Neutrogena Clear & Defend+ Gel Moisturiser with Niacinamide & Panthenol

Neutrogena Clear & Defend+ Gel Moisturiser with Niacinamide & Panthenol

Efficacy100/100IrritancyLow·100% recommend (1 review)

Works for

Moisturizing
Niacinamide, Panthenol + 6 more
Works well
What the product description says
“Clear & Defend+ Gel Moisturiser with Niacinamide & Panthenol”
From product name

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: glycerin, caprylyl glycol.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: dimethicone, c13-14 isoparaffin.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: niacinamide, panthenol

NiacinamideHeroEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~3.2–4.8%
PanthenolHero· HumectantEffect: HighHelps attract water to the upper layer of the skin and can help improve skin barrier function~2–3%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~5–7.5%
DimethiconeKey active· Emollient, OcclusiveEffect: HighA silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish~4.5–6.7%
Dimethicone crosspolymerKey activeEffect: MediumUsed to create a thicker product texture. Helps soften the upper layer of the skin and might be able to prevent moisture loss from its surface~0.2–0.75%
C13-14 isoparaffin· EmollientEffect: LowHelps soften the upper layer of the skin, dissolve other ingredients and create a thicker product consistency~1.1–1.7%
Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~0.55–1.25%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.05–0.3%
Evens skin tone
Niacinamide
Works well

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: niacinamide

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

NiacinamideKey activeEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~3.2–4.8%
Anti-blemish
Niacinamide
Works well

This product can help reduce breakouts and clogged pores because it contains the following ingredient: niacinamide. This ingredient is used for treating acne and can have a noticeable effect.

NiacinamideHeroEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~3.2–4.8%
Anti-aging
Side benefit · Niacinamide, Tocopherol
Works well

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains niacinamide.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

NiacinamideKey activeEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~3.2–4.8%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.05–0.3%

Can it cause trouble?

Irritancy
5 flagged ingredients
Low risk
We flag 5 ingredients with irritancy potential; the product's overall irritancy is low. The table lists each ingredient's own rating.
IngredientFunctionIrritationEst. amount
Zea mays starchUsed to thicken the product's consistencyMedium~2.5–3.7%est.
PolyacrylamideUsed to improve product texture and help oil and water mix togetherMedium~1.7–2.6%est.
Caprylyl glycolHelps preserve products and creates a nice product textureMedium~0.55–1.25%est.
EthylhexylglycerinA preservativeMedium~0.35–0.8%est.
Laureth-7Helps oil and water mix togetherMedium~0.1–0.5%est.
Comedogenic
1 ingredient rated 2 or more on the 0–5 pore-clogging scale
1 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Zea mays starchUsed to thicken the product's consistency3/5~2.5–3.7%est.

User reviews

Would you recommend?
100%·yes

1 of 1 community members would buy it again.

100% would0% wouldn't
  • Sal3000· Apr 2025Recommends

    Fantastic gel moisturizer. Really pleasant.

What reviewers noticed
Marker shows the average response

Ingredients

Filter by role to see what each ingredient is doing.

Water~40–60%
Formula
Irritation risk
Low

Plain old water

More about Water
Glycerin~5–7.5%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Dimethicone~4.5–6.7%
Key active
Irritation risk
Low
Works for
MoisturizingMattifying

A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish

More about Dimethicone
Niacinamide~3.2–4.8%
Hero · Moisturizing, Anti-blemish
Irritation risk
Low
Works for
Anti-agingAnti-blemishEvens skin toneMoisturizingReduces irritationAnti-inflammatoryAntibacterialReduces redness

Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production

More about Niacinamide
Zea mays starch~2.5–3.7%
Comedogenic 3/5Irritant · medium
Irritation risk
Medium
Comedogenicity
3/5
Works for
Mattifying

Used to thicken the product's consistency

More about Zea mays starch
Panthenol~2–3%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingReduces rednessReduces irritation

Helps attract water to the upper layer of the skin and can help improve skin barrier function

More about Panthenol
Polyacrylamide~1.7–2.6%
Irritant · medium
Irritation risk
Medium

Used to improve product texture and help oil and water mix together

More about Polyacrylamide
Phenoxyethanol~0.5–1%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Cetearyl olivate~1.4–2.1%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about Cetearyl olivate
C13-14 isoparaffin~1.1–1.7%
Formula
Irritation risk
Low
Works for
Moisturizing

Helps soften the upper layer of the skin, dissolve other ingredients and create a thicker product consistency

