Juice Beauty STEM CELLULAR Anti-Wrinkle Overnight Cream

Juice Beauty STEM CELLULAR Anti-Wrinkle Overnight Cream

Efficacy87/100IrritancyHigh
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Works for

2 of 2 advertised claims delivered

Moisturizing
24 ingredients credited for this claim
Strong support
What the product description says
“This Product Is: an overnight moisturizing facial cream”
Source: Credo Beauty

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: glycerin, sodium hyaluronate.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: butyrospermum parkii butter, caprylic/capric triglyceride.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: palmitoyl tripeptide-5, panthenol

SqualaneKey active· Emollient, OcclusiveEffect: HighAn oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.~0.55–1.35%
Vitis vinifera seed oilKey active· EmollientEffect: HighA great emollient that can also have anti-oxidant properties~0.55–1.35%
Caprylic/capric triglycerideKey active· Emollient, OcclusiveEffect: HighA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin~2.6–3.9%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~0.85–1.3%
Butyrospermum parkii butterKey active· Emollient, OcclusiveEffect: HighA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals~0.6–1.4%
Beta-glucanKey activeEffect: HighHelps attract water to the upper layer of the skin, calm down inflammation and irritation, restore the barrier function and support wound healing. It can be helpful in reducing fine lines and wrinkles~0.15–0.5%
Helianthus annuus seed oilKey active· Emollient, OcclusiveEffect: HighA great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function~2–3.1%
Oenothera biennis oilKey active· EmollientEffect: HighHelps soften the upper layer of the skin and can support skin barrier function~0.55–1.25%
Palmitoyl tripeptide-5HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.7%
PanthenolHero· HumectantEffect: HighHelps attract water to the upper layer of the skin and can help improve skin barrier function~0.2–0.7%
Simmondsia chinensis seed oilKey active· Emollient, OcclusiveEffect: HighSoftens the upper layer of skin and helps restore the healthy skin barrier. Has shown to help calm down inflammation in skin. It is a stable oil, meaning that it retains its properties even when exposed to air.~0.85–1.25%
Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~0.15–0.6%
Sodium pcaKey active· HumectantEffect: HighNaturally present in skin and helps to attract water to its upper layer~0.15–0.55%
Cetyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together~1.3–2%
Diheptyl succinateKey active· EmollientEffect: MediumHelps to soften the upper layer of the skin and creates a nice product finish on the skin~0.15–0.7%
Capryloyl glycerin/sebacic acid copolymerKey activeEffect: MediumHelps soften the upper layer of the skin~0.5–1.15%
Stearic acid· EmollientEffect: LowHelps oil and water mix together and works as an emollient~1.1–1.6%
Glyceryl stearate citrate· EmollientEffect: LowHelps oil and water mix together while softening the upper layer of the skin~0.85–1.3%
Glyceryl stearate· EmollientEffect: LowAn emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together~1.7–2.6%
Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~0.1–0.45%
Aloe barbadensis leaf juice· HumectantEffect: LowTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin~2.8–4.2%
AllantoinUnder-dosedEffect: HighHelps calm down inflammation in skin and can help reduce itching. Helps to repair the skin barrier and keep skin hydrated~0.15–0.6%
GluconolactoneUnder-dosedEffect: HighA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals~0.05–0.2%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.45–1.05%
Anti-aging
7 ingredients credited for this claim
Moderate support
What the product description says
“STEM CELLULAR Anti-Wrinkle Overnight Cream”
Source: Credo Beauty

This product contains palmitoyl tripeptide-5. This ingredient might be able to help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness, but there is not enough evidence that it actually works.

Palmitoyl tripeptide-5Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.7%
Beta-glucanEffect: LowHelps attract water to the upper layer of the skin, calm down inflammation and irritation, restore the barrier function and support wound healing. It can be helpful in reducing fine lines and wrinkles~0.15–0.5%
Butyrospermum parkii butterEffect: LowA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals~0.6–1.4%
Aloe barbadensis leaf juiceEffect: LowTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin~2.8–4.2%
GluconolactoneUnder-dosedEffect: HighA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals~0.05–0.2%
Ascorbic acidUnder-dosedEffect: HighThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging~0.15–0.65%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.45–1.05%

Can it cause trouble?

