ADVANCED CLINICALS Cica Serum

ADVANCED CLINICALS Cica Serum

Efficacy75/100IrritancyMedium

Works for

Moisturizing
Dimethicone, Glycerin + 8 more
Works
What the product description says
“This silky, extra hydrating serum features Glucoshield.”
Source: Advanced Clinicals

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: glucosamine hcl, glycerin.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: dimethicone, caprylyl glycol.

DimethiconeKey active· Emollient, OcclusiveEffect: HighA silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish~3.7–5.5%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~2.6–4%
Pyrus malus fruit extractKey activeEffect: MediumCan have some moisturizing properties due to its sugar content~2–3%
Peg-12 dimethiconeKey activeEffect: MediumHelps soften the upper layer of the skin and create a nice product texture~1.7–2.6%
Lactobacillus fermentKey active· HumectantEffect: HighA fermentation product created by bacteria Lactobacillus. The fermented product has anti-bacterial properties and might be helpful in calming down inflammation, but studies are lacking. Helps attract water to the upper layer of the skin. Can be used as a preservative~1.4–2.1%
Dimethicone crosspolymerKey activeEffect: MediumUsed to create a thicker product texture. Helps soften the upper layer of the skin and might be able to prevent moisture loss from its surface~0.8–1.2%
Glucosamine hclKey active· HumectantEffect: HighMight be able to stimulate production of skin's natural moisturizing compounds such as hyaluronic acid. Could be helpful for evening the skin tone.~0.45–1%
Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~0.1–0.35%
Camellia sinensis leaf extractEffect: Low, below effective doseCan contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation~0.4–0.95%
Sclerocarya birrea seed oilUnder-dosedAn emollient that helps to soften the skin. It has a high contetn of oleic acid that might weaken the skin barrier. Might have some anti-oxidant properties. It might be somewhat helpful against hyperpigmentation.~0.55–1.25%
Anti-aging
Centella asiatica leaf extract, Glucosamine hcl + 2 more
May help
What the product description says
“a probiotic ferment which actively protects against discoloration and wrinkles.”
Source: Advanced Clinicals

This product contains centella asiatica leaf extract. This ingredient might be able to help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness, but there is not enough evidence that it actually works.

Centella asiatica leaf extractKey activeEffect: MediumA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. It can be irritating to sensitive skin. Might be helpful in preventing stretch marks. It could, however, itself be irritating.~1.2–1.9%
Glucosamine hclEffect: LowMight be able to stimulate production of skin's natural moisturizing compounds such as hyaluronic acid. Could be helpful for evening the skin tone.~0.45–1%
Camellia sinensis leaf extractEffect: Low, below effective doseCan contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation~0.4–0.95%
Tetrahexyldecyl ascorbateUnder-dosedBeing a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.~0.95–1.45%
Evens skin tone
Glucosamine hcl, Camellia sinensis leaf extract + 1 more
May help
What the product description says
“As a result, you'll see smoother, softer, more even skin with less visible imperfections like wrinkles, scars and spots.”
Source: Advanced Clinicals

The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually works: glucosamine hcl.

Glucosamine hclKey activeEffect: MediumMight be able to stimulate production of skin's natural moisturizing compounds such as hyaluronic acid. Could be helpful for evening the skin tone.~0.45–1%
Camellia sinensis leaf extractEffect: Low, below effective doseCan contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation~0.4–0.95%
Tetrahexyldecyl ascorbateUnder-dosedBeing a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.~0.95–1.45%

Can it cause trouble?

Irritancy
1 strong irritant: Parfum
Medium risk
We flagged 10 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Lonicera caprifolium flower extractA plant extract that might help neutralize free radicals in skin. Can contain volalite oils and be irritatingHigh~0.3–0.75%est.
ParfumAn aromatic blend of unspecified and possibly irritating ingredientsHigh~0.05–0.25%est.
Pyrus malus fruit extractCan have some moisturizing properties due to its sugar contentMedium~2–3%est.
Centella asiatica leaf extractA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. It can be irritating to sensitive skin. Might be helpful in preventing stretch marks. It could, however, itself be irritating.Medium~1.2–1.9%est.
Tetrahexyldecyl ascorbateBeing a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.Medium~0.95–1.45%est.
Sclerocarya birrea seed oilAn emollient that helps to soften the skin. It has a high contetn of oleic acid that might weaken the skin barrier. Might have some anti-oxidant properties. It might be somewhat helpful against hyperpigmentation.Medium~0.55–1.25%est.
Disodium edtaStabilizes the product formulationMedium~0.15–0.6%est.
Caprylyl glycolHelps preserve products and creates a nice product textureMedium~0.1–0.35%est.
EthylhexylglycerinA preservativeMedium~0.05–0.2%est.
Hexylene glycolHelps create a more spreadable product textureMedium~0.05–0.15%est.
Comedogenic
Clean of flagged comedogenic ingredients
None flagged

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Ingredients

Filter by role to see what each ingredient is doing.

