Dr. Denese

Dr. Denese Triple Strength Neck Wrinkle Smoother

Name: Dr. Denese - Triple Strength Neck Wrinkle Smoother
Brand: Dr. Denese

Efficacy100/100IrritancyHigh

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Works for

1 of 1 advertised claim delivered

Anti-aging

Retinol, Palmitoyl oligopeptide + 11 more

Strong evidence

What the product description says

“Triple Strength Neck Wrinkle Smoother”

From product name

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains retinol.

These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: palmitoyl oligopeptide, palmitoyl pentapeptide-4, palmitoyl tetrapeptide-7.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

RetinolHeroEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~0.35–0.6%

Palmitoyl oligopeptideKey activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.7–1.05%

Palmitoyl tetrapeptide-7Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.45–0.7%

Palmitoyl pentapeptide-4Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.35–0.65%

Butyrospermum parkii butterEffect: LowA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals~5.7–7%

Glucosamine hclEffect: LowMight be able to stimulate production of skin's natural moisturizing compounds such as hyaluronic acid. Could be helpful for evening the skin tone.~0.35–0.65%

Algae extractEffect: LowPlant extract that helps the skin to attract water and make it more smooth for touch. Also shows promise of anti-aging properties, but research is not extensive yet~0.3–0.6%

Prunus amygdalus dulcis oilEffect: LowAn emollient that softens the skin~3.2–4%

Retinyl palmitateUnder-dosedEffect: MediumThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect~0.2–0.4%

NiacinUnder-dosedEffect: MediumA form of vitamin B3. It is similar in action to niacinamide, but is more likely to cause red flashes in skin as the side effect~0.25–0.45%

Centella asiatica extractUnder-dosedEffect: MediumA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.~0.3–0.55%

TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.25–0.45%

Ascorbyl palmitateEffect: Low, below effective doseBeing a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.~0.25–0.45%

Exfoliation

Not advertised by the brand · Retinol, Retinyl palmitate

Strong evidence

This product can help exfoliate the skin. In other words, it helps break down the bonds between dead cells on the surface of the skin and speed up the skin turnover. Skin often appears softer and brighter after exfoliation, but overdoing it can result in disrupted skin barrier. The following ingredient is doing the exfoliating job in this product: retinol.

RetinolKey activeEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~0.35–0.6%

Retinyl palmitateEffect: Low, below effective doseThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect~0.2–0.4%

Moisturizing

Not advertised by the brand · Palmitoyl pentapeptide-4, Palmitoyl tetrapeptide-7 + 24 more

Strong evidence

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: algae extract, glucosamine hcl.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: butyrospermum parkii butter, algae extract.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: palmitoyl oligopeptide, palmitoyl pentapeptide-4, palmitoyl tetrapeptide-7

Palmitoyl pentapeptide-4HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.35–0.65%

Algae extractKey active· Humectant, EmollientEffect: HighPlant extract that helps the skin to attract water and make it more smooth for touch. Also shows promise of anti-aging properties, but research is not extensive yet~0.3–0.6%

Triticum vulgare germ oilKey active· EmollientEffect: HighA good emoillient. Contains vitamin E which can help neutralise free radicals, however the oil is unstable. Avoid if you have gluten or wheat sensitivity (including food allergies).~0.3–0.5%

Beta-sitosterolKey active· EmollientEffect: HighA phytosterol that can support skin's barrier function and help the skin stay hydrated~0.25–0.5%

Butyrospermum parkii butterKey active· Emollient, OcclusiveEffect: HighA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals~5.7–7%

Calcium pantothenateKey activeEffect: HighHelps support skin barrier function improving skin hydration and reducing sensitivity~0.25–0.45%

Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~0.3–0.55%

Glycine soja oilKey active· EmollientEffect: HighA good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.~2.3–2.9%

