Dermelect Smooth Upper Lip and Perioral Anti-Aging

Dermelect Smooth Upper Lip and Perioral Anti-Aging

Efficacy100/100IrritancyMedium
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Works for

3 of 3 advertised claims delivered

Anti-aging
5 ingredients credited for this claim
Strong support
What the product description says
“Smooth Upper Lip and Perioral Anti-Aging”
From product name

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains retinol.

These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: palmitoyl oligopeptide, palmitoyl tetrapeptide-7.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

RetinolHeroEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~0.05–0.3%
Palmitoyl oligopeptideKey activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.75%
Palmitoyl tetrapeptide-7Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.15–0.6%
Hydrolyzed hibiscus esculentus extractEffect: LowA plant extract that might contain a peptide (Myoxinol). It could be helpful in attracting water to the upper layer of the skin and might have some anti-aging effect, but the research is lacking and it is rarely used in a high enough concentration~0.1–0.45%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.1–0.4%
Moisturizing
16 ingredients credited for this claim
Strong support
What the product description says
“Smooth Upper Lip and Perioral Anti-Aging”
From product name

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: glycerin, sodium hyaluronate.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: dimethicone, c12-15 alkyl benzoate.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: palmitoyl oligopeptide, palmitoyl tetrapeptide-7

Palmitoyl tetrapeptide-7Hero· EmollientEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.15–0.6%
Palmitoyl oligopeptideHeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.75%
DimethiconeKey active· Emollient, OcclusiveEffect: HighA silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish~1.4–2.1%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~0.35–0.85%
Soluble collagenKey active· HumectantEffect: HighA typically plant-derived compound that is supposed mimic human collagen. Cannot penetrate the skin barrier so is not particularly useful in skincare products beyond attracting water to the upper layer of the skin~0.05–0.25%
Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~0.35–0.8%
Cetearyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture~5.6–8.4%
Ethylhexyl palmitateKey active· EmollientEffect: MediumAn emollient that helps soften the skin and create a nice product texture~1.1–1.6%
C12-15 alkyl benzoateKey active· EmollientEffect: MediumEnhances the product texture and makes it more spreadable. Helps reduce water loss from the outer layer of skin. Extands the shelf life by preventing bacteria growth~2.1–3.1%
Dextrin· HumectantEffect: LowA sugar that is used to stabilize the product formulation. Can help attract water to the upper layer of the skin~0.1–0.5%
Hydrogenated polyisobutene· Emollient, OcclusiveEffect: LowUsed to improve the product consistency and soften the upper layer of the skin~1.8–2.7%
Isopropyl palmitate· EmollientEffect: LowHelps soften the upper layer of the skin and create a thicker product consistency~1.4–2.1%
Hydrolyzed hibiscus esculentus extractEffect: LowA plant extract that might contain a peptide (Myoxinol). It could be helpful in attracting water to the upper layer of the skin and might have some anti-aging effect, but the research is lacking and it is rarely used in a high enough concentration~0.1–0.45%
Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~0.3–0.75%
Caprylic/capric triglycerideUnder-dosedEffect: HighA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin~0.9–1.4%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.1–0.4%
Evens skin tone
2 ingredients credited for this claim
Strong support
What the product description says
“Advanced brighteners help visibly fade shadowy pigmentation under the nose.”
Source: Dermstore

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: retinol.

The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually can help even out the skin tone: arbutin.

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

RetinolHeroEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~0.05–0.3%
ArbutinKey activeEffect: MediumBeta-arbutin. Can help to reduce hyperpigmentation and has an anti-oxidant effect when used in high enough concentration. Is less effective compared to alpha-arbutin~0.05–0.25%
Anti-blemish
Not advertised by the brand · 1 ingredient credited for this claim
Strong support

This product can help reduce breakouts and clogged pores because it contains the following ingredient: retinol. This ingredient is used for treating acne and can have a noticeable effect.

RetinolHeroEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~0.05–0.3%
Exfoliation
Not advertised by the brand · 1 ingredient credited for this claim
Strong support

This product can help exfoliate the skin. In other words, it helps break down the bonds between dead cells on the surface of the skin and speed up the skin turnover. Skin often appears softer and brighter after exfoliation, but overdoing it can result in disrupted skin barrier. The following ingredient is doing the exfoliating job in this product: retinol.

RetinolKey activeEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~0.05–0.3%
Anti-oxidation
Not advertised by the brand · 3 ingredients credited for this claim
Strong support

This product contains antioxidants (retinol) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

The following ingredients - arbutin also can have an antioxidant effect, but there is less evidence to confirm their effectiveness in skin.

RetinolKey activeEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~0.05–0.3%
ArbutinKey activeEffect: MediumBeta-arbutin. Can help to reduce hyperpigmentation and has an anti-oxidant effect when used in high enough concentration. Is less effective compared to alpha-arbutin~0.05–0.25%
TocopherolUnder-dosedEffect: HighPure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.1–0.4%

Can it cause trouble?

