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MISSHA Vitamin B12 Double Hydrop Ampouler
MISSHA

MISSHA Vitamin B12 Double Hydrop Ampouler

Efficacy100/100IrritancyHigh
See all ingredients

Works for

Moisturizing
Niacinamide, Ceramide 3 + 28 more
Works well
What the product description says
“The MISSHA Vitamin B12 Double Hydrop Ampouler has been specially formulated to help improve hydration and skin clarity.”
Source: Mankind

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: cyclomethicone, diglycerin.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: dimethicone, beta-sitosterol.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: ceramide 3, niacinamide, panthenol

NiacinamideHeroEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~0.7–1.05%
Ceramide 3Hero· EmollientEffect: HighA type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin~0.2–0.4%
PanthenolHero· HumectantEffect: HighHelps attract water to the upper layer of the skin and can help improve skin barrier function~0.15–0.3%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~3–3.6%
DiglycerinKey active· HumectantEffect: HighHelps attract water to the upper layer of the skin~2.2–2.7%
Methyl gluceth-20Key active· HumectantEffect: MediumHelps attract water to the upper layer of the skin and soften it~1.5–1.8%
Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~1–1.2%
Ethylhexyl palmitateKey active· EmollientEffect: MediumAn emollient that helps soften the skin and create a nice product texture~0.55–0.85%
Polyglyceryl-10 oleateKey activeEffect: MediumHelps soften the upper layer of the skin~0.35–0.65%
DimethiconeKey active· Emollient, OcclusiveEffect: HighA silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish~0.3–0.55%
Macadamia ternifolia seed oilKey active· EmollientEffect: MediumPlant oil from nuts that helps soften the upper layer of the skin. Contains a high concentration of oleic acid that can weaken skin's barrier function and increase water-loss while enhancing penetration of other ingredients~0.3–0.5%
Glyceryl linolenateKey active· EmollientEffect: MediumHelps soften the upper layer of the skin~0.3–0.5%
PhytosterolsKey active· EmollientEffect: HighLipids that work as an emollient and can be helpful in repairing skin barrier function~0.25–0.5%
Beta-sitosterolKey active· EmollientEffect: HighA phytosterol that can support skin's barrier function and help the skin stay hydrated~0.25–0.5%
CholesterolKey active· EmollientEffect: HighAn emollient that is naturally found in skin~0.25–0.45%
CyclomethiconeKey active· Humectant, EmollientEffect: HighA type of silicone that leaves a nice silky finish on the skin and can help soften its upper layer~0.25–0.5%
UbiquinoneKey activeEffect: HighCoenzyme Q10. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergen~0.2–0.35%
CyanocobalaminKey activeEffect: HighCan support skin barrier function and reduce inflammation in skin~0.2–0.35%
GlutathioneKey activeEffect: HighA peptide that can help neutralize free radicals in skin and reduce melanin production resulting in skin lightening effect and reduction in hyperpigmentation. It can also help attract moisture to the upper layer of the skin~0.2–0.4%
Hydroxydecyl ubiquinoneKey activeEffect: HighAn analogue of coenzyme Q10 that has a lower molecular weight, which can improve its ability to penetrate the skin. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergen~0.2–0.4%
AdenosineKey activeEffect: MediumMight help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)~0.2–0.35%
Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~1.8–2.2%
Cetyl ethylhexanoate· EmollientEffect: LowAn emollient that helps soften the skin and creates a thicker product texture~0.5–0.75%
Pentylene glycol· EmollientEffect: LowUsed to preserve products, dissolve other ingredients and create a nice product texture~0.3–0.6%
BiotinEffect: LowMight have some moisturising properties. Is not effective when applied topically beyond some moisturizing effect~0.25–0.45%
Polyquaternium-51Effect: LowAn emollient that helps create a nice silky finish on the skin~0.25–0.5%
Propylene glycol· HumectantEffect: LowHelps oil and water mix together and can enhance the penetration of other ingredients into the skin. It can be irritating~0.25–0.4%
Hydrogenated polydecene· EmollientEffect: LowHelps to soften the upper layer of the skin and create a nice product texture~0.2–0.35%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.25–0.45%
Caprylic/capric triglycerideUnder-dosedA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin~0.25–0.45%
Evens skin tone
Side benefit · Niacinamide, Glutathione + 2 more
Works well

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: glutathione, niacinamide

The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually can help even out the skin tone: resveratrol.

