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PharmaClinix Anti Agex Serum
PharmaClinix

PharmaClinix Anti Agex Serum

Efficacy100/100IrritancyMedium
See all ingredients

Works for

Exfoliation
Salicylic acid
Works well
What the product description says
“Polypeptides work to precisely target wrinkles, filling them in from the inside, while Retinaldehyde and Salicylic Acid exfoliate and renew epidermal cells, for smoother, plumper skin.”
Source: Face the future

This product can help exfoliate the skin. In other words, it helps break down the bonds between dead cells on the surface of the skin and speed up the skin turnover. Skin often appears softer and brighter after exfoliation, but overdoing it can result in disrupted skin barrier. The following ingredient is doing the exfoliating job in this product: salicylic acid.

Salicylic acidKey activeEffect: HighUsed for skin exfoliation. It has an anti-inflammatory and anti-bacterial effect, helps to unclog pores, prevent blemishes and speed up healing of the existing ones. Sometimes referred to as a BHA (beta-hydroxy acid)~1.1–1.7%
Anti-aging
Retinal, Ascorbic acid + 7 more
Works well
What the product description says
“Polypeptides work to precisely target wrinkles, filling them in from the inside, while Retinaldehyde and Salicylic Acid exfoliate and renew epidermal cells, for smoother, plumper skin.”
Source: Face the future

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains ascorbic acid, retinal, niacinamide.

These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: ascorbyl tetraisopalmitate, ferulic acid, palmitoyl tripeptide-38.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

RetinalHeroEffect: HighOne step removed from the biologically active in skin form of vitamin A. Once converted to the retinoic acid in the skin, retinal is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. Concentrations of 0.05% and 0.1% are shown to be effective. It can, however, be irritating~3.9–5.8%
Ascorbic acidHeroEffect: HighThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging~0.3–0.75%
Ascorbyl tetraisopalmitateKey activeEffect: MediumA vitamin C derivative. Studies show that is might be effective in reducing hyperpigmentation, but there are no studies confirming that it is effectively converted into the bioavailable form of Vitamin C in skin. It is not clear how this derivative compares in effectiveness to the topical application of bioavailable form of vitamin C (L-ascorbic acid)~7.7–11.5%
NiacinamideKey activeEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~2.7–4%
Palmitoyl tripeptide-38Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~1.4–2.1%
Ferulic acidKey activeEffect: MediumA potent anti-oxidant that has been shown to be effective in neutralizing free radicals in skin. There seem to have a synergetic effect of ferulic acid, vitamin E and C, meaning that when the ingredients are used together, they enhance each other's ability protect the skin against free radicals. Ferulic acid also helps to stabilize other ingredients - including vitamins C and E. It can help to even out the skin tone. Ferulic acid is approved for use as a sunscreen ingredient in Japan in concentrations up to 10%~0.55–1.35%
Hyaluronic acidEffect: LowOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin. Naturally present in skin. Typically has large molecule size unless advertised otherwise on the product label. Helps support skin's barrier function and may help to reduce inflammation~4.7–7.1%
TocopherolEffect: LowPure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~1–1.6%
Camellia sinensis leaf extractEffect: LowCan contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation~0.45–1.1%
Moisturizing
Niacinamide, Palmitoyl tripeptide-38 + 5 more
Works well
What the product description says
“Hyaluronic Acid combats dehydration, providing deep and intense hydration for dull, dry skin.”
Source: Face the future

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: hyaluronic acid.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: helianthus annuus seed oil, ascorbyl tetraisopalmitate.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: niacinamide, palmitoyl tripeptide-38

NiacinamideHeroEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~2.7–4%
Palmitoyl tripeptide-38HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~1.4–2.1%
Hyaluronic acidKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin. Naturally present in skin. Typically has large molecule size unless advertised otherwise on the product label. Helps support skin's barrier function and may help to reduce inflammation~4.7–7.1%
Helianthus annuus seed oilKey active· Emollient, OcclusiveEffect: HighA great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function~0.35–0.85%
Ascorbyl tetraisopalmitate· EmollientEffect: LowA vitamin C derivative. Studies show that is might be effective in reducing hyperpigmentation, but there are no studies confirming that it is effectively converted into the bioavailable form of Vitamin C in skin. It is not clear how this derivative compares in effectiveness to the topical application of bioavailable form of vitamin C (L-ascorbic acid)~7.7–11.5%
TocopherolEffect: LowPure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~1–1.6%
Camellia sinensis leaf extractEffect: LowCan contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation~0.45–1.1%
Evens skin tone
Retinal, Ascorbic acid + 5 more
Works well
What the product description says
“Dark spots are lightened with a blend of ingredients that work to inhibit melanin synthesis.”
Source: Face the future

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: ascorbic acid, retinal.

