DERMAFIRM

DERMAFIRM Ultra Soothing Formula R4

Name: DERMAFIRM - Ultra Soothing Formula R4
Brand: DERMAFIRM

Efficacy100/100IrritancyHigh

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Works for

1 of 1 advertised claim delivered

Moisturizing

Copper tripeptide-1, Palmitoyl oligopeptide + 27 more

Strong evidence

What the product description says

“A multi-function moisturiser helps replenishes and nourishes skin after cleansing.”

Source: Yesstyle

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: alanine, arginine.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: arginine, dimethicone.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: copper tripeptide-1, palmitoyl oligopeptide

IsoleucineKey activeEffect: HighAn amino acid that can help attract water to the upper layer of the skin and support skin's barrier function~0.2–0.4%

TyrosineKey activeEffect: High~0.2–0.4%

AlanineKey active· HumectantEffect: HighAn amino-acid that helps to attract water to the upper layer of the skin and might help to lighten the skin, but solid evidence is lacking~0.2–0.4%

ArginineKey active· Humectant, OcclusiveEffect: HighAn amino acid that is naturally present in skin and helps keep it hydrated. When used together with AHAs, it can reduce their irritating effect on the skin~0.2–0.35%

Aspartic acidKey active· HumectantEffect: HighAn amino-acid that helps increase skin hydration and might help to slightly improve skin firmness, potentially reducing lines and wrinkles~0.2–0.4%

Copper tripeptide-1HeroEffect: HighA naturally occurring peptide. One of the most studied peptides in dermatology. It is sometimes abbreviated GHK-Cu. Belongs to the class of carrier peptides. It stimulates both synthesis and breakdown of collagen in skin. It is released in skin wounds and inflammation to support healing. It accelerates wound-healing of the skin and can stimulate hair growth. There are preliminary studies that confirm that copper tripeptide can help support collagen production reducing fine lines and wrinkles and decrease inflammation in skin.~0.15–0.3%

CysteineKey activeEffect: HighMight help neutralize free radicals in skin and might be helpful against hyperpigmentation~0.1–0.15%

DimethiconeKey active· Emollient, OcclusiveEffect: HighA silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish~4.1–5%

Glutamic acidKey active· HumectantEffect: HighAn amino-acid that helps attract water to the upper layer of the skin~0.2–0.4%

GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~3–3.6%

GlycineKey active· HumectantEffect: HighHelps to attract water to the upper layer of the skin and can help restore the skin barrier function~0.15–0.3%

HistidineKey active· HumectantEffect: High~0.2–0.4%

LysineKey activeEffect: HighAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.2–0.4%

Palmitoyl oligopeptideHeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.45%

SerineKey activeEffect: HighAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.2–0.35%

Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~0.25–0.45%

ThreonineKey activeEffect: HighAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.2–0.4%

Macadamia ternifolia seed oilKey active· EmollientEffect: MediumPlant oil from nuts that helps soften the upper layer of the skin. Contains a high concentration of oleic acid that can weaken skin's barrier function and increase water-loss while enhancing penetration of other ingredients~1–1.3%

Glyceryl stearate seKey activeEffect: MediumUsed to stabilize the product formulations and works as an emollient~1.3–1.5%

ProlineKey activeEffect: Medium~0.2–0.4%

GlucoseKey active· HumectantEffect: MediumHelps attract water to the upper layer of the skin. Could be helpful in restoring the skin barrier function~0.15–0.3%

Vegetable oilKey active· EmollientEffect: MediumAn oil from a mixture of different vegetables. Helps soften the upper layer of the skin~0.25–0.45%

AdenosineKey activeEffect: MediumMight help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)~0.25–0.4%

Cetearyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture~2.2–2.7%

Portulaca oleracea extract· HumectantEffect: LowA plant extract that has some anti-oxidant activity, but solid research is lacking. Can help attract water to the upper layer of the skin~0.15–0.3%

Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~5.6–6.9%

Centella asiatica extractUnder-dosedEffect: HighA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.~0.2–0.4%

Caprylic/capric triglycerideUnder-dosedEffect: HighA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin~0.25–0.5%

TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.25–0.4%

Anti-aging

Not advertised by the brand · Adenosine, Serine + 9 more

Strong evidence

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains adenosine.

