Works for:
based on ingredients and %- Anti-aging
- Evens skin tone
- Anti-oxidation
- Moisturizing
Can it cause trouble?
- Irritation risk: high
- Comedogenic risk ingredients: 5
Key actives
Product Summary
Based on the ingredients included, "THE FACE SHOP - Dr. Belmeur Total Youth Biome Cream" works well for moisturizing the skin. This moisturizer uses a good combo of humectants and emollients. These both types of ingredients are essentials for improving the skin hydration and keeping the skin barrier healthy. Acetyl hexapeptide-8, panthenol, glycerin, hydrolyzed collagen and polyglycerin-3 in this product (humectants) attract water molecules to the upper layer of the skin (the water comes from the outside air or from the deeper layers of the skin if the air is dry). Emollients in this formulation (ceramide np, palmitoyl tetrapeptide-7, palmitoyl tripeptide-1, cholesterol and glycosphingolipids) help to reduce the moisture loss from the skin. They also soften the skin surface and relieve the feeling of dryness and tightness.
Ingredient callouts
- As a plus, this moisturizer also contains Ceramides (ceramide np 0.20% - 0.40%). Ceramides are a type of lipids that our skin produces itself. They are a building block of the skin's barrier. Ceramides used in skincare are synthetic or extracted from plants. They work well for softening the skin surface and "patch holes" in the skin's barrier.
- This moisturizer also contains Peptides (palmitoyl tetrapeptide-7 0.25% - 0.50%, palmitoyl tripeptide-1 0.25% - 0.50% and acetyl hexapeptide-8 0.25% - 0.45%). Peptides are a very big group of ingredients. They all consist of a different combination of aminoacids. Our skin produces Peptides naturally. Some of them work as natural antibiotics, promote wound-healing and production of collagen. The scientists are still studying how effective the topical application of Peptides is, but it is very likely that they are helpful. Peptides might be able to support skin barrier restoration and even have an anti-aging benefit. At the very least, they certainly help attract water to the skin and support the hydration in this way.
- Adenosine 0.20% - 0.35%. It is a compound that in involved in many biological processes inside the skin cells. According one high-quality clinical trial, topical Adenosine in low concentrations can somewhat help improve "deep wrinkles" - the wrinkles that appear with age in places where our faces are most dynamic (for example, on the forehead or in the corners of the eyes).
Irritation risk
There are quite a few common irritants in this product, including ingredients without particular skin benefits. We would not recommend it for sensitive skin. We assess the overall irritancy of this moisturizer to be high. For a detailed overview of all potential irritants: click here
You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.
Price
The product retails for 33.70$ in the United States.
For a detailed price comparison: click here.
Anti-aging
What does the product description say?
Helps brighten skin tone, reduce the appearance of fine lines, and restore skin elasticity.
Source: Yesstyle
This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains adenosine.
These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: acetyl hexapeptide-8, palmitoyl tetrapeptide-7, palmitoyl tripeptide-1.
Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.
Might help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself
Being a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.
Anti-oxidation
This product contains antioxidants (glycyrrhetinic acid) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).
Active compound of licorice root. Works to calm down inflammation, as an anti-oxidant, and might be helpful in lightening the skin and reducing hyperpigmentation
A great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals
Might help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)
A plant oil that might help neutralize free radicals and have an anti-bacterial effect
A plant extract that can help lighten the skin and calm down inflammation. Might be helpful in neutralizing free radicals
Carrot extract. Might have anti-oxidant properties and be used to add orange color
Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself
Being a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.
Moisturizing
This product can help improve hydration of the skin with the two types of ingredients.
The first type is called “humectants”:
these ingredients help attract water.
When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from
within deeper layers of the skin. The following ingredients in this product do the job:
glycerin, hydrolyzed collagen.
This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: butyrospermum parkii butter, caprylic/capric triglyceride.
