Sepai

Sepai Restart Recovery Serum

Name: Sepai - Restart Recovery Serum
Brand: Sepai

Efficacy100/100IrritancyHigh

See all ingredients

Works for

Anti-aging

Niacinamide, Adenosine + 7 more

Works well

What the product description says

“An advocate for smart-aging, the formulation helps to rewind the aging clock by acting as a 'personal trainer' for skin, teaching it to be active again and to optimise performance.”

Source: Lookfantastic US

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains adenosine, niacinamide.

These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: centella asiatica leaf extract, palmitoyl tripeptide-8, serine.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

NiacinamideKey activeEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~1.7–2%

AdenosineKey activeEffect: HighMight help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)~1.1–1.4%

Palmitoyl tripeptide-8Key activeEffect: Medium~0.25–0.5%

Centella asiatica leaf extractKey activeEffect: MediumA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. It can be irritating to sensitive skin. Might be helpful in preventing stretch marks. It could, however, itself be irritating.~0.25–0.5%

SerineKey activeEffect: MediumAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.25–0.5%

Thermus thermophillus fermentEffect: LowMight be helpful in neutralising free radicals in skin and have some hydration properties~3.1–3.8%

Decarboxy carnosine hclEffect: LowMight be able to protect the skin from free radicals, but further evidence of effectiveness is needed~0.5–0.75%

Copper gluconateEffect: Low, below effective doseTypically used to stabilize the product formulations. It is a salt of polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing~0.25–0.5%

Zinc gluconateEffect: Low, below effective doseTypically used to stabilize the product formulations. It is a salt of a polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing. Due to the zinc content, might help calm down inflammation in skin~0.25–0.5%

Evens skin tone

Not advertised by the brand · Niacinamide, Copper gluconate + 1 more

Works well

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: niacinamide

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

Anti-oxidation

Not advertised by the brand · Decarboxy carnosine hcl, Superoxide dismutase + 12 more

Works well

This product contains antioxidants (superoxide dismutase) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

The following ingredients - decarboxy carnosine hcl, ginkgo biloba leaf extract, imperata cylindrica root extract also can have an antioxidant effect, but there is less evidence to confirm their effectiveness in skin.

Decarboxy carnosine hclKey activeEffect: MediumMight be able to protect the skin from free radicals, but further evidence of effectiveness is needed~0.5–0.75%

Superoxide dismutaseKey activeEffect: HighAn antioxidant enzyme that is naturally present in skin. It can help support skin barrier function and reduce inflammation in skin. It is used in topical medications for inflammatory skin conditions including atopic dermatitis (eczema) and psoriasis. There are three types of natural Superoxide Dismutase in human skin. The compound used in topical treatments and cosmetics are mimics of typically one of these natural variants~0.35–0.65%

Imperata cylindrica root extractKey activeEffect: MediumA plat extract that might help neutralize free radicals in skin and attract water to its upper layer~0.3–0.6%

Ginkgo biloba leaf extractKey activeEffect: MediumA plant extract that might help neutralize free radicals and reduce inflammation in skin. It can be irritating~0.25–0.5%

Thermus thermophillus fermentEffect: LowMight be helpful in neutralising free radicals in skin and have some hydration properties~3.1–3.8%

AdenosineEffect: LowMight help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)~1.1–1.4%

Undaria pinnatifida extractEffect: LowA seaweed extract that helps attract water to the upper layer of the skin and might have an anti-oxidant effect~0.4–0.65%

Viscum album leaf extractEffect: LowA plant extract that has anti-inflammatory and anti-bacterial properties and might help neutralize free radicals in skin, but solid research is lacking~0.4–0.65%

Vaccinium myrtillus fruit extractEffect: LowA plant extract that might help neutralize free radicals in skin, but research on its efficacy in skin is lacking~0.25–0.5%

Triticum vulgare germ extractEffect: Low, below effective dosePlant extract that might have moisturizing properties. Avoid if you suffer from wheat or gluten intolerance~0.3–0.55%

Oryza sativa extractEffect: Low, below effective doseA grain extract that helps to create a thicker product consistency. It might have some anti-oxidant properties and help attract water to the upper layer of the skin~0.3–0.55%

Panax ginseng root extractEffect: Low, below effective doseA plant extract that might have some anti-inflammatory properties, but solid evidence is lacking. It can be irritating~0.3–0.6%

Anti-blemish

Not advertised by the brand · Niacinamide, Centella asiatica leaf extract + 3 more

Works well

This product can help reduce breakouts and clogged pores because it contains the following ingredient: niacinamide. This ingredient is used for treating acne and can have a noticeable effect.

NiacinamideHeroEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~1.7–2%

Centella asiatica leaf extractEffect: LowA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. It can be irritating to sensitive skin. Might be helpful in preventing stretch marks. It could, however, itself be irritating.~0.25–0.5%

Ginkgo biloba leaf extractEffect: LowA plant extract that might help neutralize free radicals and reduce inflammation in skin. It can be irritating~0.25–0.5%

Moisturizing

Not advertised by the brand · Panthenol, Niacinamide + 21 more

Works well

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: dextran, faex.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: sphingolipids.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: niacinamide, palmitoyl tripeptide-8, panthenol

PanthenolHero· HumectantEffect: HighHelps attract water to the upper layer of the skin and can help improve skin barrier function~2.4–3%

Palmitoyl tripeptide-8HeroEffect: High~0.25–0.5%

GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~4.4–5.4%

Thermus thermophillus fermentKey active· HumectantEffect: HighMight be helpful in neutralising free radicals in skin and have some hydration properties~3.1–3.8%

AdenosineKey activeEffect: MediumMight help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)~1.1–1.4%

Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~0.45–0.7%

Lactobacillus/soybean ferment extractKey activeEffect: MediumA fermentation product created by bacteria Lactobacillus out of soybean. The fermented product helps to attract water to the upper layer of the skin and has anti-bacterial properties. It might be helpful in calming down inflammation and could be helpful in evening out skin tone, but studies are lacking~0.45–0.65%

Undaria pinnatifida extractKey activeEffect: HighA seaweed extract that helps attract water to the upper layer of the skin and might have an anti-oxidant effect~0.4–0.65%

SphingolipidsKey active· EmollientEffect: HighSphingolipids are a group of lipids with a common chemical structure. Some of them are naturally present in skin and can be converted to ceramides~0.3–0.55%

Imperata cylindrica root extractKey active· HumectantEffect: HighA plat extract that might help neutralize free radicals in skin and attract water to its upper layer~0.3–0.6%

DextranKey active· HumectantEffect: HighHelps attract water to the most upper layer of the skin. Derived from sugar~0.3–0.5%

Saccharide isomerateKey active· HumectantEffect: HighHelps attract water to the upper layer of the skin~0.3–0.55%

PhospholipidsKey activeEffect: MediumEmollients that are naturaly present in skin. In addition, they help water and oil mix together in the product~0.3–0.5%

SerineKey activeEffect: HighAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.25–0.5%

FaexKey active· HumectantEffect: HighYeast extract. Helps to attract water to the upper layer of the skin~0.25–0.5%

Magnesium aspartateKey activeEffect: MediumMight be helpful in restoring skin barrier function and calm down inflammation in skin~0.25–0.5%

Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~0.2–0.4%

Triticum vulgare germ extractUnder-dosedPlant extract that might have moisturizing properties. Avoid if you suffer from wheat or gluten intolerance~0.3–0.55%

Copper gluconateUnder-dosedTypically used to stabilize the product formulations. It is a salt of polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing~0.25–0.5%

Zinc gluconateUnder-dosedTypically used to stabilize the product formulations. It is a salt of a polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing. Due to the zinc content, might help calm down inflammation in skin~0.25–0.5%

Can it cause trouble?

Irritancy

5 strong irritants: Citrus aurantium dulcis fruit extract, Citrus aurantium bergamia fruit extract + 3 more — patch-test recommended

High risk

We flagged 24 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.

IngredientFunctionIrritationEst. amount

Citrus aurantium dulcis fruit extractA plant extract that is used as a fragrance. Can be irritating and lead to photosensitivityHigh~0.25–0.5%est.

