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MEDI-PEEL Centella Mezzo Cream
MEDI-PEEL

MEDI-PEEL Centella Mezzo Cream

Efficacy50/100IrritancyHigh
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Works for

1 of 2 advertised claims delivered

Moisturizing
Acetyl hexapeptide-8, Oligopeptide-32 + 25 more
Strong evidence
What the product description says
“Skin damage + skin scar + skin protection + skin regeneration + skin calming 5.”
Source: N/A

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: arginine, betaine.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: arginine, dimethicone.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: acetyl hexapeptide-8, copper tripeptide-1, oligopeptide-32, palmitoyl pentapeptide-4

AsiaticosideKey activeEffect: HighAn active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (madecasosside, asiatic acid and madecassic acid), asiaticoside has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritating~0.2–0.4%
ArginineKey active· Humectant, OcclusiveEffect: HighAn amino acid that is naturally present in skin and helps keep it hydrated. When used together with AHAs, it can reduce their irritating effect on the skin~0.25–0.45%
Centella asiatica extractKey activeEffect: HighA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.~1.2–1.5%
Glyceryl acrylate/acrylic acid copolymerKey active· HumectantEffect: HighHelps attract water to the upper layer of the skin and provide a longer-lasting hydration. Can create a thicker product consistency~0.2–0.4%
Madecassic acidKey activeEffect: HighAn active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (asiaticoside, madecasosside and asiatic acid), madecassic acid has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritating~0.2–0.4%
Acetyl hexapeptide-8Hero· HumectantEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.4%
Oligopeptide-32HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.45%
Palmitoyl pentapeptide-4HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.55%
Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~0.2–0.4%
Vitis vinifera seed oilKey active· EmollientEffect: HighA great emollient that can also have anti-oxidant properties~0.2–0.35%
BetaineKey active· HumectantEffect: HighHelps attract water to the upper layer of the skin and improves the product texture~1.5–1.8%
Asiatic acidKey activeEffect: HighAn active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (asiaticoside, madecasosside and madecassic acid) asiatic acid has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritating~0.5–0.75%
Copper tripeptide-1HeroEffect: HighA naturally occurring peptide. One of the most studied peptides in dermatology. It is sometimes abbreviated GHK-Cu. Belongs to the class of carrier peptides. It stimulates both synthesis and breakdown of collagen in skin. It is released in skin wounds and inflammation to support healing. It accelerates wound-healing of the skin and can stimulate hair growth. There are preliminary studies that confirm that copper tripeptide can help support collagen production reducing fine lines and wrinkles and decrease inflammation in skin.~0.25–0.45%
DimethiconeKey active· Emollient, OcclusiveEffect: HighA silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish~0.3–0.55%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~0.3–0.55%
Macadamia ternifolia seed oilKey active· EmollientEffect: MediumPlant oil from nuts that helps soften the upper layer of the skin. Contains a high concentration of oleic acid that can weaken skin's barrier function and increase water-loss while enhancing penetration of other ingredients~0.3–0.55%
AdenosineKey activeEffect: MediumMight help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)~0.25–0.5%
Leontopodium alpinum callus culture extractKey active· HumectantEffect: MediumA plant stem cell extract that might help neutralize free radicals and reduce inflammation in skin~0.25–0.45%
Cetearyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture~0.2–0.35%
Hydrogenated polydecene· EmollientEffect: LowHelps to soften the upper layer of the skin and create a nice product texture~3–3.7%
Glyceryl stearate· EmollientEffect: LowAn emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together~0.45–0.7%
Propylene glycol· HumectantEffect: LowHelps oil and water mix together and can enhance the penetration of other ingredients into the skin. It can be irritating~3.9–4.7%
Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~2.3–2.8%
Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~0.25–0.45%
NiacinamideUnder-dosedEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~0.25–0.45%
Caprylic/capric triglycerideUnder-dosedEffect: HighA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin~0.25–0.45%
Aloe barbadensis leaf extractEffect: Low, below effective doseTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin~0.95–1.15%
Anti-blemish
Centella asiatica extract, Niacinamide
Weak evidence
What the product description says
“Solutions for Acne and Blemishes Redness and Sensitive Dry and Dullness Product Function Whitening, Anti-wrinkle How to use Gently spread the desired amount from center of the face outward Product Benefits 1.”
Source: N/A

Effective ingredients missing or their concentration is too low.

