ADVANCED CLINICALS Collagen Face Cream

ADVANCED CLINICALS Collagen Face Cream

Efficacy58/100IrritancyHigh
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Works for

2 of 3 advertised claims delivered

Moisturizing
17 ingredients credited for this claim
Strong support
What the product description says
“Collagen Face Cream”
From product name

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: glucosamine hcl, glycerin.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: dimethicone, helianthus annuus extract.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: palmitoyl tetrapeptide-7, palmitoyl tripeptide-1

GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~3.8–4.7%
Helianthus annuus extractKey active· EmollientEffect: HighHelps soften the upper layer of the skin~0.35–0.65%
Lactobacillus fermentKey active· HumectantEffect: HighA fermentation product created by bacteria Lactobacillus. The fermented product has anti-bacterial properties and might be helpful in calming down inflammation, but studies are lacking. Helps attract water to the upper layer of the skin. Can be used as a preservative~0.45–0.7%
Palmitoyl tetrapeptide-7Hero· EmollientEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.6%
Palmitoyl tripeptide-1Hero· EmollientEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.35–0.6%
Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~0.7–1.05%
DimethiconeKey active· Emollient, OcclusiveEffect: HighA silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish~2.4–3%
Glucosamine hclKey active· HumectantEffect: HighMight be able to stimulate production of skin's natural moisturizing compounds such as hyaluronic acid. Could be helpful for evening the skin tone.~0.45–0.7%
Pyrus malus fruit extractKey activeEffect: MediumCan have some moisturizing properties due to its sugar content~3.1–3.7%
Sclerocarya birrea seed oilKey active· Humectant, EmollientEffect: MediumAn emollient that helps to soften the skin. It has a high contetn of oleic acid that might weaken the skin barrier. Might have some anti-oxidant properties. It might be somewhat helpful against hyperpigmentation.~2–2.4%
Oryza sativa extractEffect: LowA grain extract that helps to create a thicker product consistency. It might have some anti-oxidant properties and help attract water to the upper layer of the skin~1.5–1.8%
Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~0.95–1.15%
Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~0.2–0.35%
Chenopodium quinoa seed extractUnder-dosedEffect: HighHelps soften the upper layer of the skin~0.3–0.6%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.2–0.4%
Aloe barbadensis leaf juiceEffect: Low, below effective doseTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin~1.2–1.4%
Camellia sinensis leaf extractEffect: Low, below effective doseCan contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation~0.45–0.7%
Anti-aging
7 ingredients credited for this claim
Moderate support
What the product description says
“Marula oil is rich in anti-aging amino acids, moisturizing fatty acids, protective antioxidants and blemish-blasting antimicrobial properties.”
Source: Advanced Clinicals

This product contains palmitoyl tetrapeptide-7, palmitoyl tripeptide-1. These ingredients might be able to help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness, but there is not enough evidence that it actually works.

Palmitoyl tetrapeptide-7Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.6%
Palmitoyl tripeptide-1Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.35–0.6%
Glucosamine hclEffect: LowMight be able to stimulate production of skin's natural moisturizing compounds such as hyaluronic acid. Could be helpful for evening the skin tone.~0.45–0.7%
Ascorbic acidUnder-dosedEffect: HighThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging~0.25–0.45%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.2–0.4%
Camellia sinensis leaf extractEffect: Low, below effective doseCan contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation~0.45–0.7%
Aloe barbadensis leaf juiceEffect: Low, below effective doseTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin~1.2–1.4%
Anti-blemish
3 ingredients credited for this claim
Weak support
What the product description says
“Marula oil is rich in anti-aging amino acids, moisturizing fatty acids, protective antioxidants and blemish-blasting antimicrobial properties.”
Source: Advanced Clinicals

Effective ingredients missing or their concentration is too low.

Rosmarinus officinalis leaf extractUnder-dosedEffect: MediumCan be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating~0.3–0.55%
Camellia sinensis leaf extractEffect: Low, below effective doseCan contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation~0.45–0.7%
Aloe barbadensis leaf juiceEffect: Low, below effective doseTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin~1.2–1.4%
Evens skin tone
Not advertised by the brand · 3 ingredients credited for this claim
Moderate support

The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually works: glucosamine hcl.

