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Replenix Vitamin C Pro Collagen Serum
Replenix

Replenix Vitamin C Pro Collagen Serum

Efficacy100/100IrritancyMedium
See all ingredients

Works for

Anti-aging
Tetrahexyldecyl ascorbate, Ascorbyl glucoside + 5 more
Works well
What the product description says
“Visibly reduces fine lines and wrinkles”
Source: Dermstore

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains tetrahexyldecyl ascorbate.

These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: ascorbyl glucoside, retinyl palmitate.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

Tetrahexyldecyl ascorbateKey activeEffect: HighBeing a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.~8.2–12.4%
Ascorbyl glucosideKey activeEffect: MediumA vitamin C derivative that is more stable but less potent than pure form of vitamin C. Has a potential to boost collagen production, nutralise free radicals and reduce hyperpigmentation, but the required concentration is likely to be much higher than for the pure form of vitamin C, limiting the ingredient's effectiveness in products~3.4–5%
Retinyl palmitateKey activeEffect: MediumThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect~0.15–0.65%
Phyllanthus emblica fruit extractEffect: LowA plant extract that might be helpful in neutralizing free radicals and have a skin lightening effect if used in high enough concentrations~1.7–2.5%
UbiquinoneEffect: LowCoenzyme Q10. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergen~0.05–0.25%
Ascorbyl palmitateEffect: Low, below effective doseBeing a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.~0.9–1.4%
Ascorbic acidUnder-dosedThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging~2.6–3.9%
Evens skin tone
Tetrahexyldecyl ascorbate, Ascorbyl glucoside + 4 more
Works well
What the product description says
“This highly stabilized vitamin C serum is formulated with an advanced, proprietary time-released delivery system to lessen the appearance of fine lines, wrinkles, discoloration and age spots.”
Source: Dermstore

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: alpha-arbutin, tetrahexyldecyl ascorbate

The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually can help even out the skin tone: ascorbyl glucoside, phyllanthus emblica fruit extract, retinyl palmitate.

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

Tetrahexyldecyl ascorbateKey activeEffect: HighBeing a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.~8.2–12.4%
Ascorbyl glucosideKey activeEffect: MediumA vitamin C derivative that is more stable but less potent than pure form of vitamin C. Has a potential to boost collagen production, nutralise free radicals and reduce hyperpigmentation, but the required concentration is likely to be much higher than for the pure form of vitamin C, limiting the ingredient's effectiveness in products~3.4–5%
Alpha-arbutinKey activeEffect: HighMight help reduce hyperpigmentation when used regularly over a long period of time. Is more effective than beta-arbutin~2.1–3.2%
Retinyl palmitateKey activeEffect: MediumThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect~0.15–0.65%
Phyllanthus emblica fruit extractEffect: LowA plant extract that might be helpful in neutralizing free radicals and have a skin lightening effect if used in high enough concentrations~1.7–2.5%
Ascorbic acidUnder-dosedThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging~2.6–3.9%
Anti-oxidation
Side benefit · Tetrahexyldecyl ascorbate, Ascorbyl glucoside + 6 more
Works well

This product contains antioxidants (superoxide dismutase, tetrahexyldecyl ascorbate, ubiquinone) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

The following ingredients - ascorbyl glucoside, phyllanthus emblica fruit extract also can have an antioxidant effect, but there is less evidence to confirm their effectiveness in skin.

Tetrahexyldecyl ascorbateKey activeEffect: HighBeing a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.~8.2–12.4%
Ascorbyl glucosideKey activeEffect: MediumA vitamin C derivative that is more stable but less potent than pure form of vitamin C. Has a potential to boost collagen production, nutralise free radicals and reduce hyperpigmentation, but the required concentration is likely to be much higher than for the pure form of vitamin C, limiting the ingredient's effectiveness in products~3.4–5%
Phyllanthus emblica fruit extractKey activeEffect: MediumA plant extract that might be helpful in neutralizing free radicals and have a skin lightening effect if used in high enough concentrations~1.7–2.5%
Superoxide dismutaseKey activeEffect: HighAn antioxidant enzyme that is naturally present in skin. It can help support skin barrier function and reduce inflammation in skin. It is used in topical medications for inflammatory skin conditions including atopic dermatitis (eczema) and psoriasis. There are three types of natural Superoxide Dismutase in human skin. The compound used in topical treatments and cosmetics are mimics of typically one of these natural variants~0.1–0.3%
UbiquinoneKey activeEffect: HighCoenzyme Q10. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergen~0.05–0.25%
Ascorbyl palmitateEffect: Low, below effective doseBeing a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.~0.9–1.4%
Tocopheryl acetateEffect: Low, below effective doseA more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.~0.35–0.8%
Ascorbic acidUnder-dosedThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging~2.6–3.9%

Can it cause trouble?