Centella asiatica extractEffect: LowA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.~1.2–1.5%
NiacinamideUnder-dosedEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~0.25–0.45%
Anti-oxidation
Not advertised by the brand · Asiaticoside, Centella asiatica extract + 8 more
Strong evidence

This product contains antioxidants (asiaticoside) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

The following ingredients - centella asiatica extract, ficus carica fruit extract also can have an antioxidant effect, but there is less evidence to confirm their effectiveness in skin.

AsiaticosideKey activeEffect: HighAn active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (madecasosside, asiatic acid and madecassic acid), asiaticoside has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritating~0.2–0.4%
Centella asiatica extractKey activeEffect: MediumA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.~1.2–1.5%
Ficus carica fruit extractKey activeEffect: MediumA plant extract that can help neutralize free radicals. The concentrations typically used in cosmetics are too small to have an effect~0.25–0.45%
Solanum melongena fruit extractEffect: LowEggplant fruit extract. Might have some anti-oxidant effect~1.8–2.2%
AdenosineEffect: LowMight help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)~0.25–0.5%
Zanthoxylum piperitum fruit extractEffect: LowPlant extract that has some anti-oxidant properties. It can be irritating. Can be used to improve the product's smell~0.25–0.45%
Leontopodium alpinum callus culture extractEffect: LowA plant stem cell extract that might help neutralize free radicals and reduce inflammation in skin~0.25–0.45%
Vitis vinifera seed oilEffect: LowA great emollient that can also have anti-oxidant properties~0.2–0.35%
Punica granatum fruit extractEffect: LowA fruit extract that is used to add a fragrance to the product. It might have some antioxidant properties~0.25–0.45%
Tocopheryl acetateEffect: Low, below effective doseA more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.~0.25–0.45%
Anti-aging
Not advertised by the brand · Adenosine, Oligopeptide-32 + 6 more
Strong evidence

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains adenosine.

These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: acetyl hexapeptide-8, asiaticoside, centella asiatica extract, copper tripeptide-1, oligopeptide-32, palmitoyl pentapeptide-4.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

AdenosineKey activeEffect: HighMight help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)~0.25–0.5%
Oligopeptide-32Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.45%
Copper tripeptide-1Key activeEffect: MediumA naturally occurring peptide. One of the most studied peptides in dermatology. It is sometimes abbreviated GHK-Cu. Belongs to the class of carrier peptides. It stimulates both synthesis and breakdown of collagen in skin. It is released in skin wounds and inflammation to support healing. It accelerates wound-healing of the skin and can stimulate hair growth. There are preliminary studies that confirm that copper tripeptide can help support collagen production reducing fine lines and wrinkles and decrease inflammation in skin.~0.25–0.45%
Centella asiatica extractKey activeEffect: MediumA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.~1.2–1.5%
AsiaticosideKey activeEffect: MediumAn active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (madecasosside, asiatic acid and madecassic acid), asiaticoside has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritating~0.2–0.4%
Acetyl hexapeptide-8Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.4%
Palmitoyl pentapeptide-4Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.55%
NiacinamideUnder-dosedEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~0.25–0.45%

Can it cause trouble?

