Sesderma

Sesderma SESRETINAL Mature Skin Liposomal Serum

Name: Sesderma - SESRETINAL Mature Skin Liposomal Serum
Brand: Sesderma

Efficacy100/100IrritancyHigh

See all ingredients

Works for

Anti-aging

Retinal, Gluconolactone + 11 more

Works well

What the product description says

“Intensive, anti-aging treatment.”

Source: Sesderma

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains retinal, bakuchiol, gluconolactone, glycolic acid.

These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: nicotiana benthamiana hexapeptide-40 sh-oligopeptide-1.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

RetinalHeroEffect: HighOne step removed from the biologically active in skin form of vitamin A. Once converted to the retinoic acid in the skin, retinal is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. Concentrations of 0.05% and 0.1% are shown to be effective. It can, however, be irritating~0.25–0.5%

GluconolactoneKey activeEffect: HighA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals~0.65–1%

BakuchiolKey activeEffect: HighA plant extract that is, though different in chemical structure, acts similar to retinoids. First studies show that it can help reduce fine lines and wrinkles, improve skin tone, reduce clogged pores and blemishes, and reduce inflammation. There is no conclusive evidence that bakuchiol is as effective as retinol however. The study that directly compared retinol with bakuchiol used bakuchiol applied twice daily compared to once per day for the retinol. According to this study, bakuchiol is less irritating than retinol. Bakuchiol is extracted from seeds of Babchi plant. Other parts of the plant contain coumarins that could cause allergic and irritant reactions. These compounds should be removed in the extraction process when bakuchiol is produced, but it is a good idea to be cautious and stay away from products that include the Babchi plant extracts other than purified bakuchiol to avoid irritation~0.25–0.45%

Glycolic acidKey activeEffect: HighAn alpha-hydroxy acid (AHA) that helps to remove the dead skin cells on the surface of the skin reveling a more even, smoother complexation. It is also able to stimulate collagen production with long-term use. Could help to reduce pore congestion. It can be irritating to the skin. Apply sunscreen daily if using products with glycolic acid~0.25–0.45%

Nicotiana benthamiana hexapeptide-40 sh-oligopeptide-1Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.15–0.25%

Glucosamine hclEffect: LowMight be able to stimulate production of skin's natural moisturizing compounds such as hyaluronic acid. Could be helpful for evening the skin tone.~0.25–0.45%

Nicotiana benthamiana sh-polypeptide-15 hexapeptide-40Effect: Low~0.15–0.25%

TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.2–0.35%

Ascorbyl palmitateEffect: Low, below effective doseBeing a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.~0.2–0.35%

Lycium barbarum fruit extractEffect: Low, below effective doseA plant extract that can help neutralize free radicals in skin and attract water to its upper layer~0.15–0.3%

NiacinUnder-dosedA form of vitamin B3. It is similar in action to niacinamide, but is more likely to cause red flashes in skin as the side effect~0.25–0.5%

Lactic acidUnder-dosedAn exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)~0.15–0.3%

Retinyl palmitateUnder-dosedThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect~0.15–0.3%

Evens skin tone

Side benefit the brand mentions · Retinal, Mandelic acid + 8 more

Works well

What the product description says

“Evens out the skin tone.”

Source: Sesderma

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: retinal.

In addition, this product contains bakuchiol, gluconolactone, glycolic acid, mandelic acid. This ingredient (ingredients) might help reduce hyperpigmentation, but the effect, if any, is likely to be small.

The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually can help even out the skin tone: glucosamine hcl, glycyrrhetinic acid.