Citrus aurantium bergamia fruit extract—High~0.25–0.5%est.

Citrus nobilis fruit extract—High~0.25–0.5%est.

Ginkgo biloba leaf extractA plant extract that might help neutralize free radicals and reduce inflammation in skin. It can be irritatingHigh~0.25–0.5%est.

Panax ginseng root extractA plant extract that might have some anti-inflammatory properties, but solid evidence is lacking. It can be irritatingHigh~0.3–0.6%est.

Citrus grandis fruit extract—High~0.25–0.45%est.

Benzyl alcoholA preservative. Can be used to mask unpleasant smell. Can be irritatingHigh~0.15–0.3%est.

ParfumAn aromatic blend of unspecified and possibly irritating ingredientsHigh~0.15–0.25%est.

Thermus thermophillus fermentMight be helpful in neutralising free radicals in skin and have some hydration propertiesMedium~3.1–3.8%est.

Acacia senegal gumHelps mask the small of other ingredients and improve the product textureMedium~0.7–1.1%est.

Viscum album leaf extractA plant extract that has anti-inflammatory and anti-bacterial properties and might help neutralize free radicals in skin, but solid research is lackingMedium~0.4–0.65%est.

Imperata cylindrica root extractA plat extract that might help neutralize free radicals in skin and attract water to its upper layerMedium~0.3–0.6%est.

Centella asiatica leaf extractA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. It can be irritating to sensitive skin. Might be helpful in preventing stretch marks. It could, however, itself be irritating.Medium~0.25–0.5%est.

Copper gluconateTypically used to stabilize the product formulations. It is a salt of polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missingMedium~0.25–0.5%est.

Zinc gluconateTypically used to stabilize the product formulations. It is a salt of a polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing. Due to the zinc content, might help calm down inflammation in skinMedium~0.25–0.5%est.

Vaccinium myrtillus fruit extractA plant extract that might help neutralize free radicals in skin, but research on its efficacy in skin is lackingMedium~0.25–0.5%est.

Triticum vulgare germ extractPlant extract that might have moisturizing properties. Avoid if you suffer from wheat or gluten intoleranceMedium~0.3–0.55%est.

Potassium sorbateA preservativeMedium~0.3–0.55%est.

Sodium citrateHelps to control the skin's pH level. Maintains the skin's natural film of amino-lactic acids and oils. Helps to preserve productsMedium~0.25–0.5%est.

Benzoic acidA preservativeMedium~0.25–0.5%est.

Sorbic acidA preservativeMedium~0.25–0.45%est.

Citric acidCan work as an exfoliant but is typically used to adjust the product pHMedium~0.25–0.45%est.

Dehydroacetic acidA preservativeMedium~0.2–0.4%est.

EthylhexylglycerinA preservativeMedium~0.2–0.35%est.

Comedogenic

2 ingredients rated 2 or more on the 0–5 pore-clogging scale

2 flagged

These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.

IngredientFunctionRatingEst. amount

Spirulina platensis powder—3/5~0.3–0.5%est.

Triticum vulgare germ extractPlant extract that might have moisturizing properties. Avoid if you suffer from wheat or gluten intolerance3/5~0.3–0.55%est.

Alternatives

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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%

Formula

Irritation risk: Low

Plain old water

More about Water

Glycerin~4.4–5.4%

Key active

Irritation risk: Low

Works for

Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin

Propanediol~4.1–5%

Formula

Irritation risk: Low

Acts as a solvent for other ingredients. Speeds up the absorption of other ingredients into the skin

More about Propanediol

Thermus thermophillus ferment~3.1–3.8%

Key activeIrritant · medium

Irritation risk: Medium

Works for

MoisturizingAnti-oxidationAnti-aging

Might be helpful in neutralising free radicals in skin and have some hydration properties

More about Thermus thermophillus ferment

Panthenol~2.4–3%

Hero · Moisturizing

Irritation risk: Low

Works for

Reduces rednessMoisturizingReduces irritation

Helps attract water to the upper layer of the skin and can help improve skin barrier function