Irritancy
9 strong irritants: Parfum, Linalool + 7 more — patch-test recommended
High risk
We flagged 27 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Propylene glycolHelps oil and water mix together and can enhance the penetration of other ingredients into the skin. It can be irritatingHigh~3.9–4.7%est.
ParfumAn aromatic blend of unspecified and possibly irritating ingredientsHigh~0.55–0.85%est.
LinaloolA fragrance. Can be irritatingHigh~0.2–0.4%est.
LimoneneA common frangrance that can easily irritate skin, especially if exposed to air, light or heatHigh~0.2–0.4%est.
Illicium verum fruit extractAnise fruit extract. Used as a fragrance. Can be irritatingHigh~0.2–0.4%est.
Butylphenyl methylpropionalA fragrance. Can trigger allergic reactions and be irritatingHigh~0.25–0.45%est.
Punica granatum fruit extractA fruit extract that is used to add a fragrance to the product. It might have some antioxidant propertiesHigh~0.25–0.45%est.
GeraniolA fragrance. Can be irritatingHigh~0.25–0.4%est.
Zanthoxylum piperitum fruit extractPlant extract that has some anti-oxidant properties. It can be irritating. Can be used to improve the product's smellHigh~0.25–0.45%est.
Hexyl cinnamalA fragrance with jasmine smell. A likely irritantHigh~0.25–0.4%est.
Benzyl benzoateFragrance with sweet balsamic smell. Help to preserve products and dissolve other ingredients. Could trigger allergic reactions and be irritatingHigh~0.2–0.35%est.
Caprylyl glycolHelps preserve products and creates a nice product textureMedium~2.3–2.8%est.
Solanum melongena fruit extractEggplant fruit extract. Might have some anti-oxidant effectMedium~1.8–2.2%est.
Centella asiatica extractA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.Medium~1.2–1.5%est.
Aloe barbadensis leaf extractTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skinMedium~0.95–1.15%est.
Asiatic acidAn active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (asiaticoside, madecasosside and madecassic acid) asiatic acid has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritatingMedium~0.5–0.75%est.
EthylhexylglycerinA preservativeMedium~0.35–0.65%est.
Glyceryl acrylate/acrylic acid copolymerHelps attract water to the upper layer of the skin and provide a longer-lasting hydration. Can create a thicker product consistencyMedium~0.2–0.4%est.
Tocopheryl acetateA more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.Medium~0.25–0.45%est.
AsiaticosideAn active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (madecasosside, asiatic acid and madecassic acid), asiaticoside has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritatingMedium~0.2–0.4%est.
Ficus carica fruit extractA plant extract that can help neutralize free radicals. The concentrations typically used in cosmetics are too small to have an effectMedium~0.25–0.45%est.
Macadamia ternifolia seed oilPlant oil from nuts that helps soften the upper layer of the skin. Contains a high concentration of oleic acid that can weaken skin's barrier function and increase water-loss while enhancing penetration of other ingredientsMedium~0.3–0.55%est.
1,2-hexanediolA preservativeMedium~0.2–0.4%est.
Disodium edtaStabilizes the product formulationMedium~0.2–0.4%est.
Madecassic acidAn active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (asiaticoside, madecasosside and asiatic acid), madecassic acid has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritatingMedium~0.2–0.4%est.
Caprylic/capric triglycerideA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerinMedium~0.25–0.45%est.
Vitis vinifera seed oilA great emollient that can also have anti-oxidant propertiesMedium~0.2–0.35%est.
Comedogenic
1 ingredient rated 2 or more on the 0–5 pore-clogging scale
1 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Cetearyl alcoholA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture2/5~0.2–0.35%est.
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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%
Formula
Irritation risk
Low

Plain old water

More about Water
Allantoin panthenol~5.3–6.5%
Formula
Irritation risk
Low
More about Allantoin panthenol
Propylene glycol~3.9–4.7%
Irritant · high
Irritation risk
High
Works for
Moisturizing

Helps oil and water mix together and can enhance the penetration of other ingredients into the skin. It can be irritating

More about Propylene glycol
Hydrogenated polydecene~3–3.7%
Formula
Irritation risk
Low
Works for
Moisturizing

Helps to soften the upper layer of the skin and create a nice product texture

More about Hydrogenated polydecene
Caprylyl glycol~2.3–2.8%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol
Solanum melongena fruit extract~1.8–2.2%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidation

Eggplant fruit extract. Might have some anti-oxidant effect

More about Solanum melongena fruit extract
Betaine~1.5–1.8%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps attract water to the upper layer of the skin and improves the product texture

More about Betaine
Centella asiatica extract~1.2–1.5%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Reduces irritationAnti-inflammatoryReduces rednessMoisturizingAnti-agingAnti-oxidationAnti-blemish

A plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.

More about Centella asiatica extract
Ginkgo biloba nut extract~1–1.3%
Formula
Irritation risk
Low
More about Ginkgo biloba nut extract
Aloe barbadensis leaf extract~0.95–1.15%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Traditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin

More about Aloe barbadensis leaf extract
Parfum~0.55–0.85%
Irritant · high
Irritation risk
High

An aromatic blend of unspecified and possibly irritating ingredients

More about Parfum
Asiatic acid~0.5–0.75%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Anti-inflammatoryReduces irritationMoisturizing

An active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (asiaticoside, madecasosside and madecassic acid) asiatic acid has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritating

More about Asiatic acid
Usnea barbata extract~0.45–0.7%
Formula
Irritation risk
Low
More about Usnea barbata extract
Glyceryl stearate~0.45–0.7%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together

More about Glyceryl stearate
Ethylhexylglycerin~0.35–0.65%
Irritant · medium
Irritation risk
Medium

A preservative

More about Ethylhexylglycerin
Sorbitan stearate~0.4–0.6%
Formula
Irritation risk
Low
Works for
Cleansing

Helps water and oil mix together

More about Sorbitan stearate
Pulsatilla koreana extract~0.3–0.6%
Formula
Irritation risk
Low
More about Pulsatilla koreana extract
Palmitoyl pentapeptide-4~0.3–0.55%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl pentapeptide-4
Peg-100 stearate~0.4–0.6%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix togehter and creates a nice product texture

More about Peg-100 stearate
Oligopeptide-32~0.25–0.45%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Oligopeptide-32
Linalool~0.2–0.4%
Irritant · high
Irritation risk
High

A fragrance. Can be irritating

More about Linalool
Limonene~0.2–0.4%
Irritant · high
Irritation risk
High

A common frangrance that can easily irritate skin, especially if exposed to air, light or heat

More about Limonene
Sodium hyaluronate~0.2–0.4%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate
Glyceryl acrylate/acrylic acid copolymer~0.2–0.4%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps attract water to the upper layer of the skin and provide a longer-lasting hydration. Can create a thicker product consistency

More about Glyceryl acrylate/acrylic acid copolymer
Dipropylene glycol~0.2–0.35%
Formula
Irritation risk
Low

Helps to dissolve other ingredients in a formulation. Slows down the rate of product drying

More about Dipropylene glycol
Acetyl hexapeptide-8~0.2–0.4%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Acetyl hexapeptide-8
Tocopheryl acetate~0.25–0.45%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidation

A more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.

More about Tocopheryl acetate
Copper tripeptide-1~0.25–0.45%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A naturally occurring peptide. One of the most studied peptides in dermatology. It is sometimes abbreviated GHK-Cu. Belongs to the class of carrier peptides. It stimulates both synthesis and breakdown of collagen in skin. It is released in skin wounds and inflammation to support healing. It accelerates wound-healing of the skin and can stimulate hair growth. There are preliminary studies that confirm that copper tripeptide can help support collagen production reducing fine lines and wrinkles and decrease inflammation in skin.

More about Copper tripeptide-1
Morus alba fruit extract~0.25–0.45%
Formula
Irritation risk
Low
More about Morus alba fruit extract
Oligopeptide-29~0.25–0.5%
Formula
Irritation risk
Low
More about Oligopeptide-29
Illicium verum fruit extract~0.2–0.4%
Irritant · high
Irritation risk
High

Anise fruit extract. Used as a fragrance. Can be irritating

More about Illicium verum fruit extract
Butylphenyl methylpropional~0.25–0.45%
Irritant · high
Irritation risk
High

A fragrance. Can trigger allergic reactions and be irritating

More about Butylphenyl methylpropional
Glycerin~0.3–0.55%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Arginine~0.25–0.45%
Key active
Irritation risk
Low
Works for
Moisturizing

An amino acid that is naturally present in skin and helps keep it hydrated. When used together with AHAs, it can reduce their irritating effect on the skin

More about Arginine
Asiaticoside~0.2–0.4%
Key activeIrritant · medium
Irritation risk
Medium
Works for
MoisturizingAnti-oxidationReduces irritationAnti-aging

An active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (madecasosside, asiatic acid and madecassic acid), asiaticoside has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritating

More about Asiaticoside
Ficus carica fruit extract~0.25–0.45%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Anti-oxidation

A plant extract that can help neutralize free radicals. The concentrations typically used in cosmetics are too small to have an effect

More about Ficus carica fruit extract
Punica granatum fruit extract~0.25–0.45%
Irritant · high
Irritation risk
High
Works for
Anti-oxidation

A fruit extract that is used to add a fragrance to the product. It might have some antioxidant properties

More about Punica granatum fruit extract
Macadamia ternifolia seed oil~0.3–0.55%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

Plant oil from nuts that helps soften the upper layer of the skin. Contains a high concentration of oleic acid that can weaken skin's barrier function and increase water-loss while enhancing penetration of other ingredients