These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: aspartic acid, copper tripeptide-1, lysine, palmitoyl oligopeptide, serine, threonine.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

AdenosineKey activeEffect: HighMight help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)~0.25–0.4%

SerineKey activeEffect: MediumAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.2–0.35%

ThreonineKey activeEffect: MediumAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.2–0.4%

Copper tripeptide-1Key activeEffect: MediumA naturally occurring peptide. One of the most studied peptides in dermatology. It is sometimes abbreviated GHK-Cu. Belongs to the class of carrier peptides. It stimulates both synthesis and breakdown of collagen in skin. It is released in skin wounds and inflammation to support healing. It accelerates wound-healing of the skin and can stimulate hair growth. There are preliminary studies that confirm that copper tripeptide can help support collagen production reducing fine lines and wrinkles and decrease inflammation in skin.~0.15–0.3%

Palmitoyl oligopeptideKey activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.45%

Aspartic acidKey activeEffect: MediumAn amino-acid that helps increase skin hydration and might help to slightly improve skin firmness, potentially reducing lines and wrinkles~0.2–0.4%

LysineKey activeEffect: MediumAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.2–0.4%

Ascorbic acidUnder-dosedEffect: HighThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging~0.2–0.35%

Centella asiatica extractUnder-dosedEffect: MediumA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.~0.2–0.4%

Magnesium ascorbyl phosphateEffect: Low, below effective doseA derivative of vitamin C that is more stable, but less bioavailable than the pure form of vitamin C. It does not penetrate the skin well, but has been shown to convert to pure vitamin C once in skin. It can be helpful in stimulating collagen production and lightening the skin tone, but the required concentration is likely to be very high~0.3–0.6%

Anti-oxidation

Not advertised by the brand · Cysteine, Portulaca oleracea extract + 6 more

Moderate evidence

This product contains antioxidants (cysteine) that might be able to help neutralize free radicals in skin to lessen the damage it gets from the UV light (sun). There is not enough evidence to confirm their effectiveness in skin though.

CysteineKey activeEffect: MediumMight help neutralize free radicals in skin and might be helpful against hyperpigmentation~0.1–0.15%

Portulaca oleracea extractEffect: LowA plant extract that has some anti-oxidant activity, but solid research is lacking. Can help attract water to the upper layer of the skin~0.15–0.3%

Perilla ocymoides leaf extractEffect: LowA plant extract that might help neutralize free radicals in skin but solid research is lacking. Contains a number of volatile compounds and could be irritating~0.15–0.3%

AdenosineEffect: LowMight help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)~0.25–0.4%

TocopherolUnder-dosedEffect: HighPure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.25–0.4%

Can it cause trouble?

Irritancy

5 strong irritants: Sorbitan sesquioleate, Hamamelis virginiana extract + 3 more — patch-test recommended

High risk

We flagged 17 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.

IngredientFunctionIrritationEst. amount

Sorbitan sesquioleateUsed to help oil and water mix together. Can be irritatingHigh~0.7–1%est.

Hamamelis virginiana extractA plant extract that can help calm down inflammation in skin. Can, however, itself be irritatingHigh~0.5–0.75%est.

ParfumAn aromatic blend of unspecified and possibly irritating ingredientsHigh~0.3–0.5%est.

Perilla ocymoides leaf extractA plant extract that might help neutralize free radicals in skin but solid research is lacking. Contains a number of volatile compounds and could be irritatingHigh~0.15–0.3%est.

Eugenia caryophyllus flower extractA plant extract that is used as a fragrance. Can be irritatingHigh~0.25–0.4%est.

Ascorbic acidThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of agingHigh~0.2–0.35%est.

1,2-hexanediolA preservativeMedium~0.7–1.05%est.

Polysorbate 60Helps oil and water mix togetherMedium~1.5–1.9%est.

Macadamia ternifolia seed oilPlant oil from nuts that helps soften the upper layer of the skin. Contains a high concentration of oleic acid that can weaken skin's barrier function and increase water-loss while enhancing penetration of other ingredientsMedium~1–1.3%est.

Cetearyl glucosideHelps water and oil in the product mix well together and improves product textureMedium~0.5–0.75%est.