More about Panthenol

Marrubium vulgare extract~1.8–2.3%

Formula

Irritation risk: Low

More about Marrubium vulgare extract

Niacinamide~1.7–2%

Hero · Moisturizing, Anti-blemish

Irritation risk: Low

Works for

Anti-agingAnti-blemishEvens skin toneMoisturizingReduces irritationAnti-inflammatoryAntibacterialReduces redness

Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production

More about Niacinamide

Tuber magnatum extract~1.4–1.7%

Formula

Irritation risk: Low

More about Tuber magnatum extract

Adenosine~1.1–1.4%

Key active

Irritation risk: Low

Works for

Anti-agingMoisturizingAnti-oxidation

Might help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)

More about Adenosine

Hydrolyzed manihot esculenta tuber extract~0.9–1.15%

Formula

Irritation risk: Low

More about Hydrolyzed manihot esculenta tuber extract

Acacia senegal gum~0.7–1.1%

Irritant · medium

Irritation risk: Medium

Helps mask the small of other ingredients and improve the product texture

More about Acacia senegal gum

Hydrolyzed candida saitoana extract~0.55–0.85%

Formula

Irritation risk: Low

More about Hydrolyzed candida saitoana extract

Decarboxy carnosine hcl~0.5–0.75%

Key active

Irritation risk: Low

Works for

Anti-oxidationAnti-aging

Might be able to protect the skin from free radicals, but further evidence of effectiveness is needed

More about Decarboxy carnosine hcl

Sodium hyaluronate~0.45–0.7%

Key active

Irritation risk: Low

Works for

Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate

Lactobacillus/soybean ferment extract~0.45–0.65%

Key active

Irritation risk: Low

Works for

Moisturizing

A fermentation product created by bacteria Lactobacillus out of soybean. The fermented product helps to attract water to the upper layer of the skin and has anti-bacterial properties. It might be helpful in calming down inflammation and could be helpful in evening out skin tone, but studies are lacking

More about Lactobacillus/soybean ferment extract

Viscum album leaf extract~0.4–0.65%

Irritant · medium

Irritation risk: Medium

Works for

Anti-oxidationAntibacterialAnti-inflammatory

A plant extract that has anti-inflammatory and anti-bacterial properties and might help neutralize free radicals in skin, but solid research is lacking

More about Viscum album leaf extract

Undaria pinnatifida extract~0.4–0.65%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-oxidation

A seaweed extract that helps attract water to the upper layer of the skin and might have an anti-oxidant effect

More about Undaria pinnatifida extract

Superoxide dismutase~0.35–0.65%

Key active

Irritation risk: Low

Works for

Anti-inflammatoryMoisturizingAnti-oxidation

An antioxidant enzyme that is naturally present in skin. It can help support skin barrier function and reduce inflammation in skin. It is used in topical medications for inflammatory skin conditions including atopic dermatitis (eczema) and psoriasis. There are three types of natural Superoxide Dismutase in human skin. The compound used in topical treatments and cosmetics are mimics of typically one of these natural variants

More about Superoxide dismutase

Imperata cylindrica root extract~0.3–0.6%

Key activeIrritant · medium

Irritation risk: Medium

Works for

MoisturizingAnti-oxidationAnti-inflammatory

A plat extract that might help neutralize free radicals in skin and attract water to its upper layer

More about Imperata cylindrica root extract

Saccharide isomerate~0.3–0.55%

Key active

Irritation risk: Low

Works for

Moisturizing

Helps attract water to the upper layer of the skin

More about Saccharide isomerate

Mimosa tenuiflora bark extract~0.3–0.55%

Formula

Irritation risk: Low

More about Mimosa tenuiflora bark extract

Crocus sativus flower extract~0.3–0.55%

Formula

Irritation risk: Low

More about Crocus sativus flower extract

Centella asiatica leaf extract~0.25–0.5%

Key activeIrritant · medium

Irritation risk: Medium

Works for

Anti-inflammatoryReduces irritationReduces rednessAnti-agingAnti-blemish

A plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. It can be irritating to sensitive skin. Might be helpful in preventing stretch marks. It could, however, itself be irritating.

