Perricone MD Essential Fx Acyl-Glutathione: Intensive Overnight Cream

Perricone MD Essential Fx Acyl-Glutathione: Intensive Overnight Cream

Efficacy100/100IrritancyHigh
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Works for

2 of 2 advertised claims delivered

Moisturizing
16 ingredients credited for this claim
Strong support
What the product description says
“A velvety-rich, intensely moisturizing overnight treatment with nutrition that delivers nourishment throughout the night.”
Source: Perricone MD

This product can help soften the skin and reduce its moisture loss with emollients and occlusives: butyrospermum parkii butter, dimethicone.

Keep in mind that this product does not contain effective ingredients to attract water to the upper layer of the skin. This is why an additional product with humectants like glycerin or hyaluronic acid can be helpful (apply it before this product for the best results).

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: niacinamide

Helianthus annuus seed oilKey active· Emollient, OcclusiveEffect: HighA great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function~0.25–0.45%
Myristyl myristateKey active· Emollient, OcclusiveEffect: HighAn emollient. Is not recommended for acne-prone skin as it can be comedogenic~4.2–5.2%
NiacinamideHeroEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~3.2–3.9%
Salvia hispanica seed oilKey active· EmollientEffect: HighChia seed oil. Helps to soften the upper layer of the skin and might be helpful in repairing skin barrier~0.3–0.6%
Butyrospermum parkii butterKey active· Emollient, OcclusiveEffect: HighA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals~6.4–7.8%
DimethiconeKey active· Emollient, OcclusiveEffect: HighA silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish~1.7–2.1%
Magnesium aspartateKey activeEffect: MediumMight be helpful in restoring skin barrier function and calm down inflammation in skin~0.25–0.5%
C12-15 alkyl benzoateKey active· EmollientEffect: MediumEnhances the product texture and makes it more spreadable. Helps reduce water loss from the outer layer of skin. Extands the shelf life by preventing bacteria growth~2.4–3%
Glyceryl stearate· EmollientEffect: LowAn emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together~0.25–0.45%
Stearic acid· EmollientEffect: LowHelps oil and water mix together and works as an emollient~2.1–2.5%
Linum usitatissimum seed oilEffect: Low~0.3–0.55%
Lactic acidUnder-dosedEffect: HighAn exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)~0.35–0.6%
Copper gluconateUnder-dosedEffect: HighTypically used to stabilize the product formulations. It is a salt of polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing~0.25–0.4%
Zinc gluconateUnder-dosedEffect: HighTypically used to stabilize the product formulations. It is a salt of a polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing. Due to the zinc content, might help calm down inflammation in skin~0.25–0.5%
Macadamia integrifolia seed oilUnder-dosedEffect: MediumA plant oil that helps soften the upper layer of the skin~0.35–0.65%
LecithinEffect: Low, below effective doseUsed mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin~0.45–0.7%
Anti-aging
5 ingredients credited for this claim
Strong support
What the product description says
“Visibly improves etched creases making them appear more shallow.”
Source: Perricone MD

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains niacinamide.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

NiacinamideKey activeEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~3.2–3.9%
Butyrospermum parkii butterEffect: LowA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals~6.4–7.8%
Lactic acidUnder-dosedEffect: MediumAn exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)~0.35–0.6%
Zinc gluconateEffect: Low, below effective doseTypically used to stabilize the product formulations. It is a salt of a polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing. Due to the zinc content, might help calm down inflammation in skin~0.25–0.5%
Copper gluconateEffect: Low, below effective doseTypically used to stabilize the product formulations. It is a salt of polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing~0.25–0.4%
Evens skin tone
Not advertised by the brand · 4 ingredients credited for this claim
Strong support

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: niacinamide

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

NiacinamideKey activeEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~3.2–3.9%
Lactic acidUnder-dosedEffect: HighAn exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)~0.35–0.6%
Zinc gluconateEffect: Low, below effective doseTypically used to stabilize the product formulations. It is a salt of a polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing. Due to the zinc content, might help calm down inflammation in skin~0.25–0.5%
Copper gluconateEffect: Low, below effective doseTypically used to stabilize the product formulations. It is a salt of polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing~0.25–0.4%
Anti-blemish
Not advertised by the brand · 4 ingredients credited for this claim
Strong support

This product can help reduce breakouts and clogged pores because it contains the following ingredient: niacinamide. This ingredient is used for treating acne and can have a noticeable effect.

NiacinamideHeroEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~3.2–3.9%
Rosmarinus officinalis leaf extractUnder-dosedEffect: MediumCan be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating~0.15–0.3%
Copper gluconateEffect: Low, below effective doseTypically used to stabilize the product formulations. It is a salt of polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing~0.25–0.4%
Zinc gluconateEffect: Low, below effective doseTypically used to stabilize the product formulations. It is a salt of a polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing. Due to the zinc content, might help calm down inflammation in skin~0.25–0.5%

Can it cause trouble?