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

NiacinamideKey activeEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~0.7–1.05%
GlutathioneKey activeEffect: HighA peptide that can help neutralize free radicals in skin and reduce melanin production resulting in skin lightening effect and reduction in hyperpigmentation. It can also help attract moisture to the upper layer of the skin~0.2–0.4%
ResveratrolEffect: LowHelps neutralize free radicals in skin and might help reduce fine lines and wrinkles, as well as even out the skin tone~0.2–0.4%
Retinyl palmitateUnder-dosedThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect~0.2–0.4%
Anti-aging
Side benefit · Niacinamide, Adenosine + 7 more
Works well

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains adenosine, niacinamide.

These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: astaxanthin, hydroxydecyl ubiquinone, resveratrol.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

NiacinamideKey activeEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~0.7–1.05%
AdenosineKey activeEffect: HighMight help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)~0.2–0.35%
Hydroxydecyl ubiquinoneKey activeEffect: MediumAn analogue of coenzyme Q10 that has a lower molecular weight, which can improve its ability to penetrate the skin. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergen~0.2–0.4%
ResveratrolKey activeEffect: MediumHelps neutralize free radicals in skin and might help reduce fine lines and wrinkles, as well as even out the skin tone~0.2–0.4%
AstaxanthinKey activeEffect: MediumHelps neutralize free radicals in skin and might help to calm down inflammation~0.2–0.35%
UbiquinoneEffect: LowCoenzyme Q10. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergen~0.2–0.35%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.25–0.45%
Sodium ascorbyl phosphateEffect: Low, below effective doseA stable derivative of vitamin C. It is oil-soluble which means it is more likely to penetrate the skin compared to the pure form of vitamin C (which is water-soluble), but it is less bio-available and is way less effective in stimulating collagen and reducing wrinkles compared to the pure form of vitamin C (L-ascorbic acid) and its other derivatives (for example, magnesium ascorbyl phosphate). At the same time, this vitamin C derivative has been shown in studies to be effective in reducing acne, blemishes and clogged pores. It is less irritating then the pure form of vitamin C~0.2–0.35%
Retinyl palmitateUnder-dosedThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect~0.2–0.4%
Anti-blemish
Side benefit · Niacinamide, Sodium ascorbyl phosphate + 1 more
Works well

This product can help reduce breakouts and clogged pores because it contains the following ingredient: niacinamide. This ingredient is used for treating acne and can have a noticeable effect.

NiacinamideHeroEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~0.7–1.05%
Sodium ascorbyl phosphateUnder-dosedA stable derivative of vitamin C. It is oil-soluble which means it is more likely to penetrate the skin compared to the pure form of vitamin C (which is water-soluble), but it is less bio-available and is way less effective in stimulating collagen and reducing wrinkles compared to the pure form of vitamin C (L-ascorbic acid) and its other derivatives (for example, magnesium ascorbyl phosphate). At the same time, this vitamin C derivative has been shown in studies to be effective in reducing acne, blemishes and clogged pores. It is less irritating then the pure form of vitamin C~0.2–0.35%
Retinyl palmitateUnder-dosedThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect~0.2–0.4%
Anti-oxidation
Side benefit · Astaxanthin, Glutathione + 13 more
Works well

This product contains antioxidants (astaxanthin, glutathione, hydroxydecyl ubiquinone, resveratrol, ubiquinone) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