More about C13-14 isoparaffin
Sorbitan olivate~0.55–1.35%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about Sorbitan olivate
Caprylyl glycol~0.55–1.25%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol
Ethylhexylglycerin~0.35–0.8%
Irritant · medium
Irritation risk
Medium

A preservative

More about Ethylhexylglycerin
Dimethicone crosspolymer~0.2–0.75%
Key active
Irritation risk
Low
Works for
Moisturizing

Used to create a thicker product texture. Helps soften the upper layer of the skin and might be able to prevent moisture loss from its surface

More about Dimethicone crosspolymer
Carbomer~0.15–0.55%
Formula
Irritation risk
Low
Works for
Cleansing

Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations

More about Carbomer
Laureth-7~0.1–0.5%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps oil and water mix together

More about Laureth-7
Sodium hydroxide~0.1–0.35%
Formula
Irritation risk
Low

Used to adjust the product's pH

More about Sodium hydroxide
Tocopherol~0.05–0.3%
Formula
Irritation risk
Low
Works for
Anti-oxidationMoisturizingAnti-agingAnti-inflammatory

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol
Ingredient list view

Water, Glycerin, Dimethicone, Niacinamide, Zea mays starch, Panthenol, Polyacrylamide, Phenoxyethanol, Cetearyl olivate, C13-14 isoparaffin, Sorbitan olivate, Caprylyl glycol, Ethylhexylglycerin, Dimethicone crosspolymer, Carbomer, Laureth-7, Sodium hydroxide, Tocopherol

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🇬🇧 Amazon UK (UK)Price as of 11/8 06:29 GMT
≈ $10.74
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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
NeutrogenaClear & Defend+ Gel Moisturiser with Niacinamide & PanthenolYOUR PRODUCTTHE formularxBarrier Relief Lightweight Ceramide MoisturizerBootsNo7 HydraLuminous+ Night GelCOSRXDerma Water Barrier Moisturizer
Match—97%95%95%
Price—$9.04——
Shared key ingredients—4 of 44 of 44 of 4
Key difference—Colloidal OatmealAnhydroxylitolCeramide Np
Irritancy Low Low Low Low
Drying alcohol————
View product Shop Shop Shop

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Product summary

Based on the ingredients included, "Neutrogena - Clear & Defend+ Gel Moisturiser with Niacinamide & Panthenol" works well for moisturizing the skin. As we expect from a proper moisturizer, the formula includes a combo of effective humectants and emollients. These are the two different types of ingredients that are essential for improving the skin hydration and supporting a healthy skin barrier. Panthenol, glycerin and caprylyl glycol in this product (humectants) attract water molecules to the upper layer of the skin (the water comes from the outside air or from the deeper layers of the skin if the air is dry). Dimethicone, c13-14 isoparaffin and caprylyl glycol in this product help decrease the water evoporation from the skin, so that it stays hydrated for longer. These ingredients also soften the skin and take away the feeling of tightness and dryness.

Ingredient callouts

  • We particularly like that there is a good concentration of Niacinamide (3.20% - 4.80%) in this moisturizer. Niacinamide is a well-studied multi-tasking active. It is a great ingredient to have in a moisturizer. It is stable, and can work well in almost any hydrating formulation. There is solid evidence that Niacinamide can help support skin barrier, regulate oil production and reduce acne and clogged pores. It also helps to fight photodamage and help improve the skin tone, reducing pigmentation marks.
  • Panthenol (pro-vitamin B5) at about 2.00% - 3.00% concentration. In this concentration, Panthenol works effectively to improve the skin barrier and reduce inflammation.
This product contains ingredients that could be beneficial, but their concentrations are too low in this formulation: vitamin e

Irritation risk

This product does not contain known common irritants and is suitable for sensitive skin. We assess the overall irritancy of this moisturizer to be low. For a detailed overview of all potential irritants: click here

You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.

What our users say

Based on 1 review 100% recommend this product
  • When it comes to comedogenicity, the reviewer found that it does not clog pores.
Our users describe the finish of this product as matt, They find the product's texture to be light and In terms of the smell, our users report that no smell.

Neutrogena Clear & Defend+ Gel Moisturiser with Niacinamide & Panthenol
NeutrogenaClear & Defend+ Gel Moisturiser with Niacinamide & Panthenol

Affiliate links · As an Amazon Associate, WIMJ earns from qualifying purchases.

As an Amazon Associate, WIMJ earns from qualifying purchases.