In addition, this product contains niacinamide, salicylic acid. This ingredient (ingredients) might help reduce hyperpigmentation, but the effect, if any, is likely to be small.

The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually can help even out the skin tone: ascorbyl tetraisopalmitate, ferulic acid.

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

RetinalHeroEffect: HighOne step removed from the biologically active in skin form of vitamin A. Once converted to the retinoic acid in the skin, retinal is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. Concentrations of 0.05% and 0.1% are shown to be effective. It can, however, be irritating~3.9–5.8%
Ascorbic acidHeroEffect: HighThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging~0.3–0.75%
Ascorbyl tetraisopalmitateKey activeEffect: MediumA vitamin C derivative. Studies show that is might be effective in reducing hyperpigmentation, but there are no studies confirming that it is effectively converted into the bioavailable form of Vitamin C in skin. It is not clear how this derivative compares in effectiveness to the topical application of bioavailable form of vitamin C (L-ascorbic acid)~7.7–11.5%
NiacinamideKey activeEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~2.7–4%
Ferulic acidKey activeEffect: MediumA potent anti-oxidant that has been shown to be effective in neutralizing free radicals in skin. There seem to have a synergetic effect of ferulic acid, vitamin E and C, meaning that when the ingredients are used together, they enhance each other's ability protect the skin against free radicals. Ferulic acid also helps to stabilize other ingredients - including vitamins C and E. It can help to even out the skin tone. Ferulic acid is approved for use as a sunscreen ingredient in Japan in concentrations up to 10%~0.55–1.35%
Salicylic acidEffect: LowUsed for skin exfoliation. It has an anti-inflammatory and anti-bacterial effect, helps to unclog pores, prevent blemishes and speed up healing of the existing ones. Sometimes referred to as a BHA (beta-hydroxy acid)~1.1–1.7%
Camellia sinensis leaf extractEffect: LowCan contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation~0.45–1.1%
Anti-oxidation
Side benefit · Ascorbic acid, Ascorbyl tetraisopalmitate + 3 more
Works well

This product contains antioxidants (ascorbic acid, ascorbyl tetraisopalmitate, ferulic acid, tocopherol) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

The following ingredients - camellia sinensis leaf extract also can have an antioxidant effect, but there is less evidence to confirm their effectiveness in skin.

Ascorbic acidHeroEffect: HighThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging~0.3–0.75%
Ascorbyl tetraisopalmitateKey activeEffect: HighA vitamin C derivative. Studies show that is might be effective in reducing hyperpigmentation, but there are no studies confirming that it is effectively converted into the bioavailable form of Vitamin C in skin. It is not clear how this derivative compares in effectiveness to the topical application of bioavailable form of vitamin C (L-ascorbic acid)~7.7–11.5%
TocopherolKey activeEffect: HighPure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~1–1.6%
Ferulic acidKey activeEffect: HighA potent anti-oxidant that has been shown to be effective in neutralizing free radicals in skin. There seem to have a synergetic effect of ferulic acid, vitamin E and C, meaning that when the ingredients are used together, they enhance each other's ability protect the skin against free radicals. Ferulic acid also helps to stabilize other ingredients - including vitamins C and E. It can help to even out the skin tone. Ferulic acid is approved for use as a sunscreen ingredient in Japan in concentrations up to 10%~0.55–1.35%
Camellia sinensis leaf extractKey activeEffect: MediumCan contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation~0.45–1.1%
Anti-blemish
Side benefit · Retinal, Niacinamide + 2 more
Works well

This product can help reduce breakouts and clogged pores because it contains the following ingredient: niacinamide, retinal, salicylic acid. These ingredients is used for treating acne and can have a noticeable effect.

