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Product summary

"MyChelle Dermaceuticals - Supreme Polypeptide Cream" is a well-rounded moisturizing product. To work well, any moisturizer needs to include a combination of water-binding and emollient ingredients. MyChelle Dermaceuticals - Supreme Polypeptide Cream ticks this box. Glycerin, hyaluronic acid, honey, hydrolyzed rice protein and mel in this product (humectants) attract water molecules to the upper layer of the skin (the water comes from the outside air or from the deeper layers of the skin if the air is dry). Emollients in this formulation (ribes nigrum seed oil, sphingolipids, butyrospermum parkii butter, caprylic/capric triglyceride and helianthus annuus seed oil) help to reduce the moisture loss from the skin. They also soften the skin surface and relieve the feeling of dryness and tightness.

Ingredient callouts

  • This moistruizer also contains peptides (palmitoyl tripeptide-5 0.30% - 0.60% and palmitoyl tripeptide-38 0.30% - 0.55%). Peptides is a very big group of ingredients. They all consist of a different combination of amino-acids. Our skin produces peptides naturally. Some of them work as natural anti-biotics, promote wound-healing and production of collagen. The scientists are still studying how effective the topical application of peptides is, but it is very likely that peptides in skincare are helpful. They might be able to support skin barrier restoration and even have an anti-aging benefit. At the very least, they certainly help attract water to the skin and support the hydration in this way.

Irritation risk

There are quite a few common irritants in this product, including ingredients without particular skin benefits. We would not recommend it for sensitive skin. We assess the overall irritancy of this moisturizer to be high. For a detailed overview of all potential irritants: click here

You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.

About the brand

According to Cruelty-Free Kitty "MyChelle Dermaceuticals" is cruelty free and so is its parent company.


The product retails for 132.67A$ in Australia and from 45.61$ up to 56.00$ in the United States.

For a detailed price comparison: click here.