Irritancy
4 strong irritants: Citrus limon juice, Citrus limon leaf cell extract + 2 more — patch-test recommended
High risk
We flagged 17 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Citrus limon juice—High~22–34%est.
Pyrus malus juiceApple juice. Might help attract water to the skin. Can be irritatingHigh~3.9–5.8%est.
Citrus limon leaf cell extract—High~0.35–0.85%est.
Ascorbic acidThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of agingHigh~0.15–0.65%est.
Chamomilla recutita extractPlant extract that can have healing and anti-inflammatory properties. It is a potential allergen and can be irritatingHigh~0.15–0.7%est.
Cinnamomum camphora wood oil—High~0.05–0.2%est.
Litsea cubeba fruit oilAn essential oil with a lemon-like smell that is extracted from a fruit grown in Asia. Used as a fragranceHigh~0.05–0.1%est.
Vitis vinifera juice—Medium~4.1–6.1%est.
Aloe barbadensis leaf juiceTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skinMedium~2.8–4.2%est.
Caprylic/capric triglycerideA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerinMedium~2.6–3.9%est.
Simmondsia chinensis seed oilSoftens the upper layer of skin and helps restore the healthy skin barrier. Has shown to help calm down inflammation in skin. It is a stable oil, meaning that it retains its properties even when exposed to air.Medium~0.85–1.25%est.
Vitis vinifera seed oilA great emollient that can also have anti-oxidant propertiesMedium~0.55–1.35%est.
Oenothera biennis oilHelps soften the upper layer of the skin and can support skin barrier functionMedium~0.55–1.25%est.
Narcissus tazetta bulb extractMight contain compounds called dormins that in theory could help lighten skin and reduce hyperpigmentation, but solid research is lackingMedium~0.4–0.9%est.
EthylhexylglycerinA preservativeMedium~0.1–0.4%est.
Caprylyl glycolHelps preserve products and creates a nice product textureMedium~0.1–0.45%est.
GluconolactoneA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicalsMedium~0.05–0.2%est.
Comedogenic
1 ingredient rated 2 or more on the 0–5 pore-clogging scale
1 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Butyrospermum parkii butterA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals3/5~0.6–1.4%est.
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Ingredients

Filter by role to see what each ingredient is doing.

Citrus limon juice~22–34%
Irritant · high
Pyrus malus juice~3.9–5.8%
Irritant · high
Irritation risk
High

Apple juice. Might help attract water to the skin. Can be irritating

More about Pyrus malus juice
Vitis vinifera juice~4.1–6.1%
Irritant · medium
Aloe barbadensis leaf juice~2.8–4.2%
Irritant · medium
Irritation risk
Medium
Works for
MoisturizingReduces irritationReduces rednessAntibacterialAnti-inflammatoryAnti-agingAnti-blemish

Traditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin

More about Aloe barbadensis leaf juice
Caprylic/capric triglyceride~2.6–3.9%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin

More about Caprylic/capric triglyceride
Helianthus annuus seed oil~2–3.1%
Key active
Irritation risk
Low
Works for
Moisturizing

A great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function

More about Helianthus annuus seed oil
Glyceryl stearate~1.7–2.6%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together

More about Glyceryl stearate
Stearyl alcohol~1.5–2.3%
Formula
Irritation risk
Low
Works for
Cleansing

An emollient that helps soften the skin

More about Stearyl alcohol
Cetyl alcohol~1.3–2%
Key active
Irritation risk
Low
Works for
CleansingMoisturizing

A non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together

More about Cetyl alcohol
Stearic acid~1.1–1.6%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

Helps oil and water mix together and works as an emollient

More about Stearic acid
Glycerin~0.85–1.3%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Glyceryl stearate citrate~0.85–1.3%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

Helps oil and water mix together while softening the upper layer of the skin

More about Glyceryl stearate citrate
Simmondsia chinensis seed oil~0.85–1.25%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

Softens the upper layer of skin and helps restore the healthy skin barrier. Has shown to help calm down inflammation in skin. It is a stable oil, meaning that it retains its properties even when exposed to air.

More about Simmondsia chinensis seed oil
Butyrospermum parkii butter~0.6–1.4%
Key activeComedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
MoisturizingAnti-oxidationAnti-aging

A great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals

More about Butyrospermum parkii butter
Vitis vinifera seed oil~0.55–1.35%
Key activeIrritant · medium
Irritation risk
Medium
Works for
MoisturizingAnti-oxidation

A great emollient that can also have anti-oxidant properties

More about Vitis vinifera seed oil
Squalane~0.55–1.35%
Key active
Irritation risk
Low
Works for
Moisturizing

An oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.

More about Squalane
Oenothera biennis oil~0.55–1.25%
Key activeIrritant · medium
Irritation risk
Medium
Works for
MoisturizingAnti-oxidationAnti-blemishAnti-inflammatory

Helps soften the upper layer of the skin and can support skin barrier function

More about Oenothera biennis oil
Tocopherol~0.45–1.05%
Formula
Irritation risk
Low
Works for
Anti-oxidationMoisturizingAnti-inflammatoryAnti-aging

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol
Capryloyl glycerin/sebacic acid copolymer~0.5–1.15%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps soften the upper layer of the skin

More about Capryloyl glycerin/sebacic acid copolymer
Narcissus tazetta bulb extract~0.4–0.9%
Irritant · medium
Irritation risk
Medium
Works for
Evens skin toneAnti-oxidation

Might contain compounds called dormins that in theory could help lighten skin and reduce hyperpigmentation, but solid research is lacking

More about Narcissus tazetta bulb extract
Citrus limon leaf cell extract~0.35–0.85%
Irritant · high
Malus domestica fruit cell culture extract~0.35–0.85%
Formula
Vitis vinifera fruit cell extract~0.35–0.75%
Formula
Palmitoyl tripeptide-5~0.2–0.7%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tripeptide-5
Panthenol~0.2–0.7%
Hero · Moisturizing
Irritation risk
Low
Works for
Reduces rednessMoisturizingReduces irritation

