Works for
3 of 3 advertised claims delivered
Anti-aging8 ingredients credited for this claimStrong support
“This anti wrinkle cream with retinol works great as an am pm moisturizer face cream.”
This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains retinol, niacinamide.
These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: acetyl octapeptide-3, retinyl palmitate.
Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.
Evens skin tone4 ingredients credited for this claimStrong support
“With regular use of our All in 1 ultimate peptide collagen cream at 4-6 weeks some users reported a decrease in the appearance of fine lines and wrinkles and a more even-toned and supple-looking skin.”
This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: retinol.
In addition, this product contains niacinamide. This ingredient (ingredients) might help reduce hyperpigmentation, but the effect, if any, is likely to be small.
The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually can help even out the skin tone: retinyl palmitate.
Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.
Moisturizing14 ingredients credited for this claimStrong support
“This anti wrinkle cream with retinol works great as an am pm moisturizer face cream.”
This product can help improve hydration of the skin with the two types of ingredients.
The first type is called “humectants”:
these ingredients help attract water.
When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from
within deeper layers of the skin. The following ingredients in this product do the job:
glycerin, saccharomyces/copper ferment.
This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: dimethicone, carthamus tinctorius seed oil.
The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: acetyl octapeptide-3, niacinamide
Anti-blemishNot advertised by the brand · 4 ingredients credited for this claimStrong support
This product can help reduce breakouts and clogged pores because it contains the following ingredient: niacinamide, retinol. These ingredients is used for treating acne and can have a noticeable effect.
The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually works: retinyl palmitate
Anti-oxidationNot advertised by the brand · 7 ingredients credited for this claimStrong support
This product contains antioxidants (retinol, thioctic acid, ubiquinone) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).
ExfoliationNot advertised by the brand · 2 ingredients credited for this claimStrong support
This product can help exfoliate the skin. In other words, it helps break down the bonds between dead cells on the surface of the skin and speed up the skin turnover. Skin often appears softer and brighter after exfoliation, but overdoing it can result in disrupted skin barrier. The following ingredient is doing the exfoliating job in this product: retinol.
Can it cause trouble?
Irritancy6 strong irritants: Retinyl palmitate, Retinol + 4 more — patch-test recommendedHigh risk
Comedogenic1 ingredient rated 2 or more on the 0–5 pore-clogging scale1 flagged
User reviews
Be the first — your take helps the next person decide.
Ingredients
Filter by role to see what each ingredient is doing.
Water~45–55%
Carthamus tinctorius seed oil~6.4–7.9%
- Irritation risk
- Low
An emollient that helps soften the skin and might help calm down inflammation
More about Carthamus tinctorius seed oilCyclopentasiloxane~4.4–5.4%
- Irritation risk
- Low
A silicone that helps improve the product texture and spreadability. Can absorb oil creating a short-term mattifying effect on the skin
More about CyclopentasiloxaneCetearyl alcohol~2.6–3.2%
- Irritation risk
- Low
- Comedogenicity
- 2/5
A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture
More about Cetearyl alcoholPolysorbate 60~2.3–2.9%
Dimethicone~2.1–2.5%
- Irritation risk
- Low
A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish
More about DimethiconeNiacinamide~1.7–2.1%
- Irritation risk
- Low
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
More about NiacinamideSodium hyaluronate~1.4–1.7%
- Irritation risk
- Low
One of the best moisturizing ingredients. Attracts water into the upper layer of the skin
More about Sodium hyaluronateRetinyl palmitate~1.2–1.4%
- Irritation risk
- High
Three steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect
More about Retinyl palmitateAscorbic acid~0.95–1.15%
- Irritation risk
- High
The most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging
More about Ascorbic acidRetinol~0.65–1%
- Irritation risk
- High
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
More about RetinolTocopherol~0.6–0.85%
- Irritation risk
- Low
Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself
More about TocopherolCarnitine~1.1–1.4%
Glycerin~0.5–0.75%
- Irritation risk
- Low
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
More about GlycerinChamomilla recutita flower extract~0.45–0.65%
- Irritation risk
- High
Plant extract that can have healing and anti-inflammatory properties. It is a potential allergen and can be irritating
More about Chamomilla recutita flower extractCitrus aurantium dulcis flower extract~0.4–0.6%
- Irritation risk
- High
Salvia officinalis leaf extract~0.45–0.7%
- Irritation risk
- High
Sage leaf extract. It can be irritating
More about Salvia officinalis leaf extractCitrus aurantium bergamia fruit extract~0.3–0.6%
- Irritation risk
- High
Vitis vinifera seed oil~0.35–0.6%
- Irritation risk
- Medium
A great emollient that can also have anti-oxidant properties
More about Vitis vinifera seed oilSaccharomyces/copper ferment~0.25–0.5%
- Irritation risk
- Low
Yeast extract that contains copper. Can help to attract water to the upper layer of the skin and can help in skin wound healing
More about Saccharomyces/copper fermentDimethylaminoethanol tartrate~0.25–0.5%
- Irritation risk
- Low
Thioctic acid~0.2–0.4%
Ubiquinone~0.2–0.4%
- Irritation risk
- Low
Coenzyme Q10. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergen
More about UbiquinonePhenoxyethanol~0.15–0.3%
- Irritation risk
- Low
A preservative. It helps prevent bacterial growth in cosmetic products
More about PhenoxyethanolEthylhexylglycerin~0.15–0.25%
Parfum~0.1–0.2%
- Irritation risk
- High
An aromatic blend of unspecified and possibly irritating ingredients
More about ParfumCollagen~0.1–0.2%
- Irritation risk
- Low
Cannot penetrate the skin barrier so is not particularly useful in skincare products
More about CollagenMalus domestica fruit cell culture extract~0.1–0.15%
- Irritation risk
- Low
Acetyl octapeptide-3~0.05–0.1%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Acetyl octapeptide-3Ingredient list view
Water, Carthamus tinctorius seed oil, Cyclopentasiloxane, Cetearyl alcohol, Polysorbate 60, Dimethicone, Niacinamide, Sodium hyaluronate, Retinyl palmitate, Ascorbic acid, Retinol, Tocopherol, Carnitine, Glycerin, Chamomilla recutita flower extract, Citrus aurantium dulcis flower extract, Salvia officinalis leaf extract, Citrus aurantium bergamia fruit extract, Vitis vinifera seed oil, Saccharomyces/copper ferment, Dimethylaminoethanol tartrate, Thioctic acid, Ubiquinone, Phenoxyethanol, Ethylhexylglycerin, Parfum, Collagen, Malus domestica fruit cell culture extract, Acetyl octapeptide-3
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Worth comparing, line by line.
Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.
| DermedicineAll In OneYOUR PRODUCT | Dermedecine5-in-1 Super Charged Gel | EpilogicThe total package | Geologie0.2% Retinol Night Cream | |
|---|---|---|---|---|
| Match | — | 76% | 64% | 61% |
| Price | — | $45.00 | $96.00 | $55.00 |
| Shared key ingredients | — | 15 of 16 | 10 of 16 | 6 of 16 |
| Key difference | — | — | Glycine Soja Oil | Cocos Nucifera Oil |
| Irritancy | High | High | High | Medium |
| Drying alcohol | — | — | — | — |
| View product | Shop | Shop | Shop |
Product summary
Based on the ingredients included, "Dermedicine - All In One" works well for moisturizing the skin. This moisturizer uses a good combo of humectants and emollients. These both types of ingredients are essentials for improving the skin hydration and keeping the skin barrier healthy. Acetyl octapeptide-3, glycerin, saccharomyces/copper ferment and sodium hyaluronate in this product (humectants) attract water molecules to the upper layer of the skin (the water comes from the outside air or from the deeper layers of the skin if the air is dry). Carthamus tinctorius seed oil, vitis vinifera seed oil, dimethicone, cetearyl alcohol and cyclopentasiloxane in this product help decrease the water evoporation from the skin, so that it stays hydrated for longer. These ingredients also soften the skin and take away the feeling of tightness and dryness.
Ingredient callouts
- We love that this moisturizer contains a good concentration of niacinamide 1.70% - 2.10%. Niacinamide is a perfect active in a moistruizer because it helps calm down inflamation in skin and support the skin barrier. More than that, it is helpful for most common skin concerns: it helps regulat oil production, help reduce acne and clogged pores, improve skin tone and prevent pigmentation marks. It also helps fight photodamage.
- This product also contains Vitamin C (Ascorbic Acid). It can be an effective active for anti-aging and evening out the skin tone, but in this moisturizer it is used for stabilizing other ingredients in the formulation. In this concentration (0.95% - 1.15%) it cannot have a noticeable benefit for the skin.
- This moisturizer contains an effective form of Retinoids (vitamin A): retinol 0.65% - 1.00%. Retinoids are potent multitasking actives. They work to improve and prevent early signs of aging, reduce hyperpigmentation (age spots and post-acne marks), and prevent inflamed blemishes and clogged pores. The downside of Retinoids is that they can be irritating. If you are not already using a Retinoid in your routine, it is best to start slowly and apply the Retinoid product only a few times per week. If your skin tolerates it well, you can gradually increase the frequency to daily. Because of the irritation risk of Retinoids, we recommend to have another, retinoid-free moisturizer in your routine to use on the alternate days or when your skin feels dry.
- This moisturizer also contains Peptides (acetyl octapeptide-3 0.05% - 0.10%). Peptides are a very big group of ingredients. They all consist of a different combination of aminoacids. Our skin produces Peptides naturally. Some of them work as natural antibiotics, promote wound-healing and production of collagen. The scientists are still studying how effective the topical application of Peptides is, but it is very likely that they are helpful. Peptides might be able to support skin barrier restoration and even have an anti-aging benefit. At the very least, they certainly help attract water to the skin and support the hydration in this way.
Irritation risk
We assess the overall irritancy of this moisturizer to be high. For a detailed overview of all potential irritants: click here
You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.
Sources cited in this review
Every concentration estimate and effectiveness label is anchored to one of these 13 studies and safety reviews.
- 1
- 2Final Report on the Safety Assessment of Dimethicone Copolyoljournals.sagepub.com
- 3
- 4
- 5Hyaluronic acid: A key molecule in skin agingncbi.nlm.nih.gov
- 6
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