Magnesium ascorbyl phosphateA derivative of vitamin C that is more stable, but less bioavailable than the pure form of vitamin C. It does not penetrate the skin well, but has been shown to convert to pure vitamin C once in skin. It can be helpful in stimulating collagen production and lightening the skin tone, but the required concentration is likely to be very highMedium~0.3–0.6%est.

EthylhexylglycerinA preservativeMedium~0.3–0.5%est.

Disodium edtaStabilizes the product formulationMedium~0.2–0.35%est.

Hydrogenated phosphatidylcholineHelps oil and water mix togetherMedium~0.2–0.35%est.

Portulaca oleracea extractA plant extract that has some anti-oxidant activity, but solid research is lacking. Can help attract water to the upper layer of the skinMedium~0.15–0.3%est.

Centella asiatica extractA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.Medium~0.2–0.4%est.

Caprylic/capric triglycerideA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerinMedium~0.25–0.5%est.

Comedogenic

2 ingredients rated 2 or more on the 0–5 pore-clogging scale

2 flagged

These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.

IngredientFunctionRatingEst. amount

Cetearyl alcoholA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture2/5~2.2–2.7%est.

Glyceryl stearate seUsed to stabilize the product formulations and works as an emollient2/5~1.3–1.5%est.

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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%

Formula

Irritation risk: Low

Plain old water

More about Water

Butylene glycol~5.6–6.9%

Formula

Irritation risk: Low

Works for

Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol

Dimethicone~4.1–5%

Key active

Irritation risk: Low

Works for

MoisturizingMattifying

A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish

More about Dimethicone

Glycerin~3–3.6%

Key active

Irritation risk: Low

Works for

Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin

Cetearyl alcohol~2.2–2.7%

Key activeComedogenic 2/5

Irritation risk: Low
Comedogenicity: 2/5

Works for

CleansingMoisturizing

A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture

More about Cetearyl alcohol

1,2-hexanediol~0.7–1.05%

Irritant · medium

Irritation risk: Medium

A preservative

More about 1,2-hexanediol

Polysorbate 60~1.5–1.9%

Irritant · medium

Irritation risk: Medium

Works for

Cleansing

Helps oil and water mix together

More about Polysorbate 60

Glyceryl stearate se~1.3–1.5%

Key activeComedogenic 2/5

Irritation risk: Low
Comedogenicity: 2/5

Works for

CleansingMoisturizing

Used to stabilize the product formulations and works as an emollient

More about Glyceryl stearate se

Macadamia ternifolia seed oil~1–1.3%

Key activeIrritant · medium

Irritation risk: Medium

Works for

Moisturizing

Plant oil from nuts that helps soften the upper layer of the skin. Contains a high concentration of oleic acid that can weaken skin's barrier function and increase water-loss while enhancing penetration of other ingredients

More about Macadamia ternifolia seed oil

Sorbitan sesquioleate~0.7–1%

Irritant · high

Irritation risk: High

Works for

Cleansing

Used to help oil and water mix together. Can be irritating

More about Sorbitan sesquioleate

Hamamelis virginiana extract~0.5–0.75%

Irritant · high

Irritation risk: High

Works for

Anti-inflammatory

A plant extract that can help calm down inflammation in skin. Can, however, itself be irritating

More about Hamamelis virginiana extract

Cetearyl glucoside~0.5–0.75%

Irritant · medium

Irritation risk: Medium

Works for

Cleansing

Helps water and oil in the product mix well together and improves product texture

More about Cetearyl glucoside

Carbomer~0.4–0.65%

Formula

Irritation risk: Low

Works for

Cleansing

Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations

More about Carbomer

Magnesium ascorbyl phosphate~0.3–0.6%

Irritant · medium

Irritation risk: Medium

Works for

Evens skin toneAnti-agingAnti-oxidation

A derivative of vitamin C that is more stable, but less bioavailable than the pure form of vitamin C. It does not penetrate the skin well, but has been shown to convert to pure vitamin C once in skin. It can be helpful in stimulating collagen production and lightening the skin tone, but the required concentration is likely to be very high