Irritancy
2 strong irritants: Retinol, Iodopropynyl butylcarbamate
Medium risk
We flagged 8 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
RetinolTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritatingHigh~0.05–0.3%est.
Iodopropynyl butylcarbamateA preservative. Can be irritatingHigh~0.01–0.02%est.
Polysorbate 60Helps oil and water mix togetherMedium~3.2–4.9%est.
Behentrimonium methosulfateHelps oil and water mix togetherMedium~2.8–4.2%est.
Isopropyl palmitateHelps soften the upper layer of the skin and create a thicker product consistencyMedium~1.4–2.1%est.
Caprylic/capric triglycerideA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerinMedium~0.9–1.4%est.
Hydrolyzed hibiscus esculentus extractA plant extract that might contain a peptide (Myoxinol). It could be helpful in attracting water to the upper layer of the skin and might have some anti-aging effect, but the research is lacking and it is rarely used in a high enough concentrationMedium~0.1–0.45%est.
ArbutinBeta-arbutin. Can help to reduce hyperpigmentation and has an anti-oxidant effect when used in high enough concentration. Is less effective compared to alpha-arbutinMedium~0.05–0.25%est.
Comedogenic
3 ingredients rated 2 or more on the 0–5 pore-clogging scale
3 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Isopropyl palmitateHelps soften the upper layer of the skin and create a thicker product consistency3/5~1.4–2.1%est.
Ethylhexyl palmitateAn emollient that helps soften the skin and create a nice product texture3/5~1.1–1.6%est.
Cetearyl alcoholA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture2/5~5.6–8.4%est.
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Ingredients

Filter by role to see what each ingredient is doing.

Water~40–60%
Formula
Irritation risk
Low

Plain old water

More about Water
Cetearyl alcohol~5.6–8.4%
Key activeComedogenic 2/5
Irritation risk
Low
Comedogenicity
2/5
Works for
CleansingMoisturizing

A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture

More about Cetearyl alcohol
Polysorbate 60~3.2–4.9%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps oil and water mix together

More about Polysorbate 60
Behentrimonium methosulfate~2.8–4.2%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps oil and water mix together

More about Behentrimonium methosulfate
C12-15 alkyl benzoate~2.1–3.1%
Key active
Irritation risk
Low
Works for
Moisturizing

Enhances the product texture and makes it more spreadable. Helps reduce water loss from the outer layer of skin. Extands the shelf life by preventing bacteria growth

More about C12-15 alkyl benzoate
Hydrogenated polyisobutene~1.8–2.7%
Formula
Irritation risk
Low
Works for
Moisturizing

Used to improve the product consistency and soften the upper layer of the skin

More about Hydrogenated polyisobutene
Isopropyl palmitate~1.4–2.1%
Comedogenic 3/5Irritant · medium
Irritation risk
Medium
Comedogenicity
3/5
Works for
Moisturizing

Helps soften the upper layer of the skin and create a thicker product consistency

More about Isopropyl palmitate
Dimethicone~1.4–2.1%
Key active
Irritation risk
Low
Works for
MoisturizingMattifying

A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish

More about Dimethicone
Ethylhexyl palmitate~1.1–1.6%
Key activeComedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
Moisturizing

An emollient that helps soften the skin and create a nice product texture

More about Ethylhexyl palmitate
Caprylic/capric triglyceride~0.9–1.4%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin

More about Caprylic/capric triglyceride
Phenoxyethanol~0.5–1%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Silica dimethyl silylate~0.45–1.05%
Formula
Irritation risk
Low

Used to create a thicker product consistency

More about Silica dimethyl silylate
Butylene glycol~0.4–0.9%
Formula
Irritation risk
Low
Works for
Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol
Sodium hyaluronate~0.35–0.8%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate
Glycerin~0.35–0.85%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Butylene glycol~0.3–0.75%
Formula
Irritation risk
Low
Works for
Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol
Carbomer~0.3–0.7%
Formula
Irritation risk
Low
Works for
Cleansing

Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations

More about Carbomer
Polysorbate 20~0.2–0.75%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about Polysorbate 20
Palmitoyl oligopeptide~0.2–0.75%
Hero · Moisturizing
Irritation risk
Low
Works for
CleansingMoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl oligopeptide
Palmitoyl tetrapeptide-7~0.15–0.6%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tetrapeptide-7
Hydrolyzed hibiscus esculentus extract~0.1–0.45%
Irritant · medium
Irritation risk
Medium
Works for
MoisturizingAnti-aging

A plant extract that might contain a peptide (Myoxinol). It could be helpful in attracting water to the upper layer of the skin and might have some anti-aging effect, but the research is lacking and it is rarely used in a high enough concentration

More about Hydrolyzed hibiscus esculentus extract
Dextrin~0.1–0.5%
Formula
Irritation risk
Low
Works for
Moisturizing

A sugar that is used to stabilize the product formulation. Can help attract water to the upper layer of the skin

More about Dextrin
Sodium ascorbate~0.1–0.4%
Formula
Tocopherol~0.1–0.4%
Under-dosed
Irritation risk
Low
Works for
Anti-oxidationAnti-agingMoisturizingAnti-inflammatory

