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Dermedicine Anti-Aging Facelift Face Cream
Dermedicine

Dermedicine Anti-Aging Facelift Face Cream

Efficacy100/100IrritancyHigh
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Works for

3 of 3 advertised claims delivered

Evens skin tone
Retinol, Niacinamide
Strong evidence
What the product description says
“Touted face lift in a jar, our premium Anti-Aging Facelift cream is the ultimate powerhouse formula combining Retinol with Peptides, Stem Cells, Retinol, Hyaluronic Acid, Vitamin E, Melatonin, Chamomile, Sage, and Grape Seed to be stimulating and boosting, helping your complexion appear more even, youthful and bright while helping to fade the appearance of fine lines and wrinkles, blotchiness and unevenness that becomes more apparent as we age.”
Source: Dermdeicine

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: retinol.

In addition, this product contains niacinamide. This ingredient (ingredients) might help reduce hyperpigmentation, but the effect, if any, is likely to be small.

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

NiacinamideKey activeEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~4.3–5.3%
RetinolHeroEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~0.3–0.6%
Moisturizing
Acetyl hexapeptide-8, Niacinamide + 14 more
Strong evidence
What the product description says
“Anti-Aging Facelift Face Cream”
From product name

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: glycerin, hyaluronic acid.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: dimethicone, glycine soja oil.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: acetyl hexapeptide-8, niacinamide, palmitoyl tripeptide-1, palmitoyl tripeptide-37, palmitoyl tripeptide-5

Vitis vinifera seed oilKey active· EmollientEffect: HighA great emollient that can also have anti-oxidant properties~0.1–0.2%
Acetyl hexapeptide-8Hero· HumectantEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.55%
Saccharomyces/copper fermentKey active· HumectantEffect: HighYeast extract that contains copper. Can help to attract water to the upper layer of the skin and can help in skin wound healing~0.5–0.7%
UbiquinoneKey activeEffect: HighCoenzyme Q10. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergen~0.05–0.1%
Persea gratissima oilKey active· EmollientEffect: HighAn emollient that helps soften the skin and could be helpful in repairing its barrier function~2.3–2.9%
DimethiconeKey active· Emollient, OcclusiveEffect: HighA silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish~1.5–1.8%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~1.7–2.1%
Glycine soja oilKey active· EmollientEffect: HighA good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.~1.9–2.3%
Hyaluronic acidKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin. Naturally present in skin. Typically has large molecule size unless advertised otherwise on the product label. Helps support skin's barrier function and may help to reduce inflammation~0.9–1.1%
NiacinamideHeroEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~4.3–5.3%
Palmitoyl tripeptide-1Hero· EmollientEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.6%
Palmitoyl tripeptide-37HeroEffect: High~0.25–0.45%
Palmitoyl tripeptide-5HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.4–0.6%
CarnitineKey activeEffect: Medium~1.1–1.3%
Cetearyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture~6.2–7.6%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~1.1–1.3%
Anti-aging
Retinol, Niacinamide + 10 more
Strong evidence
What the product description says
“Anti-Aging Facelift Face Cream”
From product name

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains retinol, niacinamide.

These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: acetyl hexapeptide-8, palmitoyl tripeptide-1, palmitoyl tripeptide-37, palmitoyl tripeptide-5.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

RetinolHeroEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~0.3–0.6%
NiacinamideKey activeEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~4.3–5.3%
Acetyl hexapeptide-8Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.55%
Palmitoyl tripeptide-1Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.6%
Palmitoyl tripeptide-37Key activeEffect: Medium~0.25–0.45%
Palmitoyl tripeptide-5Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.4–0.6%
Hyaluronic acidEffect: LowOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin. Naturally present in skin. Typically has large molecule size unless advertised otherwise on the product label. Helps support skin's barrier function and may help to reduce inflammation~0.9–1.1%
MelatoninEffect: LowA compound that can regulate sleep cycles in humans and animals. When used in cosmetics, comes from plant sources. It can work as anti-oxidant in skin when applied topically in skincare~0.25–0.4%
Thioctic acidEffect: Low~0.55–0.85%
UbiquinoneEffect: LowCoenzyme Q10. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergen~0.05–0.1%
Sodium ascorbyl phosphateEffect: Low, below effective doseA stable derivative of vitamin C. It is oil-soluble which means it is more likely to penetrate the skin compared to the pure form of vitamin C (which is water-soluble), but it is less bio-available and is way less effective in stimulating collagen and reducing wrinkles compared to the pure form of vitamin C (L-ascorbic acid) and its other derivatives (for example, magnesium ascorbyl phosphate). At the same time, this vitamin C derivative has been shown in studies to be effective in reducing acne, blemishes and clogged pores. It is less irritating then the pure form of vitamin C~0.4–0.65%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~1.1–1.3%
Anti-oxidation
Not advertised by the brand · Ubiquinone, Retinol + 6 more
Strong evidence