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

Mandelic acidKey activeEffect: HighHelps shed the upper layer of dead cells from the surface of the skin revealing smoother, brighter skin. It can help to reduce hyperpigmentation. It has anti-bacterial properties, and might help to reduce blemishes, as well as fine lines and wrinkles. It is considered to be gentler than glycolic acid~1–1.2%

Glucosamine hclKey activeEffect: MediumMight be able to stimulate production of skin's natural moisturizing compounds such as hyaluronic acid. Could be helpful for evening the skin tone.~0.25–0.45%

Glycyrrhetinic acidKey activeEffect: MediumActive compound of licorice root. Works to calm down inflammation, as an anti-oxidant, and might be helpful in lightening the skin and reducing hyperpigmentation~0.15–0.3%

NiacinUnder-dosedA form of vitamin B3. It is similar in action to niacinamide, but is more likely to cause red flashes in skin as the side effect~0.25–0.5%

Exfoliation

Side benefit · Mandelic acid, Gluconolactone + 3 more

Works well

This product can help exfoliate the skin. In other words, it helps break down the bonds between dead cells on the surface of the skin and speed up the skin turnover. Skin often appears softer and brighter after exfoliation, but overdoing it can result in disrupted skin barrier. The following ingredient is doing the exfoliating job in this product: gluconolactone, glycolic acid, mandelic acid.

Retinyl palmitateEffect: Low, below effective doseThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect~0.15–0.3%

Moisturizing

Side benefit · Ceramide np, Ceramide ap + 22 more

Works well

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: glucosamine hcl, glycerin.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: cholesterol, c12-15 alkyl benzoate.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: ceramide ap, ceramide eop, ceramide np, nicotiana benthamiana hexapeptide-40 sh-oligopeptide-1, phytosphingosine

Ceramide npHero· EmollientEffect: HighA type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin~1.3–1.6%

Ceramide apHero· EmollientEffect: HighA type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin~0.55–0.8%

PhytosphingosineHero· EmollientEffect: HighA type of lipid that is naturally present in skin. It might help in repairing skin barrier function and has anti-bacterial effect~0.4–0.65%

Nicotiana benthamiana hexapeptide-40 sh-oligopeptide-1HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.15–0.25%

Ceramide eopHero· EmollientEffect: HighA type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin~0.15–0.3%

C12-15 alkyl benzoateKey active· EmollientEffect: MediumEnhances the product texture and makes it more spreadable. Helps reduce water loss from the outer layer of skin. Extands the shelf life by preventing bacteria growth~2.3–2.8%

CholesterolKey active· EmollientEffect: HighAn emollient that is naturally found in skin~0.5–0.7%

Glucosamine hclKey active· HumectantEffect: HighMight be able to stimulate production of skin's natural moisturizing compounds such as hyaluronic acid. Could be helpful for evening the skin tone.~0.25–0.45%

GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~0.2–0.4%

Elaeis guineensis oilKey active· EmollientEffect: MediumHelps soften the upper layer of the skin~0.2–0.4%

Cetearyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture~0.2–0.35%

Gossypium herbaceum seed oilKey activeEffect: MediumCottonseed oil. It is used as an emollient and occlusive in products. It is rich palmitic, oleic acid, and linoleic fatty acids.~0.2–0.35%

Nicotiana benthamiana sh-polypeptide-15 hexapeptide-40Key activeEffect: High~0.15–0.25%

Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~0.15–0.3%

Bis-peg-18 methyl ether dimethyl silane· Humectant, EmollientEffect: LowA type of silicone that helps soften the upper layer of the skin and create a nice product texture~5.1–6.3%

Hydrogenated polydecene· EmollientEffect: LowHelps to soften the upper layer of the skin and create a nice product texture~3.9–4.8%

Glyceryl stearate· EmollientEffect: LowAn emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together~1.5–1.9%

Linum usitatissimum seed oilEffect: Low~0.15–0.25%

LecithinEffect: Low, below effective doseUsed mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin~0.25–0.4%

NiacinUnder-dosedA form of vitamin B3. It is similar in action to niacinamide, but is more likely to cause red flashes in skin as the side effect~0.25–0.5%

Lycium barbarum fruit extractUnder-dosedA plant extract that can help neutralize free radicals in skin and attract water to its upper layer~0.15–0.3%

Anti-blemish

Side benefit · Retinal, Mandelic acid + 6 more

Works well

This product can help reduce breakouts and clogged pores because it contains the following ingredient: retinal. This ingredient is used for treating acne and can have a noticeable effect.