The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: acetyl hexapeptide-8, ceramide np, palmitoyl tetrapeptide-7, palmitoyl tripeptide-1, panthenol
An emollient that is naturally found in skin
A type of lipids naturally present in skin. They can be converted to ceramides in skin
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
Helps attract water to the upper layer of the skin and can help improve skin barrier function
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
Helps to attract water to the upper layer of the skin
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A typically plant-derived compound that is supposed mimic human collagen. Cannot penetrate the skin barrier so is not particularly useful in skincare products beyond attracting water to the upper layer of the skin
A great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals
A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin
A great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function
A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin
Helps attract water to the upper layer of the skin. Is often used to adjust the pH level of the product
An oil from a mixture of different vegetables. Helps soften the upper layer of the skin
Might help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)
A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture
Used to stabilize the product formulations and works as an emollient
An oil from a mixture of different vegetables. Helps soften the upper layer of the skin
A "broth" with parts of dead cells of lactobacteria. Might be helpful supporting diverse microbiome in skin, but evidence is lacking
An emollient that helps soften the skin but is not effective for restoring its barrier function. Might be helpful to calm down inflammation
Emollients that are naturaly present in skin. In addition, they help water and oil mix together in the product
A silicone that serves as an emollient. Helps create a nice non-greasy feels
Helps preserve products and creates a nice product texture
Helps to soften the upper layer of the skin and create a nice product texture
An oil from a mixture of different vegetables. Helps soften the upper layer of the skin
Helps soften the upper layer of the skin while creating a non-greasy feel on the skin. Helps to dissolve other ingredients
A sugar that is used to stabilize the product formulation. Can help attract water to the upper layer of the skin
An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together
Non-drying alcohol that helps water and oil mix together. Also serves as an emollient
Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin
Used as a fragrance. Can be irritating
A salt derived from licorice. Works as an emollient to soften the upper layer of the skin and can help calm down inflammation. Might be helpful for skin lightening
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself
Helps oil and water mix together and works as an emollient
Evens skin tone
What does the product description say?
Helps brighten skin tone, reduce the appearance of fine lines, and restore skin elasticity.
Source: Yesstyle
The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually works: glycyrrhetinic acid, glycyrrhiza glabra root extract.
Active compound of licorice root. Works to calm down inflammation, as an anti-oxidant, and might be helpful in lightening the skin and reducing hyperpigmentation
A plant extract that can help lighten the skin and calm down inflammation. Might be helpful in neutralizing free radicals
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
A salt derived from licorice. Works as an emollient to soften the upper layer of the skin and can help calm down inflammation. Might be helpful for skin lightening
How honest is this product?
| Promise | Can it deliver? |
|---|---|
| Anti-aging | |
| Evens skin tone |
Total Promises Fulfilled score: 87/100.
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Potential irritants
Comedogenic ingredients
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| Product | Similarity | Price | Irritancy |
|---|---|---|---|
 THE FACE SHOP Dr. Belmeur Total Youth Biome Cream | Current | $33.70 | |
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Key Actives
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself
A great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals
Helps attract water to the upper layer of the skin and can help improve skin barrier function
A salt derived from licorice. Works as an emollient to soften the upper layer of the skin and can help calm down inflammation. Might be helpful for skin lightening
A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin
Might help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)
Active compound of licorice root. Works to calm down inflammation, as an anti-oxidant, and might be helpful in lightening the skin and reducing hyperpigmentation
An emollient that is naturally found in skin
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin
Helps to attract water to the upper layer of the skin
A great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function
A typically plant-derived compound that is supposed mimic human collagen. Cannot penetrate the skin barrier so is not particularly useful in skincare products beyond attracting water to the upper layer of the skin
A type of lipids naturally present in skin. They can be converted to ceramides in skin
Helps attract water to the upper layer of the skin. Is often used to adjust the pH level of the product
Potential irritants
A plant oil with a high content of volatile compounds that can irritate the skin and lead to allergic reactions. Can lead to photosensitivity
A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin
An emollient that helps soften the skin but is not effective for restoring its barrier function. Might be helpful to calm down inflammation
A gelling agent that thickens the product consistency and leaves the skin with a velvety finish
Maintains the texture of skincare products. Allows the product to spread evenly. Helps oil and water mix together
Cedarwood oil. Used as a fragrance. Can be irritating
A plant extract that can help lighten the skin and calm down inflammation. Might be helpful in neutralizing free radicals
Active compound of licorice root. Works to calm down inflammation, as an anti-oxidant, and might be helpful in lightening the skin and reducing hyperpigmentation
Being a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.