Theobroma cacao seed butterKey active· EmollientEffect: HighHelps soften the upper layer of the skin and can be helpful in restoring the skin barrier function. Might have some anti-oxidant effect~2–2.5%

Palmitoyl tetrapeptide-7Hero· EmollientEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.45–0.7%

Palmitoyl oligopeptideHeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.7–1.05%

Glucosamine hclKey active· HumectantEffect: HighMight be able to stimulate production of skin's natural moisturizing compounds such as hyaluronic acid. Could be helpful for evening the skin tone.~0.35–0.65%

GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~4.2–5.2%

Chlorella vulgaris extractKey activeEffect: MediumA plant extract that can help to attract water to the upper layer of the skin and might have some anti-oxidant and anti-inflammatory properties~0.25–0.45%

CollagenKey activeEffect: MediumCannot penetrate the skin barrier so is not particularly useful in skincare products~0.3–0.55%

Prunus amygdalus dulcis oilKey active· EmollientEffect: MediumAn emollient that softens the skin~3.2–4%

Hydrolyzed wheat proteinKey active· HumectantEffect: MediumCan help attract water to the upper layer of the skin. Avoid if sensitive to gluten~0.25–0.45%

Hydrogenated polydecene· EmollientEffect: LowHelps to soften the upper layer of the skin and create a nice product texture~1.4–1.7%

Sorbitol· HumectantEffect: LowHelps attract water to the upper layer of the skin and improves the product texture~0.25–0.45%

Yeast extractUnder-dosedEffect: HighHelps attract water to the upper layer of the skin and might have some anti-oxidant and skin lightening properties. It can help calm down inflammation in skin~0.25–0.45%

Simmondsia chinensis seed oilUnder-dosedEffect: HighSoftens the upper layer of skin and helps restore the healthy skin barrier. Has shown to help calm down inflammation in skin. It is a stable oil, meaning that it retains its properties even when exposed to air.~0.3–0.55%

Centella asiatica extractUnder-dosedEffect: HighA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.~0.3–0.55%

NiacinUnder-dosedEffect: HighA form of vitamin B3. It is similar in action to niacinamide, but is more likely to cause red flashes in skin as the side effect~0.25–0.45%

Aloe barbadensis leaf extractEffect: Low, below effective doseTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin~0.3–0.6%

Cucumis sativus fruit extractEffect: Low, below effective doseMight be somewhat helpful in reducing hyperpigmentation and neutralizing free radicals but its typical concentration in a product is too low for having an effect~0.25–0.45%

Evens skin tone

Not advertised by the brand · Retinol, Glucosamine hcl + 3 more

Strong evidence

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: retinol.

The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually can help even out the skin tone: glucosamine hcl.

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

Glucosamine hclKey activeEffect: MediumMight be able to stimulate production of skin's natural moisturizing compounds such as hyaluronic acid. Could be helpful for evening the skin tone.~0.35–0.65%

NiacinUnder-dosedEffect: MediumA form of vitamin B3. It is similar in action to niacinamide, but is more likely to cause red flashes in skin as the side effect~0.25–0.45%

Yeast extractEffect: Low, below effective doseHelps attract water to the upper layer of the skin and might have some anti-oxidant and skin lightening properties. It can help calm down inflammation in skin~0.25–0.45%

Anti-blemish

Not advertised by the brand · Retinol, Centella asiatica extract + 2 more

Strong evidence

This product can help reduce breakouts and clogged pores because it contains the following ingredient: retinol. This ingredient is used for treating acne and can have a noticeable effect.

