Works for:
based on ingredients and %- Anti-aging
- Moisturizing
- Anti-oxidation
Can it cause trouble?
- Irritation risk: high
- Comedogenic risk ingredients: 2
Key actives
Product Summary
Judging from the ingredient list, "Sepai - Global+ Recovery Moisturiser" works well for improving skin hydration The formulation is based on a combination of good humectants and emollients. Both are needed to increase the skin hydration level. Humectants in this product (panthenol, dextran, faex, glycerin and imperata cylindrica root extract) help to increase the water content in the upper layer of the skin. (These ingredients do so by "capturing" water molecules from the outside air or from within the deeper layers of the skin). Emollients in this formulation (sesamum indicum seed oil, sphingolipids and caprylic/capric triglyceride) help to reduce the moisture loss from the skin. They also soften the skin surface and relieve the feeling of dryness and tightness.
Ingredient callouts
- We like that this moisturizer contains peptides (palmitoyl tripeptide-8 0.40% - 0.60%). There are many different kind of peptides and they are naturally present in our skin. They all are a combination of amino-acids. Some of them work as natural anti-biotics, promote wound-healing and production of collagen. The science is still not settled on how effective peptides in skincare are, but it is very likely that they have a benefit. Peptides might help restore the skin barrier and fight the signs of aging. At the very least, peptides work as humectants: they attract water to the upper layer of the skin and improve its hydration.
- Adenosine 0.45% - 0.65% in this moisturizer adds an anti-aging benefit. Adenosine is a compound that in involved in many biological processes inside the skin cells. According one high-quality clinical trial, topical adenosine in low concentrations can help improve "deep wrinkles" - the wrinkles that appear with age in places where our faces are most dynamic (for example, on the forehead or in the corners of the eyes).
- This formulation also includes panthenol (pro-vitamin B5) at about 0.65% - 0.95% concentration. In this concentration, panthenol works effectively to improve the skin barrier and reduce inflammation.
Irritation risk
This moisturizer contains a bunch of common irritants, including ingredients that do not provide any known benefit for the skin. It might not be the best choice if your skin is sensitive. We assess the overall irritancy of this moisturizer to be high. For a detailed overview of all potential irritants: click here
You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.
Price
The product retails for 230.50$ in the United States, for 292.30CA$ in Canada and from 133.60£ up to 167.00£ in the United Kingdom.
For a detailed price comparison: click here.
Works for
Anti-aging
What does the product description say?
The Sepai Global Recovery Moisturizer is a lightweight, oil-free face cream that targets the five main causes of skin aging to help rewind the aging clock.
Source: Lookfantastic US
This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains adenosine.
These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: centella asiatica leaf extract, palmitoyl tripeptide-8, serine.
Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.
Might help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)
A plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. It can be irritating to sensitive skin. Might be helpful in preventing stretch marks. It could, however, itself be irritating.
An amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles
Might be helpful in neutralising free radicals in skin and have some hydration properties
Might be able to protect the skin from free radicals, but further evidence of effectiveness is needed
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
Typically used to stabilize the product formulations. It is a salt of polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing
Typically used to stabilize the product formulations. It is a salt of a polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing. Due to the zinc content, might help calm down inflammation in skin
Traditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin
Anti-oxidation
This product contains antioxidants (superoxide dismutase) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).
The following ingredients - decarboxy carnosine hcl, ginkgo biloba leaf extract, imperata cylindrica root extract also can have an antioxidant effect, but there is less evidence to confirm their effectiveness in skin.
An antioxidant enzyme that is naturally present in skin. It can help support skin barrier function and reduce inflammation in skin. It is used in topical medications for inflammatory skin conditions including atopic dermatitis (eczema) and psoriasis. There are three types of natural Superoxide Dismutase in human skin. The compound used in topical treatments and cosmetics are mimics of typically one of these natural variants
A plant extract that might help neutralize free radicals and reduce inflammation in skin. It can be irritating
A plat extract that might help neutralize free radicals in skin and attract water to its upper layer
Might be able to protect the skin from free radicals, but further evidence of effectiveness is needed
Might help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)
Might be helpful in neutralising free radicals in skin and have some hydration properties
A seaweed extract that helps attract water to the upper layer of the skin and might have an anti-oxidant effect
A plant extract that might help neutralize free radicals in skin, but research on its efficacy in skin is lacking
A plant extract that has anti-inflammatory and anti-bacterial properties and might help neutralize free radicals in skin, but solid research is lacking
A more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.