Helps attract water to the upper layer of the skin and can help improve skin barrier function

More about Panthenol
Allantoin~0.15–0.6%
Under-dosed
Irritation risk
Low
Works for
MoisturizingAnti-inflammatoryReduces irritationReduces rednessAnti-blemishExfoliation

Helps calm down inflammation in skin and can help reduce itching. Helps to repair the skin barrier and keep skin hydrated

More about Allantoin
Ascorbic acid~0.15–0.65%
Under-dosedIrritant · high
Irritation risk
High
Works for
Anti-oxidationEvens skin toneAnti-aging

The most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging

More about Ascorbic acid
Chamomilla recutita extract~0.15–0.7%
Irritant · high
Irritation risk
High
Works for
Anti-inflammatory

Plant extract that can have healing and anti-inflammatory properties. It is a potential allergen and can be irritating

More about Chamomilla recutita extract
Sodium hyaluronate~0.15–0.6%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate
Sodium pca~0.15–0.55%
Key active
Irritation risk
Low
Works for
Moisturizing

Naturally present in skin and helps to attract water to its upper layer

More about Sodium pca
Beta-glucan~0.15–0.5%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-inflammatoryReduces irritationAnti-agingAnti-blemishAnti-oxidation

Helps attract water to the upper layer of the skin, calm down inflammation and irritation, restore the barrier function and support wound healing. It can be helpful in reducing fine lines and wrinkles

More about Beta-glucan
Diheptyl succinate~0.15–0.7%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps to soften the upper layer of the skin and creates a nice product finish on the skin

More about Diheptyl succinate
Ethylhexylglycerin~0.1–0.4%
Irritant · medium
Irritation risk
Medium

A preservative

More about Ethylhexylglycerin
Sodium phytate~0.1–0.35%
Formula
Irritation risk
Low

Used to stabilize product formulations

More about Sodium phytate
Carbomer~0.1–0.35%
Formula
Irritation risk
Low
Works for
Cleansing

Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations

More about Carbomer
Caprylyl glycol~0.1–0.45%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol
Gluconolactone~0.05–0.2%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
MoisturizingAnti-agingEvens skin toneExfoliationAnti-blemishAnti-oxidation

A polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals

More about Gluconolactone
Cinnamomum camphora wood oil~0.05–0.2%
Irritant · high
Litsea cubeba fruit oil~0.05–0.1%
Irritant · high
Irritation risk
High
Works for
Antibacterial

An essential oil with a lemon-like smell that is extracted from a fruit grown in Asia. Used as a fragrance

More about Litsea cubeba fruit oil
Ingredient list view

Citrus limon juice, Pyrus malus juice, Vitis vinifera juice, Aloe barbadensis leaf juice, Caprylic/capric triglyceride, Helianthus annuus seed oil, Glyceryl stearate, Stearyl alcohol, Cetyl alcohol, Stearic acid, Glycerin, Glyceryl stearate citrate, Simmondsia chinensis seed oil, Butyrospermum parkii butter, Vitis vinifera seed oil, Squalane, Oenothera biennis oil, Tocopherol, Capryloyl glycerin/sebacic acid copolymer, Narcissus tazetta bulb extract, Citrus limon leaf cell extract, Malus domestica fruit cell culture extract, Vitis vinifera fruit cell extract, Palmitoyl tripeptide-5, Panthenol, Allantoin, Ascorbic acid, Chamomilla recutita extract, Sodium hyaluronate, Sodium pca, Beta-glucan, Diheptyl succinate, Ethylhexylglycerin, Sodium phytate, Carbomer, Caprylyl glycol, Gluconolactone, Cinnamomum camphora wood oil, Litsea cubeba fruit oil

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
Juice BeautySTEM CELLULAR Anti-Wrinkle Overnight CreamYOUR PRODUCTearthscureNano Peptide Moisturizer + Amino AcidsLendava ShopGood Night Face CreamAbibYesStyle Exclusive PDRN Volume Fill-it Booster Crème 2.5 Tube Mini 5pcs Bundle Set
Match—56%56%56%
Price$56.30$38.00−$18.30$98.00+$41.70$37.53−$18.77
Shared key ingredients—7 of 158 of 158 of 15
Key difference—Palmitoyl Tripeptide-1NiacinamideCopper Tripeptide-1
Irritancy High Medium Medium Medium
Drying alcohol————
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Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 32 studies and safety reviews.

  1. 1
  2. 2
  3. 3
  4. 4
  5. 5
  6. 6
    Vitamin E in dermatologyncbi.nlm.nih.gov
Juice Beauty STEM CELLULAR Anti-Wrinkle Overnight Cream
Juice BeautySTEM CELLULAR Anti-Wrinkle Overnight Cream

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As an Amazon Associate, WIMJ earns from qualifying purchases.