NiacinUnder-dosedEffect: MediumA form of vitamin B3. It is similar in action to niacinamide, but is more likely to cause red flashes in skin as the side effect~0.25–0.45%

Centella asiatica extractEffect: Low, below effective doseA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.~0.3–0.55%

Anti-oxidation

Not advertised by the brand · Retinol, Pyridoxine hcl + 12 more

Strong evidence

This product contains antioxidants (retinol) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

Pyridoxine hclEffect: LowMight help neutralize free radicals in skin~0.25–0.45%

Chlorella vulgaris extractEffect: LowA plant extract that can help to attract water to the upper layer of the skin and might have some anti-oxidant and anti-inflammatory properties~0.25–0.45%

Theobroma cacao seed butterEffect: LowHelps soften the upper layer of the skin and can be helpful in restoring the skin barrier function. Might have some anti-oxidant effect~2–2.5%

Prunus amygdalus dulcis oilEffect: LowAn emollient that softens the skin~3.2–4%

Glucosamine hclEffect: LowMight be able to stimulate production of skin's natural moisturizing compounds such as hyaluronic acid. Could be helpful for evening the skin tone.~0.35–0.65%

Triticum vulgare germ oilEffect: LowA good emoillient. Contains vitamin E which can help neutralise free radicals, however the oil is unstable. Avoid if you have gluten or wheat sensitivity (including food allergies).~0.3–0.5%

TocopherolUnder-dosedEffect: HighPure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.25–0.45%

Yeast extractUnder-dosedEffect: MediumHelps attract water to the upper layer of the skin and might have some anti-oxidant and skin lightening properties. It can help calm down inflammation in skin~0.25–0.45%

Tocopheryl acetateEffect: Low, below effective doseA more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.~0.25–0.5%

Can it cause trouble?

Irritancy

4 strong irritants: Retinol, Equisetum arvense extract + 2 more — patch-test recommended

High risk

We flagged 18 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.

IngredientFunctionIrritationEst. amount

RetinolTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritatingHigh~0.35–0.6%est.

Anthemis nobilis flower extractA plant extract that one one hand, can contain compounds that can help calm down skin irritation, but, on the other hand, its other compounds (especially fragrant ones) can themselves be irritatingHigh~0.2–0.4%est.

Equisetum arvense extractA plant extract that might have anti-oxidant properties. Can be irritatingHigh~0.25–0.5%est.

NiacinA form of vitamin B3. It is similar in action to niacinamide, but is more likely to cause red flashes in skin as the side effectHigh~0.25–0.45%est.

Retinyl palmitateThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effectHigh~0.2–0.4%est.

AlcoholCan be drying and contribute to skin irritation. Used in formulars to dissolve other ingredients, create a thinner product consistency or for its antibacterial propertiesHigh~0.15–0.25%est.

Glycine soja oilA good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.Medium~2.3–2.9%est.

Aloe barbadensis leaf extractTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skinMedium~0.3–0.6%est.

Hydrolyzed wheat proteinCan help attract water to the upper layer of the skin. Avoid if sensitive to glutenMedium~0.25–0.45%est.

Phytic acidAn alpha-hydroxy acid (AHA), but is mostly used to stabilize product formulations in cosmeticsMedium~0.25–0.45%est.

Simmondsia chinensis seed oilSoftens the upper layer of skin and helps restore the healthy skin barrier. Has shown to help calm down inflammation in skin. It is a stable oil, meaning that it retains its properties even when exposed to air.Medium~0.3–0.55%est.

Cucumis sativus fruit extractMight be somewhat helpful in reducing hyperpigmentation and neutralizing free radicals but its typical concentration in a product is too low for having an effectMedium~0.25–0.45%est.

Centella asiatica extractA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.Medium~0.3–0.55%est.

Chlorella vulgaris extractA plant extract that can help to attract water to the upper layer of the skin and might have some anti-oxidant and anti-inflammatory propertiesMedium~0.25–0.45%est.

Tocopheryl acetateA more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.Medium~0.25–0.5%est.

Pyridoxine hclMight help neutralize free radicals in skinMedium~0.25–0.45%est.

Ascorbyl palmitateBeing a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.Medium~0.25–0.45%est.

Sorbic acidA preservativeMedium~0.15–0.25%est.

Comedogenic

6 ingredients rated 2 or more on the 0–5 pore-clogging scale

6 flagged

These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.