This product contains antioxidants (retinol, thioctic acid, ubiquinone) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

The following ingredients - melatonin also can have an antioxidant effect, but there is less evidence to confirm their effectiveness in skin.

UbiquinoneKey activeEffect: HighCoenzyme Q10. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergen~0.05–0.1%
RetinolKey activeEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~0.3–0.6%
Thioctic acidKey activeEffect: High~0.55–0.85%
MelatoninKey activeEffect: MediumA compound that can regulate sleep cycles in humans and animals. When used in cosmetics, comes from plant sources. It can work as anti-oxidant in skin when applied topically in skincare~0.25–0.4%
Vitis vinifera seed oilEffect: LowA great emollient that can also have anti-oxidant properties~0.1–0.2%
TocopherolUnder-dosedEffect: HighPure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~1.1–1.3%
Sodium ascorbyl phosphateUnder-dosedEffect: MediumA stable derivative of vitamin C. It is oil-soluble which means it is more likely to penetrate the skin compared to the pure form of vitamin C (which is water-soluble), but it is less bio-available and is way less effective in stimulating collagen and reducing wrinkles compared to the pure form of vitamin C (L-ascorbic acid) and its other derivatives (for example, magnesium ascorbyl phosphate). At the same time, this vitamin C derivative has been shown in studies to be effective in reducing acne, blemishes and clogged pores. It is less irritating then the pure form of vitamin C~0.4–0.65%
Anthemis nobilis flower oilEffect: Low, below effective doseAn essential oil that is used as a fragrance and can be irritating. It might have some anti-oxidant effect in skin~0.15–0.3%
Exfoliation
Not advertised by the brand · Retinol
Strong evidence

This product can help exfoliate the skin. In other words, it helps break down the bonds between dead cells on the surface of the skin and speed up the skin turnover. Skin often appears softer and brighter after exfoliation, but overdoing it can result in disrupted skin barrier. The following ingredient is doing the exfoliating job in this product: retinol.

RetinolKey activeEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~0.3–0.6%
Anti-blemish
Not advertised by the brand · Niacinamide, Retinol + 2 more
Strong evidence

This product can help reduce breakouts and clogged pores because it contains the following ingredient: niacinamide, retinol. These ingredients is used for treating acne and can have a noticeable effect.

NiacinamideHeroEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~4.3–5.3%
RetinolHeroEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~0.3–0.6%
CarnitineEffect: Low~1.1–1.3%
Sodium ascorbyl phosphateUnder-dosedEffect: HighA stable derivative of vitamin C. It is oil-soluble which means it is more likely to penetrate the skin compared to the pure form of vitamin C (which is water-soluble), but it is less bio-available and is way less effective in stimulating collagen and reducing wrinkles compared to the pure form of vitamin C (L-ascorbic acid) and its other derivatives (for example, magnesium ascorbyl phosphate). At the same time, this vitamin C derivative has been shown in studies to be effective in reducing acne, blemishes and clogged pores. It is less irritating then the pure form of vitamin C~0.4–0.65%

Can it cause trouble?

