2 of 2 advertised claims delivered
“A velvety-rich, intensely moisturizing overnight treatment with nutrition that delivers nourishment throughout the night.”
This product can help soften the skin and reduce its moisture loss with emollients and occlusives: butyrospermum parkii butter, dimethicone.
Keep in mind that this product does not contain effective ingredients to attract water to the upper layer of the skin. This is why an additional product with humectants like glycerin or hyaluronic acid can be helpful (apply it before this product for the best results).
The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: niacinamide
“Visibly improves etched creases making them appear more shallow.”
This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains niacinamide.
Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.
This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: niacinamide
Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.
This product can help reduce breakouts and clogged pores because it contains the following ingredient: niacinamide. This ingredient is used for treating acne and can have a noticeable effect.

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Filter by role to see what each ingredient is doing.
A great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals
More about Butyrospermum parkii butterAn emollient. Is not recommended for acne-prone skin as it can be comedogenic
More about Myristyl myristateIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
More about NiacinamideEnhances the product texture and makes it more spreadable. Helps reduce water loss from the outer layer of skin. Extands the shelf life by preventing bacteria growth
More about C12-15 alkyl benzoateHelps oil and water mix together and works as an emollient
More about Stearic acidA silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish
More about DimethiconeUsed to create a thicker product consistency
More about Sodium acrylates copolymerUsed mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin
More about LecithinAn exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)
More about Lactic acidA plant oil that helps soften the upper layer of the skin
More about Macadamia integrifolia seed oilChia seed oil. Helps to soften the upper layer of the skin and might be helpful in repairing skin barrier
More about Salvia hispanica seed oilMight be helpful in restoring skin barrier function and calm down inflammation in skin
More about Magnesium aspartateTypically used to stabilize the product formulations. It is a salt of a polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing. Due to the zinc content, might help calm down inflammation in skin
More about Zinc gluconateTypically used to stabilize the product formulations. It is a salt of polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing
More about Copper gluconateA great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function
More about Helianthus annuus seed oilCan be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating
More about Rosmarinus officinalis leaf extractHelps stabilize the product formulation
More about Tetrasodium glutamate diacetateAn emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together
More about Glyceryl stearateHelps oil and water mix togehter and creates a nice product texture
More about Peg-100 stearateA preservative. It helps prevent bacterial growth in cosmetic products
More about PhenoxyethanolAn aromatic blend of unspecified and possibly irritating ingredients
More about ParfumA fragrance. A likely allergen and can be irritating
More about HydroxycitronellalA common frangrance that can easily irritate skin, especially if exposed to air, light or heat
More about LimoneneWater, Butyrospermum parkii butter, Myristyl myristate, Niacinamide, C12-15 alkyl benzoate, Stearic acid, Dimethicone, Sodium acrylates copolymer, Palmitoyl glycine, S-palmitoylglutathione, Ethylhexylglycerin, Myristyl laurate, Ribose, Lecithin, Lactic acid, Linum usitatissimum seed oil, Macadamia integrifolia seed oil, Salvia hispanica seed oil, Magnesium aspartate, Zinc gluconate, Copper gluconate, Helianthus annuus seed oil, Rosmarinus officinalis leaf extract, Tetrasodium glutamate diacetate, Sodium hydroxide, Glyceryl stearate, Peg-100 stearate, Phenoxyethanol, Parfum, Citronellol, Hydroxycitronellal, Limonene, Linalool
Retailers ranked by price — lowest first.
Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.
| Perricone MDEssential Fx Acyl-Glutathione: Intensive Overnight CreamYOUR PRODUCT | January LabsRetexturizing Night Cream | Matte BeautyHydroquinone Cream USP, 6% Skin Bleaching Cream | UltraceuticalsEven skin tone smoothing moisturiser | |
|---|---|---|---|---|
| Match | — | 82% | 81% | 79% |
| Price | $55.19 | $86.00+$30.81 | — | $95.00+$39.81 |
| Shared key ingredients | — | 3 of 11 | 1 of 11 | 3 of 11 |
| Key difference | — | Palmitoyl Tripeptide-5 | Hydroquinone | 3-O-Ethyl Ascorbic Acid |
| Irritancy | High | Medium | Medium | Medium |
| Drying alcohol | — | — | — | — |
| View product | Shop | Shop | Shop |
Based on the ingredient list, "Perricone MD - Essential Fx Acyl-Glutathione: Intensive Overnight Cream" can work well for skin moisturization.
This moisturizer contains a bunch of common irritants, including ingredients that do not provide any known benefit for the skin. It might not be the best choice if your skin is sensitive. We assess the overall irritancy of this moisturizer to be high. For a detailed overview of all potential irritants: click here
You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.
According to Cruelty-Free Kitty "Perricone MD" is cruelty free and so is its parent company.
The product retails from 122.00$ up to 185.00$ in the United States and from 41.40£ up to 129.00£ in the United Kingdom.
For a detailed price comparison: click here.
Every concentration estimate and effectiveness label is anchored to one of these 22 studies and safety reviews.
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