AstaxanthinKey activeEffect: HighHelps neutralize free radicals in skin and might help to calm down inflammation~0.2–0.35%
GlutathioneKey activeEffect: HighA peptide that can help neutralize free radicals in skin and reduce melanin production resulting in skin lightening effect and reduction in hyperpigmentation. It can also help attract moisture to the upper layer of the skin~0.2–0.4%
ResveratrolKey activeEffect: HighHelps neutralize free radicals in skin and might help reduce fine lines and wrinkles, as well as even out the skin tone~0.2–0.4%
UbiquinoneKey activeEffect: HighCoenzyme Q10. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergen~0.2–0.35%
Hydroxydecyl ubiquinoneKey activeEffect: HighAn analogue of coenzyme Q10 that has a lower molecular weight, which can improve its ability to penetrate the skin. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergen~0.2–0.4%
Hippophae rhamnoides fruit extractEffect: LowA plant extract that might help neutralize free radicals in skin, but research on its effectiveness is lacking~4.3–5.2%
Vaccinium macrocarpon fruit extractEffect: LowA berry extract. Might have some anti-oxidant properties~0.25–0.4%
Coptis japonica root extractEffect: LowA plant extract that might have some anti-oxidant properties~0.2–0.35%
Myrciaria dubia fruit extractEffect: LowA plant extract that might help neutralize free radicals in skin, but research on its effectiveness is lacking~0.2–0.35%
AdenosineEffect: LowMight help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)~0.2–0.35%
Euterpe oleracea fruit extractEffect: LowA plant extract that can have some anti-oxidant effect in skin~0.15–0.3%
Terminalia ferdinandiana fruit extractEffect: LowA plant extract that might have some anti-oxidant effect in skin, but evidence is lacking~0.1–0.25%
Tocopheryl acetateEffect: Low, below effective doseA more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.~0.25–0.5%
TocopherolUnder-dosedPure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.25–0.45%
Sodium ascorbyl phosphateUnder-dosedA stable derivative of vitamin C. It is oil-soluble which means it is more likely to penetrate the skin compared to the pure form of vitamin C (which is water-soluble), but it is less bio-available and is way less effective in stimulating collagen and reducing wrinkles compared to the pure form of vitamin C (L-ascorbic acid) and its other derivatives (for example, magnesium ascorbyl phosphate). At the same time, this vitamin C derivative has been shown in studies to be effective in reducing acne, blemishes and clogged pores. It is less irritating then the pure form of vitamin C~0.2–0.35%

Can it cause trouble?