More about Magnesium ascorbyl phosphate

Parfum~0.3–0.5%

Irritant · high

Irritation risk: High

An aromatic blend of unspecified and possibly irritating ingredients

More about Parfum

Tromethamine~0.3–0.55%

Formula

Irritation risk: Low

Helps adjust pH in products

More about Tromethamine

Ethylhexylglycerin~0.3–0.5%

Irritant · medium

Irritation risk: Medium

A preservative

More about Ethylhexylglycerin

Sodium hyaluronate~0.25–0.45%

Key active

Irritation risk: Low

Works for

Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate

Adenosine~0.25–0.4%

Key active

Irritation risk: Low

Works for

Anti-agingMoisturizingAnti-oxidation

Might help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)

More about Adenosine

Vegetable oil~0.25–0.45%

Key active

Irritation risk: Low

Works for

Moisturizing

An oil from a mixture of different vegetables. Helps soften the upper layer of the skin

More about Vegetable oil

Disodium edta~0.2–0.35%

Irritant · medium

Irritation risk: Medium

Stabilizes the product formulation

More about Disodium edta

Hydrogenated phosphatidylcholine~0.2–0.35%

Irritant · medium

Irritation risk: Medium

Works for

Cleansing

Helps oil and water mix together

More about Hydrogenated phosphatidylcholine

Xanthan gum~0.2–0.35%

Formula

Irritation risk: Low

Works for

Cleansing

Used to create a thicker product consistency

More about Xanthan gum

Glucose~0.15–0.3%

Key active

Irritation risk: Low

Works for

Moisturizing

Helps attract water to the upper layer of the skin. Could be helpful in restoring the skin barrier function

More about Glucose

Portulaca oleracea extract~0.15–0.3%

Irritant · medium

Irritation risk: Medium

Works for

MoisturizingAnti-oxidation

A plant extract that has some anti-oxidant activity, but solid research is lacking. Can help attract water to the upper layer of the skin

More about Portulaca oleracea extract

Sodium guaiazulene sulfonate~0.15–0.3%

Formula

Irritation risk: Low

Works for

Cleansing

More about Sodium guaiazulene sulfonate

Perilla ocymoides leaf extract~0.15–0.3%

Irritant · high

Irritation risk: High

Works for

Anti-oxidation

A plant extract that might help neutralize free radicals in skin but solid research is lacking. Contains a number of volatile compounds and could be irritating

More about Perilla ocymoides leaf extract

Lactobacillus/rice ferment~0.15–0.3%

Formula

Irritation risk: Low

More about Lactobacillus/rice ferment

Centella asiatica extract~0.2–0.4%

Under-dosedIrritant · medium

Irritation risk: Medium

Works for

Reduces irritationAnti-inflammatoryReduces rednessMoisturizingAnti-agingAnti-oxidationAnti-blemish

A plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.

More about Centella asiatica extract

Glycine~0.15–0.3%

Key active

Irritation risk: Low

Works for

Moisturizing

Helps to attract water to the upper layer of the skin and can help restore the skin barrier function

More about Glycine

Phaseolus radiatus seed extract~0.2–0.35%

Formula

Irritation risk: Low

More about Phaseolus radiatus seed extract

Oryza sativa bran extract~0.15–0.3%

Formula

Irritation risk: Low

Used to thicken the product consistency

More about Oryza sativa bran extract

Nardostachys chinensis root extract~0.2–0.35%

Formula

Irritation risk: Low

More about Nardostachys chinensis root extract

Gleditsia australis fruit extract~0.2–0.35%

Formula

Irritation risk: Low

More about Gleditsia australis fruit extract

Eugenia caryophyllus flower extract~0.25–0.4%

Irritant · high

Irritation risk: High

A plant extract that is used as a fragrance. Can be irritating

More about Eugenia caryophyllus flower extract

Cimicifuga racemosa root extract~0.25–0.45%

Formula

Irritation risk: Low

More about Cimicifuga racemosa root extract

Bletia hyacinthina bulb extract~0.2–0.4%

Formula

Irritation risk: Low

More about Bletia hyacinthina bulb extract

Amomum xanthioides seed extract~0.2–0.4%

Formula

Irritation risk: Low

More about Amomum xanthioides seed extract

Serine~0.2–0.35%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-aging

An amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles

More about Serine

Arginine~0.2–0.35%

Key active

Irritation risk: Low

Works for

Moisturizing

An amino acid that is naturally present in skin and helps keep it hydrated. When used together with AHAs, it can reduce their irritating effect on the skin