In addition, this product contains bakuchiol. It can help in reducing blemishes, even though it is less effective.

The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually works: gluconolactone, glycolic acid, mandelic acid

Mandelic acidKey activeEffect: MediumHelps shed the upper layer of dead cells from the surface of the skin revealing smoother, brighter skin. It can help to reduce hyperpigmentation. It has anti-bacterial properties, and might help to reduce blemishes, as well as fine lines and wrinkles. It is considered to be gentler than glycolic acid~1–1.2%

GluconolactoneKey activeEffect: MediumA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals~0.65–1%

Glycolic acidKey activeEffect: MediumAn alpha-hydroxy acid (AHA) that helps to remove the dead skin cells on the surface of the skin reveling a more even, smoother complexation. It is also able to stimulate collagen production with long-term use. Could help to reduce pore congestion. It can be irritating to the skin. Apply sunscreen daily if using products with glycolic acid~0.25–0.45%

PhytosphingosineEffect: LowA type of lipid that is naturally present in skin. It might help in repairing skin barrier function and has anti-bacterial effect~0.4–0.65%

NiacinUnder-dosedA form of vitamin B3. It is similar in action to niacinamide, but is more likely to cause red flashes in skin as the side effect~0.25–0.5%

Anti-oxidation

Side benefit · Gluconolactone, Bakuchiol + 6 more

Works well

This product contains antioxidants (bakuchiol, glycyrrhetinic acid) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

The following ingredients - gluconolactone also can have an antioxidant effect, but there is less evidence to confirm their effectiveness in skin.

Glycyrrhetinic acidKey activeEffect: HighActive compound of licorice root. Works to calm down inflammation, as an anti-oxidant, and might be helpful in lightening the skin and reducing hyperpigmentation~0.15–0.3%

Glucosamine hclEffect: LowMight be able to stimulate production of skin's natural moisturizing compounds such as hyaluronic acid. Could be helpful for evening the skin tone.~0.25–0.45%

Tocopheryl acetateEffect: Low, below effective doseA more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.~0.15–0.3%

TocopherolUnder-dosedPure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.2–0.35%

Lycium barbarum fruit extractUnder-dosedA plant extract that can help neutralize free radicals in skin and attract water to its upper layer~0.15–0.3%

Can it cause trouble?

Irritancy

4 strong irritants: Retinal, Alcohol + 2 more — patch-test recommended

High risk

We flagged 24 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.

IngredientFunctionIrritationEst. amount

Mandelic acidHelps shed the upper layer of dead cells from the surface of the skin revealing smoother, brighter skin. It can help to reduce hyperpigmentation. It has anti-bacterial properties, and might help to reduce blemishes, as well as fine lines and wrinkles. It is considered to be gentler than glycolic acidHigh~1–1.2%est.

RetinalOne step removed from the biologically active in skin form of vitamin A. Once converted to the retinoic acid in the skin, retinal is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. Concentrations of 0.05% and 0.1% are shown to be effective. It can, however, be irritatingHigh~0.25–0.5%est.

Glycolic acidAn alpha-hydroxy acid (AHA) that helps to remove the dead skin cells on the surface of the skin reveling a more even, smoother complexation. It is also able to stimulate collagen production with long-term use. Could help to reduce pore congestion. It can be irritating to the skin. Apply sunscreen daily if using products with glycolic acidHigh~0.25–0.45%est.

NiacinA form of vitamin B3. It is similar in action to niacinamide, but is more likely to cause red flashes in skin as the side effectHigh~0.25–0.5%est.

AlcoholCan be drying and contribute to skin irritation. Used in formulars to dissolve other ingredients, create a thinner product consistency or for its antibacterial propertiesHigh~0.15–0.3%est.