More about Centella asiatica leaf extract

Faex~0.25–0.5%

Key active

Irritation risk: Low

Works for

Moisturizing

Yeast extract. Helps to attract water to the upper layer of the skin

More about Faex

Yeast~0.25–0.5%

Formula

Irritation risk: Low

More about Yeast

Levure

Not recognized

Citrus aurantium dulcis fruit extract~0.25–0.5%

Irritant · high

Irritation risk: High

A plant extract that is used as a fragrance. Can be irritating and lead to photosensitivity

More about Citrus aurantium dulcis fruit extract

Palmitoyl tripeptide-8~0.25–0.5%

Hero · Moisturizing

Irritation risk: Low

Works for

MoisturizingAnti-aging

More about Palmitoyl tripeptide-8

Citrus aurantium bergamia fruit extract~0.25–0.5%

Irritant · high

Irritation risk: High

More about Citrus aurantium bergamia fruit extract

Copper gluconate~0.25–0.5%

Under-dosedIrritant · medium

Irritation risk: Medium

Works for

MoisturizingEvens skin toneAnti-blemishExfoliationAnti-oxidationAnti-aging

Typically used to stabilize the product formulations. It is a salt of polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing

More about Copper gluconate

Citrus nobilis fruit extract~0.25–0.5%

Irritant · high

Irritation risk: High

More about Citrus nobilis fruit extract

Magnesium aspartate~0.25–0.5%

Key active

Irritation risk: Low

Works for

Anti-inflammatoryMoisturizing

Might be helpful in restoring skin barrier function and calm down inflammation in skin

More about Magnesium aspartate

Ginkgo biloba leaf extract~0.25–0.5%

Key activeIrritant · high

Irritation risk: High

Works for

Anti-oxidationAnti-blemishAntibacterialAnti-inflammatory

A plant extract that might help neutralize free radicals and reduce inflammation in skin. It can be irritating

More about Ginkgo biloba leaf extract

Zinc gluconate~0.25–0.5%

Under-dosedIrritant · medium

Irritation risk: Medium

Works for

MoisturizingAnti-inflammatoryAnti-agingEvens skin toneAnti-oxidationExfoliationAnti-blemish

Typically used to stabilize the product formulations. It is a salt of a polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing. Due to the zinc content, might help calm down inflammation in skin

More about Zinc gluconate

Oryza sativa extract~0.3–0.55%

Formula

Irritation risk: Low

Works for

MoisturizingAnti-oxidation

A grain extract that helps to create a thicker product consistency. It might have some anti-oxidant properties and help attract water to the upper layer of the skin

More about Oryza sativa extract

Spirulina platensis powder~0.3–0.5%

Comedogenic 3/5

Irritation risk: Low
Comedogenicity: 3/5

More about Spirulina platensis powder

Panax ginseng root extract~0.3–0.6%

Irritant · high

Irritation risk: High

Works for

Anti-inflammatoryAnti-oxidation

A plant extract that might have some anti-inflammatory properties, but solid evidence is lacking. It can be irritating

More about Panax ginseng root extract

Sphingolipids~0.3–0.55%

Key active

Irritation risk: Low

Works for

Moisturizing

Sphingolipids are a group of lipids with a common chemical structure. Some of them are naturally present in skin and can be converted to ceramides

More about Sphingolipids

Vaccinium myrtillus fruit extract~0.25–0.5%

Irritant · medium

Irritation risk: Medium

Works for

Anti-oxidation

A plant extract that might help neutralize free radicals in skin, but research on its efficacy in skin is lacking

More about Vaccinium myrtillus fruit extract

Serine~0.25–0.5%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-aging

An amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles

More about Serine

Triticum vulgare germ extract~0.3–0.55%

Under-dosedComedogenic 3/5Irritant · medium

Irritation risk: Medium
Comedogenicity: 3/5

Works for

MoisturizingAnti-oxidation

Plant extract that might have moisturizing properties. Avoid if you suffer from wheat or gluten intolerance

