ZO Skin Health Pigment Control Crème 4% HQ - RX

ZO Skin Health Pigment Control Crème 4% HQ - RX

Efficacy100/100IrritancyMedium

Works for

Evens skin tone
Ascorbic acid, Hydroquinone + 1 more
Works well
What the product description says
“Pigment Control Crème 4% HQ - RX”
Source: Zo Skin Health

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: ascorbic acid, hydroquinone.

In addition, this product contains glycolic acid. This ingredient (ingredients) might help reduce hyperpigmentation, but the effect, if any, is likely to be small.

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

Ascorbic acidHeroEffect: HighThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging~8.8–10.7%
HydroquinoneHeroEffect: HighA potent anti-pigmentation active. It can have serious side-effects though and ideally is used under supervision of a doctor. It should not be used over a long period of time (over a year).4%
Glycolic acidKey activeEffect: HighAn alpha-hydroxy acid (AHA) that helps to remove the dead skin cells on the surface of the skin reveling a more even, smoother complexation. It is also able to stimulate collagen production with long-term use. Could help to reduce pore congestion. It can be irritating to the skin. Apply sunscreen daily if using products with glycolic acid~0.55–0.85%
Exfoliation
Side benefit · Glycolic acid
Works well

This product can help exfoliate the skin. In other words, it helps break down the bonds between dead cells on the surface of the skin and speed up the skin turnover. Skin often appears softer and brighter after exfoliation, but overdoing it can result in disrupted skin barrier. The following ingredient is doing the exfoliating job in this product: glycolic acid.

Glycolic acidKey activeEffect: HighAn alpha-hydroxy acid (AHA) that helps to remove the dead skin cells on the surface of the skin reveling a more even, smoother complexation. It is also able to stimulate collagen production with long-term use. Could help to reduce pore congestion. It can be irritating to the skin. Apply sunscreen daily if using products with glycolic acid~0.55–0.85%
Anti-oxidation
Side benefit · Ascorbic acid, Ascorbyl palmitate + 4 more
Works well

This product contains antioxidants (ascorbic acid) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

Ascorbic acidHeroEffect: HighThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging~8.8–10.7%
Ascorbyl palmitateEffect: LowBeing a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.~6–7.3%
Beta-glucanEffect: LowHelps attract water to the upper layer of the skin, calm down inflammation and irritation, restore the barrier function and support wound healing. It can be helpful in reducing fine lines and wrinkles~4.2–5.2%
Brassica oleracea italica extractEffect: LowMight have some anti-inflammatory properties but research is lacking~3–3.6%
Tocopheryl acetateEffect: Low, below effective doseA more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.~0.05–0.15%
TocopherolUnder-dosedPure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.1–0.15%
Anti-aging
Side benefit the brand mentions · Ascorbic acid, Glycolic acid + 3 more
Works well
What the product description says
“Retinol Skin Brightener 1% Retinol Skin Brightener 1% retinol clinically proven improve visible discoloration $130.”
Source: Zo Skin Health

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains ascorbic acid, glycolic acid.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

Ascorbic acidHeroEffect: HighThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging~8.8–10.7%
Glycolic acidKey activeEffect: HighAn alpha-hydroxy acid (AHA) that helps to remove the dead skin cells on the surface of the skin reveling a more even, smoother complexation. It is also able to stimulate collagen production with long-term use. Could help to reduce pore congestion. It can be irritating to the skin. Apply sunscreen daily if using products with glycolic acid~0.55–0.85%
Ascorbyl palmitateEffect: LowBeing a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.~6–7.3%
Beta-glucanEffect: LowHelps attract water to the upper layer of the skin, calm down inflammation and irritation, restore the barrier function and support wound healing. It can be helpful in reducing fine lines and wrinkles~4.2–5.2%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.1–0.15%
Moisturizing
Side benefit · Beta-glucan, Cetyl alcohol + 4 more
Works

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: glycerin, caprylyl glycol.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: helianthus annuus seed oil, cetyl alcohol.