ParfumAn aromatic blend of unspecified and possibly irritating ingredientsHigh~0.15–0.25%est.

Glyceryl oleateHelps oil and water mix together. Can be irritatingHigh~0.2–0.4%est.

Retinyl palmitateThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effectHigh~0.15–0.3%est.

Ceteth-20Helps water and oil mix togetherMedium~2.8–3.4%est.

GluconolactoneA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicalsMedium~0.65–1%est.

BakuchiolA plant extract that is, though different in chemical structure, acts similar to retinoids. First studies show that it can help reduce fine lines and wrinkles, improve skin tone, reduce clogged pores and blemishes, and reduce inflammation. There is no conclusive evidence that bakuchiol is as effective as retinol however. The study that directly compared retinol with bakuchiol used bakuchiol applied twice daily compared to once per day for the retinol. According to this study, bakuchiol is less irritating than retinol. Bakuchiol is extracted from seeds of Babchi plant. Other parts of the plant contain coumarins that could cause allergic and irritant reactions. These compounds should be removed in the extraction process when bakuchiol is produced, but it is a good idea to be cautious and stay away from products that include the Babchi plant extracts other than purified bakuchiol to avoid irritationMedium~0.25–0.45%est.

Lycium barbarum fruit extractA plant extract that can help neutralize free radicals in skin and attract water to its upper layerMedium~0.15–0.3%est.

Glycyrrhetinic acidActive compound of licorice root. Works to calm down inflammation, as an anti-oxidant, and might be helpful in lightening the skin and reducing hyperpigmentationMedium~0.15–0.3%est.

Tocopheryl acetateA more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.Medium~0.15–0.3%est.

PhosphatidylcholineUsed to enhance the delivery of other ingredientsMedium~0.15–0.3%est.

EthylhexylglycerinA preservativeMedium~0.15–0.3%est.

Sodium lauroyl lactylateHelps water and oil mix togetherMedium~0.2–0.35%est.

TriethanolamineUsed to adjust pH of the product and can help improve the product's smellMedium~0.2–0.4%est.

Disodium edtaStabilizes the product formulationMedium~0.2–0.35%est.

Ascorbyl palmitateBeing a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.Medium~0.2–0.35%est.

Citric acidCan work as an exfoliant but is typically used to adjust the product pHMedium~0.2–0.35%est.

Lactic acidAn exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)Medium~0.15–0.3%est.

Potassium sorbateA preservativeMedium~0.15–0.3%est.

Calcium chlorideHelps create a thicker product consistency. Might be irritatingMedium~0.1–0.2%est.

Comedogenic

2 ingredients rated 2 or more on the 0–5 pore-clogging scale

2 flagged

These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.

IngredientFunctionRatingEst. amount

Gossypium herbaceum seed oilCottonseed oil. It is used as an emollient and occlusive in products. It is rich palmitic, oleic acid, and linoleic fatty acids.3/5~0.2–0.35%est.

Cetearyl alcoholA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture2/5~0.2–0.35%est.

Alternatives

Cheaper, or higher on efficacy

be the skin Vegan Retinal Bakuchiol Serum

Cheaper72% match

$27.44

colibri skincare Vitamin A Serum

Cheaper71% match

$17.24

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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%

Formula

Irritation risk: Low

Plain old water

More about Water

Bis-peg-18 methyl ether dimethyl silane~5.1–6.3%

Formula

Irritation risk: Low

Works for

CleansingMoisturizing

A type of silicone that helps soften the upper layer of the skin and create a nice product texture

More about Bis-peg-18 methyl ether dimethyl silane

Hydrogenated polydecene~3.9–4.8%

Formula

Irritation risk: Low

Works for

Moisturizing

Helps to soften the upper layer of the skin and create a nice product texture

More about Hydrogenated polydecene

Ceteth-20~2.8–3.4%

Irritant · medium

Irritation risk: Medium

Works for

Cleansing

Helps water and oil mix together

More about Ceteth-20

C12-15 alkyl benzoate~2.3–2.8%

Key active

Irritation risk: Low

Works for

Moisturizing

Enhances the product texture and makes it more spreadable. Helps reduce water loss from the outer layer of skin. Extands the shelf life by preventing bacteria growth