Irritancy
4 strong irritants: Retinol, Citrus aurantium amara flower extract + 2 more — patch-test recommended
High risk
We flagged 12 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
RetinolTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritatingHigh~0.3–0.6%est.
Citrus aurantium amara flower extractUsed as a fragrance for its citrus smell. Can be irritatingHigh~0.2–0.4%est.
Anthemis nobilis flower oilAn essential oil that is used as a fragrance and can be irritating. It might have some anti-oxidant effect in skinHigh~0.15–0.3%est.
Chamomilla recutita extractPlant extract that can have healing and anti-inflammatory properties. It is a potential allergen and can be irritatingHigh~0.2–0.35%est.
Salvia officinalis extract—High~0.25–0.45%est.
Citrus aurantium bergamia fruit extract—High~0.15–0.25%est.
Polysorbate 60Helps oil and water mix togetherMedium~2.8–3.4%est.
Persea gratissima oilAn emollient that helps soften the skin and could be helpful in repairing its barrier functionMedium~2.3–2.9%est.
Glycine soja oilA good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.Medium~1.9–2.3%est.
Sodium ascorbyl phosphateA stable derivative of vitamin C. It is oil-soluble which means it is more likely to penetrate the skin compared to the pure form of vitamin C (which is water-soluble), but it is less bio-available and is way less effective in stimulating collagen and reducing wrinkles compared to the pure form of vitamin C (L-ascorbic acid) and its other derivatives (for example, magnesium ascorbyl phosphate). At the same time, this vitamin C derivative has been shown in studies to be effective in reducing acne, blemishes and clogged pores. It is less irritating then the pure form of vitamin CMedium~0.4–0.65%est.
EthylhexylglycerinA preservativeMedium~0.1–0.15%est.
Vitis vinifera seed oilA great emollient that can also have anti-oxidant propertiesMedium~0.1–0.2%est.
Comedogenic
2 ingredients rated 2 or more on the 0–5 pore-clogging scale
2 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Cetearyl alcoholA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture2/5~6.2–7.6%est.
Glycine soja oilA good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.2/5~1.9–2.3%est.
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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%
Formula
Irritation risk
Low

Plain old water

More about Water
Cetearyl alcohol~6.2–7.6%
Key activeComedogenic 2/5
Irritation risk
Low
Comedogenicity
2/5
Works for
CleansingMoisturizing

A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture

More about Cetearyl alcohol
Niacinamide~4.3–5.3%
Hero · Moisturizing, Anti-blemish
Irritation risk
Low
Works for
Anti-blemishEvens skin toneAnti-agingMoisturizingReduces irritationAnti-inflammatoryReduces rednessAntibacterial

Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production

More about Niacinamide
Polysorbate 60~2.8–3.4%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps oil and water mix together

More about Polysorbate 60
Persea gratissima oil~2.3–2.9%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

An emollient that helps soften the skin and could be helpful in repairing its barrier function

More about Persea gratissima oil
Glycine soja oil~1.9–2.3%
Key activeComedogenic 2/5Irritant · medium
Irritation risk
Medium
Comedogenicity
2/5
Works for
Moisturizing

A good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.

More about Glycine soja oil
Glycerin~1.7–2.1%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Dimethicone~1.5–1.8%
Key active
Irritation risk
Low
Works for
MoisturizingMattifying

A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish

More about Dimethicone
Tocopherol~1.1–1.3%
Under-dosed
Irritation risk
Low
Works for
Anti-oxidationAnti-agingAnti-inflammatoryMoisturizing

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol
Hyaluronic acid~0.9–1.1%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-inflammatoryAnti-aging

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin. Naturally present in skin. Typically has large molecule size unless advertised otherwise on the product label. Helps support skin's barrier function and may help to reduce inflammation

More about Hyaluronic acid
Dimethyl mea~0.65–1%
Formula
Irritation risk
Low
More about Dimethyl mea
Thioctic acid~0.55–0.85%
Key active
Irritation risk
Low
Works for
Anti-oxidationAnti-aging
More about Thioctic acid
Saccharomyces/copper ferment~0.5–0.7%
Key active
Irritation risk
Low
Works for
Moisturizing

Yeast extract that contains copper. Can help to attract water to the upper layer of the skin and can help in skin wound healing

More about Saccharomyces/copper ferment
Carnitine~1.1–1.3%
Key active
Irritation risk
Low
Works for
MattifyingCleansingMoisturizingAnti-blemish
More about Carnitine
Sodium ascorbyl phosphate~0.4–0.65%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
Anti-blemishAnti-oxidationAnti-aging