Irritancy
4 strong irritants: Citrus aurantium bergamia fruit oil, Citrus aurantium dulcis peel oil + 2 more — patch-test recommended
High risk
We flagged 35 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Coptis japonica root extractA plant extract that might have some anti-oxidant propertiesHigh~0.2–0.35%est.
Citrus aurantium bergamia fruit oilA plant oil with a high content of volatile compounds that can irritate the skin and lead to allergic reactions. Can lead to photosensitivityHigh~0.15–0.3%est.
Citrus aurantium dulcis peel oilAn essentil oil from orange peel. Potential allergen and can be irritatingHigh~0.2–0.4%est.
Propylene glycolHelps oil and water mix together and can enhance the penetration of other ingredients into the skin. It can be irritatingHigh~0.25–0.4%est.
Retinyl palmitateThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effectHigh~0.2–0.4%est.
Citrus paradisi fruit extract—High~0.25–0.45%est.
Vaccinium macrocarpon fruit extractA berry extract. Might have some anti-oxidant propertiesHigh~0.25–0.4%est.
1,2-hexanediolA preservativeMedium~8.1–9.9%est.
Hippophae rhamnoides fruit extractA plant extract that might help neutralize free radicals in skin, but research on its effectiveness is lackingMedium~4.3–5.2%est.
Cetyl ethylhexanoateAn emollient that helps soften the skin and creates a thicker product textureMedium~0.5–0.75%est.
Pentylene glycolUsed to preserve products, dissolve other ingredients and create a nice product textureMedium~0.3–0.6%est.
Sodium citrateHelps to control the skin's pH level. Maintains the skin's natural film of amino-lactic acids and oils. Helps to preserve productsMedium~0.25–0.45%est.
Citric acidCan work as an exfoliant but is typically used to adjust the product pHMedium~0.25–0.4%est.
Caprylic/capric triglycerideA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerinMedium~0.25–0.45%est.
Sodium polyacryloyldimethyl taurateHelps oil and water mix togetherMedium~0.2–0.35%est.
Acrylates/c10-30 alkyl acrylate crosspolymerMaintains the texture of skincare products. Allows the product to spread evenly. Helps oil and water mix togetherMedium~0.2–0.4%est.
EthylhexylglycerinA preservativeMedium~0.2–0.35%est.
Disodium edtaStabilizes the product formulationMedium~0.2–0.35%est.
Sodium ascorbyl phosphateA stable derivative of vitamin C. It is oil-soluble which means it is more likely to penetrate the skin compared to the pure form of vitamin C (which is water-soluble), but it is less bio-available and is way less effective in stimulating collagen and reducing wrinkles compared to the pure form of vitamin C (L-ascorbic acid) and its other derivatives (for example, magnesium ascorbyl phosphate). At the same time, this vitamin C derivative has been shown in studies to be effective in reducing acne, blemishes and clogged pores. It is less irritating then the pure form of vitamin CMedium~0.2–0.35%est.
ResveratrolHelps neutralize free radicals in skin and might help reduce fine lines and wrinkles, as well as even out the skin toneMedium~0.2–0.4%est.
XanthophyllsA yellow colorantMedium~0.2–0.4%est.
GlutathioneA peptide that can help neutralize free radicals in skin and reduce melanin production resulting in skin lightening effect and reduction in hyperpigmentation. It can also help attract moisture to the upper layer of the skinMedium~0.2–0.4%est.
Hydroxydecyl ubiquinoneAn analogue of coenzyme Q10 that has a lower molecular weight, which can improve its ability to penetrate the skin. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergenMedium~0.2–0.4%est.
AstaxanthinHelps neutralize free radicals in skin and might help to calm down inflammationMedium~0.2–0.35%est.
PhytosterolsLipids that work as an emollient and can be helpful in repairing skin barrier functionMedium~0.25–0.5%est.
Macadamia ternifolia seed oilPlant oil from nuts that helps soften the upper layer of the skin. Contains a high concentration of oleic acid that can weaken skin's barrier function and increase water-loss while enhancing penetration of other ingredientsMedium~0.3–0.5%est.
Tocopheryl acetateA more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.Medium~0.25–0.5%est.
Glyceryl linoleateHelps oil and water mix togetherMedium~0.3–0.55%est.
Choleth-24Helps oil and water mix togetherMedium~0.25–0.5%est.
Ceteth-24Helps oil and water mix togetherMedium~0.35–0.6%est.
Glyceryl arachidonateHelps water and oil mix togetherMedium~0.3–0.55%est.
Potassium cetyl phosphateHelps oil and water mix togetherMedium~0.3–0.5%est.
Myrciaria dubia fruit extractA plant extract that might help neutralize free radicals in skin, but research on its effectiveness is lackingMedium~0.2–0.35%est.
Euterpe oleracea fruit extractA plant extract that can have some anti-oxidant effect in skinMedium~0.15–0.3%est.
Terminalia ferdinandiana fruit extractA plant extract that might have some anti-oxidant effect in skin, but evidence is lackingMedium~0.1–0.25%est.
Comedogenic
1 ingredient rated 2 or more on the 0–5 pore-clogging scale
1 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Ethylhexyl palmitateAn emollient that helps soften the skin and create a nice product texture3/5~0.55–0.85%est.
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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%
Formula
Irritation risk
Low

Plain old water

More about Water
1,2-hexanediol~8.1–9.9%
Irritant · medium
Irritation risk
Medium

A preservative

More about 1,2-hexanediol
Hippophae rhamnoides fruit extract~4.3–5.2%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidation

A plant extract that might help neutralize free radicals in skin, but research on its effectiveness is lacking

More about Hippophae rhamnoides fruit extract
Glycerin~3–3.6%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Diglycerin~2.2–2.7%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps attract water to the upper layer of the skin

More about Diglycerin
Butylene glycol~1.8–2.2%
Formula
Irritation risk
Low
Works for
Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol
Methyl gluceth-20~1.5–1.8%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps attract water to the upper layer of the skin and soften it

More about Methyl gluceth-20
Propanediol~1.3–1.6%
Formula
Irritation risk
Low

Acts as a solvent for other ingredients. Speeds up the absorption of other ingredients into the skin