More about C12-15 alkyl benzoate

Propanediol~1.8–2.2%

Formula

Irritation risk: Low

Acts as a solvent for other ingredients. Speeds up the absorption of other ingredients into the skin

More about Propanediol

Glyceryl stearate~1.5–1.9%

Formula

Irritation risk: Low

Works for

CleansingMoisturizing

An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together

More about Glyceryl stearate

Ceramide np~1.3–1.6%

Hero · Moisturizing

Irritation risk: Low

Works for

MoisturizingReduces irritationAnti-inflammatory

A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin

More about Ceramide np

Mandelic acid~1–1.2%

Key activeIrritant · high

Irritation risk: High

Works for

Evens skin toneExfoliationAnti-blemishAntibacterial

Helps shed the upper layer of dead cells from the surface of the skin revealing smoother, brighter skin. It can help to reduce hyperpigmentation. It has anti-bacterial properties, and might help to reduce blemishes, as well as fine lines and wrinkles. It is considered to be gentler than glycolic acid

More about Mandelic acid

Gluconolactone~0.65–1%

Key activeIrritant · medium

Irritation risk: Medium

Works for

MoisturizingAnti-agingEvens skin toneExfoliationAnti-blemishAnti-oxidation

A polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals

More about Gluconolactone

Ceramide ap~0.55–0.8%

Hero · Moisturizing

Irritation risk: Low

Works for

Reduces irritationMoisturizingAnti-inflammatory

More about Ceramide ap

Cholesterol~0.5–0.7%

Key active

Irritation risk: Low

Works for

CleansingMoisturizing

An emollient that is naturally found in skin

More about Cholesterol

Phytosphingosine~0.4–0.65%

Hero · Moisturizing

Irritation risk: Low

Works for

MoisturizingAnti-inflammatoryAnti-blemish

A type of lipid that is naturally present in skin. It might help in repairing skin barrier function and has anti-bacterial effect

More about Phytosphingosine

Retinal~0.25–0.5%

Hero · Anti-aging, Evens skin tone, Anti-blemishIrritant · high

Irritation risk: High

Works for

Evens skin toneAnti-agingAnti-blemish

One step removed from the biologically active in skin form of vitamin A. Once converted to the retinoic acid in the skin, retinal is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. Concentrations of 0.05% and 0.1% are shown to be effective. It can, however, be irritating

More about Retinal

Glycolic acid~0.25–0.45%

Key activeIrritant · high

Irritation risk: High

Works for

Anti-agingEvens skin toneExfoliationAnti-blemish

An alpha-hydroxy acid (AHA) that helps to remove the dead skin cells on the surface of the skin reveling a more even, smoother complexation. It is also able to stimulate collagen production with long-term use. Could help to reduce pore congestion. It can be irritating to the skin. Apply sunscreen daily if using products with glycolic acid

More about Glycolic acid

Glucosamine hcl~0.25–0.45%

Key active

Irritation risk: Low

Works for

AntibacterialMoisturizingEvens skin toneAnti-oxidationAnti-aging

Might be able to stimulate production of skin's natural moisturizing compounds such as hyaluronic acid. Could be helpful for evening the skin tone.