IngredientFunctionRatingEst. amount

Butyrospermum parkii butterA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals3/5~5.7–7%est.

Theobroma cacao seed butterHelps soften the upper layer of the skin and can be helpful in restoring the skin barrier function. Might have some anti-oxidant effect3/5~2–2.5%est.

Algae extractPlant extract that helps the skin to attract water and make it more smooth for touch. Also shows promise of anti-aging properties, but research is not extensive yet3/5~0.3–0.6%est.

Triticum vulgare germ oilA good emoillient. Contains vitamin E which can help neutralise free radicals, however the oil is unstable. Avoid if you have gluten or wheat sensitivity (including food allergies).3/5~0.3–0.5%est.

Chlorella vulgaris extractA plant extract that can help to attract water to the upper layer of the skin and might have some anti-oxidant and anti-inflammatory properties3/5~0.25–0.45%est.

Glycine soja oilA good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.2/5~2.3–2.9%est.

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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%

Formula

Irritation risk: Low

Plain old water

More about Water

Butyrospermum parkii butter~5.7–7%

Key activeComedogenic 3/5

Irritation risk: Low
Comedogenicity: 3/5

Works for

MoisturizingAnti-oxidationAnti-aging

A great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals

More about Butyrospermum parkii butter

Glycerin~4.2–5.2%

Key active

Irritation risk: Low

Works for

Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin

Prunus amygdalus dulcis oil~3.2–4%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-oxidationAnti-aging

An emollient that softens the skin

More about Prunus amygdalus dulcis oil

Glycine soja oil~2.3–2.9%

Key activeComedogenic 2/5Irritant · medium

Irritation risk: Medium
Comedogenicity: 2/5

Works for

Moisturizing

A good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.

More about Glycine soja oil

Theobroma cacao seed butter~2–2.5%

Key activeComedogenic 3/5

Irritation risk: Low
Comedogenicity: 3/5

Works for

MoisturizingAnti-oxidationAnti-dandruff

Helps soften the upper layer of the skin and can be helpful in restoring the skin barrier function. Might have some anti-oxidant effect

More about Theobroma cacao seed butter

Sodium acrylate/sodium acryloyldimethyl taurate copolymer~1.5–1.8%

Formula

Irritation risk: Low

Used to create a thicker product consistency

More about Sodium acrylate/sodium acryloyldimethyl taurate copolymer

Hydrogenated polydecene~1.4–1.7%

Formula

Irritation risk: Low

Works for

Moisturizing

Helps to soften the upper layer of the skin and create a nice product texture

More about Hydrogenated polydecene

Laureth-8~1.1–1.4%

Formula

Irritation risk: Low

Works for

Cleansing

More about Laureth-8

Hydrogenated lecithin~0.8–1.2%

Formula

Irritation risk: Low

Works for

Cleansing

Helps to retain moisture by creating a protective barrier on the skin. Rich in fatty acids. Improves product texture and helps with the penetration of other ingredients.

More about Hydrogenated lecithin

Palmitoyl oligopeptide~0.7–1.05%

Hero · Moisturizing

Irritation risk: Low

Works for

CleansingMoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl oligopeptide

Elaeis guineensis extract~0.5–0.75%

Formula

Irritation risk: Low

More about Elaeis guineensis extract

Tripeptide-33~0.45–0.7%

Formula

Irritation risk: Low

More about Tripeptide-33

Palmitoyl tetrapeptide-7~0.45–0.7%

Hero · Moisturizing

Irritation risk: Low

Works for

MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tetrapeptide-7

Palmitoyl pentapeptide-4~0.35–0.65%

Hero · Moisturizing

Irritation risk: Low

Works for

MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl pentapeptide-4

Retinol~0.35–0.6%

Hero · Anti-aging, Evens skin tone, Anti-blemishIrritant · high

Irritation risk: High

Works for

Evens skin toneAnti-blemishMattifyingExfoliationAnti-oxidationAnti-aging

Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating

More about Retinol

Glucosamine hcl~0.35–0.65%

Key active

Irritation risk: Low

Works for

MoisturizingAntibacterialEvens skin toneAnti-oxidationAnti-aging

Might be able to stimulate production of skin's natural moisturizing compounds such as hyaluronic acid. Could be helpful for evening the skin tone.