More about Propanediol
Sodium hyaluronate~1–1.2%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate
Niacinamide~0.7–1.05%
Hero · Moisturizing, Anti-blemish
Irritation risk
Low
Works for
Anti-agingEvens skin toneMoisturizingAnti-blemishReduces irritationAntibacterialReduces rednessAnti-inflammatory

Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production

More about Niacinamide
Ethylhexyl palmitate~0.55–0.85%
Key activeComedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
Moisturizing

An emollient that helps soften the skin and create a nice product texture

More about Ethylhexyl palmitate
Cetyl ethylhexanoate~0.5–0.75%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

An emollient that helps soften the skin and creates a thicker product texture

More about Cetyl ethylhexanoate
Polyglyceryl-10 oleate~0.35–0.65%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps soften the upper layer of the skin

More about Polyglyceryl-10 oleate
Hydrogenated lecithin~0.3–0.6%
Formula
Irritation risk
Low
Works for
Cleansing

Helps to retain moisture by creating a protective barrier on the skin. Rich in fatty acids. Improves product texture and helps with the penetration of other ingredients.

More about Hydrogenated lecithin
Pentylene glycol~0.3–0.6%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Used to preserve products, dissolve other ingredients and create a nice product texture

More about Pentylene glycol
Maltodextrin~0.3–0.55%
Formula
Irritation risk
Low
Works for
Mattifying

Used to stabilize the product formulation and can help absorb oil

More about Maltodextrin
Sodium citrate~0.25–0.45%
Irritant · medium
Irritation risk
Medium

Helps to control the skin's pH level. Maintains the skin's natural film of amino-lactic acids and oils. Helps to preserve products

More about Sodium citrate
Citric acid~0.25–0.4%
Irritant · medium
Irritation risk
Medium

Can work as an exfoliant but is typically used to adjust the product pH

More about Citric acid
Cyanocobalamin~0.2–0.35%
Key active
Irritation risk
Low
Works for
Anti-inflammatoryMoisturizing

Can support skin barrier function and reduce inflammation in skin

More about Cyanocobalamin
Caprylic/capric triglyceride~0.25–0.45%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin

More about Caprylic/capric triglyceride
Ceramide 3~0.2–0.4%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingReduces irritationAnti-inflammatory

A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin

More about Ceramide 3
Panthenol~0.15–0.3%
Hero · Moisturizing
Irritation risk
Low
Works for
Reduces rednessMoisturizingReduces irritation

Helps attract water to the upper layer of the skin and can help improve skin barrier function

More about Panthenol
Sodium polyacryloyldimethyl taurate~0.2–0.35%
Irritant · medium
Irritation risk
Medium

Helps oil and water mix together

More about Sodium polyacryloyldimethyl taurate
Hydrogenated polydecene~0.2–0.35%
Formula
Irritation risk
Low
Works for
Moisturizing

Helps to soften the upper layer of the skin and create a nice product texture

More about Hydrogenated polydecene
Trideceth-10~0.25–0.5%
Formula
Irritation risk
Low
Works for
Cleansing
More about Trideceth-10
C12-14 pareth-12~0.2–0.35%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about C12-14 pareth-12
Tromethamine~0.2–0.35%
Formula
Irritation risk
Low

Helps adjust pH in products

More about Tromethamine
Acrylates/c10-30 alkyl acrylate crosspolymer~0.2–0.4%
Irritant · medium
Irritation risk
Medium

Maintains the texture of skincare products. Allows the product to spread evenly. Helps oil and water mix together

More about Acrylates/c10-30 alkyl acrylate crosspolymer
Carbomer~0.2–0.35%
Formula
Irritation risk
Low
Works for
Cleansing

Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations

More about Carbomer
Ethylhexylglycerin~0.2–0.35%
Irritant · medium
Irritation risk
Medium

A preservative

More about Ethylhexylglycerin
Adenosine~0.2–0.35%
Key active
Irritation risk
Low
Works for
Anti-agingMoisturizingAnti-oxidation

Might help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)

More about Adenosine
Xanthan gum~0.2–0.35%
Formula
Irritation risk
Low
Works for
Cleansing

