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Mesoestetic Cosmelan 2 Depigmentation Cream
Mesoestetic

Mesoestetic Cosmelan 2 Depigmentation Cream

Efficacy100/100IrritancyHigh·100% recommend (2 reviews)
See all ingredients

Works for

Moisturizing
Niacinamide, C12-15 alkyl benzoate + 9 more
Works well
What the product description says
“works to improve your skin texture”
Source: N/A

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: glycerin, mannitol.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: cocos nucifera oil, cholesterol.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: niacinamide

NiacinamideHeroEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~1.4–1.7%
C12-15 alkyl benzoateKey active· EmollientEffect: MediumEnhances the product texture and makes it more spreadable. Helps reduce water loss from the outer layer of skin. Extands the shelf life by preventing bacteria growth~0.65–1%
Coco-caprylate/caprateKey active· EmollientEffect: MediumHelps to soften the upper layer of the skin without creating a greasy texture~0.45–0.7%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~0.35–0.65%
UbiquinoneKey activeEffect: HighCoenzyme Q10. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergen~0.25–0.45%
Cocos nucifera oilKey active· Emollient, OcclusiveEffect: HighAn emollient. Found to be as effective as a moisturizer for dry skin as mineral oil. Could be comedogenic~0.25–0.45%
CholesterolKey active· EmollientEffect: HighAn emollient that is naturally found in skin~0.25–0.5%
MannitolKey active· HumectantEffect: HighHelps to attract water to the upper layer of the skin~0.25–0.4%
Glyceryl stearate· EmollientEffect: LowAn emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together~4.8–5.9%
Peg-8· HumectantEffect: LowUsed to create a nice product consistency~1.9–2.3%
Ppg-15 stearyl ether· EmollientEffect: LowHelp soften the upper layer of the skin and create a nice product consistency~0.5–0.8%
Evens skin tone
Retinol, Niacinamide + 6 more
Works well
What the product description says
“unify your skin tone and add brightness”
Source: N/A

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: retinol.

In addition, this product contains niacinamide. This ingredient (ingredients) might help reduce hyperpigmentation, but the effect, if any, is likely to be small.

The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually can help even out the skin tone: glycyrrhiza glabra root extract, hexylresorcinol.

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

RetinolHeroEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~0.2–0.4%
NiacinamideKey activeEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~1.4–1.7%
HexylresorcinolEffect: LowMight be helpful in reducing hyperpigmentation and neutralizing free radicals in skin~0.55–0.8%
Glycyrrhiza glabra root extractEffect: LowA plant extract that can help lighten the skin and calm down inflammation. Might be helpful in neutralizing free radicals~0.25–0.5%
Magnesium ascorbyl phosphateEffect: Low, below effective doseA derivative of vitamin C that is more stable, but less bioavailable than the pure form of vitamin C. It does not penetrate the skin well, but has been shown to convert to pure vitamin C once in skin. It can be helpful in stimulating collagen production and lightening the skin tone, but the required concentration is likely to be very high~0.25–0.45%
Ascorbic acidUnder-dosedThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging~0.25–0.45%
PhloretinUnder-dosedA potent antioxidant that is able to penetrate the skin barrier. It can help neutralize free radicals in skin, fight photodamage and reduce hyperpigmentation. It is, however, unstable and loses effectiveness when exposed to light. Effective products with phloretin must come in air-tight opaque packaging and use a sophisticated delivery technology~0.25–0.5%
Retinyl palmitateUnder-dosedThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect~0.2–0.4%
Anti-oxidation
Side benefit · Hexylresorcinol, Ubiquinone + 6 more
Works well

This product contains antioxidants (retinol, ubiquinone) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

The following ingredients - hexylresorcinol also can have an antioxidant effect, but there is less evidence to confirm their effectiveness in skin.