A stable derivative of vitamin C. It is oil-soluble which means it is more likely to penetrate the skin compared to the pure form of vitamin C (which is water-soluble), but it is less bio-available and is way less effective in stimulating collagen and reducing wrinkles compared to the pure form of vitamin C (L-ascorbic acid) and its other derivatives (for example, magnesium ascorbyl phosphate). At the same time, this vitamin C derivative has been shown in studies to be effective in reducing acne, blemishes and clogged pores. It is less irritating then the pure form of vitamin C

More about Sodium ascorbyl phosphate
Palmitoyl tripeptide-5~0.4–0.6%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tripeptide-5
Retinol~0.3–0.6%
Hero · Anti-aging, Evens skin tone, Anti-blemishIrritant · high
Irritation risk
High
Works for
Anti-agingAnti-oxidationEvens skin toneAnti-blemishMattifyingExfoliation

Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating

More about Retinol
Acetyl hexapeptide-8~0.3–0.55%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Acetyl hexapeptide-8
Palmitoyl tripeptide-1~0.3–0.6%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tripeptide-1
Palmitoyl tripeptide-37~0.25–0.45%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging
More about Palmitoyl tripeptide-37
Melatonin~0.25–0.4%
Key active
Irritation risk
Low
Works for
Anti-oxidationAnti-aging

A compound that can regulate sleep cycles in humans and animals. When used in cosmetics, comes from plant sources. It can work as anti-oxidant in skin when applied topically in skincare

More about Melatonin
Citrus aurantium amara flower extract~0.2–0.4%
Irritant · high
Irritation risk
High

Used as a fragrance for its citrus smell. Can be irritating

More about Citrus aurantium amara flower extract
Anthemis nobilis flower oil~0.15–0.3%
Irritant · high
Irritation risk
High
Works for
Anti-inflammatoryAnti-oxidation

An essential oil that is used as a fragrance and can be irritating. It might have some anti-oxidant effect in skin

More about Anthemis nobilis flower oil
Chamomilla recutita extract~0.2–0.35%
Irritant · high
Irritation risk
High
Works for
Anti-inflammatory

Plant extract that can have healing and anti-inflammatory properties. It is a potential allergen and can be irritating

More about Chamomilla recutita extract
Salvia officinalis extract~0.25–0.45%
Irritant · high
Irritation risk
High
More about Salvia officinalis extract
Citrus aurantium bergamia fruit extract~0.15–0.25%
Irritant · high
Irritation risk
High
More about Citrus aurantium bergamia fruit extract
Phenoxyethanol~0.15–0.25%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Ethylhexylglycerin~0.1–0.15%
Irritant · medium
Irritation risk
Medium

A preservative

More about Ethylhexylglycerin
Vitis vinifera seed oil~0.1–0.2%
Key activeIrritant · medium
Irritation risk
Medium
Works for
MoisturizingAnti-oxidation

A great emollient that can also have anti-oxidant properties

More about Vitis vinifera seed oil
Ubiquinone~0.05–0.1%
Key active
Irritation risk
Low
Works for
Anti-oxidationMoisturizingAnti-aging

Coenzyme Q10. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergen

More about Ubiquinone
Ingredient list view

Water, Cetearyl alcohol, Niacinamide, Polysorbate 60, Persea gratissima oil, Glycine soja oil, Glycerin, Dimethicone, Tocopherol, Hyaluronic acid, Dimethyl mea, Thioctic acid, Saccharomyces/copper ferment, Carnitine, Sodium ascorbyl phosphate, Palmitoyl tripeptide-5, Retinol, Acetyl hexapeptide-8, Palmitoyl tripeptide-1, Palmitoyl tripeptide-37, Melatonin, Citrus aurantium amara flower extract, Anthemis nobilis flower oil, Chamomilla recutita extract, Salvia officinalis extract, Citrus aurantium bergamia fruit extract, Phenoxyethanol, Ethylhexylglycerin, Vitis vinifera seed oil, Ubiquinone