More about Glucosamine hcl

Collagen~0.3–0.55%

Key active

Irritation risk: Low

Works for

Moisturizing

Cannot penetrate the skin barrier so is not particularly useful in skincare products

More about Collagen

Sodium hyaluronate~0.3–0.55%

Key active

Irritation risk: Low

Works for

Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate

Aloe barbadensis leaf extract~0.3–0.6%

Irritant · medium

Irritation risk: Medium

Works for

Moisturizing

Traditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin

More about Aloe barbadensis leaf extract

Hydrolyzed wheat protein~0.25–0.45%

Key activeIrritant · medium

Irritation risk: Medium

Works for

Moisturizing

Can help attract water to the upper layer of the skin. Avoid if sensitive to gluten

More about Hydrolyzed wheat protein

Algae extract~0.3–0.6%

Key activeComedogenic 3/5

Irritation risk: Low
Comedogenicity: 3/5

Works for

MoisturizingAnti-aging

Plant extract that helps the skin to attract water and make it more smooth for touch. Also shows promise of anti-aging properties, but research is not extensive yet

More about Algae extract

Yeast extract~0.25–0.45%

Under-dosed

Irritation risk: Low

Works for

MoisturizingAnti-oxidationReduces irritationAnti-inflammatoryEvens skin tone

Helps attract water to the upper layer of the skin and might have some anti-oxidant and skin lightening properties. It can help calm down inflammation in skin

More about Yeast extract

Phytic acid~0.25–0.45%

Irritant · medium

Irritation risk: Medium

An alpha-hydroxy acid (AHA), but is mostly used to stabilize product formulations in cosmetics

More about Phytic acid

Triticum vulgare germ oil~0.3–0.5%

Key activeComedogenic 3/5

Irritation risk: Low
Comedogenicity: 3/5

Works for

MoisturizingAnti-oxidation

A good emoillient. Contains vitamin E which can help neutralise free radicals, however the oil is unstable. Avoid if you have gluten or wheat sensitivity (including food allergies).

More about Triticum vulgare germ oil

Simmondsia chinensis seed oil~0.3–0.55%

Under-dosedIrritant · medium

Irritation risk: Medium

Works for

Moisturizing

Softens the upper layer of skin and helps restore the healthy skin barrier. Has shown to help calm down inflammation in skin. It is a stable oil, meaning that it retains its properties even when exposed to air.

More about Simmondsia chinensis seed oil

Sorbitol~0.25–0.45%

Formula

Irritation risk: Low

Works for

Moisturizing

Helps attract water to the upper layer of the skin and improves the product texture

More about Sorbitol

Tocopherol~0.25–0.45%

Under-dosed

Irritation risk: Low

Works for

Anti-oxidationAnti-inflammatoryAnti-agingMoisturizing

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol

Anthemis nobilis flower extract~0.2–0.4%

Irritant · high

Irritation risk: High

Works for

Anti-inflammatoryReduces irritation

A plant extract that one one hand, can contain compounds that can help calm down skin irritation, but, on the other hand, its other compounds (especially fragrant ones) can themselves be irritating

More about Anthemis nobilis flower extract

Urtica dioica extract~0.25–0.4%

Formula

Irritation risk: Low

More about Urtica dioica extract

Equisetum arvense extract~0.25–0.5%

Irritant · high

Irritation risk: High

A plant extract that might have anti-oxidant properties. Can be irritating

More about Equisetum arvense extract

Cucumis sativus fruit extract~0.25–0.45%

Irritant · medium

Irritation risk: Medium

Works for

MoisturizingAnti-oxidation

Might be somewhat helpful in reducing hyperpigmentation and neutralizing free radicals but its typical concentration in a product is too low for having an effect

More about Cucumis sativus fruit extract

Centella asiatica extract~0.3–0.55%

Under-dosedIrritant · medium

Irritation risk: Medium

Works for

Reduces rednessReduces irritationMoisturizingAnti-inflammatoryAnti-agingAnti-oxidationAnti-blemish

A plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.