HexylresorcinolKey activeEffect: MediumMight be helpful in reducing hyperpigmentation and neutralizing free radicals in skin~0.55–0.8%
UbiquinoneKey activeEffect: HighCoenzyme Q10. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergen~0.25–0.45%
RetinolKey activeEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~0.2–0.4%
Glycyrrhiza glabra root extractEffect: LowA plant extract that can help lighten the skin and calm down inflammation. Might be helpful in neutralizing free radicals~0.25–0.5%
Tocopheryl acetateEffect: Low, below effective doseA more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.~0.25–0.45%
Magnesium ascorbyl phosphateEffect: Low, below effective doseA derivative of vitamin C that is more stable, but less bioavailable than the pure form of vitamin C. It does not penetrate the skin well, but has been shown to convert to pure vitamin C once in skin. It can be helpful in stimulating collagen production and lightening the skin tone, but the required concentration is likely to be very high~0.25–0.45%
Ascorbic acidUnder-dosedThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging~0.25–0.45%
PhloretinUnder-dosedA potent antioxidant that is able to penetrate the skin barrier. It can help neutralize free radicals in skin, fight photodamage and reduce hyperpigmentation. It is, however, unstable and loses effectiveness when exposed to light. Effective products with phloretin must come in air-tight opaque packaging and use a sophisticated delivery technology~0.25–0.5%
Anti-aging
Side benefit · Retinol, Niacinamide + 5 more
Works well

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains retinol, niacinamide.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

RetinolHeroEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~0.2–0.4%
NiacinamideKey activeEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~1.4–1.7%
UbiquinoneEffect: LowCoenzyme Q10. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergen~0.25–0.45%
Magnesium ascorbyl phosphateEffect: Low, below effective doseA derivative of vitamin C that is more stable, but less bioavailable than the pure form of vitamin C. It does not penetrate the skin well, but has been shown to convert to pure vitamin C once in skin. It can be helpful in stimulating collagen production and lightening the skin tone, but the required concentration is likely to be very high~0.25–0.45%
Ascorbic acidUnder-dosedThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging~0.25–0.45%
PhloretinUnder-dosedA potent antioxidant that is able to penetrate the skin barrier. It can help neutralize free radicals in skin, fight photodamage and reduce hyperpigmentation. It is, however, unstable and loses effectiveness when exposed to light. Effective products with phloretin must come in air-tight opaque packaging and use a sophisticated delivery technology~0.25–0.5%
Retinyl palmitateUnder-dosedThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect~0.2–0.4%
Exfoliation
Side benefit · Retinol, Retinyl palmitate
Works well

This product can help exfoliate the skin. In other words, it helps break down the bonds between dead cells on the surface of the skin and speed up the skin turnover. Skin often appears softer and brighter after exfoliation, but overdoing it can result in disrupted skin barrier. The following ingredient is doing the exfoliating job in this product: retinol.

RetinolKey activeEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~0.2–0.4%
Retinyl palmitateEffect: Low, below effective doseThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect~0.2–0.4%
Anti-blemish
Side benefit · Niacinamide, Retinol + 1 more
Works well

This product can help reduce breakouts and clogged pores because it contains the following ingredient: niacinamide, retinol. These ingredients is used for treating acne and can have a noticeable effect.

NiacinamideHeroEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~1.4–1.7%
RetinolHeroEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~0.2–0.4%
Retinyl palmitateUnder-dosedThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect~0.2–0.4%

Can it cause trouble?