More about Macadamia ternifolia seed oil
Geraniol~0.25–0.4%
Irritant · high
Irritation risk
High

A fragrance. Can be irritating

More about Geraniol
Niacinamide~0.25–0.45%
Under-dosed
Irritation risk
Low
Works for
Evens skin toneAnti-blemishAnti-agingMoisturizingReduces irritationAnti-inflammatoryReduces rednessAntibacterial

Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production

More about Niacinamide
Dimethicone~0.3–0.55%
Key active
Irritation risk
Low
Works for
MoisturizingMattifying

A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish

More about Dimethicone
Adenosine~0.25–0.5%
Key active
Irritation risk
Low
Works for
Anti-agingMoisturizingAnti-oxidation

Might help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)

More about Adenosine
Zanthoxylum piperitum fruit extract~0.25–0.45%
Irritant · high
Irritation risk
High
Works for
Anti-oxidation

Plant extract that has some anti-oxidant properties. It can be irritating. Can be used to improve the product's smell

More about Zanthoxylum piperitum fruit extract
Hexyl cinnamal~0.25–0.4%
Irritant · high
Irritation risk
High

A fragrance with jasmine smell. A likely irritant

More about Hexyl cinnamal
Leontopodium alpinum callus culture extract~0.25–0.45%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-inflammatoryAnti-oxidation

A plant stem cell extract that might help neutralize free radicals and reduce inflammation in skin

More about Leontopodium alpinum callus culture extract
Carbomer~0.25–0.45%
Formula
Irritation risk
Low
Works for
Cleansing

Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations

More about Carbomer
Butylene glycol~0.25–0.45%
Formula
Irritation risk
Low
Works for
Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol
1,2-hexanediol~0.2–0.4%
Irritant · medium
Irritation risk
Medium

A preservative

More about 1,2-hexanediol
Disodium edta~0.2–0.4%
Irritant · medium
Irritation risk
Medium

Stabilizes the product formulation

More about Disodium edta
Madecassic acid~0.2–0.4%
Key activeIrritant · medium
Irritation risk
Medium
Works for
MoisturizingReduces irritation

An active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (asiaticoside, madecasosside and asiatic acid), madecassic acid has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritating

More about Madecassic acid
Benzyl benzoate~0.2–0.35%
Irritant · high
Irritation risk
High

Fragrance with sweet balsamic smell. Help to preserve products and dissolve other ingredients. Could trigger allergic reactions and be irritating

More about Benzyl benzoate
Caprylic/capric triglyceride~0.25–0.45%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin

More about Caprylic/capric triglyceride
Cetearyl alcohol~0.2–0.35%
Key activeComedogenic 2/5
Irritation risk
Low
Comedogenicity
2/5
Works for
CleansingMoisturizing

A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture

More about Cetearyl alcohol
Vitis vinifera seed oil~0.2–0.35%
Key activeIrritant · medium
Irritation risk
Medium
Works for
MoisturizingAnti-oxidation

A great emollient that can also have anti-oxidant properties

More about Vitis vinifera seed oil
Ingredient list view

Water, Allantoin panthenol, Propylene glycol, Hydrogenated polydecene, Caprylyl glycol, Solanum melongena fruit extract, Betaine, Centella asiatica extract, Ginkgo biloba nut extract, Aloe barbadensis leaf extract, Parfum, Asiatic acid, Usnea barbata extract, Glyceryl stearate, Ethylhexylglycerin, Sorbitan stearate, Pulsatilla koreana extract, Palmitoyl pentapeptide-4, Peg-100 stearate, Oligopeptide-32, Linalool, Limonene, Sodium hyaluronate, Glyceryl acrylate/acrylic acid copolymer, Dipropylene glycol, Acetyl hexapeptide-8, Tocopheryl acetate, Copper tripeptide-1, Morus alba fruit extract, Oligopeptide-29, Illicium verum fruit extract, Butylphenyl methylpropional, Glycerin, Arginine, Asiaticoside, Ficus carica fruit extract, Punica granatum fruit extract, Macadamia ternifolia seed oil, Geraniol, Niacinamide, Dimethicone, Adenosine, Zanthoxylum piperitum fruit extract, Hexyl cinnamal, Leontopodium alpinum callus culture extract, Carbomer, Butylene glycol, 1,2-hexanediol, Disodium edta, Madecassic acid, Benzyl benzoate, Caprylic/capric triglyceride, Cetearyl alcohol, Vitis vinifera seed oil