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Amazon USPrice as of 10/27/2026 15:12 GMT
$25.99
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Dermdeicine
$85.00
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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
DermedicineAnti-Aging Facelift Face CreamYOUR PRODUCTAHCHydrating Essential Real Eye Cream for FaceskintificRetinol Skin Renewal Moisturizer Acne & Anti-Aging Night Creamepi.logicThe total package
Match—79%78%78%
Price$25.99$21.39−$4.60$14.90−$11.09$96.00+$70.01
Shared key ingredients—7 of 186 of 1813 of 18
Key difference—Copper Tripeptide-1Ceramide As—
Irritancy High High Medium High
Drying alcohol— Contains drying alcohol ——
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Product summary

"Dermedicine - Anti-Aging Facelift Face Cream" is a well-rounded moisturizing product. The formulation is based on a combination of good humectants and emollients. Both are needed to increase the skin hydration level. Humectants in this product (acetyl hexapeptide-8, glycerin, hyaluronic acid and saccharomyces/copper ferment) help to increase the water content in the upper layer of the skin. (These ingredients do so by "capturing" water molecules from the outside air or from within the deeper layers of the skin). Palmitoyl tripeptide-1, glycine soja oil, persea gratissima oil, vitis vinifera seed oil and dimethicone in this product help decrease the water evoporation from the skin, so that it stays hydrated for longer. These ingredients also soften the skin and take away the feeling of tightness and dryness.

Ingredient callouts

  • We love that this moisturizer contains a good concentration of niacinamide 4.30% - 5.30%. Niacinamide is a perfect active in a moistruizer because it helps calm down inflamation in skin and support the skin barrier. More than that, it is helpful for most common skin concerns: it helps regulat oil production, help reduce acne and clogged pores, improve skin tone and prevent pigmentation marks. It also helps fight photodamage.
  • This moisturizer contains an effective form of Retinoids (vitamin A): retinol 0.30% - 0.60%. Retinoids are potent multitasking actives. They work to improve and prevent early signs of aging, reduce hyperpigmentation (age spots and post-acne marks), and prevent inflamed blemishes and clogged pores. The downside of Retinoids is that they can be irritating. If you are not already using a Retinoid in your routine, it is best to start slowly and apply the Retinoid product only a few times per week. If your skin tolerates it well, you can gradually increase the frequency to daily. Because of the irritation risk of Retinoids, we recommend to have another, retinoid-free moisturizer in your routine to use on the alternate days or when your skin feels dry.
  • This moisturizer also contains Peptides (palmitoyl tripeptide-37 0.25% - 0.45%, palmitoyl tripeptide-1 0.30% - 0.60%, acetyl hexapeptide-8 0.30% - 0.55% and palmitoyl tripeptide-5 0.40% - 0.60%). Peptides are a very big group of ingredients. They all consist of a different combination of aminoacids. Our skin produces Peptides naturally. Some of them work as natural antibiotics, promote wound-healing and production of collagen. The scientists are still studying how effective the topical application of Peptides is, but it is very likely that they are helpful. Peptides might be able to support skin barrier restoration and even have an anti-aging benefit. At the very least, they certainly help attract water to the skin and support the hydration in this way.
This product contains ingredients that could be beneficial, but their concentrations are too low in this formulation: sodium ascorbyl phosphate and vitamin e

Irritation risk

We assess the overall irritancy of this moisturizer to be high. For a detailed overview of all potential irritants: click here

You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.

Price

The product retails for 85.00$ in the United States.

For a detailed price comparison: click here.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 21 studies and safety reviews.

  1. 1
    Niacinamide - mechanisms of action and its topical use in dermatologyncbi.nlm.nih.gov
  2. 2
    Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology, 3(2), 88–93. doi:10.1111/j.1473-2130.2004.00115.x ncbi.nlm.nih.gov
  3. 3
    Glycerol and the skin: holistic approach to its origin and functionsncbi.nlm.nih.gov
  4. 4
    Dimethicone as a protective ingredient in topical medicationsjaad.org
  5. 5
    Final Report on the Safety Assessment of Dimethicone Copolyoljournals.sagepub.com
  6. 6
    Vitamin E in dermatologyncbi.nlm.nih.gov
Dermedicine Anti-Aging Facelift Face Cream
DermedicineAnti-Aging Facelift Face Cream
Buy on Amazon$25.99 · as of 10/27 15:12 GMT

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Buy on Amazon$25.99 · as of 10/27 15:12 GMT

As an Amazon Associate, WIMJ earns from qualifying purchases.