Irritancy
3 strong irritants: Retinyl palmitate, Retinol + 1 more — patch-test recommended
High risk
We flagged 17 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Retinyl palmitateThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effectHigh~0.2–0.4%est.
RetinolTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritatingHigh~0.2–0.4%est.
Ascorbic acidThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of agingHigh~0.25–0.45%est.
ParfumAn aromatic blend of unspecified and possibly irritating ingredientsHigh~0.05–0.1%est.
Peg-75 stearateHelps water and oil mix togetherMedium~2.3–2.8%est.
Peg-8Used to create a nice product consistencyMedium~1.9–2.3%est.
EthoxydiglycolHelps to improve the product consistencyMedium~0.75–1.15%est.
HexylresorcinolMight be helpful in reducing hyperpigmentation and neutralizing free radicals in skinMedium~0.55–0.8%est.
Glyceryl behenateUsed to create a thicker product consistency and help soften the upper layer of the skinMedium~0.45–0.7%est.
Glycyrrhiza glabra root extractA plant extract that can help lighten the skin and calm down inflammation. Might be helpful in neutralizing free radicalsMedium~0.25–0.5%est.
Magnesium ascorbyl phosphateA derivative of vitamin C that is more stable, but less bioavailable than the pure form of vitamin C. It does not penetrate the skin well, but has been shown to convert to pure vitamin C once in skin. It can be helpful in stimulating collagen production and lightening the skin tone, but the required concentration is likely to be very highMedium~0.25–0.45%est.
PhloretinA potent antioxidant that is able to penetrate the skin barrier. It can help neutralize free radicals in skin, fight photodamage and reduce hyperpigmentation. It is, however, unstable and loses effectiveness when exposed to light. Effective products with phloretin must come in air-tight opaque packaging and use a sophisticated delivery technologyMedium~0.25–0.5%est.
Tocopheryl acetateA more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.Medium~0.25–0.45%est.
PhosphatidylcholineUsed to enhance the delivery of other ingredientsMedium~0.25–0.5%est.
Phytic acidAn alpha-hydroxy acid (AHA), but is mostly used to stabilize product formulations in cosmeticsMedium~0.2–0.4%est.
BhtA preservativeMedium~0.2–0.35%est.
Sodium metabisulfiteA preservativeMedium~0.1–0.2%est.
Comedogenic
1 ingredient rated 2 or more on the 0–5 pore-clogging scale
1 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Cocos nucifera oilAn emollient. Found to be as effective as a moisturizer for dry skin as mineral oil. Could be comedogenic3/5~0.25–0.45%est.
Alternatives
The closest match we found
Smart Night Clinical MD Multi-Dimensional Repair Treatment Retinol
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Closest match84% match
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User reviews

Would you recommend?
100%·yes

2 of 2 community members would buy it again.

100% would0% wouldn't
  • Batifrut· Jun 2025Recommends

    It's great for evening skin tone and reducing melasma spots. However you need to use it consistently and for a long period of time. I only use it over the spot. It does stains cloth.

What reviewers noticed
Marker shows the average response

Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%
Formula
Irritation risk
Low

Plain old water

More about Water
Glyceryl stearate~4.8–5.9%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together

More about Glyceryl stearate
Glycofurol~4.2–5.1%
Formula
Irritation risk
Low
More about Glycofurol
Silica~3.1–3.7%
Formula
Irritation risk
Low

Used to absorb oil and can temporarily mattify skin

More about Silica
Peg-75 stearate~2.3–2.8%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps water and oil mix together

More about Peg-75 stearate
Peg-8~1.9–2.3%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Used to create a nice product consistency

More about Peg-8
Kojic dipalmitate~1.6–1.9%
Formula
Irritation risk
Low
More about Kojic dipalmitate
Niacinamide~1.4–1.7%
Hero · Moisturizing, Anti-blemish
Irritation risk
Low
Works for
Anti-agingEvens skin toneMoisturizingAnti-blemishReduces irritationAnti-inflammatoryReduces rednessAntibacterial

Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production

More about Niacinamide
Glycereth-26~1.1–1.3%
Formula
Irritation risk
Low

Helps create a thicker product consistency

More about Glycereth-26
Ethoxydiglycol~0.75–1.15%
Irritant · medium
Irritation risk
Medium

Helps to improve the product consistency

More about Ethoxydiglycol
C12-15 alkyl benzoate~0.65–1%
Key active
Irritation risk
Low
Works for
Moisturizing