More about Glucosamine hcl

Niacin~0.25–0.5%

Under-dosedIrritant · high

Irritation risk: High

Works for

MoisturizingAnti-agingAnti-blemishEvens skin tone

A form of vitamin B3. It is similar in action to niacinamide, but is more likely to cause red flashes in skin as the side effect

More about Niacin

Copper sulfate~0.25–0.4%

Formula

Irritation risk: Low

More about Copper sulfate

Bakuchiol~0.25–0.45%

Key activeIrritant · medium

Irritation risk: Medium

Works for

Anti-oxidationAnti-inflammatoryAnti-blemishEvens skin toneAnti-aging

A plant extract that is, though different in chemical structure, acts similar to retinoids. First studies show that it can help reduce fine lines and wrinkles, improve skin tone, reduce clogged pores and blemishes, and reduce inflammation. There is no conclusive evidence that bakuchiol is as effective as retinol however. The study that directly compared retinol with bakuchiol used bakuchiol applied twice daily compared to once per day for the retinol. According to this study, bakuchiol is less irritating than retinol. Bakuchiol is extracted from seeds of Babchi plant. Other parts of the plant contain coumarins that could cause allergic and irritant reactions. These compounds should be removed in the extraction process when bakuchiol is produced, but it is a good idea to be cautious and stay away from products that include the Babchi plant extracts other than purified bakuchiol to avoid irritation

More about Bakuchiol

Lycium barbarum fruit extract~0.15–0.3%

Under-dosedIrritant · medium

Irritation risk: Medium

Works for

Anti-oxidationMoisturizingAnti-agingAnti-inflammatory

A plant extract that can help neutralize free radicals in skin and attract water to its upper layer

More about Lycium barbarum fruit extract

Glycyrrhetinic acid~0.15–0.3%

Key activeIrritant · medium

Irritation risk: Medium

Works for

Anti-oxidationAnti-inflammatoryEvens skin tone

Active compound of licorice root. Works to calm down inflammation, as an anti-oxidant, and might be helpful in lightening the skin and reducing hyperpigmentation

More about Glycyrrhetinic acid

Sodium hyaluronate~0.15–0.3%

Key active

Irritation risk: Low

Works for

Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate

Zinc chloride~0.1–0.2%

Formula

Irritation risk: Low

More about Zinc chloride

Nicotiana benthamiana hexapeptide-40 sh-oligopeptide-1~0.15–0.25%

Hero · Moisturizing

Irritation risk: Low

Works for

MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Nicotiana benthamiana hexapeptide-40 sh-oligopeptide-1

Nicotiana benthamiana sh-polypedtide-7~0.15–0.25%

Formula

Irritation risk: Low

More about Nicotiana benthamiana sh-polypedtide-7

Nicotiana benthamiana hexapeptide-40 sh-polypeptide-5~0.15–0.25%

Formula

Irritation risk: Low

More about Nicotiana benthamiana hexapeptide-40 sh-polypeptide-5

Bidens pilosa extract~0.15–0.25%

Formula

Irritation risk: Low

More about Bidens pilosa extract

Nicotiana benthamiana sh-polypeptide-15 hexapeptide-40~0.15–0.25%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-aging

More about Nicotiana benthamiana sh-polypeptide-15 hexapeptide-40

Ceramide eop~0.15–0.3%

Hero · Moisturizing

Irritation risk: Low

Works for

MoisturizingReduces irritationAnti-inflammatory

More about Ceramide eop

Phenoxyethanol~0.15–0.3%

Formula

Irritation risk: Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol

Cetearyl alcohol~0.2–0.35%

Key activeComedogenic 2/5

Irritation risk: Low
Comedogenicity: 2/5

Works for

CleansingMoisturizing

A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture

More about Cetearyl alcohol

Tocopheryl acetate~0.15–0.3%

Irritant · medium

Irritation risk: Medium

Works for

Anti-oxidation

A more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.

