Pacifica Beauty Wake Up Beautiful Overnight Retinoid Cream

Pacifica Beauty Wake Up Beautiful Overnight Retinoid Cream

Efficacy87/100IrritancyHigh
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Works for

2 of 2 advertised claims delivered

Anti-aging
Hydroxypinacolone retinoate, Melatonin + 1 more
Strong evidence
What the product description says
“Powerful combination of Granactive Retinoid, melatonin and mushrooms that works while you sleep to help combat signs of aging”
Source: Pacifica

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains hydroxypinacolone retinoate.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

Hydroxypinacolone retinoateHeroEffect: HighA derivative of the most potent form of vitamin A, retinoic acid. The ingredient can be sold under name Granactive Retinoid. Note that if a skincare brand discloses the concentration of Granactive Retinoid in a product, the concentration refers to a diluted form of Hydroxypinacolone Retinoate: 1% of Granactive Retinoid corresponds to 0.1% of Hydroxypinacolone Retinoate. Hydroxypinacolone Retinoate (HPR) is a unique derivative of retinoic acid because it can directly work in the skin and does not require additional conversion steps. According to studies done by the manufacturer on models of human skin (not real people), this derivative is more effective than other cosmetic versions of retinoids (such as retinol, retinaldehyde, and retinyl palmitate), and, at the same time, causes less irritation. It has been also demonstrated to be more stable than retinol which makes formulating with easier and increases the chances that a product with it will maintain its effectiveness after opening. The packaging should still ideally be air-tight. HPR is available over the counter in the EU, UK, Asia, Australia and New Zealand, but is only with a prescription in Canada.~0.01–0.05%
MelatoninEffect: LowA compound that can regulate sleep cycles in humans and animals. When used in cosmetics, comes from plant sources. It can work as anti-oxidant in skin when applied topically in skincare~1–1.5%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.15–0.55%
Moisturizing
Chenopodium quinoa seed oil, Helianthus annuus seed oil + 8 more
Good evidence
What the product description says
“This light-as-a-pillow, nighttime moisturizer is packed with potent ingredients to help hydrate and repair skin while you sleep.”
Source: Pacifica

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: glycerin.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: helianthus annuus seed oil, chenopodium quinoa seed oil.

Chenopodium quinoa seed oilKey active· EmollientEffect: HighA plant oil that contains a high percentage of linoleic acid. It softens the upper layer of the skin and can help strengthen the skin barrier~0.9–1.3%
Helianthus annuus seed oilKey active· Emollient, OcclusiveEffect: HighA great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function~2.8–4.2%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~3.6–5.3%
Cetyl estersKey active· EmollientEffect: MediumHelps soften upper layer of the skin and can enhance penetration of other ingredients into the upper layer of the skin~1.7–2.6%
Coco-caprylate/caprateKey active· EmollientEffect: MediumHelps to soften the upper layer of the skin without creating a greasy texture~2.1–3.2%
Glyceryl stearate seKey activeEffect: MediumUsed to stabilize the product formulations and works as an emollient~5–7.5%
Rosa damascena flower oilEffect: LowUsed as a fragrance. Can be irritating~0.15–0.55%
Caprylic/capric triglycerideUnder-dosedEffect: HighA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin~0.15–0.65%
Rosa damascena flower waterEffect: Low, below effective doseUsed to add a nice rose smell to the product. Might help attract water to the upper layer of the skin and have some anti-oxidant effect. Can be irritating~0.5–1.2%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.15–0.55%
Evens skin tone
Not advertised by the brand · Hydroxypinacolone retinoate
Strong evidence

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: hydroxypinacolone retinoate.

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

Hydroxypinacolone retinoateHeroEffect: HighA derivative of the most potent form of vitamin A, retinoic acid. The ingredient can be sold under name Granactive Retinoid. Note that if a skincare brand discloses the concentration of Granactive Retinoid in a product, the concentration refers to a diluted form of Hydroxypinacolone Retinoate: 1% of Granactive Retinoid corresponds to 0.1% of Hydroxypinacolone Retinoate. Hydroxypinacolone Retinoate (HPR) is a unique derivative of retinoic acid because it can directly work in the skin and does not require additional conversion steps. According to studies done by the manufacturer on models of human skin (not real people), this derivative is more effective than other cosmetic versions of retinoids (such as retinol, retinaldehyde, and retinyl palmitate), and, at the same time, causes less irritation. It has been also demonstrated to be more stable than retinol which makes formulating with easier and increases the chances that a product with it will maintain its effectiveness after opening. The packaging should still ideally be air-tight. HPR is available over the counter in the EU, UK, Asia, Australia and New Zealand, but is only with a prescription in Canada.~0.01–0.05%
Anti-blemish
Not advertised by the brand · Hydroxypinacolone retinoate
Strong evidence