Beta-glucanKey activeEffect: HighHelps attract water to the upper layer of the skin, calm down inflammation and irritation, restore the barrier function and support wound healing. It can be helpful in reducing fine lines and wrinkles~4.2–5.2%
Cetyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together~1.6–2%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~0.65–1%
Helianthus annuus seed oilKey active· Emollient, OcclusiveEffect: HighA great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function~0.55–0.8%
Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~1.8–2.2%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.1–0.15%

Can it cause trouble?

Irritancy
1 strong irritant: Hydroquinone
Medium risk
We flagged 12 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
HydroquinoneA potent anti-pigmentation active. It can have serious side-effects though and ideally is used under supervision of a doctor. It should not be used over a long period of time (over a year).High4%
Ascorbic acidThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of agingHigh~8.8–10.7%est.
Glycolic acidAn alpha-hydroxy acid (AHA) that helps to remove the dead skin cells on the surface of the skin reveling a more even, smoother complexation. It is also able to stimulate collagen production with long-term use. Could help to reduce pore congestion. It can be irritating to the skin. Apply sunscreen daily if using products with glycolic acidHigh~0.55–0.85%est.
Sodium lauryl sulfateA cleansing agent (SLS). It can be irritatingHigh~0.65–0.95%est.
Ascorbyl palmitateBeing a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.Medium~6–7.3%est.
Brassica oleracea italica extractMight have some anti-inflammatory properties but research is lackingMedium~3–3.6%est.
Caprylyl glycolHelps preserve products and creates a nice product textureMedium~1.8–2.2%est.
ChlorphenesinA preservativeMedium~0.16–0.32%est.
Disodium edtaStabilizes the product formulationMedium~0.5–1%est.
Quillaja saponaria bark extractHelps water and oil mix togetherMedium~0.65–0.95%est.
Sodium metabisulfiteA preservativeMedium~0.1–0.2%est.
Tocopheryl acetateA more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.Medium~0.05–0.15%est.
Comedogenic
1 ingredient rated 2 or more on the 0–5 pore-clogging scale
1 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Sodium lauryl sulfateA cleansing agent (SLS). It can be irritating3/5~0.65–0.95%est.

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Ingredients

Filter by role to see what each ingredient is doing.

Hydroquinone4%
Hero · Evens skin toneIrritant · high
Irritation risk
High
Works for
Evens skin tone

A potent anti-pigmentation active. It can have serious side-effects though and ideally is used under supervision of a doctor. It should not be used over a long period of time (over a year).

More about Hydroquinone
Water~45–55%
Formula
Irritation risk
Low

Plain old water

More about Water
Ascorbic acid~8.8–10.7%
Hero · Anti-aging, Anti-oxidation, Evens skin toneIrritant · high
Irritation risk
High
Works for
Anti-oxidationEvens skin toneAnti-aging

The most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging

More about Ascorbic acid
Ascorbyl palmitate~6–7.3%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidationAnti-aging

Being a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.

More about Ascorbyl palmitate
Beta-glucan~4.2–5.2%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-inflammatoryReduces irritationAnti-agingAnti-blemishAnti-oxidation

Helps attract water to the upper layer of the skin, calm down inflammation and irritation, restore the barrier function and support wound healing. It can be helpful in reducing fine lines and wrinkles

More about Beta-glucan
Brassica oleracea italica extract~3–3.6%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidation

Might have some anti-inflammatory properties but research is lacking

More about Brassica oleracea italica extract
C10-16 alcohols~2.3–2.9%
Formula
Caprylyl glycol~1.8–2.2%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol
Cetyl alcohol~1.6–2%
Key active
Irritation risk
Low
Works for
CleansingMoisturizing

A non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together

More about Cetyl alcohol
Chlorphenesin~0.16–0.32%
Irritant · medium
Irritation risk
Medium

A preservative

More about Chlorphenesin
Dioscorea villosa root extract~1.1–1.3%
Formula
Disodium edta~0.5–1%
Irritant · medium
Irritation risk
Medium

Stabilizes the product formulation

More about Disodium edta
Glycerin~0.65–1%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Glycolic acid~0.55–0.85%
Key activeIrritant · high
Irritation risk
High
Works for
Anti-agingEvens skin toneExfoliationAnti-blemish