Typically used to stabilize the product formulations. It is a salt of polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing
Typically used to stabilize the product formulations. It is a salt of a polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing. Due to the zinc content, might help calm down inflammation in skin
Plant extract that might have moisturizing properties. Avoid if you suffer from wheat or gluten intolerance
A plant extract that might have some anti-inflammatory properties, but solid evidence is lacking. It can be irritating
An emollient that helps soften the upper layer of the skin. Might have some weak anti-oxidant properties
Moisturizing
What does the product description say?
Global+ Recovery Moisturiser
Source: From product name
This product can help improve hydration of the skin with the two types of ingredients.
The first type is called “humectants”:
these ingredients help attract water.
When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from
within deeper layers of the skin. The following ingredients in this product do the job:
dextran, faex.
This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: caprylic/capric triglyceride, sesamum indicum seed oil.
The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: palmitoyl tripeptide-8, panthenol
One of the best moisturizing ingredients. Attracts water into the upper layer of the skin
An antioxidant enzyme that is naturally present in skin. It can help support skin barrier function and reduce inflammation in skin. It is used in topical medications for inflammatory skin conditions including atopic dermatitis (eczema) and psoriasis. There are three types of natural Superoxide Dismutase in human skin. The compound used in topical treatments and cosmetics are mimics of typically one of these natural variants
Might be helpful in neutralising free radicals in skin and have some hydration properties
A seaweed extract that helps attract water to the upper layer of the skin and might have an anti-oxidant effect
A plat extract that might help neutralize free radicals in skin and attract water to its upper layer
Helps attract water to the upper layer of the skin and can help improve skin barrier function
Helps attract water to the upper layer of the skin
An amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles
A good moisturizing plant oil. Due to the high linoleic acid content, it helps soften the upper layer of the skin, reduce water loss and support skin barrier function
Sphingolipids are a group of lipids with a common chemical structure. Some of them are naturally present in skin and can be converted to ceramides
A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin
Helps attract water to the most upper layer of the skin. Derived from sugar
Yeast extract. Helps to attract water to the upper layer of the skin
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
A fermentation product created by bacteria Lactobacillus out of soybean. The fermented product helps to attract water to the upper layer of the skin and has anti-bacterial properties. It might be helpful in calming down inflammation and could be helpful in evening out skin tone, but studies are lacking
Emollients that are naturaly present in skin. In addition, they help water and oil mix together in the product
Might help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)
Might be helpful in restoring skin barrier function and calm down inflammation in skin
Used to stabilize the product formulations and works as an emollient
Helps attract water to the upper layer of the skin and helps to improve appearance of the product
Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin
Typically used to stabilize the product formulations. It is a salt of a polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing. Due to the zinc content, might help calm down inflammation in skin
An emollient that helps soften the upper layer of the skin. Might have some weak anti-oxidant properties
Typically used to stabilize the product formulations. It is a salt of polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
Plant extract that might have moisturizing properties. Avoid if you suffer from wheat or gluten intolerance
Traditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin
How honest is this product?
| Promise | Can it deliver? |
|---|---|
| Anti-aging | |
| Moisturizing |
Total Promises Fulfilled score: 100/100.