This product can help reduce breakouts and clogged pores because it contains the following ingredient: hydroxypinacolone retinoate. This ingredient is used for treating acne and can have a noticeable effect.

Hydroxypinacolone retinoateHeroEffect: HighA derivative of the most potent form of vitamin A, retinoic acid. The ingredient can be sold under name Granactive Retinoid. Note that if a skincare brand discloses the concentration of Granactive Retinoid in a product, the concentration refers to a diluted form of Hydroxypinacolone Retinoate: 1% of Granactive Retinoid corresponds to 0.1% of Hydroxypinacolone Retinoate. Hydroxypinacolone Retinoate (HPR) is a unique derivative of retinoic acid because it can directly work in the skin and does not require additional conversion steps. According to studies done by the manufacturer on models of human skin (not real people), this derivative is more effective than other cosmetic versions of retinoids (such as retinol, retinaldehyde, and retinyl palmitate), and, at the same time, causes less irritation. It has been also demonstrated to be more stable than retinol which makes formulating with easier and increases the chances that a product with it will maintain its effectiveness after opening. The packaging should still ideally be air-tight. HPR is available over the counter in the EU, UK, Asia, Australia and New Zealand, but is only with a prescription in Canada.~0.01–0.05%
Anti-oxidation
Not advertised by the brand · Melatonin, Sambucus nigra flower extract + 2 more
Moderate evidence

This product contains antioxidants (melatonin) that might be able to help neutralize free radicals in skin to lessen the damage it gets from the UV light (sun). There is not enough evidence to confirm their effectiveness in skin though.

MelatoninKey activeEffect: MediumA compound that can regulate sleep cycles in humans and animals. When used in cosmetics, comes from plant sources. It can work as anti-oxidant in skin when applied topically in skincare~1–1.5%
Sambucus nigra flower extractEffect: LowA plant extract that might help neutralize free radicals in skin~0.15–0.65%
TocopherolUnder-dosedEffect: HighPure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.15–0.55%
Rosa damascena flower waterEffect: Low, below effective doseUsed to add a nice rose smell to the product. Might help attract water to the upper layer of the skin and have some anti-oxidant effect. Can be irritating~0.5–1.2%

Can it cause trouble?

Irritancy
6 strong irritants: Hydroxypinacolone retinoate, Rosa damascena flower water + 4 more — patch-test recommended
High risk
We flagged 12 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Hydroxypinacolone retinoateA derivative of the most potent form of vitamin A, retinoic acid. The ingredient can be sold under name Granactive Retinoid. Note that if a skincare brand discloses the concentration of Granactive Retinoid in a product, the concentration refers to a diluted form of Hydroxypinacolone Retinoate: 1% of Granactive Retinoid corresponds to 0.1% of Hydroxypinacolone Retinoate. Hydroxypinacolone Retinoate (HPR) is a unique derivative of retinoic acid because it can directly work in the skin and does not require additional conversion steps. According to studies done by the manufacturer on models of human skin (not real people), this derivative is more effective than other cosmetic versions of retinoids (such as retinol, retinaldehyde, and retinyl palmitate), and, at the same time, causes less irritation. It has been also demonstrated to be more stable than retinol which makes formulating with easier and increases the chances that a product with it will maintain its effectiveness after opening. The packaging should still ideally be air-tight. HPR is available over the counter in the EU, UK, Asia, Australia and New Zealand, but is only with a prescription in Canada.High~0.01–0.05%est.
Rosa damascena flower waterUsed to add a nice rose smell to the product. Might help attract water to the upper layer of the skin and have some anti-oxidant effect. Can be irritatingHigh~0.5–1.2%est.
Citrus aurantium amara flower extractUsed as a fragrance for its citrus smell. Can be irritatingHigh~0.4–1%est.
Jasminum officinale flower extractFragrance. Can be irritatingHigh~0.35–0.85%est.
Lavandula angustifolia flower extractEssential oil that can be irritatingHigh~0.4–0.9%est.
Rose extractUsed as a fragrance. Can be irritatingHigh~0.3–0.75%est.
Sambucus nigra flower extractA plant extract that might help neutralize free radicals in skinHigh~0.15–0.65%est.
Rosa damascena flower oilUsed as a fragrance. Can be irritatingHigh~0.15–0.55%est.
Caprylic/capric triglycerideA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerinMedium~0.15–0.65%est.
Potassium sorbateA preservativeMedium~0.1–0.3%est.
Citric acidCan work as an exfoliant but is typically used to adjust the product pHMedium~0.05–0.25%est.
EthylhexylglycerinA preservativeMedium~0.05–0.15%est.
Comedogenic
1 ingredient rated 2 or more on the 0–5 pore-clogging scale
1 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Glyceryl stearate seUsed to stabilize the product formulations and works as an emollient2/5~5–7.5%est.
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Ingredients