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
MEDI-PEELCentella Mezzo CreamYOUR PRODUCTTOSOWOONGJeju Mayu CreamVT CosmeticsPDRN Reedle Shot Cream 50mlJin Jung sungHybrid Face & Eye Cream
Match—88%87%86%
Price$20.64—$106.11+$85.47$18.30−$2.34
Shared key ingredients—12 of 1912 of 1913 of 19
Key difference—Oligopeptide-1Tripeptide-1Madecassoside
Irritancy High Medium Medium High
Drying alcohol————
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Product summary

"MEDI-PEEL - Centella Mezzo Cream" is a well-rounded moisturizing product. As we expect from a proper moisturizer, the formula includes a combo of effective humectants and emollients. These are the two different types of ingredients that are essential for improving the skin hydration and supporting a healthy skin barrier. Acetyl hexapeptide-8, arginine, betaine, glycerin and glyceryl acrylate/acrylic acid copolymer in this product (humectants) attract water molecules to the upper layer of the skin (the water comes from the outside air or from the deeper layers of the skin if the air is dry). Vitis vinifera seed oil, arginine, dimethicone, cetearyl alcohol and macadamia ternifolia seed oil in this product help decrease the water evoporation from the skin, so that it stays hydrated for longer. These ingredients also soften the skin and take away the feeling of tightness and dryness.

Ingredient callouts

  • This moisturizer also contains Peptides (copper tripeptide-1 0.25% - 0.45%, acetyl hexapeptide-8 0.20% - 0.40%, oligopeptide-32 0.25% - 0.45% and palmitoyl pentapeptide-4 0.30% - 0.55%). Peptides are a very big group of ingredients. They all consist of a different combination of aminoacids. Our skin produces Peptides naturally. Some of them work as natural antibiotics, promote wound-healing and production of collagen. The scientists are still studying how effective the topical application of Peptides is, but it is very likely that they are helpful. Peptides might be able to support skin barrier restoration and even have an anti-aging benefit. At the very least, they certainly help attract water to the skin and support the hydration in this way.
  • Adenosine 0.25% - 0.50%. It is a compound that in involved in many biological processes inside the skin cells. According one high-quality clinical trial, topical Adenosine in low concentrations can somewhat help improve "deep wrinkles" - the wrinkles that appear with age in places where our faces are most dynamic (for example, on the forehead or in the corners of the eyes).
  • Actives derived from an extract of the Centella Asiatica plant (also known as Gotu Kola) - madecassic acid 0.20% - 0.40%, asiaticoside 0.20% - 0.40% and asiatic acid 0.50% - 0.75% The Centella Asiatica Actives, even in low concentration, can help reduce inflammation in skin, strengthen the skin barrier and reduce photodamage. They can also help to decrease scarring.
This product contains ingredients that could be beneficial, but their concentrations are too low in this formulation: caprylic/capric triglyceride and niacinamide

Irritation risk

This moisturizer contains a bunch of common irritants, including ingredients that do not provide any known benefit for the skin. It might not be the best choice if your skin is sensitive. We assess the overall irritancy of this moisturizer to be high. For a detailed overview of all potential irritants: click here

You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.

Price

The product retails from 18.31$ up to 22.20$ in the United States and for 20.25£ in the United Kingdom.

For a detailed price comparison: click here.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 31 studies and safety reviews.

  1. 1
    Surfactants and experimental irritant contact dermatitisncbi.nlm.nih.gov
  2. 2
    Propylene Glycolpubmed.ncbi.nlm.nih.gov
  3. 3
    Skin-sensitizing and irritant properties of propylene glycolonlinelibrary.wiley.com
  4. 4
    Safety Assessment of Polyene Group as Used in Cosmeticscir-safety.org
  5. 5
    In Vitro antioxidative and anti-inflammatory activities of the ethanol extract of eggplant (Solanum melongena) stalks in macrophage RAW 264.7 cellstandfonline.com
  6. 6
    Anti-Inflammatory Effect of Titrated Extract of Centella asiatica in Phthalic Anhydride-Induced Allergic Dermatitis Animal Modelmdpi.com
MEDI-PEEL Centella Mezzo Cream
MEDI-PEELCentella Mezzo Cream
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