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Derma E Anti-Wrinkle Retinol Night Treatment
Derma E

Derma E Anti-Wrinkle Retinol Night Treatment

Efficacy100/100IrritancyMedium
See all ingredients

Works for

Moisturizing
Palmitoyl tripeptide-1, Palmitoyl tetrapeptide-7 + 9 more
Works well
What the product description says
“The concentrated formula works overtime while you sleep, combining line-smoothing Retinol with our exclusive collagen-supporting Multi-Peptide blend to firm & plump skin.”
Source: Derma E

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: glycerin, methyl gluceth-20.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: caprylic/capric triglyceride, cetearyl alcohol.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: palmitoyl tetrapeptide-7, palmitoyl tripeptide-1

Palmitoyl tripeptide-1Hero· EmollientEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.6–1.35%
Palmitoyl tetrapeptide-7Hero· EmollientEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.45–1.1%
Caprylic/capric triglycerideKey active· Emollient, OcclusiveEffect: HighA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin~3.8–5.7%
EctoinKey activeEffect: HighSoftens the upper layer of the skin and can support skin barrier function~0.3–0.75%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~0.15–0.5%
Cetearyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture~0.15–0.55%
Methyl gluceth-20Key active· HumectantEffect: MediumHelps attract water to the upper layer of the skin and soften it~0.05–0.3%
Aloe barbadensis leaf juice· HumectantEffect: LowTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin~5.9–8.8%
Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~1.9–2.8%
NiacinamideUnder-dosedIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~0.35–0.85%
GluconolactoneUnder-dosedA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals~0.15–0.55%
Anti-aging
Retinol, Palmitoyl tripeptide-1 + 4 more
Works well
What the product description says
“Anti-Wrinkle Retinol Night Treatment”
Source: Derma E

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains retinol.

These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: palmitoyl tetrapeptide-7, palmitoyl tripeptide-1.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

RetinolHeroEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~1–1.5%
Palmitoyl tripeptide-1Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.6–1.35%
Palmitoyl tetrapeptide-7Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.45–1.1%
Aloe barbadensis leaf juiceEffect: LowTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin~5.9–8.8%
NiacinamideUnder-dosedIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~0.35–0.85%
GluconolactoneUnder-dosedA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals~0.15–0.55%
Anti-oxidation
Side benefit · Retinol, Glycyrrhiza glabra root extract + 1 more
Works well

This product contains antioxidants (retinol) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

RetinolKey activeEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~1–1.5%
Glycyrrhiza glabra root extractEffect: LowA plant extract that can help lighten the skin and calm down inflammation. Might be helpful in neutralizing free radicals~0.2–0.75%
GluconolactoneUnder-dosedA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals~0.15–0.55%
Exfoliation
Side benefit · Retinol, Gluconolactone
Works well

This product can help exfoliate the skin. In other words, it helps break down the bonds between dead cells on the surface of the skin and speed up the skin turnover. Skin often appears softer and brighter after exfoliation, but overdoing it can result in disrupted skin barrier. The following ingredient is doing the exfoliating job in this product: retinol.

RetinolKey activeEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~1–1.5%
GluconolactoneUnder-dosedA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals~0.15–0.55%
Evens skin tone
Side benefit · Retinol, Glycyrrhiza glabra root extract + 2 more
Works well

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: retinol.

The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually can help even out the skin tone: glycyrrhiza glabra root extract.

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

RetinolHeroEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~1–1.5%
Glycyrrhiza glabra root extractEffect: LowA plant extract that can help lighten the skin and calm down inflammation. Might be helpful in neutralizing free radicals~0.2–0.75%
NiacinamideUnder-dosedIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~0.35–0.85%
GluconolactoneUnder-dosedA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals~0.15–0.55%
Anti-blemish
Side benefit · Retinol, Aloe barbadensis leaf juice + 2 more
Works well

This product can help reduce breakouts and clogged pores because it contains the following ingredient: retinol. This ingredient is used for treating acne and can have a noticeable effect.

RetinolHeroEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~1–1.5%
Aloe barbadensis leaf juiceEffect: LowTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin~5.9–8.8%
NiacinamideUnder-dosedIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~0.35–0.85%
GluconolactoneUnder-dosedA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals~0.15–0.55%

Can it cause trouble?

Irritancy
1 strong irritant: Retinol
Medium risk
We flagged 6 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
RetinolTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritatingHigh~1–1.5%est.
Aloe barbadensis leaf juiceTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skinMedium~5.9–8.8%est.
Caprylic/capric triglycerideA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerinMedium~3.8–5.7%est.
Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymerA gelling agent that thickens the product consistency and leaves the skin with a velvety finishMedium~1.3–1.9%est.
Glycyrrhiza glabra root extractA plant extract that can help lighten the skin and calm down inflammation. Might be helpful in neutralizing free radicalsMedium~0.2–0.75%est.
GluconolactoneA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicalsMedium~0.15–0.55%est.
Comedogenic
1 ingredient rated 2 or more on the 0–5 pore-clogging scale
1 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Cetearyl alcoholA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture2/5~0.15–0.55%est.
Alternatives
Cheaper, or higher on efficacy
Hyper Retinol EX 1.0 Serum
ISNTREE Hyper Retinol EX 1.0 Serum
Cheaper80% match
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Ingredients

Filter by role to see what each ingredient is doing.

Water~40–60%
Formula
Irritation risk
Low

Plain old water

More about Water
Aloe barbadensis leaf juice~5.9–8.8%
Irritant · medium
Irritation risk
Medium
Works for
MoisturizingAntibacterialAnti-inflammatoryReduces rednessReduces irritationAnti-blemishAnti-aging

Traditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin

More about Aloe barbadensis leaf juice
Caprylic/capric triglyceride~3.8–5.7%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin

More about Caprylic/capric triglyceride
C13-15 alkane~2.7–4%
Formula
Irritation risk
Low

Helps dissolve other ingredients in the formula

More about C13-15 alkane
Butylene glycol~1.9–2.8%
Formula
Irritation risk
Low
Works for
Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol
Polyacrylate crosspolymer-6~1.5–2.3%
Formula
Irritation risk
Low
More about Polyacrylate crosspolymer-6
Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer~1.3–1.9%
Irritant · medium
Irritation risk
Medium

A gelling agent that thickens the product consistency and leaves the skin with a velvety finish

More about Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer
Retinol~1–1.5%
Hero · Anti-aging, Evens skin tone, Anti-blemishIrritant · high
Irritation risk
High
Works for
Anti-oxidationAnti-agingEvens skin toneAnti-blemishMattifyingExfoliation

Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating

More about Retinol
Nephelium lappaceum leaf extract~0.85–1.3%
Formula
Irritation risk
Low
More about Nephelium lappaceum leaf extract
Palmitoyl tripeptide-1~0.6–1.35%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tripeptide-1
Palmitoyl tetrapeptide-7~0.45–1.1%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tetrapeptide-7
Niacinamide~0.35–0.85%
Under-dosed
Irritation risk
Low
Works for
Anti-blemishEvens skin toneMoisturizingAnti-agingReduces irritationReduces rednessAnti-inflammatoryAntibacterial

Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production

More about Niacinamide
Ectoin~0.3–0.75%
Key active
Irritation risk
Low
Works for
Moisturizing

Softens the upper layer of the skin and can support skin barrier function

More about Ectoin
Glycyrrhiza glabra root extract~0.2–0.75%
Irritant · medium
Irritation risk
Medium
Works for
Reduces rednessEvens skin toneAnti-inflammatoryAnti-oxidationAntibacterial

A plant extract that can help lighten the skin and calm down inflammation. Might be helpful in neutralizing free radicals