More about Triticum vulgare germ extract

Phospholipids~0.3–0.5%

Key active

Irritation risk: Low

Works for

Moisturizing

Emollients that are naturaly present in skin. In addition, they help water and oil mix together in the product

More about Phospholipids

Citrus grandis fruit extract~0.25–0.45%

Irritant · high

Irritation risk: High

More about Citrus grandis fruit extract

Carbomer~0.3–0.5%

Formula

Irritation risk: Low

Works for

Cleansing

Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations

More about Carbomer

Dextran~0.3–0.5%

Key active

Irritation risk: Low

Works for

Moisturizing

Helps attract water to the most upper layer of the skin. Derived from sugar

More about Dextran

Potassium sorbate~0.3–0.55%

Irritant · medium

Irritation risk: Medium

A preservative

More about Potassium sorbate

Sodium citrate~0.25–0.5%

Irritant · medium

Irritation risk: Medium

Helps to control the skin's pH level. Maintains the skin's natural film of amino-lactic acids and oils. Helps to preserve products

More about Sodium citrate

Sodium benzoate~0.3–0.5%

Formula

Irritation risk: Low

A preservative

More about Sodium benzoate

Sodium hydroxide~0.25–0.5%

Formula

Irritation risk: Low

Used to adjust the product's pH

More about Sodium hydroxide

Benzoic acid~0.25–0.5%

Irritant · medium

Irritation risk: Medium

A preservative

More about Benzoic acid

Sorbic acid~0.25–0.45%

Irritant · medium

Irritation risk: Medium

A preservative

More about Sorbic acid

Citric acid~0.25–0.45%

Irritant · medium

Irritation risk: Medium

Can work as an exfoliant but is typically used to adjust the product pH

More about Citric acid

Dehydroacetic acid~0.2–0.4%

Irritant · medium

Irritation risk: Medium

A preservative

More about Dehydroacetic acid

Benzyl alcohol~0.15–0.3%

Irritant · high

Irritation risk: High

A preservative. Can be used to mask unpleasant smell. Can be irritating

More about Benzyl alcohol

Butylene glycol~0.2–0.4%

Formula

Irritation risk: Low

Works for

Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol

Ethylhexylglycerin~0.2–0.35%

Irritant · medium

Irritation risk: Medium

A preservative

More about Ethylhexylglycerin

Phenoxyethanol~0.15–0.25%

Formula

Irritation risk: Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol

Parfum~0.15–0.25%

Irritant · high

Irritation risk: High

An aromatic blend of unspecified and possibly irritating ingredients

More about Parfum

Mica~0.15–0.3%

Formula

Irritation risk: Low

Creates an illusion of smoother and more radiant skin tone. Adds shimmer to the skin by reflecting light

More about Mica

Titanium dioxide~0.1–0.2%

Formula

Irritation risk: Low

Works for

Sun protection

Works as a UV filter when used in high concentrations. It is photostable and is effective mostly against the UVB light, with some protection in the UVA range. In small concentrations, used for its ability to improve the color of cosmetic products. Is usually well tolerated by the skin

More about Titanium dioxide

Ci 77891~0.1–0.15%

Formula

Irritation risk: Low

More about Ci 77891

Ingredient list view

Water, Glycerin, Propanediol, Thermus thermophillus ferment, Panthenol, Marrubium vulgare extract, Niacinamide, Tuber magnatum extract, Adenosine, Hydrolyzed manihot esculenta tuber extract, Acacia senegal gum, Hydrolyzed candida saitoana extract, Decarboxy carnosine hcl, Sodium hyaluronate, Lactobacillus/soybean ferment extract, Viscum album leaf extract, Undaria pinnatifida extract, Superoxide dismutase, Imperata cylindrica root extract, Saccharide isomerate, Mimosa tenuiflora bark extract, Crocus sativus flower extract, Centella asiatica leaf extract, Faex, Yeast, Unknown, Citrus aurantium dulcis fruit extract, Palmitoyl tripeptide-8, Citrus aurantium bergamia fruit extract, Copper gluconate, Citrus nobilis fruit extract, Magnesium aspartate, Ginkgo biloba leaf extract, Zinc gluconate, Oryza sativa extract, Spirulina platensis powder, Panax ginseng root extract, Sphingolipids, Vaccinium myrtillus fruit extract, Serine, Triticum vulgare germ extract, Phospholipids, Citrus grandis fruit extract, Carbomer, Dextran, Potassium sorbate, Sodium citrate, Sodium benzoate, Sodium hydroxide, Benzoic acid, Sorbic acid, Citric acid, Dehydroacetic acid, Benzyl alcohol, Butylene glycol, Ethylhexylglycerin, Phenoxyethanol, Parfum, Mica, Titanium dioxide, Ci 77891