Irritancy
6 strong irritants: Rosmarinus officinalis leaf extract, Parfum + 4 more — patch-test recommended
High risk
We flagged 12 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Rosmarinus officinalis leaf extractCan be helpful in reducing inflammation in skin, including inflamed acne. It can be irritatingHigh~0.15–0.3%est.
ParfumAn aromatic blend of unspecified and possibly irritating ingredientsHigh~0.15–0.25%est.
CitronellolA fragrance. Can be irritatingHigh~0.1–0.25%est.
HydroxycitronellalA fragrance. A likely allergen and can be irritatingHigh~0.1–0.2%est.
LimoneneA common frangrance that can easily irritate skin, especially if exposed to air, light or heatHigh~0.1–0.15%est.
LinaloolA fragrance. Can be irritatingHigh~0.05–0.1%est.
Myristyl myristateAn emollient. Is not recommended for acne-prone skin as it can be comedogenicMedium~4.2–5.2%est.
Sodium acrylates copolymerUsed to create a thicker product consistencyMedium~1.4–1.7%est.
EthylhexylglycerinA preservativeMedium~0.65–0.95%est.
Lactic acidAn exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)Medium~0.35–0.6%est.
Zinc gluconateTypically used to stabilize the product formulations. It is a salt of a polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing. Due to the zinc content, might help calm down inflammation in skinMedium~0.25–0.5%est.
Copper gluconateTypically used to stabilize the product formulations. It is a salt of polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missingMedium~0.25–0.4%est.
Comedogenic
2 ingredients rated 2 or more on the 0–5 pore-clogging scale
2 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Butyrospermum parkii butterA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals3/5~6.4–7.8%est.
Myristyl myristateAn emollient. Is not recommended for acne-prone skin as it can be comedogenic3/5~4.2–5.2%est.
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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%
Formula
Irritation risk
Low

Plain old water

More about Water
Butyrospermum parkii butter~6.4–7.8%
Key activeComedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
MoisturizingAnti-oxidationAnti-aging

A great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals

More about Butyrospermum parkii butter
Myristyl myristate~4.2–5.2%
Key activeComedogenic 3/5Irritant · medium
Irritation risk
Medium
Comedogenicity
3/5
Works for
Moisturizing

An emollient. Is not recommended for acne-prone skin as it can be comedogenic

More about Myristyl myristate
Niacinamide~3.2–3.9%
Hero · Moisturizing, Anti-blemish
Irritation risk
Low
Works for
Anti-agingEvens skin toneAnti-blemishMoisturizingReduces irritationAnti-inflammatoryAntibacterialReduces redness

Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production

More about Niacinamide
C12-15 alkyl benzoate~2.4–3%
Key active
Irritation risk
Low
Works for
Moisturizing

Enhances the product texture and makes it more spreadable. Helps reduce water loss from the outer layer of skin. Extands the shelf life by preventing bacteria growth

More about C12-15 alkyl benzoate
Stearic acid~2.1–2.5%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

Helps oil and water mix together and works as an emollient

More about Stearic acid
Dimethicone~1.7–2.1%
Key active
Irritation risk
Low
Works for
MoisturizingMattifying

A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish

More about Dimethicone
Sodium acrylates copolymer~1.4–1.7%
Irritant · medium
Irritation risk
Medium

Used to create a thicker product consistency

More about Sodium acrylates copolymer
Palmitoyl glycine~1.2–1.5%
Formula
S-palmitoylglutathione~0.9–1.1%
Formula
Ethylhexylglycerin~0.65–0.95%
Irritant · medium
Irritation risk
Medium

A preservative

More about Ethylhexylglycerin
Myristyl laurate~0.55–0.8%
Formula
Irritation risk
Low
Works for
Cleansing
More about Myristyl laurate
Ribose~0.45–0.7%
Formula
Irritation risk
Low
More about Ribose
Lecithin~0.45–0.7%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

Used mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin

More about Lecithin
Lactic acid~0.35–0.6%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
Evens skin toneMoisturizingExfoliationAnti-aging

An exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)

More about Lactic acid
Linum usitatissimum seed oil~0.3–0.55%
Formula
Irritation risk
Low
Works for
Moisturizing
More about Linum usitatissimum seed oil
Macadamia integrifolia seed oil~0.35–0.65%
Under-dosed
Irritation risk
Low
Works for
Moisturizing

A plant oil that helps soften the upper layer of the skin

More about Macadamia integrifolia seed oil
Salvia hispanica seed oil~0.3–0.6%
Key active
Irritation risk
Low
Works for
Moisturizing

Chia seed oil. Helps to soften the upper layer of the skin and might be helpful in repairing skin barrier

More about Salvia hispanica seed oil
Magnesium aspartate~0.25–0.5%
Key active
Irritation risk
Low
Works for
Anti-inflammatoryMoisturizing

Might be helpful in restoring skin barrier function and calm down inflammation in skin

More about Magnesium aspartate
Zinc gluconate~0.25–0.5%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
MoisturizingAnti-oxidationExfoliationEvens skin toneAnti-inflammatoryAnti-agingAnti-blemish