An alpha-hydroxy acid (AHA) that helps to remove the dead skin cells on the surface of the skin reveling a more even, smoother complexation. It is also able to stimulate collagen production with long-term use. Could help to reduce pore congestion. It can be irritating to the skin. Apply sunscreen daily if using products with glycolic acid

More about Glycolic acid
Helianthus annuus seed oil~0.55–0.8%
Key active
Irritation risk
Low
Works for
Moisturizing

A great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function

More about Helianthus annuus seed oil
Maltodextrin~0.65–1%
Formula
Irritation risk
Low
Works for
Mattifying

Used to stabilize the product formulation and can help absorb oil

More about Maltodextrin
Phenoxyethanol~0.4–0.6%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Quillaja saponaria bark extract~0.65–0.95%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps water and oil mix together

More about Quillaja saponaria bark extract
Smilax aristolochiifolia root extract~0.25–0.5%
Formula
Sodium lauryl sulfate~0.65–0.95%
Comedogenic 3/5Irritant · high
Irritation risk
High
Comedogenicity
3/5
Works for
Cleansing

A cleansing agent (SLS). It can be irritating

More about Sodium lauryl sulfate
Sodium metabisulfite~0.1–0.2%
Irritant · medium
Irritation risk
Medium

A preservative

More about Sodium metabisulfite
Stachys officinalis flower/leaf/stem extract~0.15–0.25%
Formula
Stearyl alcohol~0.15–0.3%
Formula
Irritation risk
Low
Works for
Cleansing

An emollient that helps soften the skin

More about Stearyl alcohol
Tocopherol~0.1–0.15%
Under-dosed
Irritation risk
Low
Works for
Anti-oxidationAnti-agingAnti-inflammatoryMoisturizing

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol
Tocopheryl acetate~0.05–0.15%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidation

A more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.

More about Tocopheryl acetate
Yucca schidigera root extract~0.05–0.1%
Formula
Ingredient list view

Hydroquinone, Water, Ascorbic acid, Ascorbyl palmitate, Beta-glucan, Brassica oleracea italica extract, C10-16 alcohols, Caprylyl glycol, Cetyl alcohol, Chlorphenesin, Dioscorea villosa root extract, Disodium edta, Glycerin, Glycolic acid, Helianthus annuus seed oil, Maltodextrin, Phenoxyethanol, Quillaja saponaria bark extract, Smilax aristolochiifolia root extract, Sodium lauryl sulfate, Sodium metabisulfite, Stachys officinalis flower/leaf/stem extract, Stearyl alcohol, Tocopherol, Tocopheryl acetate, Yucca schidigera root extract

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Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
ZO Skin HealthPigment Control Crème 4% HQ - RXYOUR PRODUCTNuFaceLifter Vitamin C and Hyaluronic Acid Serum S3TarteYouth or Dare Multi-Acid & C-SerumDr Dennis GrossVITAMIN C AND LACTIC 15% FIRM AND BRIGHT SERUM
Match—78%77%77%
Price———$58.31
Shared key ingredients—3 of 63 of 63 of 6
Key difference—DimethiconeAminopropyl Ascorbyl PhosphateFerulic Acid
Irritancy Medium Low Low Low
Drying alcohol————
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Product summary

"ZO Skin Health - Pigment Control Crème 4% HQ - RX" is effective for: Anti-inflammatory, Exfoliation, Anti-aging and Evens skin tone

This product could be helpful for: Moisturizing, but its actives are not the most effective or are not well-studied.

Ingredient callouts

  • This product also contains Vitamin C (Ascorbic Acid) 8.80% - 10.70% It can be helpful in stimulating collagen production, neutralizing free radicals in skin and improving pigmentation marks. We recommend to use up this product quickly after opening: Ascorbic Acid degrades fast when it gets in contact with air and light. The moment the product turns orange, it is a sign that a significant share of the vitamin C in it is no longer effective.
  • Humectants (glycerin 0.65% - 1.00%). These ingredients help attract water to the upper layer of the skin and improve the skin hydration.

Price

The product retails from 70.00$ up to 103.00$ in the United States.

For a detailed price comparison: click here.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 19 studies and safety reviews.

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ZO Skin Health Pigment Control Crème 4% HQ - RX
ZO Skin HealthPigment Control Crème 4% HQ - RX

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