.7%
Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~0.45–0.7%
SqualaneKey active· Emollient, OcclusiveEffect: HighAn oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.~0.3–0.55%
GluconolactoneKey activeEffect: HighA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals~4.2–5.2%
Caprylic/capric triglycerideKey active· Emollient, OcclusiveEffect: HighA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin~6.6–8%
DimethiconeKey active· Emollient, OcclusiveEffect: HighA silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish~1–1.3%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~3.2–3.9%
Cetearyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture~2.4–3%
Cetyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together~1.7–2.1%
Cetyl estersKey active· EmollientEffect: MediumHelps soften upper layer of the skin and can enhance penetration of other ingredients into the upper layer of the skin~1.5–1.8%
Butyrospermum parkii butter extractUnder-dosedEffect: HighA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals~0.65–0.95%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.4–0.6%
Anti-oxidation
Not advertised by the brand · Retinol, Gluconolactone + 1 more
Strong evidence

This product contains antioxidants (retinol) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

The following ingredients - gluconolactone also can have an antioxidant effect, but there is less evidence to confirm their effectiveness in skin.

RetinolKey activeEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~0.5–0.75%
GluconolactoneKey activeEffect: MediumA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals~4.2–5.2%
TocopherolUnder-dosedEffect: HighPure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.4–0.6%

Can it cause trouble?

Irritancy
1 strong irritant: Retinol
Medium risk
We flagged 10 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
RetinolTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritatingHigh~0.5–0.75%est.
Caprylic/capric triglycerideA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerinMedium~6.6–8%est.
GluconolactoneA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicalsMedium~4.2–5.2%est.
Cetearyl glucosideHelps water and oil in the product mix well together and improves product textureMedium~0.45–0.7%est.
Jojoba estersAn emollient made of jojoba oil. Helps soften the skin and support its barrier functionMedium~0.5–0.7%est.
Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymerA gelling agent that thickens the product consistency and leaves the skin with a velvety finishMedium~0.35–0.6%est.
EthylhexylglycerinA preservativeMedium~0.25–0.45%est.
Allyl methacrylates crosspolymerUsed to stabilize product formulationsMedium~0.2–0.4%est.
Polysorbate 60Helps oil and water mix togetherMedium~0.15–0.25%est.
Citric acidCan work as an exfoliant but is typically used to adjust the product pHMedium~0.05–0.1%est.
Comedogenic
2 ingredients rated 2 or more on the 0–5 pore-clogging scale
2 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Butyrospermum parkii butter extractA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals3/5~0.65–0.95%est.
Cetearyl alcoholA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture2/5~2.4–3%est.
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Alternatives
Cheaper, or higher on efficacy
Retinol Complex Cream
Naturium Retinol Complex Cream
CheaperHigher efficacy · 100/10080% match
$15.99
Wonder Effect Advanced Retinol Day Cream
Elizabeth Grant Wonder Effect Advanced Retinol Day Cream
CheaperHigher efficacy · 100/10080% match
$52.00
View all alternatives

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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%
Formula
Irritation risk
Low

Plain old water

More about Water
Caprylic/capric triglyceride~6.6–8%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin

More about Caprylic/capric triglyceride
Gluconolactone~4.2–5.2%
Key activeIrritant · medium
Irritation risk
Medium
Works for
MoisturizingAnti-agingExfoliationEvens skin toneAnti-oxidationAnti-blemish

A polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals

More about Gluconolactone
Glycerin~3.2–3.9%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Cetearyl alcohol~2.4–3%
Key activeComedogenic 2/5
Irritation risk
Low
Comedogenicity
2/5
Works for
CleansingMoisturizing

A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture

More about Cetearyl alcohol
Helianthus annuus seed oil~2.1–2.6%
Key active
Irritation risk
Low
Works for
Moisturizing

A great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function

More about Helianthus annuus seed oil
Cetyl alcohol~1.7–2.1%
Key active
Irritation risk
Low
Works for
CleansingMoisturizing

A non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together

More about Cetyl alcohol
Cetyl esters~1.5–1.8%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps soften upper layer of the skin and can enhance penetration of other ingredients into the upper layer of the skin

More about Cetyl esters
Sodium hydroxide~1.2–1.5%
Formula
Irritation risk
Low

Used to adjust the product's pH

More about Sodium hydroxide
Dimethicone~1–1.3%
Key active
Irritation risk
Low
Works for
MoisturizingMattifying

A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish

More about Dimethicone
Hydrogenated lecithin~0.7–1.05%
Formula
Irritation risk
Low
Works for
Cleansing

Helps to retain moisture by creating a protective barrier on the skin. Rich in fatty acids. Improves product texture and helps with the penetration of other ingredients.