More about Arginine

Aspartic acid~0.2–0.4%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-aging

An amino-acid that helps increase skin hydration and might help to slightly improve skin firmness, potentially reducing lines and wrinkles

More about Aspartic acid

Glutamic acid~0.2–0.4%

Key active

Irritation risk: Low

Works for

Moisturizing

An amino-acid that helps attract water to the upper layer of the skin

More about Glutamic acid

Leucine~0.2–0.4%

Formula

Irritation risk: Low

More about Leucine

Alanine~0.2–0.4%

Key active

Irritation risk: Low

Works for

MoisturizingEvens skin tone

An amino-acid that helps to attract water to the upper layer of the skin and might help to lighten the skin, but solid evidence is lacking

More about Alanine

Lysine~0.2–0.4%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-aging

An amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles

More about Lysine

Proline~0.2–0.4%

Key active

Irritation risk: Low

Works for

Moisturizing

More about Proline

Phenylalanine~0.2–0.4%

Formula

Irritation risk: Low

More about Phenylalanine

Valine~0.2–0.35%

Formula

Irritation risk: Low

More about Valine

Threonine~0.2–0.4%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-aging

An amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles

More about Threonine

Isoleucine~0.2–0.4%

Key active

Irritation risk: Low

Works for

Moisturizing

An amino acid that can help attract water to the upper layer of the skin and support skin's barrier function

More about Isoleucine

Tocopherol~0.25–0.4%

Under-dosed

Irritation risk: Low

Works for

Anti-oxidationAnti-inflammatoryAnti-agingMoisturizing

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol

Tyrosine~0.2–0.4%

Key active

Irritation risk: Low

Works for

Moisturizing

More about Tyrosine

Histidine~0.2–0.4%

Key active

Irritation risk: Low

Works for

Moisturizing

More about Histidine

Caprylic/capric triglyceride~0.25–0.5%

Under-dosedIrritant · medium

Irritation risk: Medium

Works for

Moisturizing

A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin

More about Caprylic/capric triglyceride

Ascorbic acid~0.2–0.35%

Under-dosedIrritant · high

Irritation risk: High

Works for

Anti-agingEvens skin toneAnti-oxidation

The most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging

More about Ascorbic acid

Polyglyceryl-10 diisostearate~0.2–0.4%

Formula

Irritation risk: Low

Works for

Cleansing

More about Polyglyceryl-10 diisostearate

Hydrogenated lecithin~0.2–0.35%

Formula

Irritation risk: Low

Works for

Cleansing

Helps to retain moisture by creating a protective barrier on the skin. Rich in fatty acids. Improves product texture and helps with the penetration of other ingredients.

More about Hydrogenated lecithin

Palmitoyl oligopeptide~0.25–0.45%

Hero · Moisturizing

Irritation risk: Low

Works for

MoisturizingCleansingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl oligopeptide

Menadione~0.15–0.3%

Formula

Irritation risk: Low

More about Menadione

Copper tripeptide-1~0.15–0.3%

Hero · Moisturizing

Irritation risk: Low

Works for

MoisturizingAnti-aging

A naturally occurring peptide. One of the most studied peptides in dermatology. It is sometimes abbreviated GHK-Cu. Belongs to the class of carrier peptides. It stimulates both synthesis and breakdown of collagen in skin. It is released in skin wounds and inflammation to support healing. It accelerates wound-healing of the skin and can stimulate hair growth. There are preliminary studies that confirm that copper tripeptide can help support collagen production reducing fine lines and wrinkles and decrease inflammation in skin.