Irritancy
2 strong irritants: Ascorbic acid/orange/citrus limon/citrus aurantifolia polypeptides, Retinyl palmitate
Medium risk
We flagged 9 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Ascorbic acidThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of agingHigh~2.6–3.9%est.
Ascorbic acid/orange/citrus limon/citrus aurantifolia polypeptides—High~1.5–2.2%est.
Retinyl palmitateThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effectHigh~0.15–0.65%est.
Tetrahexyldecyl ascorbateBeing a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.Medium~8.2–12.4%est.
Ascorbyl glucosideA vitamin C derivative that is more stable but less potent than pure form of vitamin C. Has a potential to boost collagen production, nutralise free radicals and reduce hyperpigmentation, but the required concentration is likely to be much higher than for the pure form of vitamin C, limiting the ingredient's effectiveness in productsMedium~3.4–5%est.
Alpha-arbutinMight help reduce hyperpigmentation when used regularly over a long period of time. Is more effective than beta-arbutinMedium~2.1–3.2%est.
Phyllanthus emblica fruit extractA plant extract that might be helpful in neutralizing free radicals and have a skin lightening effect if used in high enough concentrationsMedium~1.7–2.5%est.
Ascorbyl palmitateBeing a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.Medium~0.9–1.4%est.
Tocopheryl acetateA more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.Medium~0.35–0.8%est.
Comedogenic
Clean of flagged comedogenic ingredients
None flagged
Alternatives
Cheaper, or higher on efficacy
All Day Vitamin Pure C 5.5 Glow Serum
JUMISO All Day Vitamin Pure C 5.5 Glow Serum
Cheaper78% match
$6.84
Vitamin C Plus E Complex
SkinMedica Vitamin C Plus E Complex
Cheaper78% match
$102.55
View all alternatives

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Ingredients

Filter by role to see what each ingredient is doing.

Methyl trimethicone~23–35%
Formula
Irritation risk
Low

A type of silicone that helps create a silky product finish and dissolve other ingredients

More about Methyl trimethicone
Tetrahexyldecyl ascorbate~8.2–12.4%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Evens skin toneAnti-agingAnti-oxidation

Being a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.

More about Tetrahexyldecyl ascorbate
Cyclopentasiloxane~5.3–8%
Formula
Irritation risk
Low
Works for
MattifyingMoisturizing

A silicone that helps improve the product texture and spreadability. Can absorb oil creating a short-term mattifying effect on the skin

More about Cyclopentasiloxane
Trimethylsiloxysilicate~4.4–6.5%
Formula
Irritation risk
Low

A type of silicone that helps create a nice product consistency and support the delivery of other ingredients

More about Trimethylsiloxysilicate
Ascorbyl glucoside~3.4–5%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Anti-oxidationAnti-agingEvens skin tone

A vitamin C derivative that is more stable but less potent than pure form of vitamin C. Has a potential to boost collagen production, nutralise free radicals and reduce hyperpigmentation, but the required concentration is likely to be much higher than for the pure form of vitamin C, limiting the ingredient's effectiveness in products

More about Ascorbyl glucoside
Ascorbic acid~2.6–3.9%
Under-dosedIrritant · high
Irritation risk
High
Works for
Anti-oxidationEvens skin toneAnti-aging

The most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging

More about Ascorbic acid
Alpha-arbutin~2.1–3.2%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Evens skin tone

Might help reduce hyperpigmentation when used regularly over a long period of time. Is more effective than beta-arbutin

More about Alpha-arbutin
Phyllanthus emblica fruit extract~1.7–2.5%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Anti-oxidationEvens skin toneAnti-aging

A plant extract that might be helpful in neutralizing free radicals and have a skin lightening effect if used in high enough concentrations

More about Phyllanthus emblica fruit extract
Ascorbic acid/orange/citrus limon/citrus aurantifolia polypeptides~1.5–2.2%
Irritant · high
Irritation risk
High
More about Ascorbic acid/orange/citrus limon/citrus aurantifolia polypeptides
Arctostaphylos uva ursi leaf extract~1.2–1.8%
Formula
Irritation risk
Low
More about Arctostaphylos uva ursi leaf extract
Ascorbyl palmitate~0.9–1.4%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidationAnti-aging

Being a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.