More about Glycyrrhiza glabra root extract
Polyglyceryl-3 laurate~0.2–0.7%
Formula
Irritation risk
Low
Works for
Cleansing
More about Polyglyceryl-3 laurate
Gluconolactone~0.15–0.55%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
ExfoliationMoisturizingAnti-agingEvens skin toneAnti-oxidationAnti-blemish

A polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals

More about Gluconolactone
Glycerin~0.15–0.5%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Cetearyl alcohol~0.15–0.55%
Key activeComedogenic 2/5
Irritation risk
Low
Comedogenicity
2/5
Works for
CleansingMoisturizing

A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture

More about Cetearyl alcohol
Methyl gluceth-20~0.05–0.3%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps attract water to the upper layer of the skin and soften it

More about Methyl gluceth-20
Polysorbate 20~0.05–0.3%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about Polysorbate 20
Carbomer~0.05–0.2%
Formula
Irritation risk
Low
Works for
Cleansing

Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations

More about Carbomer
Sodium benzoate~0.05–0.15%
Formula
Irritation risk
Low

A preservative

More about Sodium benzoate
Maltodextrin~0.05–0.1%
Formula
Irritation risk
Low
Works for
Mattifying

Used to stabilize the product formulation and can help absorb oil

More about Maltodextrin
Phenoxyethanol~0.05–0.1%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Ingredient list view

Water, Aloe barbadensis leaf juice, Caprylic/capric triglyceride, C13-15 alkane, Butylene glycol, Polyacrylate crosspolymer-6, Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, Retinol, Nephelium lappaceum leaf extract, Palmitoyl tripeptide-1, Palmitoyl tetrapeptide-7, Niacinamide, Ectoin, Glycyrrhiza glabra root extract, Polyglyceryl-3 laurate, Gluconolactone, Glycerin, Cetearyl alcohol, Methyl gluceth-20, Polysorbate 20, Carbomer, Sodium benzoate, Maltodextrin, Phenoxyethanol

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Amazon USPrice as of 11/11 18:29 GMT
$22.50
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Derma E
$24.50
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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
Derma EAnti-Wrinkle Retinol Night TreatmentYOUR PRODUCTNo7Pure Retinol 1% Night ConcentrateDrunk ElephantA-Passioni Retinol CreamREMEDY SCIENCEREMEDY for healthy aging
Match—88%84%80%
Price$24.50$42.93+$18.43$49.61+$25.11$35.00+$10.50
Shared key ingredients—6 of 86 of 87 of 8
Key difference—Acetyl Dipeptide-1 Cetyl EsterLinoleic AcidRetinal
Irritancy Medium Medium Medium Medium
Drying alcohol————
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  • differs
  • cheaper

More alternatives: ISNTREE Hyper Retinol EX 1.0 SerumSKIN&LAB Vitamin C Brightening Serum

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Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 17 studies and safety reviews.

  1. 1
    Retinoids in the treatment of skin aging: an overview of clinical efficacy and safetyncbi.nlm.nih.gov
  2. 2
    Improvement of naturally aged skin with vitamin A (retinol)ncbi.nlm.nih.gov
  3. 3
    A comparative study of the effects of retinol and retinoic acid on histological, molecular, and clinical properties of human skinonlinelibrary.wiley.com
  4. 4
    Niacinamide - mechanisms of action and its topical use in dermatologyncbi.nlm.nih.gov
  5. 5
    Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology, 3(2), 88–93. doi:10.1111/j.1473-2130.2004.00115.x ncbi.nlm.nih.gov
  6. 6
    A comparative study of gluconolactone versus benzoyl peroxide in the treatment of acnencbi.nlm.nih.gov
Derma E Anti-Wrinkle Retinol Night Treatment
Derma EAnti-Wrinkle Retinol Night Treatment
Buy at Derma E$24.50$22.50as of 11/11 18:29 GMT

Affiliate links · As an Amazon Associate, WIMJ earns from qualifying purchases.

Buy at Derma E$24.50$22.50as of 11/11 18:29 GMT

As an Amazon Associate, WIMJ earns from qualifying purchases.