More about Centella asiatica extract

Chlorella vulgaris extract~0.25–0.45%

Key activeComedogenic 3/5Irritant · medium

Irritation risk: Medium
Comedogenicity: 3/5

Works for

MoisturizingAnti-inflammatoryAnti-oxidation

A plant extract that can help to attract water to the upper layer of the skin and might have some anti-oxidant and anti-inflammatory properties

More about Chlorella vulgaris extract

Hydrolyzed

Not recognized

Algae~0.25–0.45%

Formula

Irritation risk: Low

More about Algae

Tocopheryl acetate~0.25–0.5%

Irritant · medium

Irritation risk: Medium

Works for

Anti-oxidation

A more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.

More about Tocopheryl acetate

Beta-sitosterol~0.25–0.5%

Key active

Irritation risk: Low

Works for

Moisturizing

A phytosterol that can support skin's barrier function and help the skin stay hydrated

More about Beta-sitosterol

Niacin~0.25–0.45%

Under-dosedIrritant · high

Irritation risk: High

Works for

MoisturizingAnti-blemishAnti-agingEvens skin tone

A form of vitamin B3. It is similar in action to niacinamide, but is more likely to cause red flashes in skin as the side effect

More about Niacin

Calcium pantothenate~0.25–0.45%

Key active

Irritation risk: Low

Works for

MoisturizingReduces irritation

Helps support skin barrier function improving skin hydration and reducing sensitivity

More about Calcium pantothenate

Pyridoxine hcl~0.25–0.45%

Irritant · medium

Irritation risk: Medium

Works for

Anti-oxidation

Might help neutralize free radicals in skin

More about Pyridoxine hcl

Ascorbyl palmitate~0.25–0.45%

Irritant · medium

Irritation risk: Medium

Works for

Anti-oxidationAnti-aging

Being a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.

More about Ascorbyl palmitate

Polysorbate 80~0.3–0.5%

Formula

Irritation risk: Low

Works for

Cleansing

Helps water and oil mix together

More about Polysorbate 80

Retinyl palmitate~0.2–0.4%

Under-dosedIrritant · high

Irritation risk: High

Works for

Anti-agingEvens skin toneAnti-blemishExfoliation

Three steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect

More about Retinyl palmitate

Cholecalciferol~0.2–0.4%

Formula

Irritation risk: Low

More about Cholecalciferol

Thiamine nitrate~0.2–0.4%

Formula

Irritation risk: Low

More about Thiamine nitrate

Phytonadione~0.15–0.25%

Formula

Irritation risk: Low

More about Phytonadione

Alcohol~0.15–0.25%

Irritant · high

Irritation risk: High

Works for

Antibacterial

Can be drying and contribute to skin irritation. Used in formulars to dissolve other ingredients, create a thinner product consistency or for its antibacterial properties