More about Tocopheryl acetate

Phosphatidylcholine~0.15–0.3%

Irritant · medium

Irritation risk: Medium

Works for

Cleansing

Used to enhance the delivery of other ingredients

More about Phosphatidylcholine

Alcohol~0.15–0.3%

Irritant · high

Irritation risk: High

Works for

Antibacterial

Can be drying and contribute to skin irritation. Used in formulars to dissolve other ingredients, create a thinner product consistency or for its antibacterial properties

More about Alcohol

Ammonium acryloyldimethyltaurate/vp copolymer~0.15–0.3%

Formula

Irritation risk: Low

Increases thickness of a product. Texture enhancer for oil-in-water emulsions

More about Ammonium acryloyldimethyltaurate/vp copolymer

Xanthan gum~0.15–0.3%

Formula

Irritation risk: Low

Works for

Cleansing

Used to create a thicker product consistency

More about Xanthan gum

Ethylhexylglycerin~0.15–0.3%

Irritant · medium

Irritation risk: Medium

A preservative

More about Ethylhexylglycerin

Parfum~0.15–0.25%

Irritant · high

Irritation risk: High

An aromatic blend of unspecified and possibly irritating ingredients

More about Parfum

Sodium lauroyl lactylate~0.2–0.35%

Irritant · medium

Irritation risk: Medium

Works for

Cleansing

Helps water and oil mix together

More about Sodium lauroyl lactylate

Polysorbate 20~0.2–0.4%

Formula

Irritation risk: Low

Works for

Cleansing

Helps oil and water mix together

More about Polysorbate 20

Triethanolamine~0.2–0.4%

Irritant · medium

Irritation risk: Medium

Works for

Cleansing

Used to adjust pH of the product and can help improve the product's smell

More about Triethanolamine

Disodium edta~0.2–0.35%

Irritant · medium

Irritation risk: Medium

Stabilizes the product formulation

More about Disodium edta

Sodium chloride~0.2–0.4%

Formula

Irritation risk: Low

Used to stabilize mixtures of oil and water, and create thicker, gel-like product textures

More about Sodium chloride

Sodium cholate~0.2–0.35%

Formula

Irritation risk: Low

More about Sodium cholate

Tocopherol~0.2–0.35%

Under-dosed

Irritation risk: Low

Works for

Anti-oxidationMoisturizingAnti-inflammatoryAnti-aging

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol

Lecithin~0.25–0.4%

Formula

Irritation risk: Low

Works for

CleansingMoisturizing

Used mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin

More about Lecithin

Ascorbyl palmitate~0.2–0.35%

Irritant · medium

Irritation risk: Medium

Works for

Anti-oxidationAnti-aging

Being a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.

More about Ascorbyl palmitate

Carbomer~0.2–0.35%

Formula

Irritation risk: Low

Works for

Cleansing

Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations

More about Carbomer

Glycerin~0.2–0.4%

Key active

Irritation risk: Low

Works for

Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin

Sodium hydroxide~0.2–0.35%

Formula

Irritation risk: Low

Used to adjust the product's pH

More about Sodium hydroxide

Glyceryl oleate~0.2–0.4%

Irritant · high

Irritation risk: High

Works for

Cleansing

Helps oil and water mix together. Can be irritating

More about Glyceryl oleate

Dipotassium phosphate~0.2–0.35%

Formula

Irritation risk: Low

Used to adjust the pH of the product

More about Dipotassium phosphate

Tromethamine~0.2–0.35%

Formula

Irritation risk: Low

Helps adjust pH in products

More about Tromethamine

Geranyl acetate~0.15–0.3%

Formula

Irritation risk: Low

More about Geranyl acetate

Linalyl acetate~0.2–0.35%

Formula

Irritation risk: Low

More about Linalyl acetate

Citric acid~0.2–0.35%

Irritant · medium

Irritation risk: Medium

Can work as an exfoliant but is typically used to adjust the product pH

More about Citric acid

Hydrochloric acid~0.2–0.35%

Formula

Irritation risk: Low

More about Hydrochloric acid

Potassium phosphate~0.2–0.4%

Formula

Irritation risk: Low

Helps regulate the pH of the formulation

More about Potassium phosphate

Retinyl palmitate~0.15–0.3%

Under-dosedIrritant · high

Irritation risk: High

Works for

Anti-agingEvens skin toneAnti-blemishExfoliation

Three steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect

More about Retinyl palmitate

Elaeis guineensis oil~0.2–0.4%

Key active

Irritation risk: Low

Works for

Moisturizing

Helps soften the upper layer of the skin

More about Elaeis guineensis oil

Gossypium herbaceum seed oil~0.2–0.35%

Key activeComedogenic 3/5

Irritation risk: Low
Comedogenicity: 3/5

Works for

Moisturizing

Cottonseed oil. It is used as an emollient and occlusive in products. It is rich palmitic, oleic acid, and linoleic fatty acids.