Used to create a thicker product consistency

More about Xanthan gum
Coptis japonica root extract~0.2–0.35%
Irritant · high
Irritation risk
High
Works for
Anti-oxidation

A plant extract that might have some anti-oxidant properties

More about Coptis japonica root extract
Citrus aurantium bergamia fruit oil~0.15–0.3%
Irritant · high
Irritation risk
High

A plant oil with a high content of volatile compounds that can irritate the skin and lead to allergic reactions. Can lead to photosensitivity

More about Citrus aurantium bergamia fruit oil
Disodium edta~0.2–0.35%
Irritant · medium
Irritation risk
Medium

Stabilizes the product formulation

More about Disodium edta
Cholesterol~0.25–0.45%
Key active
Irritation risk
Low
Works for
CleansingMoisturizing

An emollient that is naturally found in skin

More about Cholesterol
Sodium ascorbyl phosphate~0.2–0.35%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
Anti-blemishAnti-oxidationAnti-aging

A stable derivative of vitamin C. It is oil-soluble which means it is more likely to penetrate the skin compared to the pure form of vitamin C (which is water-soluble), but it is less bio-available and is way less effective in stimulating collagen and reducing wrinkles compared to the pure form of vitamin C (L-ascorbic acid) and its other derivatives (for example, magnesium ascorbyl phosphate). At the same time, this vitamin C derivative has been shown in studies to be effective in reducing acne, blemishes and clogged pores. It is less irritating then the pure form of vitamin C

More about Sodium ascorbyl phosphate
Resveratrol~0.2–0.4%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Anti-oxidationAnti-agingEvens skin tone

Helps neutralize free radicals in skin and might help reduce fine lines and wrinkles, as well as even out the skin tone

More about Resveratrol
Ubiquinone~0.2–0.35%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-oxidationAnti-aging

Coenzyme Q10. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergen

More about Ubiquinone
Xanthophylls~0.2–0.4%
Irritant · medium
Irritation risk
Medium

A yellow colorant

More about Xanthophylls
Glutathione~0.2–0.4%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Anti-oxidationMoisturizingEvens skin tone

A peptide that can help neutralize free radicals in skin and reduce melanin production resulting in skin lightening effect and reduction in hyperpigmentation. It can also help attract moisture to the upper layer of the skin

More about Glutathione
Hydroxydecyl ubiquinone~0.2–0.4%
Key activeIrritant · medium
Irritation risk
Medium
Works for
MoisturizingAnti-oxidationAnti-aging

An analogue of coenzyme Q10 that has a lower molecular weight, which can improve its ability to penetrate the skin. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergen

More about Hydroxydecyl ubiquinone
Astaxanthin~0.2–0.35%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Anti-oxidationAnti-agingAnti-inflammatory

Helps neutralize free radicals in skin and might help to calm down inflammation

More about Astaxanthin
Phytosterols~0.25–0.5%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

Lipids that work as an emollient and can be helpful in repairing skin barrier function

More about Phytosterols
Tocopherol~0.25–0.45%
Under-dosed
Irritation risk
Low
Works for
Anti-oxidationMoisturizingAnti-inflammatoryAnti-aging

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol
Citrus aurantium dulcis peel oil~0.2–0.4%
Irritant · high
Irritation risk
High

An essentil oil from orange peel. Potential allergen and can be irritating

More about Citrus aurantium dulcis peel oil
Dimethicone~0.3–0.55%
Key active
Irritation risk
Low
Works for
MoisturizingMattifying

A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish

More about Dimethicone
Cyclomethicone~0.25–0.5%
Key active
Irritation risk
Low
Works for
Moisturizing

A type of silicone that leaves a nice silky finish on the skin and can help soften its upper layer

More about Cyclomethicone
Macadamia ternifolia seed oil~0.3–0.5%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

Plant oil from nuts that helps soften the upper layer of the skin. Contains a high concentration of oleic acid that can weaken skin's barrier function and increase water-loss while enhancing penetration of other ingredients

More about Macadamia ternifolia seed oil
Tocopheryl acetate~0.25–0.5%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidation

A more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.