More about Ascorbyl palmitate
Water~0.6–1.35%
Formula
Irritation risk
Low

Plain old water

More about Water
Orange terpenes
Not recognized
Phospholipids~0.45–1%
Formula
Irritation risk
Low
Works for
Moisturizing

Emollients that are naturaly present in skin. In addition, they help water and oil mix together in the product

More about Phospholipids
Tocopheryl acetate~0.35–0.8%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidation

A more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.

More about Tocopheryl acetate
Retinyl palmitate~0.15–0.65%
Key activeIrritant · high
Irritation risk
High
Works for
Anti-agingEvens skin toneAnti-blemishExfoliation

Three steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect

More about Retinyl palmitate
Superoxide dismutase~0.1–0.3%
Key active
Irritation risk
Low
Works for
Anti-inflammatoryMoisturizingAnti-oxidation

An antioxidant enzyme that is naturally present in skin. It can help support skin barrier function and reduce inflammation in skin. It is used in topical medications for inflammatory skin conditions including atopic dermatitis (eczema) and psoriasis. There are three types of natural Superoxide Dismutase in human skin. The compound used in topical treatments and cosmetics are mimics of typically one of these natural variants

More about Superoxide dismutase
Ubiquinone~0.05–0.25%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-oxidationAnti-aging

Coenzyme Q10. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergen

More about Ubiquinone
Phenoxyethanol~0.05–0.25%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Ingredient list view

Methyl trimethicone, Tetrahexyldecyl ascorbate, Cyclopentasiloxane, Trimethylsiloxysilicate, Ascorbyl glucoside, Ascorbic acid, Alpha-arbutin, Phyllanthus emblica fruit extract, Ascorbic acid/orange/citrus limon/citrus aurantifolia polypeptides, Arctostaphylos uva ursi leaf extract, Ascorbyl palmitate, Water, Unknown, Phospholipids, Tocopheryl acetate, Retinyl palmitate, Superoxide dismutase, Ubiquinone, Phenoxyethanol

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Amazon USPrice as of 11/7 09:21 GMT
$128.00
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Dermstore1 fl. oz
$128.00
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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
ReplenixVitamin C Pro Collagen SerumYOUR PRODUCTJUMISOAll Day Vitamin Pure C 5.5 Glow SerumSkinMedicaVitamin C Plus E ComplexGlow Jar8% AM Vitamin C Serum
Match—78%78%75%
Price$128.00$6.84−$121.16$102.55−$25.45$42.34−$85.66
Shared key ingredients—3 of 93 of 92 of 9
Key difference—Ferulic AcidBisabololSalicylic Acid
Irritancy Medium Low Low Low
Drying alcohol————
View product Shop Shop Shop
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Product summary

"Replenix - Vitamin C Pro Collagen Serum" is effective for: Anti-aging and Evens skin tone

Ingredient callouts

  • This product also contains Vitamin C (Ascorbic Acid). It can be an effective active for anti-aging and evening out the skin tone, but in this product it is used for stabilizing other ingredients in the formulation. In this concentration (2.60% - 3.90%) it cannot have a noticeable benefit for the skin.
  • This product includes a form of Retinoids (vitamin A) - retinyl palmitate 0.15% - 0.60%, but this type of vitamin A is not very effective. It could in theory help with fine lines and wrinkles, but the effect is most likely minimal.

Price

The product retails for 125.00$ in the United States and for 114.30CA$ in Canada.

For a detailed price comparison: click here.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 14 studies and safety reviews.

  1. 1
    Double-blind, half-face study comparing topical vitamin C and vehicle for rejuvenation of photodamagencbi.nlm.nih.gov
  2. 2
    Application of tetra-isopalmitoyl ascorbic acid in cosmetic formulations: Stability studies and in vivo efficacysciencedirect.com
  3. 3
    The Roles of Vitamin C in Skin Healthncbi.nlm.nih.gov
  4. 4
    Stability, transdermal penetration, and cutaneous effects of ascorbic acid and its derivativesncbi.nlm.nih.gov
  5. 5
    Emblicamdedge.com
  6. 6
    Amla (Emblica officinalis Gaertn.) extract promotes procollagen production and inhibits matrix metalloproteinase-1 in human skin fibroblastsncbi.nlm.nih.gov
Replenix Vitamin C Pro Collagen Serum
ReplenixVitamin C Pro Collagen Serum
Buy at Dermstore$128.00$128.00as of 11/7 09:21 GMT

Affiliate links · As an Amazon Associate, WIMJ earns from qualifying purchases.

Buy at Dermstore$128.00$128.00as of 11/7 09:21 GMT

As an Amazon Associate, WIMJ earns from qualifying purchases.