More about Copper tripeptide-1

Methionine~0.1–0.2%

Formula

Irritation risk: Low

More about Methionine

Cysteine~0.1–0.15%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-oxidationEvens skin tone

Might help neutralize free radicals in skin and might be helpful against hyperpigmentation

More about Cysteine

Ingredient list view

Water, Butylene glycol, Dimethicone, Glycerin, Cetearyl alcohol, 1,2-hexanediol, Polysorbate 60, Glyceryl stearate se, Macadamia ternifolia seed oil, Sorbitan sesquioleate, Hamamelis virginiana extract, Cetearyl glucoside, Carbomer, Magnesium ascorbyl phosphate, Parfum, Tromethamine, Ethylhexylglycerin, Sodium hyaluronate, Adenosine, Vegetable oil, Disodium edta, Hydrogenated phosphatidylcholine, Xanthan gum, Glucose, Portulaca oleracea extract, Sodium guaiazulene sulfonate, Perilla ocymoides leaf extract, Lactobacillus/rice ferment, Centella asiatica extract, Glycine, Phaseolus radiatus seed extract, Oryza sativa bran extract, Nardostachys chinensis root extract, Gleditsia australis fruit extract, Eugenia caryophyllus flower extract, Cimicifuga racemosa root extract, Bletia hyacinthina bulb extract, Amomum xanthioides seed extract, Serine, Arginine, Aspartic acid, Glutamic acid, Leucine, Alanine, Lysine, Proline, Phenylalanine, Valine, Threonine, Isoleucine, Tocopherol, Tyrosine, Histidine, Caprylic/capric triglyceride, Ascorbic acid, Polyglyceryl-10 diisostearate, Hydrogenated lecithin, Palmitoyl oligopeptide, Menadione, Copper tripeptide-1, Methionine, Cysteine

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$32.50

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
	DERMAFIRMUltra Soothing Formula R4YOUR PRODUCT	JuneCellRejuvenation Lifting Skin Emulsion	MEDI-PEELPeptide 9 Volume Tox Cream Pro	EvercellDeep Wrinkle Solution Cream Syringe Type
Match	—	57%	55%	55%
Price	$32.50	—	$26.33−$6.17	$14.10−$18.40
Shared key ingredients	—	16 of 22	9 of 22	16 of 22
Key difference	—	Niacinamide	Acetyl Dipeptide-1 Cetyl Ester	Biotinoyl Tripeptide-1
Irritancy	High	High	Medium	Medium
Drying alcohol	—	Contains drying alcohol	—	—
	View product	Shop	Shop	Shop

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Product summary

Judging from the ingredient list, "DERMAFIRM - Ultra Soothing Formula R4" works well for improving skin hydration To work well, any moisturizer needs to include a combination of water-binding and emollient ingredients. DERMAFIRM - Ultra Soothing Formula R4 ticks this box. Humectants in this product (alanine, arginine, aspartic acid, glutamic acid and glycerin) help to increase the water content in the upper layer of the skin. (These ingredients do so by "capturing" water molecules from the outside air or from within the deeper layers of the skin). Emollients in this formulation (arginine, dimethicone, cetearyl alcohol, macadamia ternifolia seed oil and vegetable oil) help to reduce the moisture loss from the skin. They also soften the skin surface and relieve the feeling of dryness and tightness.

Ingredient callouts

This product also contains Vitamin C (Ascorbic Acid). It can be an effective active for anti-aging and evening out the skin tone, but in this moisturizer it is used for stabilizing other ingredients in the formulation. In this concentration (0.20% - 0.35%) it cannot have a noticeable benefit for the skin.
This moisturizer also contains Peptides (copper tripeptide-1 0.15% - 0.30% and palmitoyl oligopeptide 0.25% - 0.45%). Peptides are a very big group of ingredients. They all consist of a different combination of aminoacids. Our skin produces Peptides naturally. Some of them work as natural antibiotics, promote wound-healing and production of collagen. The scientists are still studying how effective the topical application of Peptides is, but it is very likely that they are helpful. Peptides might be able to support skin barrier restoration and even have an anti-aging benefit. At the very least, they certainly help attract water to the skin and support the hydration in this way.
Adenosine 0.25% - 0.40%. It is a compound that in involved in many biological processes inside the skin cells. According one high-quality clinical trial, topical Adenosine in low concentrations can somewhat help improve "deep wrinkles" - the wrinkles that appear with age in places where our faces are most dynamic (for example, on the forehead or in the corners of the eyes).

This product contains ingredients that could be beneficial, but their concentrations are too low in this formulation: vitamin c, caprylic/capric triglyceride, vitamin e and centella asiatica extract

Irritation risk

This formulation includes some common irritants, including ingredients that do not provide a benefit for the skin. We assess the overall irritancy of this moisturizer to be high. For a detailed overview of all potential irritants: click here

You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.