More about Alcohol

Sorbic acid~0.15–0.25%

Irritant · medium

Irritation risk: Medium

A preservative

More about Sorbic acid

Trisodium edta~0.1–0.15%

Formula

Irritation risk: Low

Helps preserve product formulations

More about Trisodium edta

Ingredient list view

Water, Butyrospermum parkii butter, Glycerin, Prunus amygdalus dulcis oil, Glycine soja oil, Theobroma cacao seed butter, Sodium acrylate/sodium acryloyldimethyl taurate copolymer, Hydrogenated polydecene, Laureth-8, Hydrogenated lecithin, Palmitoyl oligopeptide, Elaeis guineensis extract, Tripeptide-33, Palmitoyl tetrapeptide-7, Palmitoyl pentapeptide-4, Retinol, Glucosamine hcl, Collagen, Sodium hyaluronate, Aloe barbadensis leaf extract, Hydrolyzed wheat protein, Algae extract, Yeast extract, Phytic acid, Triticum vulgare germ oil, Simmondsia chinensis seed oil, Sorbitol, Tocopherol, Anthemis nobilis flower extract, Urtica dioica extract, Equisetum arvense extract, Cucumis sativus fruit extract, Centella asiatica extract, Chlorella vulgaris extract, Unknown, Algae, Tocopheryl acetate, Beta-sitosterol, Niacin, Calcium pantothenate, Pyridoxine hcl, Ascorbyl palmitate, Polysorbate 80, Retinyl palmitate, Cholecalciferol, Thiamine nitrate, Phytonadione, Alcohol, Sorbic acid, Trisodium edta

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Amazon USPrice as of 10/31/2026 06:12 GMT

$63.00

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
	Dr. DeneseTriple Strength Neck Wrinkle SmootherYOUR PRODUCT	Dr. Bailey Skin CareAdvanced Corrective Eye Cream	ReplenixBrightening Eye Cream for Discoloration	Paula's choiceResist Intensive Repair Cream
Match	—	71%	71%	70%
Price	$63.00	—	$46.50−$16.50	$38.81−$24.19
Shared key ingredients	—	6 of 20	6 of 20	7 of 20
Key difference	—	Vitamin C	Vitamin C	Niacinamide
Irritancy	High	Medium	Medium	Medium
Drying alcohol	Contains drying alcohol	—	—	—
	View product	Shop	Shop	Shop

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Product summary

Based on the ingredient list, "Dr. Denese - Triple Strength Neck Wrinkle Smoother" can work well for skin moisturization. To work well, any moisturizer needs to include a combination of water-binding and emollient ingredients. Dr. Denese - Triple Strength Neck Wrinkle Smoother ticks this box. Algae extract, glucosamine hcl, glycerin, sodium hyaluronate and hydrolyzed wheat protein in this product (humectants) attract water molecules to the upper layer of the skin (the water comes from the outside air or from the deeper layers of the skin if the air is dry). Emollients in this formulation (palmitoyl tetrapeptide-7, algae extract, beta-sitosterol, glycine soja oil and theobroma cacao seed butter) help to reduce the moisture loss from the skin. They also soften the skin surface and relieve the feeling of dryness and tightness.

Ingredient callouts

this moisturizer contains an effective form of retinoids (vitamin A): retinol 0.35% - 0.60%. Retinoids are potent multitasking actives. They work to improve and prevent early signs of aging, reduce hyperpigmentation (age spots and post-acne marks), and prevent inflamed blemishes and clogged pores. The downside of retinoids is that they can be irritating. If you are not already using a retinoid in your routine, it is best to start slowly and apply the retinoid product only a few times per week. If your skin tolerates it well, you can gradually increase the frequency to daily. Because of the irritation risk of retinoids, we recommend to have another, retinoid-free moisturizer in your routine to use on the alternative days or when your skin feels dry.
We like that this moisturizer contains peptides (palmitoyl pentapeptide-4 0.35% - 0.65%, palmitoyl tetrapeptide-7 0.45% - 0.70% and palmitoyl oligopeptide 0.70% - 1.05%). There are many different kind of peptides and they are naturally present in our skin. They all are a combination of amino-acids. Some of them work as natural anti-biotics, promote wound-healing and production of collagen. The science is still not settled on how effective peptides in skincare are, but it is very likely that they have a benefit. Peptides might help restore the skin barrier and fight the signs of aging. At the very least, peptides work as humectants: they attract water to the upper layer of the skin and improve its hydration.