Filter by role to see what each ingredient is doing.

Water~40–60%
Formula
Irritation risk
Low

Plain old water

More about Water
Glyceryl stearate se~5–7.5%
Key activeComedogenic 2/5
Irritation risk
Low
Comedogenicity
2/5
Works for
CleansingMoisturizing

Used to stabilize the product formulations and works as an emollient

More about Glyceryl stearate se
Glycerin~3.6–5.3%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Helianthus annuus seed oil~2.8–4.2%
Key active
Irritation risk
Low
Works for
Moisturizing

A great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function

More about Helianthus annuus seed oil
Coco-caprylate/caprate~2.1–3.2%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps to soften the upper layer of the skin without creating a greasy texture

More about Coco-caprylate/caprate
Cetyl esters~1.7–2.6%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps soften upper layer of the skin and can enhance penetration of other ingredients into the upper layer of the skin

More about Cetyl esters
Hydroxypinacolone retinoate~0.01–0.05%
Hero · Anti-aging, Evens skin tone, Anti-blemishIrritant · high
Irritation risk
High
Works for
Evens skin toneAnti-blemishAnti-agingExfoliation

A derivative of the most potent form of vitamin A, retinoic acid. The ingredient can be sold under name Granactive Retinoid. Note that if a skincare brand discloses the concentration of Granactive Retinoid in a product, the concentration refers to a diluted form of Hydroxypinacolone Retinoate: 1% of Granactive Retinoid corresponds to 0.1% of Hydroxypinacolone Retinoate. Hydroxypinacolone Retinoate (HPR) is a unique derivative of retinoic acid because it can directly work in the skin and does not require additional conversion steps. According to studies done by the manufacturer on models of human skin (not real people), this derivative is more effective than other cosmetic versions of retinoids (such as retinol, retinaldehyde, and retinyl palmitate), and, at the same time, causes less irritation. It has been also demonstrated to be more stable than retinol which makes formulating with easier and increases the chances that a product with it will maintain its effectiveness after opening. The packaging should still ideally be air-tight. HPR is available over the counter in the EU, UK, Asia, Australia and New Zealand, but is only with a prescription in Canada.

More about Hydroxypinacolone retinoate
Inonotus obliquus extract~1.3–1.9%
Formula
Melatonin~1–1.5%
Key active
Irritation risk
Low
Works for
Anti-oxidationAnti-aging

A compound that can regulate sleep cycles in humans and animals. When used in cosmetics, comes from plant sources. It can work as anti-oxidant in skin when applied topically in skincare

More about Melatonin
Chenopodium quinoa seed oil~0.9–1.3%
Key active
Irritation risk
Low
Works for
Moisturizing

A plant oil that contains a high percentage of linoleic acid. It softens the upper layer of the skin and can help strengthen the skin barrier

More about Chenopodium quinoa seed oil
Rosa damascena flower water~0.5–1.2%
Irritant · high
Irritation risk
High
Works for
MoisturizingAnti-oxidation

Used to add a nice rose smell to the product. Might help attract water to the upper layer of the skin and have some anti-oxidant effect. Can be irritating