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol
Retinol~0.05–0.3%
Hero · Anti-aging, Evens skin tone, Anti-blemishIrritant · high
Irritation risk
High
Works for
Anti-blemishEvens skin toneMattifyingExfoliationAnti-oxidationAnti-aging

Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating

More about Retinol
Arbutin~0.05–0.25%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Evens skin toneAnti-oxidation

Beta-arbutin. Can help to reduce hyperpigmentation and has an anti-oxidant effect when used in high enough concentration. Is less effective compared to alpha-arbutin

More about Arbutin
Soluble collagen~0.05–0.25%
Key active
Irritation risk
Low
Works for
Moisturizing

A typically plant-derived compound that is supposed mimic human collagen. Cannot penetrate the skin barrier so is not particularly useful in skincare products beyond attracting water to the upper layer of the skin

More about Soluble collagen
Iodopropynyl butylcarbamate~0.01–0.02%
Irritant · high
Irritation risk
High

A preservative. Can be irritating

More about Iodopropynyl butylcarbamate
Ingredient list view

Water, Cetearyl alcohol, Polysorbate 60, Behentrimonium methosulfate, C12-15 alkyl benzoate, Hydrogenated polyisobutene, Isopropyl palmitate, Dimethicone, Ethylhexyl palmitate, Caprylic/capric triglyceride, Phenoxyethanol, Silica dimethyl silylate, Butylene glycol, Sodium hyaluronate, Glycerin, Butylene glycol, Carbomer, Polysorbate 20, Palmitoyl oligopeptide, Palmitoyl tetrapeptide-7, Hydrolyzed hibiscus esculentus extract, Dextrin, Sodium ascorbate, Tocopherol, Retinol, Arbutin, Soluble collagen, Iodopropynyl butylcarbamate

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Dermstore
$26.60
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Amazon USPrice as of 10/9/2026 21:52 GMT
$49.00
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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
DermelectSmooth Upper Lip and Perioral Anti-AgingYOUR PRODUCTDermelect CosmeceuticalsDermelect Smooth Upper Lip and Perioral Anti AgingStriVectinAdvanced Retinol Eye CreamReplenixAll-Trans-Retinol Enriched Eye Repair
Match—88%72%71%
Price$26.60$38.00+$11.40$46.27+$19.67$92.00+$65.40
Shared key ingredients—9 of 95 of 96 of 9
Key difference——Dipeptide-2Vitamin C
Irritancy Medium Medium High Medium
Drying alcohol————
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Product summary

"Dermelect - Smooth Upper Lip and Perioral Anti-Aging" has a good moisturizing formula. The formulation is based on a combination of good humectants and emollients. Both are needed to increase the skin hydration level. Humectants in this product (glycerin, sodium hyaluronate, soluble collagen, butylene glycol and dextrin) help to increase the water content in the upper layer of the skin. (These ingredients do so by "capturing" water molecules from the outside air or from within the deeper layers of the skin). Palmitoyl tetrapeptide-7, dimethicone, c12-15 alkyl benzoate, cetearyl alcohol and ethylhexyl palmitate in this product help decrease the water evoporation from the skin, so that it stays hydrated for longer. These ingredients also soften the skin and take away the feeling of tightness and dryness.

Ingredient callouts

  • this moisturizer contains an effective form of retinoids (vitamin A): retinol 0.05% - 0.30%. Retinoids are potent multitasking actives. They work to improve and prevent early signs of aging, reduce hyperpigmentation (age spots and post-acne marks), and prevent inflamed blemishes and clogged pores. The downside of retinoids is that they can be irritating. If you are not already using a retinoid in your routine, it is best to start slowly and apply the retinoid product only a few times per week. If your skin tolerates it well, you can gradually increase the frequency to daily. Because of the irritation risk of retinoids, we recommend to have another, retinoid-free moisturizer in your routine to use on the alternative days or when your skin feels dry.
  • This moistruizer also contains peptides (palmitoyl tetrapeptide-7 0.15% - 0.60% and palmitoyl oligopeptide 0.20% - 0.75%). Peptides is a very big group of ingredients. They all consist of a different combination of amino-acids. Our skin produces peptides naturally. Some of them work as natural anti-biotics, promote wound-healing and production of collagen. The scientists are still studying how effective the topical application of peptides is, but it is very likely that peptides in skincare are helpful. They might be able to support skin barrier restoration and even have an anti-aging benefit. At the very least, they certainly help attract water to the skin and support the hydration in this way.

Irritation risk

This moisturizer contains some common irritants, including those without a benefit for the skin. We assess the overall irritancy of this moisturizer to be medium. For a detailed overview of all potential irritants: click here

You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.

Price

The product retails for 95.78CA$ in Canada and from 26.60$ up to 38.00$ in the United States.

For a detailed price comparison: click here.

Dermelect Smooth Upper Lip and Perioral Anti-Aging
DermelectSmooth Upper Lip and Perioral Anti-Aging

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As an Amazon Associate, WIMJ earns from qualifying purchases.