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
	SepaiRestart Recovery SerumYOUR PRODUCT	BIODANCEPore tightening collagen ampoule	FULLightRe:dence Hyaluron Ectoin Serum	SKIN&LABVitamin C Brightening Serum
Match	—	83%	82%	82%
Price	—	$34.32	$12.06	$13.89
Shared key ingredients	—	5 of 21	6 of 21	5 of 21
Key difference	—	Palmitoyl Tripeptide-5	Copper Tripeptide-1	Retinol
Irritancy	High	Low	Medium	Medium
Drying alcohol	—	—	—	—
	View product	Shop	Shop	Shop

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Product summary

"Sepai - Restart Recovery Serum" is effective for: Anti-inflammatory, Evens skin tone, Anti-blemish, Moisturizing and Anti-aging

Ingredient callouts

A good concentration of Niacinamide (1.70% - 2.00%). Niacinamide is a well-studied multi-tasking active. It is stable, and can work well in almost any hydrating formulation. There is solid evidence that Niacinamide can help support skin barrier, regulate oil production and reduce acne and clogged pores. It also helps to fight photodamage and improve the skin tone, reducing pigmentation marks.
Peptides (palmitoyl tripeptide-8 0.25% - 0.50%). Peptides are a very big group of ingredients. They all consist of a different combination of aminoacids. Our skin produces Peptides naturally. Some of them work as natural antibiotics, promote wound-healing and production of collagen. The scientists are still studying how effective the topical application of Peptides is, but it is very likely that theynare helpful. Peptides might be able to support skin barrier restoration and even have an anti-aging benefit. At the very least, they certainly help attract water to the skin and support the hydration in this way.
Adenosine 1.10% - 1.40%. It is a compound that in involved in many biological processes inside the skin cells. According one high-quality clinical trial, topical Adenosine in low concentrations can somewhat help improve "deep wrinkles" - the wrinkles that appear with age in places where our faces are most dynamic (for example, on the forehead or in the corners of the eyes).
Panthenol (pro-vitamin B5) at about 2.40% - 3.00% concentration. In this concentration, Panthenol works effectively to improve the skin barrier and reduce inflammation.
Humectants (dextran 0.30% - 0.50%, thermus thermophillus ferment 3.10% - 3.80%, sodium hyaluronate 0.45% - 0.70%, saccharide isomerate 0.30% - 0.55%, panthenol 2.40% - 3.00%, glycerin 4.40% - 5.40%, faex 0.25% - 0.50% and imperata cylindrica root extract 0.30% - 0.60%). These ingredients help attract water to the upper layer of the skin and improve the skin hydration.

Price

The product retails for 204.30$ in the United States, for 259.00CA$ in Canada and for 148.00£ in the United Kingdom.

For a detailed price comparison: click here.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 41 studies and safety reviews.