More about Hydrogenated lecithin
Butyrospermum parkii butter extract~0.65–0.95%
Under-dosedComedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
Moisturizing

A great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals

More about Butyrospermum parkii butter extract
Retinol~0.5–0.75%
Hero · Anti-aging, Evens skin tone, Anti-blemishIrritant · high
Irritation risk
High
Works for
MattifyingAnti-agingAnti-oxidationExfoliationAnti-blemishEvens skin tone

Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating

More about Retinol
Sodium hyaluronate~0.45–0.7%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate
Cetearyl glucoside~0.45–0.7%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps water and oil in the product mix well together and improves product texture

More about Cetearyl glucoside
Jojoba esters~0.5–0.7%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

An emollient made of jojoba oil. Helps soften the skin and support its barrier function

More about Jojoba esters
Tocopherol~0.4–0.6%
Under-dosed
Irritation risk
Low
Works for
Anti-oxidationMoisturizingAnti-inflammatoryAnti-aging

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol
Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer~0.35–0.6%
Irritant · medium
Irritation risk
Medium

A gelling agent that thickens the product consistency and leaves the skin with a velvety finish

More about Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer
Polysorbate 20~0.3–0.6%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about Polysorbate 20
Ethylhexylglycerin~0.25–0.45%
Irritant · medium
Irritation risk
Medium

A preservative

More about Ethylhexylglycerin
Squalane~0.3–0.55%
Key active
Irritation risk
Low
Works for
Moisturizing

An oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.

More about Squalane
Carbomer~0.2–0.4%
Formula
Irritation risk
Low
Works for
Cleansing

Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations

More about Carbomer
Allyl methacrylates crosspolymer~0.2–0.4%
Irritant · medium
Irritation risk
Medium

Used to stabilize product formulations

More about Allyl methacrylates crosspolymer
Xanthan gum~0.2–0.35%
Formula
Irritation risk
Low
Works for
Cleansing

Used to create a thicker product consistency

More about Xanthan gum
Phenoxyethanol~0.15–0.3%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Tetrasodium glutamate diacetate~0.15–0.25%
Formula
Irritation risk
Low

Helps stabilize the product formulation

More about Tetrasodium glutamate diacetate
Polysorbate 60~0.15–0.25%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps oil and water mix together

More about Polysorbate 60
Sorbitan isostearate~0.1–0.2%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about Sorbitan isostearate
Citric acid~0.05–0.1%
Irritant · medium
Irritation risk
Medium

Can work as an exfoliant but is typically used to adjust the product pH

More about Citric acid
Ingredient list view

Water, Caprylic/capric triglyceride, Gluconolactone, Glycerin, Cetearyl alcohol, Helianthus annuus seed oil, Cetyl alcohol, Cetyl esters, Sodium hydroxide, Dimethicone, Hydrogenated lecithin, Butyrospermum parkii butter extract, Retinol, Sodium hyaluronate, Cetearyl glucoside, Jojoba esters, Tocopherol, Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, Polysorbate 20, Ethylhexylglycerin, Squalane, Carbomer, Allyl methacrylates crosspolymer, Xanthan gum, Phenoxyethanol, Tetrasodium glutamate diacetate, Polysorbate 60, Sorbitan isostearate, Citric acid

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Amazon USPrice as of 10/29/2026 09:15 GMT
$135.00
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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
ObagiRETINOL + PHAYOUR PRODUCTBiopelleEmepelle Night CreamNaturiumRetinol Complex CreamElizabeth GrantWonder Effect Advanced Retinol Day Cream
Match—82%80%80%
Price$135.00—$15.99−$119.01$52.00−$83.00
Shared key ingredients—4 of 118 of 116 of 11
Key difference—NiacinamideBakuchiolPalmitoyl Tetrapeptide-7
Irritancy Medium Low Medium Medium
Drying alcohol————
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Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 28 studies and safety reviews.

  1. 1
    A comparative study of gluconolactone versus benzoyl peroxide in the treatment of acnencbi.nlm.nih.gov
  2. 2
    The Polyhydroxy Acid Gluconolactone Protects Against Ultraviolet Radiation in an In Vitro Model of Cutaneous Photoagingonlinelibrary.wiley.com
  3. 3
    Applications of hydroxy acids: classification, mechanisms, and photoactivityncbi.nlm.nih.gov
  4. 4
    The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative studydovepress.com
  5. 5
    A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimenncbi.nlm.nih.gov
  6. 6
    The use of polyhydroxy acids (PHAs) in photoaged skin
Obagi RETINOL + PHA
ObagiRETINOL + PHA
Buy on Amazon$135.00 · as of 10/29 09:15 GMT

Affiliate links · As an Amazon Associate, WIMJ earns from qualifying purchases.

Buy on Amazon$135.00 · as of 10/29 09:15 GMT

As an Amazon Associate, WIMJ earns from qualifying purchases.