More about Gossypium herbaceum seed oil

Sodium benzoate~0.15–0.25%

Formula

Irritation risk: Low

A preservative

More about Sodium benzoate

Linum usitatissimum seed oil~0.15–0.25%

Formula

Irritation risk: Low

Works for

Moisturizing

More about Linum usitatissimum seed oil

Lactic acid~0.15–0.3%

Under-dosedIrritant · medium

Irritation risk: Medium

Works for

Evens skin toneMoisturizingExfoliationAnti-aging

An exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)

More about Lactic acid

Potassium sorbate~0.15–0.3%

Irritant · medium

Irritation risk: Medium

A preservative

More about Potassium sorbate

Calcium chloride~0.1–0.2%

Irritant · medium

Irritation risk: Medium

Helps create a thicker product consistency. Might be irritating

More about Calcium chloride

Calcium sulfate~0.2–0.4%

Formula

Irritation risk: Low

More about Calcium sulfate

Ingredient list view

Water, Bis-peg-18 methyl ether dimethyl silane, Hydrogenated polydecene, Ceteth-20, C12-15 alkyl benzoate, Propanediol, Glyceryl stearate, Ceramide np, Mandelic acid, Gluconolactone, Ceramide ap, Cholesterol, Phytosphingosine, Retinal, Glycolic acid, Glucosamine hcl, Niacin, Copper sulfate, Bakuchiol, Lycium barbarum fruit extract, Glycyrrhetinic acid, Sodium hyaluronate, Zinc chloride, Nicotiana benthamiana hexapeptide-40 sh-oligopeptide-1, Nicotiana benthamiana sh-polypedtide-7, Nicotiana benthamiana hexapeptide-40 sh-polypeptide-5, Bidens pilosa extract, Nicotiana benthamiana sh-polypeptide-15 hexapeptide-40, Ceramide eop, Phenoxyethanol, Cetearyl alcohol, Tocopheryl acetate, Phosphatidylcholine, Alcohol, Ammonium acryloyldimethyltaurate/vp copolymer, Xanthan gum, Ethylhexylglycerin, Parfum, Sodium lauroyl lactylate, Polysorbate 20, Triethanolamine, Disodium edta, Sodium chloride, Sodium cholate, Tocopherol, Lecithin, Ascorbyl palmitate, Carbomer, Glycerin, Sodium hydroxide, Glyceryl oleate, Dipotassium phosphate, Tromethamine, Geranyl acetate, Linalyl acetate, Citric acid, Hydrochloric acid, Potassium phosphate, Retinyl palmitate, Elaeis guineensis oil, Gossypium herbaceum seed oil, Sodium benzoate, Linum usitatissimum seed oil, Lactic acid, Potassium sorbate, Calcium chloride, Calcium sulfate

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🌐 Sesderma (ES)

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
	SesdermaSESRETINAL Mature Skin Liposomal SerumYOUR PRODUCT	be the skinVegan Retinal Bakuchiol Serum	colibri skincareVitamin A Serum	ArenciaRetinal Booster Shot
Match	—	72%	71%	69%
Price	—	$27.44	$17.24	$13.61
Shared key ingredients	—	6 of 20	4 of 20	6 of 20
Key difference	—	Copper Tripeptide-1	Hydroxypinacolone Retinoate	Hexapeptide-9
Irritancy	High	Medium	High	Medium
Drying alcohol	Contains drying alcohol	—	—	—
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