DefenAge Skincare Products DefenAge 8-in-1 Bioserum
- Anti-aging
- Anti-oxidation
- Moisturizing
- Evens skin tone
- +1 more
- niacinamide
- palmitoyl tripeptide-38
- caprylic/capric triglyceride
- cyclopentasiloxane
- +9 more

Price comparison
Can the product deliver on its promises?
Promise
What does the product description say?WIMJ summary for anti-aging
This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains niacinamide.
These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: alanyl glutamine, arabidopsis thaliana extract, palmitoyl tripeptide-38.
Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.
Ingredient | Effectiveness | Concentration | Irritancy |
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HIGH | |||
MEDIUM
| |||
MEDIUM
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WIMJ summary for anti-blemish
This product might be able to help reduce blemishes and clogged pores because it contains niacinamide.
Ingredient | Effectiveness | Concentration | Irritancy |
---|---|---|---|
HIGH | |||
LOW
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WIMJ summary for evens skin tone
This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: niacinamide
Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.
Ingredient | Effectiveness | Concentration | Irritancy |
---|---|---|---|
HIGH |
WIMJ summary for moisturizing
This product can help improve hydration of the skin with the two types of ingredients.
The first type is called “humectants”:
these ingredients help attract water.
When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from
within deeper layers of the skin. The following ingredients in this product do the job:
alanyl glutamine, glycerin.
This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: dimethicone, helianthus annuus seed oil.
The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: niacinamide, palmitoyl tripeptide-38
Ingredient | Effectiveness | Concentration | Irritancy |
---|---|---|---|
HIGH | |||
HIGH | |||
HIGH |
WIMJ summary for anti-oxidation
This product contains antioxidants (ubiquinone) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).
Ingredient | Effectiveness | Concentration | Irritancy |
---|---|---|---|
HIGH | |||
LOW
| |||
HIGH |
How honest is this product?
Promise | Can it deliver? |
---|---|
Anti-aging |
Potential irritants

Ingredient | Irritancy | Skin Benefit |
---|---|---|
arabidopsis thaliana extract | ||
rosmarinus officinalis leaf extract | ||
tocopheryl acetate |
Ingredients by volume
Ingredient | Estimated concentration |
---|---|
Plain old water
| 45% - 55% |
A silicone that helps improve the product texture and spreadability. Can absord oil creating a short-term mattifying effect on the skin
| 6.9% - 8.5% |
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
| 4.2% - 5.1% |
Show more |
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Questions
Skincare resources
Scientific Sources
- Glycerol and the skin: holistic approach to its origin and functions
- Niacinamide - mechanisms of action and its topical use in dermatology
- Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology, 3(2), 88–93. doi:10.1111/j.1473-2130.2004.00115.x
- Dimethicone as a protective ingredient in topical medications
- Final Report on the Safety Assessment of Dimethicone Copolyol
- Hyaluronic acid: A key molecule in skin aging
- Hyaluronan (Hyaluronic Acid): a natural moisturizer for skin care
- Repair of Damaged DNA by Arabidopsis Cell Extract
- Marine ingredients and the skin
- A comparison of the relative antioxidant potency of L‐ergothioneine and idebenone
- l-Ergothioneine Protects Skin Cells against UV-Induced Damage—A Preliminary Study
- Effect of Olive and Sunflower Seed Oil on the Adult Skin Barrier: Implications for Neonatal Skin Care
- Topically Applied Sunflower Seed Oil Prevents Invasive Bacterial Infections in Preterm Infants in Egypt
- Effect of topically applied lipids on surfactant-irritated skin
- Impact of topical oils on the skin barrier: possible implications for neonatal health in developing countries
- Allergic contact dermatitis induced by rosemary leaf extract in a cleansing gel
- Safety Assessment of Rosmarinus officinalis (Rosemary)-Derived Ingredients as Used in Cosmetics
- Cosmetic and dermatologic use of alpha hydroxy acids