Glucosamine hclKey activeEffect: MediumMight be able to stimulate production of skin's natural moisturizing compounds such as hyaluronic acid. Could be helpful for evening the skin tone.~0.45–0.7%
Ascorbic acidUnder-dosedEffect: HighThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging~0.25–0.45%
Camellia sinensis leaf extractEffect: Low, below effective doseCan contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation~0.45–0.7%

Can it cause trouble?

Irritancy
3 strong irritants: Rosa centifolia flower extract, Citrus paradisi peel oil + 1 more — patch-test recommended
High risk
We flagged 12 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Rosa centifolia flower extractContains essential oil. Can be irritatingHigh~0.5–0.75%est.
Panax ginseng root extractA plant extract that might have some anti-inflammatory properties, but solid evidence is lacking. It can be irritatingHigh~0.5–0.8%est.
Citrus paradisi peel oilUsed as a fragrance. Can be irritatingHigh~0.3–0.55%est.
Rosmarinus officinalis leaf extractCan be helpful in reducing inflammation in skin, including inflamed acne. It can be irritatingHigh~0.3–0.55%est.
Ascorbic acidThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of agingHigh~0.25–0.45%est.
Pyrus malus fruit extractCan have some moisturizing properties due to its sugar contentMedium~3.1–3.7%est.
Sclerocarya birrea seed oilAn emollient that helps to soften the skin. It has a high contetn of oleic acid that might weaken the skin barrier. Might have some anti-oxidant properties. It might be somewhat helpful against hyperpigmentation.Medium~2–2.4%est.
Aloe barbadensis leaf juiceTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skinMedium~1.2–1.4%est.
Caprylyl glycolHelps preserve products and creates a nice product textureMedium~0.2–0.35%est.
EthylhexylglycerinA preservativeMedium~0.1–0.2%est.
Hexylene glycolHelps create a more spreadable product textureMedium~0.05–0.15%est.
Citric acidCan work as an exfoliant but is typically used to adjust the product pHMedium~0.05%est.
Comedogenic
Clean of flagged comedogenic ingredients
None flagged
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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%
Formula
Irritation risk
Low

Plain old water

More about Water
Propanediol~5.3–6.4%
Formula
Irritation risk
Low

Acts as a solvent for other ingredients. Speeds up the absorption of other ingredients into the skin

More about Propanediol
Glycerin~3.8–4.7%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Pyrus malus fruit extract~3.1–3.7%
Key activeIrritant · medium
Irritation risk
Medium
Works for
MoisturizingAnti-oxidation

Can have some moisturizing properties due to its sugar content

More about Pyrus malus fruit extract
Dimethicone~2.4–3%
Key active
Irritation risk
Low
Works for
MoisturizingMattifying

A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish

More about Dimethicone
Sclerocarya birrea seed oil~2–2.4%
Key activeIrritant · medium
Irritation risk
Medium
Works for
MoisturizingAnti-oxidation

An emollient that helps to soften the skin. It has a high contetn of oleic acid that might weaken the skin barrier. Might have some anti-oxidant properties. It might be somewhat helpful against hyperpigmentation.

More about Sclerocarya birrea seed oil
Ammonium acryloyldimethyltaurate/vp copolymer~1.6–2%
Formula
Irritation risk
Low

Increases thickness of a product. Texture enhancer for oil-in-water emulsions

More about Ammonium acryloyldimethyltaurate/vp copolymer
Oryza sativa extract~1.5–1.8%
Formula
Irritation risk
Low
Works for
MoisturizingAnti-oxidation

A grain extract that helps to create a thicker product consistency. It might have some anti-oxidant properties and help attract water to the upper layer of the skin

More about Oryza sativa extract
Aloe barbadensis leaf juice~1.2–1.4%
Irritant · medium
Irritation risk
Medium
Works for
MoisturizingAnti-inflammatoryReduces irritationReduces rednessAntibacterialAnti-blemishAnti-aging

Traditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin

More about Aloe barbadensis leaf juice
Butylene glycol~0.95–1.15%
Formula
Irritation risk
Low
Works for
Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol
Sodium hyaluronate~0.7–1.05%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate
Glycine max seed extract~0.6–0.9%
Formula
Caulerpa lentillifera extract~0.55–0.85%
Formula
Rosa centifolia flower extract~0.5–0.75%
Irritant · high
Irritation risk
High

Contains essential oil. Can be irritating

More about Rosa centifolia flower extract
Panax ginseng root extract~0.5–0.8%
Irritant · high
Irritation risk
High
Works for
Anti-inflammatoryAnti-oxidation

A plant extract that might have some anti-inflammatory properties, but solid evidence is lacking. It can be irritating

More about Panax ginseng root extract
Lactobacillus ferment~0.45–0.7%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-oxidationAnti-inflammatoryReduces irritation

A fermentation product created by bacteria Lactobacillus. The fermented product has anti-bacterial properties and might be helpful in calming down inflammation, but studies are lacking. Helps attract water to the upper layer of the skin. Can be used as a preservative

More about Lactobacillus ferment
Glucosamine hcl~0.45–0.7%
Key active
Irritation risk
Low
Works for
MoisturizingAntibacterialEvens skin toneAnti-agingAnti-oxidation

Might be able to stimulate production of skin's natural moisturizing compounds such as hyaluronic acid. Could be helpful for evening the skin tone.

More about Glucosamine hcl
Camellia sinensis leaf extract~0.45–0.7%
Formula
Irritation risk
Low
Works for
AntibacterialAnti-oxidationAnti-agingMoisturizingEvens skin toneAnti-blemish

Can contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation

More about Camellia sinensis leaf extract
Hydroxyethylcellulose~0.45–0.65%
Formula
Irritation risk
Low

Used to thicken product formulations and create gel-like textures

More about Hydroxyethylcellulose
Daucus carota sativa root extract~0.35–0.6%
Formula
Irritation risk
Low
Works for
Anti-oxidation

Carrot extract. Might have anti-oxidant properties and be used to add orange color

More about Daucus carota sativa root extract
Chenopodium quinoa seed extract~0.3–0.6%
Under-dosed
Irritation risk
Low
Works for
Moisturizing

Helps soften the upper layer of the skin

More about Chenopodium quinoa seed extract
Citrus paradisi peel oil~0.3–0.55%
Irritant · high
Irritation risk
High

Used as a fragrance. Can be irritating

More about Citrus paradisi peel oil
Oryza sativa bran extract~0.3–0.55%
Formula
Irritation risk
Low

Used to thicken the product consistency

More about Oryza sativa bran extract
Rosmarinus officinalis leaf extract~0.3–0.55%
Under-dosedIrritant · high
Irritation risk
High
Works for
Anti-blemishAnti-oxidationAntibacterial

Can be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating

More about Rosmarinus officinalis leaf extract
Phenoxyethanol~0.3–0.6%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Helianthus annuus extract~0.35–0.65%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps soften the upper layer of the skin

More about Helianthus annuus extract
Palmitoyl tripeptide-1~0.35–0.6%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tripeptide-1
Palmitoyl tetrapeptide-7~0.3–0.6%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tetrapeptide-7
Carbomer~0.3–0.5%
Formula
Irritation risk
Low
Works for
Cleansing

Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations

More about Carbomer
Tetrasodium glutamate diacetate~0.25–0.5%
Formula
Irritation risk
Low

Helps stabilize the product formulation

More about Tetrasodium glutamate diacetate
Ascorbic acid~0.25–0.45%
Under-dosedIrritant · high
Irritation risk
High
Works for
Evens skin toneAnti-agingAnti-oxidation

The most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging

More about Ascorbic acid
Polysorbate 20~0.25–0.5%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about Polysorbate 20
Tocopherol~0.2–0.4%
Formula
Irritation risk
Low
Works for
Anti-oxidationAnti-inflammatoryMoisturizingAnti-aging

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol
Maltodextrin~0.2–0.35%
Formula
Irritation risk
Low
Works for
Mattifying

Used to stabilize the product formulation and can help absorb oil

More about Maltodextrin
Caprylyl glycol~0.2–0.35%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol
Ethylhexylglycerin~0.1–0.2%
Irritant · medium
Irritation risk
Medium