Water~40–60%
Formula
Irritation risk
Low

Plain old water

More about Water
Propanediol~4.3–6.5%
Formula
Irritation risk
Low

Acts as a solvent for other ingredients. Speeds up the absorption of other ingredients into the skin

More about Propanediol
Dimethicone~3.7–5.5%
Key active
Irritation risk
Low
Works for
MoisturizingMattifying

A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish

More about Dimethicone
Glycerin~2.6–4%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Pyrus malus fruit extract~2–3%
Key activeIrritant · medium
Irritation risk
Medium
Works for
MoisturizingAnti-oxidation

Can have some moisturizing properties due to its sugar content

More about Pyrus malus fruit extract
Peg-12 dimethicone~1.7–2.6%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps soften the upper layer of the skin and create a nice product texture

More about Peg-12 dimethicone
Lactobacillus ferment~1.4–2.1%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-oxidationAnti-inflammatoryReduces irritation

A fermentation product created by bacteria Lactobacillus. The fermented product has anti-bacterial properties and might be helpful in calming down inflammation, but studies are lacking. Helps attract water to the upper layer of the skin. Can be used as a preservative

More about Lactobacillus ferment
Centella asiatica leaf extract~1.2–1.9%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Reduces irritationReduces rednessAnti-inflammatoryAnti-agingAnti-blemish

A plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. It can be irritating to sensitive skin. Might be helpful in preventing stretch marks. It could, however, itself be irritating.

More about Centella asiatica leaf extract
Tetrahexyldecyl ascorbate~0.95–1.45%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
Anti-agingEvens skin toneAnti-oxidation

Being a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.

More about Tetrahexyldecyl ascorbate
Dimethicone crosspolymer~0.8–1.2%
Key active
Irritation risk
Low
Works for
Moisturizing

Used to create a thicker product texture. Helps soften the upper layer of the skin and might be able to prevent moisture loss from its surface

More about Dimethicone crosspolymer
Sclerocarya birrea seed oil~0.55–1.25%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
MoisturizingAnti-oxidation

An emollient that helps to soften the skin. It has a high contetn of oleic acid that might weaken the skin barrier. Might have some anti-oxidant properties. It might be somewhat helpful against hyperpigmentation.

More about Sclerocarya birrea seed oil
Glucosamine hcl~0.45–1%
Key active
Irritation risk
Low
Works for
AntibacterialMoisturizingEvens skin toneAnti-oxidationAnti-aging

Might be able to stimulate production of skin's natural moisturizing compounds such as hyaluronic acid. Could be helpful for evening the skin tone.

More about Glucosamine hcl
Camellia sinensis leaf extract~0.4–0.95%
Formula
Irritation risk
Low
Works for
Anti-oxidationAntibacterialAnti-agingAnti-blemishMoisturizingEvens skin tone

Can contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation

More about Camellia sinensis leaf extract
Lonicera caprifolium flower extract~0.3–0.75%
Irritant · high
Irritation risk
High
Works for
Anti-oxidation

A plant extract that might help neutralize free radicals in skin. Can contain volalite oils and be irritating

More about Lonicera caprifolium flower extract
Ammonium acryloyldimethyltaurate/vp copolymer~0.2–0.75%
Formula
Irritation risk
Low

Increases thickness of a product. Texture enhancer for oil-in-water emulsions

More about Ammonium acryloyldimethyltaurate/vp copolymer
Disodium edta~0.15–0.6%
Irritant · medium
Irritation risk
Medium

Stabilizes the product formulation

More about Disodium edta
Phenoxyethanol~0.1–0.5%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Xanthan gum~0.1–0.4%
Formula
Irritation risk
Low
Works for
Cleansing

Used to create a thicker product consistency

More about Xanthan gum
Parfum~0.05–0.25%
Irritant · high
Irritation risk
High

An aromatic blend of unspecified and possibly irritating ingredients

More about Parfum
Caprylyl glycol~0.1–0.35%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol
Ethylhexylglycerin~0.05–0.2%
Irritant · medium
Irritation risk
Medium

A preservative

More about Ethylhexylglycerin
Hexylene glycol~0.05–0.15%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps create a more spreadable product texture

More about Hexylene glycol
Sodium hydroxide~0.05–0.1%
Formula
Irritation risk
Low

Used to adjust the product's pH

More about Sodium hydroxide
Ingredient list view

Water, Propanediol, Dimethicone, Glycerin, Pyrus malus fruit extract, Peg-12 dimethicone, Lactobacillus ferment, Centella asiatica leaf extract, Tetrahexyldecyl ascorbate, Dimethicone crosspolymer, Sclerocarya birrea seed oil, Glucosamine hcl, Camellia sinensis leaf extract, Lonicera caprifolium flower extract, Ammonium acryloyldimethyltaurate/vp copolymer, Disodium edta, Phenoxyethanol, Xanthan gum, Parfum, Caprylyl glycol, Ethylhexylglycerin, Hexylene glycol, Sodium hydroxide

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
ADVANCED CLINICALSCica SerumYOUR PRODUCTJack BlackBrightening Booster Vitamin C SerumPaula's choiceC+ 25% Vitamin C + Glutathione Clinical SerumPillowtalkDermMajor Fade Active Seal Moisturizer
Match—58%56%56%
Price—$38.25$69.60—
Shared key ingredients—4 of 73 of 73 of 7
Key difference—PanthenolVitamin CHexapeptide-2
Irritancy Medium Medium Medium Low
Drying alcohol————
View product Shop Shop Shop

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Product summary

"ADVANCED CLINICALS - Cica Serum" could be helpful for: Moisturizing, Anti-aging and Evens skin tone, but its actives are not the most effective or are not well-studied.

Ingredient callouts

  • Humectants (glucosamine hcl 0.45% - 1.00%, lactobacillus ferment 1.40% - 2.10% and glycerin 2.60% - 4.00%). These ingredients help attract water to the upper layer of the skin and improve the skin hydration.

Price

The product retails for 72.13A$ in Australia and for 14.50$ in the United States.

For a detailed price comparison: click here.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 15 studies and safety reviews.

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ADVANCED CLINICALS Cica Serum
ADVANCED CLINICALSCica Serum

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