Enhances the product texture and makes it more spreadable. Helps reduce water loss from the outer layer of skin. Extands the shelf life by preventing bacteria growth

More about C12-15 alkyl benzoate
Hexylresorcinol~0.55–0.8%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Anti-oxidationEvens skin tone

Might be helpful in reducing hyperpigmentation and neutralizing free radicals in skin

More about Hexylresorcinol
Ppg-15 stearyl ether~0.5–0.8%
Formula
Irritation risk
Low
Works for
Moisturizing

Help soften the upper layer of the skin and create a nice product consistency

More about Ppg-15 stearyl ether
Coco-caprylate/caprate~0.45–0.7%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps to soften the upper layer of the skin without creating a greasy texture

More about Coco-caprylate/caprate
Ppg-1 trideceth-13~0.45–0.65%
Formula
Irritation risk
Low
Works for
Cleansing
More about Ppg-1 trideceth-13
Glyceryl behenate~0.45–0.7%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Used to create a thicker product consistency and help soften the upper layer of the skin

More about Glyceryl behenate
Poloxamer 338~0.4–0.6%
Formula
Irritation risk
Low
Works for
Cleansing
More about Poloxamer 338
Glycerin~0.35–0.65%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Glycyrrhiza glabra root extract~0.25–0.5%
Irritant · medium
Irritation risk
Medium
Works for
Reduces rednessEvens skin toneAnti-oxidationAnti-inflammatoryAntibacterial

A plant extract that can help lighten the skin and calm down inflammation. Might be helpful in neutralizing free radicals

More about Glycyrrhiza glabra root extract
Cocos nucifera oil~0.25–0.45%
Key activeComedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
Moisturizing

An emollient. Found to be as effective as a moisturizer for dry skin as mineral oil. Could be comedogenic

More about Cocos nucifera oil
Rumex occidentalis extract~0.2–0.4%
Formula
Irritation risk
Low
More about Rumex occidentalis extract
Dihydroxychalcone sulfonic acid~0.25–0.45%
Formula
Irritation risk
Low
More about Dihydroxychalcone sulfonic acid
Magnesium ascorbyl phosphate~0.25–0.45%
Irritant · medium
Irritation risk
Medium
Works for
Evens skin toneAnti-agingAnti-oxidation

A derivative of vitamin C that is more stable, but less bioavailable than the pure form of vitamin C. It does not penetrate the skin well, but has been shown to convert to pure vitamin C once in skin. It can be helpful in stimulating collagen production and lightening the skin tone, but the required concentration is likely to be very high

More about Magnesium ascorbyl phosphate
Retinyl palmitate~0.2–0.4%
Under-dosedIrritant · high
Irritation risk
High
Works for
Evens skin toneAnti-agingAnti-blemishExfoliation

Three steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect

More about Retinyl palmitate
Retinol~0.2–0.4%
Hero · Anti-aging, Evens skin tone, Anti-blemishIrritant · high
Irritation risk
High
Works for
Anti-agingEvens skin toneAnti-blemishMattifyingExfoliationAnti-oxidation

Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating

More about Retinol
Ppg-12/smdi copolymer~0.3–0.55%
Formula
Irritation risk
Low

Used to create a nice product finish

More about Ppg-12/smdi copolymer
Pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate~0.25–0.5%
Formula
Irritation risk
Low

Used to increase stability of product formulations

More about Pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate
Ubiquinone~0.25–0.45%
Key active
Irritation risk
Low
Works for
Anti-oxidationMoisturizingAnti-aging

Coenzyme Q10. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergen

More about Ubiquinone
Ascorbic acid~0.25–0.45%
Under-dosedIrritant · high
Irritation risk
High
Works for
Anti-oxidationEvens skin toneAnti-aging

The most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging

More about Ascorbic acid
Apigenin~0.25–0.45%
Formula
Irritation risk
Low
More about Apigenin
Phloretin~0.25–0.5%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
Anti-oxidationEvens skin toneAnti-aging

A potent antioxidant that is able to penetrate the skin barrier. It can help neutralize free radicals in skin, fight photodamage and reduce hyperpigmentation. It is, however, unstable and loses effectiveness when exposed to light. Effective products with phloretin must come in air-tight opaque packaging and use a sophisticated delivery technology

More about Phloretin
Tocopheryl acetate~0.25–0.45%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidation

A more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.