A preservative

More about Ethylhexylglycerin
Sodium hydroxide~0.1–0.2%
Formula
Irritation risk
Low

Used to adjust the product's pH

More about Sodium hydroxide
Hexylene glycol~0.05–0.15%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps create a more spreadable product texture

More about Hexylene glycol
Citric acid~0.05%
Irritant · medium
Irritation risk
Medium

Can work as an exfoliant but is typically used to adjust the product pH

More about Citric acid
Ingredient list view

Water, Propanediol, Glycerin, Pyrus malus fruit extract, Dimethicone, Sclerocarya birrea seed oil, Ammonium acryloyldimethyltaurate/vp copolymer, Oryza sativa extract, Aloe barbadensis leaf juice, Butylene glycol, Sodium hyaluronate, Glycine max seed extract, Caulerpa lentillifera extract, Rosa centifolia flower extract, Panax ginseng root extract, Lactobacillus ferment, Glucosamine hcl, Camellia sinensis leaf extract, Hydroxyethylcellulose, Daucus carota sativa root extract, Chenopodium quinoa seed extract, Citrus paradisi peel oil, Oryza sativa bran extract, Rosmarinus officinalis leaf extract, Phenoxyethanol, Helianthus annuus extract, Palmitoyl tripeptide-1, Palmitoyl tetrapeptide-7, Carbomer, Tetrasodium glutamate diacetate, Ascorbic acid, Polysorbate 20, Tocopherol, Maltodextrin, Caprylyl glycol, Ethylhexylglycerin, Sodium hydroxide, Hexylene glycol, Citric acid

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Advanced Clinicals
$14.95
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Amazon USPrice as of 10/12/2026 12:58 GMT
$29.99
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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
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Match—65%61%60%
Price$14.95—$60.00+$45.05—
Shared key ingredients—12 of 126 of 126 of 12
Key difference——GluconolactoneTripeptide-1
Irritancy High High Medium Medium
Drying alcohol————
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Product summary

Based on the ingredients included, "ADVANCED CLINICALS - Collagen Face Cream" works well for moisturizing the skin. This moisturizer uses a good combo of humectants and emollients. These both types of ingredients are essentials for improving the skin hydration and keeping the skin barrier healthy. Humectants in this product (glucosamine hcl, glycerin, lactobacillus ferment, sodium hyaluronate and sclerocarya birrea seed oil) help to increase the water content in the upper layer of the skin. (These ingredients do so by "capturing" water molecules from the outside air or from within the deeper layers of the skin). Emollients in this formulation (palmitoyl tetrapeptide-7, palmitoyl tripeptide-1, helianthus annuus extract, dimethicone and sclerocarya birrea seed oil) help to reduce the moisture loss from the skin. They also soften the skin surface and relieve the feeling of dryness and tightness.

Ingredient callouts

  • This product also contains Vitamin C (Ascorbic Acid). It can be an effective active for anti-aging and evening out the skin tone, but in this moisturizer it is used for stabilizing other ingredients in the formulation. In this concentration (0.25% - 0.45%) it cannot have a noticeable benefit for the skin.
  • We like that this moisturizer contains peptides (palmitoyl tripeptide-1 0.35% - 0.60% and palmitoyl tetrapeptide-7 0.30% - 0.60%). There are many different kind of Peptides and they are naturally present in our skin. They all are a combination of aminoacids. Some of them work as natural antibiotics, promote wound-healing and production of collagen. The science is still not settled on how effective Peptides are in skincare, but it is very likely that they have a benefit. Peptides might help restore the skin barrier and fight the signs of aging. At the very least, Peptides work as humectants: they attract water to the upper layer of the skin and improve its hydration.
This product contains ingredients that could be beneficial, but their concentrations are too low in this formulation: vitamin e and vitamin c

Irritation risk

There are some common irritants in this product, including ingredients that do not have benefits for the skin. We assess the overall irritancy of this moisturizer to be high. For a detailed overview of all potential irritants: click here

You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.

Price

The product retails from 14.95$ up to 26.99$ in the United States and for 95.08A$ in Australia.

For a detailed price comparison: click here.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 22 studies and safety reviews.

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