Helps preserve products and creates a nice product texture
Helps attract water to the upper layer of the skin. Is often used to adjust the pH level of the product
Comedogenic ingredients
A great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals
Used to stabilize the product formulations and works as an emollient
A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture
An oil from a mixture of different vegetables. Helps soften the upper layer of the skin
All ingredients
Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
Acts as a solvent for other ingredients. Speeds up the absorption of other ingredients into the skin
An oil from a mixture of different vegetables. Helps soften the upper layer of the skin
An oil from a mixture of different vegetables. Helps soften the upper layer of the skin
A silicone that serves as an emollient. Helps create a nice non-greasy feels
A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin
A great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals
Used to stabilize the product formulations and works as an emollient
Helps to soften the upper layer of the skin and create a nice product texture
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
Helps soften the upper layer of the skin while creating a non-greasy feel on the skin. Helps to dissolve other ingredients
A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture
Helps attract water to the upper layer of the skin and can help improve skin barrier function
An oil from a mixture of different vegetables. Helps soften the upper layer of the skin
Non-drying alcohol that helps water and oil mix together. Also serves as an emollient
An emollient that helps soften the skin but is not effective for restoring its barrier function. Might be helpful to calm down inflammation
A gelling agent that thickens the product consistency and leaves the skin with a velvety finish
Maintains the texture of skincare products. Allows the product to spread evenly. Helps oil and water mix together
Emollients that are naturaly present in skin. In addition, they help water and oil mix together in the product
Used to create thicker product consistency and stabilize emulsions
A salt derived from licorice. Works as an emollient to soften the upper layer of the skin and can help calm down inflammation. Might be helpful for skin lightening
A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin
Might help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)
A great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function
A plant oil with a high content of volatile compounds that can irritate the skin and lead to allergic reactions. Can lead to photosensitivity
A sugar that is used to stabilize the product formulation. Can help attract water to the upper layer of the skin
An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together
A typically plant-derived compound that is supposed mimic human collagen. Cannot penetrate the skin barrier so is not particularly useful in skincare products beyond attracting water to the upper layer of the skin
Cedarwood oil. Used as a fragrance. Can be irritating
Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations
A "broth" with parts of dead cells of lactobacteria. Might be helpful supporting diverse microbiome in skin, but evidence is lacking
A type of lipids naturally present in skin. They can be converted to ceramides in skin
Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
Carrot extract. Might have anti-oxidant properties and be used to add orange color
A plant oil that might help neutralize free radicals and have an anti-bacterial effect
A plant extract that can help lighten the skin and calm down inflammation. Might be helpful in neutralizing free radicals
Active compound of licorice root. Works to calm down inflammation, as an anti-oxidant, and might be helpful in lightening the skin and reducing hyperpigmentation
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
Being a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.