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Potential irritants
Comedogenic ingredients
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|---|---|---|---|
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Key Actives
Potential irritants
Comedogenic ingredients
All ingredients
Ingredient list view
Water, Caprylic/capric triglyceride, Glycerin, Glyceryl stearate se, Propanediol, Thermus thermophillus ferment, Aloe barbadensis leaf juice, Sesamum indicum seed oil, Rosa moschata oil, Argania spinosa kernel oil, Panthenol, Potassium cetyl phosphate, Adenosine, Palmitoyl tripeptide-8, Niacinamide, Tuber magnatum extract, Sodium hyaluronate, Hydrolyzed manihot esculenta tuber extract, Hydrolyzed elastin, Marrubium vulgare extract, Decarboxy carnosine hcl, Lactobacillus/soybean ferment extract, Saccharide isomerate, Crocus sativus flower extract, Panax ginseng root extract, Citrus aurantium bergamia fruit extract, Ginkgo biloba leaf extract, Undaria pinnatifida extract, Imperata cylindrica root extract, Sphingolipids, Citrus nobilis fruit extract, Phospholipids, Vaccinium myrtillus fruit extract, Superoxide dismutase, Viscum album leaf extract, Magnesium aspartate, Centella asiatica leaf extract, Copper gluconate, Citrus grandis fruit extract, Zinc gluconate, Hydrolyzed candida saitoana extract, Faex, Yeast, Unknown, Acacia senegal gum, Serine, Triticum vulgare germ extract, Citrus aurantium dulcis fruit extract, Xanthan gum, Dextran, Tocopheryl acetate, Calcium gluconate, Potassium sorbate, Sodium hydroxide, Sodium benzoate, Sodium citrate, Dehydroacetic acid, Benzoic acid, Sorbic acid, Citric acid, Benzyl alcohol, Butylene glycol, Ethylhexylglycerin, Phenoxyethanol, Parfum, Mica, Titanium dioxide, Ci 77891
- Glycerol and the skin: holistic approach to its origin and functions
- Protein and oil composition of sesame seeds (Sesamum indicum, L.) grown in the Gizan area of Saudi Arabia
- Triglyceride composition of Sesamum indicum seed oil
- Seed oil content and fatty acid composition in East African sesame (Sesamum indicum L.) accessions evaluated over 3 years
- Natural vegetable fats in the prevention of irritant contact dermatitis
- Skin moisturizing effects of panthenol-based formulations
- Safety Assessment of Panthenol, Pantothenic Acid, and Derivatives as Used in Cosmetics
- Evaluation of anti-wrinkle efficacy of adenosine-containing products using the FOITS technique
- Niacinamide - mechanisms of action and its topical use in dermatology
- Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology, 3(2), 88–93. doi:10.1111/j.1473-2130.2004.00115.x
- Hyaluronic acid: A key molecule in skin aging
- Hyaluronan (Hyaluronic Acid): a natural moisturizer for skin care
- Dynamic monitoring of glutathione redox status in UV-B irradiated reconstituted epidermis: effect of antioxidant activity on skin homeostasis
- Ginseng in Dermatology: A Review
- Antiaging effects of the mixture of Panax ginseng and Crataegus pinnatifida in human dermal fibroblasts and healthy human skin
- Safety Assessment of Ginkgo biloba-Derived Ingredients as Used in Cosmetics
- Cosmeceutical Critique: Ginkgo Biloba
- Allergic contact dermatitis from grasses
- The role of epidermal sphingolipids in dermatologic diseases
- Lonicera caerulea and Vaccinium myrtillus fruit polyphenols protect HaCaT keratinocytes against UVB-induced phototoxic stress and DNA damage
- Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition.
- A novel efficient and safe treatment for atopic dermatitis: Topical superoxide dismutase (SOD).
- Novel topical agent containing superoxide dismutase 100 000 IU and 4% of plant extracts as a mono-therapy for atopic dermatitis
- Copper/Zinc Superoxide Dismutase in Human Skin: Current Knowledge
- Photoprotective Effect of Topically Applied Superoxide Dismutase on Sunburn Reaction in Comparison with Sunscreen
- The role of superoxide dismutase (SOD) in skin disorders
- Topical formulations with superoxide dismutase: Influence of formulation composition on physical stability and enzymatic activity
- Skin protective effects of RM191A, a novel superoxide dismutase mimetic
- Triterpenes from natural sources for parenteral and topical application
- Magnesium ions inhibit the antigen-presenting function of human epidermal Langerhans cells in vivo and in vitro. Involvement of ATPase, HLA-DR, B7 molecules, and cytokines
- Centella asiatica in Dermatology: An Overview
- Contact dermatitis due to Madecassol
- Applications of hydroxy acids: classification, mechanisms, and photoactivity
- Zinc salts in dermatology
- An overview of zinc and its importance in dermatology-Part II: The association of zinc with some dermatologic disorders
- Zinc, copper and manganese enhanced keratinocyte migration through a functional modulation of keratinocyte integrins
- Evaluation of the effects of topical zinc gluconate in wound healing
- A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimen
- Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin
- Wheat in skin care
- Safety Assessment of Citrus Fruit-Derived Ingredients as Used in Cosmetics
- Photosensitivity in children: An approach to diagnosis and management
- 4 Final Report on the Safety Assessment of Sodium Dehydroacetate and Dehydroacetic Acid