Typically used to stabilize the product formulations. It is a salt of a polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing. Due to the zinc content, might help calm down inflammation in skin

More about Zinc gluconate
Copper gluconate~0.25–0.4%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
MoisturizingEvens skin toneAnti-blemishExfoliationAnti-oxidationAnti-aging

Typically used to stabilize the product formulations. It is a salt of polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing

More about Copper gluconate
Helianthus annuus seed oil~0.25–0.45%
Key active
Irritation risk
Low
Works for
Moisturizing

A great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function

More about Helianthus annuus seed oil
Rosmarinus officinalis leaf extract~0.15–0.3%
Under-dosedIrritant · high
Irritation risk
High
Works for
Anti-blemishAnti-oxidationAntibacterial

Can be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating

More about Rosmarinus officinalis leaf extract
Tetrasodium glutamate diacetate~0.2–0.35%
Formula
Irritation risk
Low

Helps stabilize the product formulation

More about Tetrasodium glutamate diacetate
Sodium hydroxide~0.2–0.35%
Formula
Irritation risk
Low

Used to adjust the product's pH

More about Sodium hydroxide
Glyceryl stearate~0.25–0.45%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together

More about Glyceryl stearate
Peg-100 stearate~0.3–0.5%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix togehter and creates a nice product texture

More about Peg-100 stearate
Phenoxyethanol~0.15–0.3%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Parfum~0.15–0.25%
Irritant · high
Irritation risk
High

An aromatic blend of unspecified and possibly irritating ingredients

More about Parfum
Citronellol~0.1–0.25%
Irritant · high
Irritation risk
High

A fragrance. Can be irritating

More about Citronellol
Hydroxycitronellal~0.1–0.2%
Irritant · high
Irritation risk
High

A fragrance. A likely allergen and can be irritating

More about Hydroxycitronellal
Limonene~0.1–0.15%
Irritant · high
Irritation risk
High

A common frangrance that can easily irritate skin, especially if exposed to air, light or heat

More about Limonene
Linalool~0.05–0.1%
Irritant · high
Irritation risk
High

A fragrance. Can be irritating

More about Linalool
Ingredient list view

Water, Butyrospermum parkii butter, Myristyl myristate, Niacinamide, C12-15 alkyl benzoate, Stearic acid, Dimethicone, Sodium acrylates copolymer, Palmitoyl glycine, S-palmitoylglutathione, Ethylhexylglycerin, Myristyl laurate, Ribose, Lecithin, Lactic acid, Linum usitatissimum seed oil, Macadamia integrifolia seed oil, Salvia hispanica seed oil, Magnesium aspartate, Zinc gluconate, Copper gluconate, Helianthus annuus seed oil, Rosmarinus officinalis leaf extract, Tetrasodium glutamate diacetate, Sodium hydroxide, Glyceryl stearate, Peg-100 stearate, Phenoxyethanol, Parfum, Citronellol, Hydroxycitronellal, Limonene, Linalool

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Perricone MD
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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
Perricone MDEssential Fx Acyl-Glutathione: Intensive Overnight CreamYOUR PRODUCTJanuary LabsRetexturizing Night CreamMatte BeautyHydroquinone Cream USP, 6% Skin Bleaching CreamUltraceuticalsEven skin tone smoothing moisturiser
Match—82%81%79%
Price$55.19$86.00+$30.81—$95.00+$39.81
Shared key ingredients—3 of 111 of 113 of 11
Key difference—Palmitoyl Tripeptide-5Hydroquinone3-O-Ethyl Ascorbic Acid
Irritancy High Medium Medium Medium
Drying alcohol————
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Product summary

Based on the ingredient list, "Perricone MD - Essential Fx Acyl-Glutathione: Intensive Overnight Cream" can work well for skin moisturization.

Ingredient callouts

  • We love that this moisturizer contains a good concentration of niacinamide 3.20% - 3.90%. Niacinamide is a perfect active in a moistruizer because it helps calm down inflamation in skin and support the skin barrier. More than that, it is helpful for most common skin concerns: it helps regulat oil production, help reduce acne and clogged pores, improve skin tone and prevent pigmentation marks. It also helps fight photodamage.
This product contains ingredients that could be beneficial, but their concentrations are too low in this formulation: copper gluconate, zinc gluconate, lecithin and lactic acid

Irritation risk

This moisturizer contains a bunch of common irritants, including ingredients that do not provide any known benefit for the skin. It might not be the best choice if your skin is sensitive. We assess the overall irritancy of this moisturizer to be high. For a detailed overview of all potential irritants: click here

You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.

About the brand

According to Cruelty-Free Kitty "Perricone MD" is cruelty free and so is its parent company.

Price

The product retails from 122.00$ up to 185.00$ in the United States and from 41.40£ up to 129.00£ in the United Kingdom.

For a detailed price comparison: click here.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 22 studies and safety reviews.

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Perricone MD Essential Fx Acyl-Glutathione: Intensive Overnight Cream
Perricone MDEssential Fx Acyl-Glutathione: Intensive Overnight Cream

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As an Amazon Associate, WIMJ earns from qualifying purchases.