More about Tocopheryl acetate
Glyceryl linoleate~0.3–0.55%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps oil and water mix together

More about Glyceryl linoleate
Glyceryl linolenate~0.3–0.5%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps soften the upper layer of the skin

More about Glyceryl linolenate
Choleth-24~0.25–0.5%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps oil and water mix together

More about Choleth-24
Ceteth-24~0.35–0.6%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps oil and water mix together

More about Ceteth-24
Beta-sitosterol~0.25–0.5%
Key active
Irritation risk
Low
Works for
Moisturizing

A phytosterol that can support skin's barrier function and help the skin stay hydrated

More about Beta-sitosterol
Glyceryl arachidonate~0.3–0.55%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps water and oil mix together

More about Glyceryl arachidonate
Propylene glycol~0.25–0.4%
Irritant · high
Irritation risk
High
Works for
Moisturizing

Helps oil and water mix together and can enhance the penetration of other ingredients into the skin. It can be irritating

More about Propylene glycol
Retinyl palmitate~0.2–0.4%
Under-dosedIrritant · high
Irritation risk
High
Works for
Anti-agingEvens skin toneAnti-blemishExfoliation

Three steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect

More about Retinyl palmitate
Phenoxyethanol~0.25–0.45%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Potassium cetyl phosphate~0.3–0.5%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps oil and water mix together

More about Potassium cetyl phosphate
Biotin~0.25–0.45%
Formula
Irritation risk
Low
Works for
Moisturizing

Might have some moisturising properties. Is not effective when applied topically beyond some moisturizing effect

More about Biotin
Citrus paradisi fruit extract~0.25–0.45%
Irritant · high
Irritation risk
High
More about Citrus paradisi fruit extract
Apium graveolens extract~0.25–0.45%
Formula
Irritation risk
Low
More about Apium graveolens extract
Prunus avium fruit extract~0.25–0.45%
Formula
Irritation risk
Low
More about Prunus avium fruit extract
Polyquaternium-51~0.25–0.5%
Formula
Irritation risk
Low
Works for
Moisturizing

An emollient that helps create a nice silky finish on the skin

More about Polyquaternium-51
Vaccinium macrocarpon fruit extract~0.25–0.4%
Irritant · high
Irritation risk
High
Works for
Anti-oxidation

A berry extract. Might have some anti-oxidant properties

More about Vaccinium macrocarpon fruit extract
Hippophae rhamnoides extract~0.2–0.4%
Formula
Irritation risk
Low
More about Hippophae rhamnoides extract
Myrciaria dubia fruit extract~0.2–0.35%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidation

A plant extract that might help neutralize free radicals in skin, but research on its effectiveness is lacking

More about Myrciaria dubia fruit extract
Rumex crispus root extract~0.15–0.25%
Formula
Irritation risk
Low
More about Rumex crispus root extract
Malpighia emarginata fruit extract~0.15–0.3%
Formula
Irritation risk
Low
More about Malpighia emarginata fruit extract
Euterpe oleracea fruit extract~0.15–0.3%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidation

A plant extract that can have some anti-oxidant effect in skin

More about Euterpe oleracea fruit extract
Terminalia ferdinandiana fruit extract~0.1–0.25%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidation

A plant extract that might have some anti-oxidant effect in skin, but evidence is lacking

More about Terminalia ferdinandiana fruit extract
Rubus chamaemorus seed extract~0.1–0.2%
Formula
Irritation risk
Low
More about Rubus chamaemorus seed extract
Ingredient list view