More about Tocopheryl acetate
Mannitol~0.25–0.4%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps to attract water to the upper layer of the skin

More about Mannitol
Phosphatidylcholine~0.25–0.5%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Used to enhance the delivery of other ingredients

More about Phosphatidylcholine
Cholesterol~0.25–0.5%
Key active
Irritation risk
Low
Works for
CleansingMoisturizing

An emollient that is naturally found in skin

More about Cholesterol
Polysorbate 80~0.25–0.45%
Formula
Irritation risk
Low
Works for
Cleansing

Helps water and oil mix together

More about Polysorbate 80
Xanthan gum~0.25–0.4%
Formula
Irritation risk
Low
Works for
Cleansing

Used to create a thicker product consistency

More about Xanthan gum
Silica dimethyl silylate~0.25–0.45%
Formula
Irritation risk
Low

Used to create a thicker product consistency

More about Silica dimethyl silylate
Phytic acid~0.2–0.4%
Irritant · medium
Irritation risk
Medium

An alpha-hydroxy acid (AHA), but is mostly used to stabilize product formulations in cosmetics

More about Phytic acid
Bht~0.2–0.35%
Irritant · medium
Irritation risk
Medium

A preservative

More about Bht
Phenoxyethanol~0.15–0.3%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Sodium metabisulfite~0.1–0.2%
Irritant · medium
Irritation risk
Medium

A preservative

More about Sodium metabisulfite
Methylparaben~0.1–0.15%
Formula
Irritation risk
Low

A preservative

More about Methylparaben
Ethylparaben~0.1–0.2%
Formula
Irritation risk
Low

A preservative

More about Ethylparaben
Propylparaben~0.1–0.2%
Formula
Irritation risk
Low

A preservative

More about Propylparaben
Parfum~0.05–0.1%
Irritant · high
Irritation risk
High

An aromatic blend of unspecified and possibly irritating ingredients

More about Parfum
Caramel~0.05–0.1%
Formula
Irritation risk
Low
More about Caramel
Ingredient list view

Water, Glyceryl stearate, Glycofurol, Silica, Peg-75 stearate, Peg-8, Kojic dipalmitate, Niacinamide, Glycereth-26, Ethoxydiglycol, C12-15 alkyl benzoate, Hexylresorcinol, Ppg-15 stearyl ether, Coco-caprylate/caprate, Ppg-1 trideceth-13, Glyceryl behenate, Poloxamer 338, Glycerin, Glycyrrhiza glabra root extract, Cocos nucifera oil, Rumex occidentalis extract, Dihydroxychalcone sulfonic acid, Magnesium ascorbyl phosphate, Retinyl palmitate, Retinol, Ppg-12/smdi copolymer, Pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate, Ubiquinone, Ascorbic acid, Apigenin, Phloretin, Tocopheryl acetate, Mannitol, Phosphatidylcholine, Cholesterol, Polysorbate 80, Xanthan gum, Silica dimethyl silylate, Phytic acid, Bht, Phenoxyethanol, Sodium metabisulfite, Methylparaben, Ethylparaben, Propylparaben, Parfum, Caramel