1
Glycerol and the skin: holistic approach to its origin and functionsncbi.nlm.nih.gov
2
Skin moisturizing effects of panthenol-based formulationspdfs.semanticscholar.org
3
Safety Assessment of Panthenol, Pantothenic Acid, and Derivatives as Used in Cosmeticscir-safety.org
4
Niacinamide - mechanisms of action and its topical use in dermatologyncbi.nlm.nih.gov
5
Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology, 3(2), 88–93. doi:10.1111/j.1473-2130.2004.00115.x ncbi.nlm.nih.gov
6
Evaluation of anti-wrinkle efficacy of adenosine-containing products using the FOITS techniquencbi.nlm.nih.gov
7
Dynamic monitoring of glutathione redox status in UV-B irradiated reconstituted epidermis: effect of antioxidant activity on skin homeostasissciencedirect.com
8
Hyaluronic acid: A key molecule in skin agingncbi.nlm.nih.gov
9
Hyaluronan (Hyaluronic Acid): a natural moisturizer for skin careresearchgate.net
10
Triterpenes from natural sources for parenteral and topical applicationthieme-connect.com
11
A novel efficient and safe treatment for atopic dermatitis: Topical superoxide dismutase (SOD).alliedacademies.org
12
Novel topical agent containing superoxide dismutase 100 000 IU and 4% of plant extracts as a mono-therapy for atopic dermatitispubmed.ncbi.nlm.nih.gov
13
Copper/Zinc Superoxide Dismutase in Human Skin: Current Knowledgefrontiersin.org
14
Photoprotective Effect of Topically Applied Superoxide Dismutase on Sunburn Reaction in Comparison with Sunscreenonlinelibrary.wiley.com
15
The role of superoxide dismutase (SOD) in skin disorderslink.springer.com
16
Topical formulations with superoxide dismutase: Influence of formulation composition on physical stability and enzymatic activityresearchgate.net
17
Skin protective effects of RM191A, a novel superoxide dismutase mimeticbiorxiv.org
18
Allergic contact dermatitis from grassespubmed.ncbi.nlm.nih.gov
19
Centella asiatica in Dermatology: An Overviewonlinelibrary.wiley.com
20
Contact dermatitis due to Madecassolonlinelibrary.wiley.com
21
Safety Assessment of Citrus Fruit-Derived Ingredients as Used in Cosmeticscir-safety.org
22
Photosensitivity in children: An approach to diagnosis and managementijdvl.com
23
Applications of hydroxy acids: classification, mechanisms, and photoactivityncbi.nlm.nih.gov
24
Magnesium ions inhibit the antigen-presenting function of human epidermal Langerhans cells in vivo and in vitro. Involvement of ATPase, HLA-DR, B7 molecules, and cytokinesncbi.nlm.nih.gov
25
Safety Assessment of Ginkgo biloba-Derived Ingredients as Used in Cosmeticscir-safety.org
26
Cosmeceutical Critique: Ginkgo Bilobamdedge.com
27
Zinc salts in dermatologyncbi.nlm.nih.gov
28
An overview of zinc and its importance in dermatology-Part II: The association of zinc with some dermatologic disordersoatext.com
29
Zinc, copper and manganese enhanced keratinocyte migration through a functional modulation of keratinocyte integrinsncbi.nlm.nih.gov
30
Evaluation of the effects of topical zinc gluconate in wound healingncbi.nlm.nih.gov
31
A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimenncbi.nlm.nih.gov
32
Antioxidant and Anti-Inflammatory Properties of Anthocyanins Extracted from Oryza sativa L. in Primary Dermal Fibroblastshindawi.com
33
Rice antioxidants: phenolic acids, flavonoids, anthocyanins, proanthocyanidins, tocopherols, tocotrienols, c-oryzanol, and phytic acidonlinelibrary.wiley.com
34
Ginseng in Dermatology: A Reviewncbi.nlm.nih.gov
35
Antiaging effects of the mixture of Panax ginseng and Crataegus pinnatifida in human dermal fibroblasts and healthy human skinncbi.nlm.nih.gov
36
The role of epidermal sphingolipids in dermatologic diseasesncbi.nlm.nih.gov
37
Lonicera caerulea and Vaccinium myrtillus fruit polyphenols protect HaCaT keratinocytes against UVB-induced phototoxic stress and DNA damagesciencedirect.com
38
Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition.ncbi.nlm.nih.gov
39
Topical palmitoyl pentapeptide provides improvement in photoaged human facial skinonlinelibrary.wiley.com
40
Wheat in skin caremdedge.com
41
4 Final Report on the Safety Assessment of Sodium Dehydroacetate and Dehydroacetic Acidjournals.sagepub.com

SepaiRestart Recovery Serum

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As an Amazon Associate, WIMJ earns from qualifying purchases.