More about Rosa damascena flower water
Citrus aurantium amara flower extract~0.4–1%
Irritant · high
Irritation risk
High

Used as a fragrance for its citrus smell. Can be irritating

More about Citrus aurantium amara flower extract
Jasminum officinale flower extract~0.35–0.85%
Irritant · high
Irritation risk
High

Fragrance. Can be irritating

More about Jasminum officinale flower extract
Lavandula angustifolia flower extract~0.4–0.9%
Irritant · high
Irritation risk
High

Essential oil that can be irritating

More about Lavandula angustifolia flower extract
Rose extract~0.3–0.75%
Irritant · high
Irritation risk
High

Used as a fragrance. Can be irritating

More about Rose extract
Paeonia officinalis flower extract~0.3–0.7%
Formula
Prunus serrulata flower extract~0.2–0.8%
Formula
Sambucus nigra flower extract~0.15–0.65%
Irritant · high
Irritation risk
High
Works for
Anti-inflammatoryAnti-oxidation

A plant extract that might help neutralize free radicals in skin

More about Sambucus nigra flower extract
Rosa damascena flower oil~0.15–0.55%
Irritant · high
Irritation risk
High
Works for
Moisturizing

Used as a fragrance. Can be irritating

More about Rosa damascena flower oil
Tocopherol~0.15–0.55%
Under-dosed
Irritation risk
Low
Works for
Anti-oxidationAnti-agingAnti-inflammatoryMoisturizing

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol
Caprylic/capric triglyceride~0.15–0.65%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin

More about Caprylic/capric triglyceride
Dimethyl isosorbide~0.1–0.45%
Formula
Irritation risk
Low

Used to dissolve other ingredients in a product and can enhance their ability to penetrate the skin

More about Dimethyl isosorbide
Sclerotium gum~0.1–0.4%
Formula
Irritation risk
Low

Used to create gel-like formulas and stabilize emulsions

More about Sclerotium gum
Potassium sorbate~0.1–0.3%
Irritant · medium
Irritation risk
Medium

A preservative

More about Potassium sorbate
Sodium benzoate~0.05–0.3%
Formula
Irritation risk
Low

A preservative

More about Sodium benzoate
Citric acid~0.05–0.25%
Irritant · medium
Irritation risk
Medium

Can work as an exfoliant but is typically used to adjust the product pH

More about Citric acid
Phenoxyethanol~0.05–0.25%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Ethylhexylglycerin~0.05–0.15%
Irritant · medium
Irritation risk
Medium

A preservative

More about Ethylhexylglycerin
Ingredient list view

Water, Glyceryl stearate se, Glycerin, Helianthus annuus seed oil, Coco-caprylate/caprate, Cetyl esters, Hydroxypinacolone retinoate, Inonotus obliquus extract, Melatonin, Chenopodium quinoa seed oil, Rosa damascena flower water, Citrus aurantium amara flower extract, Jasminum officinale flower extract, Lavandula angustifolia flower extract, Rose extract, Paeonia officinalis flower extract, Prunus serrulata flower extract, Sambucus nigra flower extract, Rosa damascena flower oil, Tocopherol, Caprylic/capric triglyceride, Dimethyl isosorbide, Sclerotium gum, Potassium sorbate, Sodium benzoate, Citric acid, Phenoxyethanol, Ethylhexylglycerin

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Retailers ranked by price — lowest first.

Amazon USPrice as of 10/29/2026 09:13 GMT
$18.87
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Target
$23.99
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Pacifica
$24.00
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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
Pacifica BeautyWake Up Beautiful Overnight Retinoid CreamYOUR PRODUCTSeriøst Bedre HudA-vitamincremenPeter Thomas RothGreen Releaf Therapeutic Sleep CreamBiopelleEmepelle Night Cream
Match—93%91%90%
Price$18.87—$88.00+$69.13—
Shared key ingredients—4 of 75 of 72 of 7
Key difference—NiacinamideGluconolactoneNiacinamide
Irritancy High Medium Medium Low
Drying alcohol————
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Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 20 studies and safety reviews.

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Pacifica Beauty Wake Up Beautiful Overnight Retinoid Cream
Pacifica BeautyWake Up Beautiful Overnight Retinoid Cream

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As an Amazon Associate, WIMJ earns from qualifying purchases.