Water, 1,2-hexanediol, Hippophae rhamnoides fruit extract, Glycerin, Diglycerin, Butylene glycol, Methyl gluceth-20, Propanediol, Sodium hyaluronate, Niacinamide, Ethylhexyl palmitate, Cetyl ethylhexanoate, Polyglyceryl-10 oleate, Hydrogenated lecithin, Pentylene glycol, Maltodextrin, Sodium citrate, Citric acid, Cyanocobalamin, Caprylic/capric triglyceride, Ceramide 3, Panthenol, Sodium polyacryloyldimethyl taurate, Hydrogenated polydecene, Trideceth-10, C12-14 pareth-12, Tromethamine, Acrylates/c10-30 alkyl acrylate crosspolymer, Carbomer, Ethylhexylglycerin, Adenosine, Xanthan gum, Coptis japonica root extract, Citrus aurantium bergamia fruit oil, Disodium edta, Cholesterol, Sodium ascorbyl phosphate, Resveratrol, Ubiquinone, Xanthophylls, Glutathione, Hydroxydecyl ubiquinone, Astaxanthin, Phytosterols, Tocopherol, Citrus aurantium dulcis peel oil, Dimethicone, Cyclomethicone, Macadamia ternifolia seed oil, Tocopheryl acetate, Glyceryl linoleate, Glyceryl linolenate, Choleth-24, Ceteth-24, Beta-sitosterol, Glyceryl arachidonate, Propylene glycol, Retinyl palmitate, Phenoxyethanol, Potassium cetyl phosphate, Biotin, Citrus paradisi fruit extract, Apium graveolens extract, Prunus avium fruit extract, Polyquaternium-51, Vaccinium macrocarpon fruit extract, Hippophae rhamnoides extract, Myrciaria dubia fruit extract, Rumex crispus root extract, Malpighia emarginata fruit extract, Euterpe oleracea fruit extract, Terminalia ferdinandiana fruit extract, Rubus chamaemorus seed extract

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🇬🇧 Mankind (UK)40 ml
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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
MISSHAVitamin B12 Double Hydrop AmpoulerYOUR PRODUCTilsoER Firming SerumSKIN&LABVitamin C Brightening SerumArenciaRice Mucin Glow Serum 30
Match—84%84%83%
Price—$24.13$12.69$16.81
Shared key ingredients—8 of 217 of 218 of 21
Key difference—RetinolRetinolRetinal
Irritancy High Medium Medium Medium
Drying alcohol————
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Product summary

"MISSHA - Vitamin B12 Double Hydrop Ampouler" is effective for: Evens skin tone, Anti-aging, Moisturizing and Anti-inflammatory

Ingredient callouts

  • this product includes a form of Retinoids (vitamin A) - retinyl palmitate 0.20% - 0.40%, but this type of vitamin A is not very effective. It could in theory help with fine lines and wrinkles, but the effect is most likely minimal.
  • Ceramides (ceramide 3 0.20% - 0.40%). Ceramides are an important part of our natural skin barrier. The Ceramides used in skincare are synthetic or come from plants. They help soften the skin and can help "fill the gaps" in the skin barrier, keeping the skin hydrated and resilient for longer.
  • Adenosine 0.20% - 0.35%. It is a compound that in involved in many biological processes inside the skin cells. According one high-quality clinical trial, topical Adenosine in low concentrations can somewhat help improve "deep wrinkles" - the wrinkles that appear with age in places where our faces are most dynamic (for example, on the forehead or in the corners of the eyes).
  • Humectants (cyclomethicone 0.25% - 0.50%, sodium hyaluronate 1.00% - 1.20%, diglycerin 2.20% - 2.70% and glycerin 3.00% - 3.60%). These ingredients help attract water to the upper layer of the skin and improve the skin hydration.

Price

The product retails for 60.80$ in the United States, from 37.45£ up to 55.00£ in the United Kingdom and for 77.00CA$ in Canada.

For a detailed price comparison: click here.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 55 studies and safety reviews.

  1. 1
    The influence of alkane chain length on the skin irritation potential of 1,2-alkanediolsncbi.nlm.nih.gov
  2. 2
    Abundance of active ingredients in sea-buckthorn oilncbi.nlm.nih.gov
  3. 3
    Glycerol and the skin: holistic approach to its origin and functionsncbi.nlm.nih.gov
  4. 4
    Hyaluronic acid: A key molecule in skin agingncbi.nlm.nih.gov
  5. 5
    Hyaluronan (Hyaluronic Acid): a natural moisturizer for skin careresearchgate.net
  6. 6
    Niacinamide - mechanisms of action and its topical use in dermatologyncbi.nlm.nih.gov
MISSHA Vitamin B12 Double Hydrop Ampouler
MISSHAVitamin B12 Double Hydrop Ampouler
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