Helps preserve products and creates a nice product texture
Helps attract water to the upper layer of the skin. Is often used to adjust the pH level of the product
Ingredient list view
Water, Butylene glycol, Glycerin, Propanediol, Vegetable oil, Olus oil, Cyclohexasiloxane, Caprylic/capric triglyceride, Butyrospermum parkii butter, Glyceryl stearate se, Hydrogenated polydecene, Niacinamide, 1,2-hexanediol, Stearic acid, Dicaprylyl ether, Cetearyl alcohol, Panthenol, Polyglycerin-3, Potassium cetyl phosphate, Hydrogenated vegetable oil, Sodium stearate, Behenyl alcohol, Olea europaea fruit oil, Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, Acrylates/c10-30 alkyl acrylate crosspolymer, Xanthan gum, Tromethamine, Phospholipids, Cellulose gum, Dipotassium glycyrrhizate, Ceramide np, Adenosine, Helianthus annuus seed oil, Citrus aurantium bergamia fruit oil, Amyris balsamifera bark oil, Dextrin, Glyceryl stearate, Theobroma cacao seed extract, Hydrolyzed collagen, Trisodium edta, Rosa damascena flower oil, Copaifera officinalis resin, Juniperus virginiana oil, Vetiveria zizanoides root oil, Santalum album oil, Polysorbate 60, Carbomer, Lactobacillus ferment lysate, Glycosphingolipids, Cholesterol, Tocopherol, Acetyl hexapeptide-8, Beta-carotene, Daucus carota sativa root extract, Daucus carota sativa seed oil, Glycyrrhiza glabra root extract, Glycyrrhetinic acid, Palmitoyl tripeptide-1, Palmitoyl tetrapeptide-7, Ascorbyl palmitate, Caprylyl glycol, Polysorbate 20, Sodium lactate, Sorbitan isostearate, Citronellol
- Glycerol and the skin: holistic approach to its origin and functions
- Safety Assessment of Polyene Group as Used in Cosmetics
- Niacinamide - mechanisms of action and its topical use in dermatology
- Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology, 3(2), 88–93. doi:10.1111/j.1473-2130.2004.00115.x
- The influence of alkane chain length on the skin irritation potential of 1,2-alkanediols
- Skin moisturizing effects of panthenol-based formulations
- Safety Assessment of Panthenol, Pantothenic Acid, and Derivatives as Used in Cosmetics
- Use of “natural” oils for moisturization: Review of olive, coconut, and sunflower seed oil
- Safety Assessment of Tromethamine as Used in Cosmetics
- Ameliorating effect of dipotassium glycyrrhizinate on an IL-4- and IL-13-induced atopic dermatitis-like skin-equivalent model
- Final report on the safety assessment of Glycyrrhetinic Acid, Potassium Glycyrrhetinate, Disodium Succinoyl Glycyrrhetinate, Glyceryl Glycyrrhetinate, Glycyrrhetinyl Stearate, Stearyl Glycyrrhetinate, Glycyrrhizic Acid, Ammonium Glycyrrhizate, Dipotassium Glycyrrhizate, Disodium Glycyrrhizate, Trisodium Glycyrrhizate, Methyl Glycyrrhizate, and Potassium Glycyrrhizinate.
- Skin hydration is significantly increased by a cream formulated to mimic the skin’s own natural moisturizing systems
- Topically Applied Ceramides Interact with the Stratum Corneum Lipid Matrix in Compromised Ex Vivo Skin
- Evaluation of anti-wrinkle efficacy of adenosine-containing products using the FOITS technique
- Effect of Olive and Sunflower Seed Oil on the Adult Skin Barrier: Implications for Neonatal Skin Care
- Topically Applied Sunflower Seed Oil Prevents Invasive Bacterial Infections in Preterm Infants in Egypt
- Effect of topically applied lipids on surfactant-irritated skin
- Impact of topical oils on the skin barrier: possible implications for neonatal health in developing countries
- Safety Assessment of Citrus-Derived Peel Oils as Used in Cosmetics
- Oxidized citrus oil (R-limonene): A frequent skin sensitizer in Europe
- Air oxidation increases skin irritation from fragrance terpenes
- Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA
- Annex I: Clinical evidence regarding sensitisation to individual fragrance chemicals and to natural extracts
- Vitamin E in dermatology
- Vitamin E and Skin Health
- New Claims for Wild Carrot (Daucus carota subsp. carota) Essential Oil
- Glycyrrhetinic acid, the active principle of licorice, can reduce the thickness of subcutaneous thigh fat through topical application
- Effects of topical application of B‐Resorcinol and Glycyrrhetinic acid monotherapy and in combination with fractional CO2 laser treatment for benign hand hyperpigmentation treatment
- 18β-Glycyrrhetinic Acid and Glabridin Prevent Oxidative DNA Fragmentation in UVB-irradiated Human Keratinocyte Cultures