RetinalHeroEffect: HighOne step removed from the biologically active in skin form of vitamin A. Once converted to the retinoic acid in the skin, retinal is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. Concentrations of 0.05% and 0.1% are shown to be effective. It can, however, be irritating~3.9–5.8%
NiacinamideHeroEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~2.7–4%
Salicylic acidHeroEffect: HighUsed for skin exfoliation. It has an anti-inflammatory and anti-bacterial effect, helps to unclog pores, prevent blemishes and speed up healing of the existing ones. Sometimes referred to as a BHA (beta-hydroxy acid)~1.1–1.7%
Camellia sinensis leaf extractEffect: LowCan contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation~0.45–1.1%

Can it cause trouble?

Irritancy
2 strong irritants: Ascorbic acid, Retinal
Medium risk
We flagged 5 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Ascorbic acidThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of agingHigh~23–34%est.
RetinalOne step removed from the biologically active in skin form of vitamin A. Once converted to the retinoic acid in the skin, retinal is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. Concentrations of 0.05% and 0.1% are shown to be effective. It can, however, be irritatingHigh~3.9–5.8%est.
Salicylic acidUsed for skin exfoliation. It has an anti-inflammatory and anti-bacterial effect, helps to unclog pores, prevent blemishes and speed up healing of the existing ones. Sometimes referred to as a BHA (beta-hydroxy acid)High~1.1–1.7%est.
Ascorbyl tetraisopalmitateA vitamin C derivative. Studies show that is might be effective in reducing hyperpigmentation, but there are no studies confirming that it is effectively converted into the bioavailable form of Vitamin C in skin. It is not clear how this derivative compares in effectiveness to the topical application of bioavailable form of vitamin C (L-ascorbic acid)Medium~7.7–11.5%est.
Citric acidCan work as an exfoliant but is typically used to adjust the product pHMedium~0.1–0.4%est.
Comedogenic
Clean of flagged comedogenic ingredients
None flagged
Alternatives
The closest match we found
Pigmentation Buster Serum: Vitamin C, Alpha Arbutin & Ferulic Acid
Standard Beauty Pigmentation Buster Serum: Vitamin C, Alpha Arbutin & Ferulic Acid
Closest match62% match
View all alternatives

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Ingredients

Filter by role to see what each ingredient is doing.

Ascorbic acid~23–34%
Hero · Anti-aging, Anti-oxidation, Evens skin toneIrritant · high
Irritation risk
High
Works for
Anti-oxidationAnti-agingEvens skin tone

The most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging

More about Ascorbic acid
Ascorbyl tetraisopalmitate~7.7–11.5%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Anti-oxidationAnti-agingEvens skin toneMoisturizing

A vitamin C derivative. Studies show that is might be effective in reducing hyperpigmentation, but there are no studies confirming that it is effectively converted into the bioavailable form of Vitamin C in skin. It is not clear how this derivative compares in effectiveness to the topical application of bioavailable form of vitamin C (L-ascorbic acid)

More about Ascorbyl tetraisopalmitate
Hyaluronic acid~4.7–7.1%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-inflammatoryAnti-aging

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin. Naturally present in skin. Typically has large molecule size unless advertised otherwise on the product label. Helps support skin's barrier function and may help to reduce inflammation

More about Hyaluronic acid
Retinal~3.9–5.8%
Hero · Anti-aging, Evens skin tone, Anti-blemishIrritant · high
Irritation risk
High
Works for
Anti-blemishEvens skin toneAnti-aging

One step removed from the biologically active in skin form of vitamin A. Once converted to the retinoic acid in the skin, retinal is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. Concentrations of 0.05% and 0.1% are shown to be effective. It can, however, be irritating

More about Retinal
Niacinamide~2.7–4%
Hero · Moisturizing, Anti-blemish
Irritation risk
Low
Works for
Anti-blemishEvens skin toneAnti-agingMoisturizingReduces irritationAnti-inflammatoryReduces rednessAntibacterial

Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production

More about Niacinamide
Salicylic acid~1.1–1.7%
Hero · Anti-blemishIrritant · high
Irritation risk
High
Works for
ExfoliationAnti-inflammatoryAnti-blemishAntibacterialEvens skin tone

Used for skin exfoliation. It has an anti-inflammatory and anti-bacterial effect, helps to unclog pores, prevent blemishes and speed up healing of the existing ones. Sometimes referred to as a BHA (beta-hydroxy acid)

More about Salicylic acid
Palmitoyl tripeptide-38~1.4–2.1%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tripeptide-38
Tocopherol~1–1.6%
Key active
Irritation risk
Low
Works for
Anti-oxidationMoisturizingAnti-inflammatoryAnti-aging

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol
Ferulic acid~0.55–1.35%
Key active
Irritation risk
Low
Works for
Anti-oxidationAnti-agingEvens skin toneAnti-inflammatory

A potent anti-oxidant that has been shown to be effective in neutralizing free radicals in skin. There seem to have a synergetic effect of ferulic acid, vitamin E and C, meaning that when the ingredients are used together, they enhance each other's ability protect the skin against free radicals. Ferulic acid also helps to stabilize other ingredients - including vitamins C and E. It can help to even out the skin tone. Ferulic acid is approved for use as a sunscreen ingredient in Japan in concentrations up to 10%

More about Ferulic acid
Camellia sinensis leaf extract~0.45–1.1%
Key active
Irritation risk
Low
Works for
AntibacterialAnti-oxidationAnti-agingAnti-blemishEvens skin toneMoisturizing

Can contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation

More about Camellia sinensis leaf extract
Ascorbic acid~0.3–0.75%
Hero · Anti-aging, Anti-oxidation, Evens skin toneIrritant · high
Irritation risk
High
Works for
Anti-agingEvens skin toneAnti-oxidation

The most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging

More about Ascorbic acid
Helianthus annuus seed oil~0.35–0.85%
Key active
Irritation risk
Low
Works for
Moisturizing

A great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function

More about Helianthus annuus seed oil
Citric acid~0.1–0.4%
Irritant · medium
Irritation risk
Medium

Can work as an exfoliant but is typically used to adjust the product pH

More about Citric acid
Ingredient list view

Ascorbic acid, Ascorbyl tetraisopalmitate, Hyaluronic acid, Retinal, Niacinamide, Salicylic acid, Palmitoyl tripeptide-38, Tocopherol, Ferulic acid, Camellia sinensis leaf extract, Ascorbic acid, Helianthus annuus seed oil, Citric acid

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
PharmaClinixAnti Agex SerumYOUR PRODUCTStandard BeautyPigmentation Buster Serum: Vitamin C, Alpha Arbutin & Ferulic AcidREVOLUTION SKINCAREDark Spot Corrector SerumBy WishtrendPure Vitamin C 15% with Ferulic Acid
Match—62%58%57%
Price——$8.85$28.27
Shared key ingredients—4 of 113 of 113 of 11
Key difference—Alpha-ArbutinSodium Ascorbyl PhosphateDiglycerin
Irritancy Medium Low Low Low
Drying alcohol————
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Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 22 studies and safety reviews.

  1. 1
    Assessment of penetration of Ascorbyl Tetraisopalmitate into biological membranes by molecular dynamicssciencedirect.com
  2. 2
    Stability evaluation of tocopheryl acetate and ascorbyl tetraisopalmitate in isolation and incorporated in cosmetic formulations using thermal analysisscielo.br
  3. 3
    A new lipophilic pro-vitamin C, tetra-isopalmitoyl ascorbic acid (VC-IP), prevents UV-induced skin pigmentation through its anti-oxidative propertiessciencedirect.com
  4. 4
    New lipophilic pro-vitamin C, tetra-isopalmitoyl ascorbic acid (VC-IP), suppresses senile lentigo through controlling of melanocytes-keratinocytes interactionmorressier.com
  5. 5
    Efficacy of a New Topical Nano-hyaluronic Acid in Humansncbi.nlm.nih.gov
  6. 6
    Physiochemical properties and application of hyaluronic acid: a systematic reviewonlinelibrary.wiley.com
PharmaClinix Anti Agex Serum
PharmaClinixAnti Agex Serum
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