Irritation risk

This formulation includes some common irritants, including ingredients that do not provide a benefit for the skin. We assess the overall irritancy of this moisturizer to be high. For a detailed overview of all potential irritants: click here

You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.

Price

The product retails for 44.99$ in the United States.

For a detailed price comparison: click here.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 30 studies and safety reviews.

1
Glycerol and the skin: holistic approach to its origin and functionsncbi.nlm.nih.gov
2
Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oilsmdpi.com
3
Cocoa polyphenols and their influence on parameters involved in ex vivo skin restructuringncbi.nlm.nih.gov
4
Safety Assessment of Polyene Group as Used in Cosmeticscir-safety.org
5
Retinoids in the treatment of skin aging: an overview of clinical efficacy and safetyncbi.nlm.nih.gov
6
Improvement of naturally aged skin with vitamin A (retinol)ncbi.nlm.nih.gov
7
A comparative study of the effects of retinol and retinoic acid on histological, molecular, and clinical properties of human skinonlinelibrary.wiley.com
8
Glucosamine: an ingredient with skin and other benefitsncbi.nlm.nih.gov
9
Hyaluronic acid: A key molecule in skin agingncbi.nlm.nih.gov
10
Hyaluronan (Hyaluronic Acid): a natural moisturizer for skin careresearchgate.net
11
Wheat in skin caremdedge.com
12
The natural yeast extract isolated by ethanol precipitation inhibits melanin synthesis by modulating tyrosinase activity and downregulating melanosome transferncbi.nlm.nih.gov
13
Evaluation of dermatological effects of cosmetic formulations containing Saccharomyces cerevisiae extract and vitaminsresearchgate.net
14
Cosmetic and dermatologic use of alpha hydroxy acidsonlinelibrary.wiley.com
15
Comparative Evaluation of Efficacy and Tolerability of Glycolic Acid, Salicylic Mandelic Acid, and Phytic Acid Combination Peels in Melasmancbi.nlm.nih.gov
16
Vitamin E in dermatologyncbi.nlm.nih.gov
17
Vitamin E and Skin Healthlpi.oregonstate.edu
18
Anti-Inflammatory Effect of Titrated Extract of Centella asiatica in Phthalic Anhydride-Induced Allergic Dermatitis Animal Modelmdpi.com
19
Centella asiatica in cosmetologyncbi.nlm.nih.gov
20
Triterpene Composition and Bioactivities of Centella asiatica mdpi.com
21
Asiaticoside induction for cell-cycle progression, proliferation and collagen synthesis in human dermal fibroblastsonlinelibrary.wiley.com
22
Assessment report on Centella asiatica (L.) Urban, herbaema.europa.eu
23
Contact dermatitis due to Madecassolonlinelibrary.wiley.com
24
The Effects of a Standardized Extract of Centella asiatica on Postlaser Resurfacing Wound Healing on the Face: A Split-Face, Double-Blind, Randomized, Placebo-Controlled Trialliebertpub.com
25
Safety Assessment of Phytosterols as Used in Cosmeticscir-safety.org
26
The Ameliorative Effect of β-sitosterol on DNCB-induced Atopic Dermatitis in Micebslonline.org
27
Calcium pantothenate modulates gene expression in proliferating human dermal fibroblastsonlinelibrary.wiley.com
28
Dexpanthenol Modulates Gene Expression in Skin Wound Healing in vivokarger.com
29
Dexapanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate-induced irritationtandfonline.com
30
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTAncbi.nlm.nih.gov

Dr. DeneseTriple Strength Neck Wrinkle Smoother

Buy on Amazon$63.00 · as of 10/31 06:12 GMT

Affiliate links · As an Amazon Associate, WIMJ earns from qualifying purchases.

Buy on Amazon$63.00 · as of 10/31 06:12 GMT

As an Amazon Associate, WIMJ earns from qualifying purchases.