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
MesoesteticCosmelan 2 Depigmentation CreamYOUR PRODUCTCliniqueSmart Night Clinical MD Multi-Dimensional Repair Treatment RetinolMarinneRetinol & Collagen Cream-Serum - 1% RetinolNo7Pure Retinol 1% Night Concentrate
Match—84%83%83%
Price—$63.16$16.00$30.69
Shared key ingredients—3 of 103 of 103 of 10
Key difference—UreaVitamin EAcetyl Dipeptide-1 Cetyl Ester
Irritancy High Medium Medium Medium
Drying alcohol————
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  • matches yours
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More alternatives: Kiehl's Micro-Dose Anti-Aging Retinol Serum with Ceramides and PeptideTransparent Lab Gentle Rejuvenation Serum

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Product summary

"Mesoestetic - Cosmelan 2 Depigmentation Cream" has a good moisturizing formula. The formulation is based on a combination of good humectants and emollients. Both are needed to increase the skin hydration level. Humectants in this product (glycerin, mannitol and peg-8) help to increase the water content in the upper layer of the skin. (These ingredients do so by "capturing" water molecules from the outside air or from within the deeper layers of the skin). Emollients in this formulation (cholesterol, cocos nucifera oil, c12-15 alkyl benzoate, coco-caprylate/caprate and glyceryl stearate) help to reduce the moisture loss from the skin. They also soften the skin surface and relieve the feeling of dryness and tightness.

Ingredient callouts

  • This product also contains Vitamin C (Ascorbic Acid). It can be an effective active for anti-aging and evening out the skin tone, but in this moisturizer it is used for stabilizing other ingredients in the formulation. In this concentration (0.25% - 0.45%) it cannot have a noticeable benefit for the skin.
  • This moisturizer contains an effective form of Retinoids (vitamin A): retinol 0.20% - 0.40%. Retinoids are potent multitasking actives. They work to improve and prevent early signs of aging, reduce hyperpigmentation (age spots and post-acne marks), and prevent inflamed blemishes and clogged pores. The downside of Retinoids is that they can be irritating. If you are not already using a Retinoid in your routine, it is best to start slowly and apply the Retinoid product only a few times per week. If your skin tolerates it well, you can gradually increase the frequency to daily. Because of the irritation risk of Retinoids, we recommend to have another, retinoid-free moisturizer in your routine to use on the alternate days or when your skin feels dry.
This product contains ingredients that could be beneficial, but their concentrations are too low in this formulation: vitamin c

Irritation risk

This formulation includes some common irritants, including ingredients that do not provide a benefit for the skin. We assess the overall irritancy of this moisturizer to be high. For a detailed overview of all potential irritants: click here

You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.

What our users say

Based on 2 reviews 100% recommend this product
  • When it comes to comedogenicity, two out of two reviewers say that the product does not clog pores.
They find the product's texture to be heavy and In terms of the smell, our users report that light fragrance - strong fragrance.

Price

The product retails for 161.95£ in the United Kingdom.

For a detailed price comparison: click here.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 18 studies and safety reviews.

  1. 1
    Niacinamide - mechanisms of action and its topical use in dermatologyncbi.nlm.nih.gov
  2. 2
    Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology, 3(2), 88–93. doi:10.1111/j.1473-2130.2004.00115.x ncbi.nlm.nih.gov
  3. 3
    Safety Assessment of Glycerin Ethoxylates as Used in Cosmeticscir-safety.org
  4. 4
    Final report on the safety assessment of PPG-11 and PPG-15 stearyl ethersncbi.nlm.nih.gov
  5. 5
    Safety Assessment of Alkyl Esters as Used in Cosmeticscir-safety.org
  6. 6
    Glycerol and the skin: holistic approach to its origin and functionsncbi.nlm.nih.gov
Mesoestetic Cosmelan 2 Depigmentation Cream
MesoesteticCosmelan 2 Depigmentation Cream
Buy at Face the FutureCheck priceAmazon

Affiliate links · As an Amazon Associate, WIMJ earns from qualifying purchases.

Buy at Face the FutureCheck priceAmazon

As an Amazon Associate, WIMJ earns from qualifying purchases.